A strategic podcast where Amy Ledin talks about the main F’s that have influenced her life and have helped her in creating her best self. She covers areas in faith, family, forgiveness, food, fitness, and formula. She will deep dive into how placing her baby for adoption at 18, losing almost 100 pounds, facing her marriage-ending affair, and battling stage 4 cancer for almost 7 years, has only made her stronger. Join Amy as she takes you through her story, her life-changing struggles, and sh ...
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Updates on new data and best practices in the care of patients with cancer across a wide variety of solid tumors and hematologic malignancies from Clinical Care Options. Gain practical clinical insights and strategies and earn CME/CE credit for selected episodes.
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204 - Six Reasons You Should Rehearse Your Day
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Discover how a simple five-minute nightly routine can transform your day with reduced stress and heightened efficiency. Host Amy Ledin shares personal insights and actionable strategies for implementing this practice, emphasizing the benefits of detailed planning for daily tasks and nutrition. She explains how mentally rehearsing your day can help …
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Experiences With Oral SERDs for HR+/HER2- Metastatic Breast Cancer
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25:55
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In this episode, Manali Bhave, MD; Annalise Labatut, PharmD, BCOP; and nurse practitioner Jamie L. Carroll, CNP, APRN, MSN, begin by discussing the landmark EMERALD study that led to FDA approval of elacestrant, the first oral selective estrogen receptor degrader (SERD) for treatment of hormone receptor–positive/HER2-negative metastatic breast canc…
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Applying the Latest Evidence and NCCN Guideline Recommendations in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
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47:23
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In this episode, Danielle M. Brander, MD; Deborah Stephens, DO; and Brian Hill, MD, PhD, discuss key aspects of the NCCN CLL guidelines and share strategies for applying these recommendations in your clinical practice to optimize treatment and outcomes. The greater discussion addresses: Optimal selection of therapy for treatment-naive CLL, includin…
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Embark on a journey of understanding, solace, and resilience as we explore grief, faith, and the human spirit. Host Amy Ledin graciously welcomes Sarah Prebianca to the podcast. Together, they have unraveled Sarah's remarkable story—a testament to resilience in the face of unimaginable loss, her daughter Georgia taken by a rare disease. Through Sar…
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Forget about the generic "What I Eat in a Day" posts flooding your social media feeds. Amy Ledin breaks away from the norm, revealing the intricacies of her weekly meal plans, complete with recipes, grocery lists, and strategic advice. Amy delves into the significance of meal timings, managing portions, and embracing mindful eating, giving you a pe…
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201 - Managing Stress and Leveraging the Body's Energy for Healing With Isaac Ho
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59:08
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In this enlightening episode, Amy Ledin welcomes back Isaac Ho for a deep dive into understanding the intricate relationship between our emotions, physical health, and overall well-being. Isaac, with 20 years of experience as a trainer and therapist, shares his journey and insights into how our bodies respond to stress and the significance of tunin…
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200 - Overcoming Emotional Immaturity with Dr. Nicole LePera (The Holistic Psychologist)
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Host Amy Ledin delves into the transformative power of emotional maturity with Dr. Nicole LePera, the Holistic Psychologist. This insightful episode explores the impact of childhood experiences, the significance of self-care in managing triggers, the effectiveness of future self-journaling for rewiring habits, and the profound benefits of community…
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Homologous Recombination Repair (HRR) Testing and Targeted Therapy in Prostate Cancer
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In this episode, Colin C. Pritchard, MD, PhD, a pathologist, and Heather H. Cheng, MD, PhD, a medical oncologist, discuss optimal biomarker testing to guide treatment decisions in advanced prostate cancer, with topics including: Rationale for targeting PARP in prostate cancer with ARI combinations Study design nuances and findings from key randomiz…
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199 - The Slow Identity Killer and How to Fix That Today
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Explore the journey of self-recovery with Amy Ledin in 'The Slow Identity Killer,' where she tackles the challenges of losing one's sense of self through life's unpredictability's. She reveals her personal struggle through a season of upheaval, including a significant loss—leading to a disruption of routine and confidence. Discover Amy's raw insigh…
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198 - Proven Mindset to Transforming Fitness From Within With Jared Hamilton
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Challenge conventional wisdom on fat loss with a fresh perspective that prioritizes mental and emotional health as the foundation for physical change. This episode Amy discusses with Jared the critical role of addressing underlying issues like binge eating, emotional eating, and self-sabotage before embarking on a weight loss journey. Learn about t…
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Real-world Perspectives on Novel HER2-Targeted and TROP-2–Directed Therapies in Advanced Breast Cancer
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36:29
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In this podcast episode, Sara M. Tolaney, MD, MPH, and Melinda Telli, MD, delve into the critical aspects of the current therapeutic landscape for patients with unresectable or metastatic HER2-low, hormone receptor–positive, and triple-negative breast cancer, including: Challenges with the pathologic testing for HER2-low expression Optimal treatmen…
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197 - How To Keep Your Diet On Track Anywhere with Sara Frenza
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Learn how to navigate the challenges of staying healthy while traveling. Amy and Sara, both fitness coaches, discuss the nuances of traveling without compromising on their health goals. They cover practical advice on planning, restraint, and making informed choices. This episode is packed with real-world strategies for anyone looking to maintain th…
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196 - Plastic Surgery: I Got My Implants Put Back In
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20:23
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Amy revisits her journey with breast implants, sharing the unexpected turn of deciding to have them reinserted after previous removal due to concerns about breast implant illness. With raw honesty, she explores the intricate balance between physical appearance and mental health, offering a nuanced perspective on cosmetic surgery. This episode unpac…
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195 - How Emotional Energy Affects Your Health
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1:05:25
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Coach and Therapist, Isaac Ho shares the journey of uncovering the hidden links between past traumas and physical health issues. Through personal experiences and professional insights, this episode sheds light on how unresolved emotional pain can manifest in the body. It delves into the transformative power of holistic healing practices, emphasizin…
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Amy Ledin raises an intriguing question at the heart of today's discussion: 'What new habits are now a part of your daily life that weren't here before?' In this thought-provoking episode, Amy discusses the journey of evolving one's identity to foster a healthier, more fulfilling life. She shares insights into the psychological shifts necessary for…
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193 - New Season, New Chapter - Back in Canada
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Amy Ledin delves into the complexities of her family's significant move back to Canada, shedding light on the emotional and logistical challenges faced together. From tackling immigration hurdles to confronting the difficulties of reuniting their family across borders, Amy shares the story of their journey with honesty and vulnerability. This episo…
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Current Considerations for Adverse Event Management With HER3-Directed Agents
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The third and final episode in a 3-part series covers the safety profile of and considerations for managing adverse events associated with HER3-targeted antibody–drug conjugates, including patritumab deruxtecan (HER3-DXd) and others, in the setting of lung cancer. Presenters in this series include: Rebecca S. Heist, MD, MPH Associate Professor of M…
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Unpacking the Potential of HER3-Targeted Therapy in NSCLC
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This second episode in a 3-part series on HER3-targeted agents in NSCLC covers current clinical trials with HER3-targeted therapy, including: Recent data on patritumab deruxtecan (HER3-DXd) in the HERTHENA-Lung01 trial The EGFRxHER3 bispecific antibodies BL-B01D1 and izalontamab The HER2xHER3 bispecific antibody zenocutuzumab The HER3-targeted anti…
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Recent Advances in ADCs and Rationale for HER3 as a Target in Lung Cancer
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This first episode in a 3-part series tackles the role of HER3 in cancer, specifically in NSCLC, and how HER3 can be effectively targeted with ADCs. Presenters in this series include: Rebecca S. Heist, MD, MPH Associate Professor of Medicine Harvard Medical School Medical Oncology Massachusetts General Hospital Boston, Massachusetts Helena Yu, MD A…
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Expert Insight on Seminal New Clinical Trial Data Presented at the 2023 IGCS Conference Informing Treatment for Endometrial, Ovarian, and Cervical Cancers
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In this episode, Brian Slomovitz, MD, MS, FACOG, and Keiichi Fujiwara, MD, PhD, share their thoughts and opinions on seminal data presented at the 2023 IGCS annual meeting for endometrial, ovarian, and cervical cancers, including: Phase III NRG GY018 trial of carboplatin and paclitaxel with or without pembrolizumab followed by pembrolizumab or plac…
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Novel Emerging Investigational Treatment Strategies for Patients With Myelofibrosis
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19:33
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In this episode, Jacqueline S. Garcia, MD, discusses novel agents and strategies in clinical trial development for treating patients with myelofibrosis, including: Navitoclax (BCL-XL/BCL-2 inhibitor) Pelabresib (BET inhibitor) Imetelstat (telomerase inhibitor) Luspatercept (erythroid maturation agent) Additional strategies Presenter: Jacqueline S. …
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A Year in Review and a Look to the Future: BTKi in CLL and MCL
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27:33
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In this episode, Ana Marin-Niebla, MD, PhD, and Stephan Stilgenbauer, MD, discuss key trial data on the use of BTK inhibitors in CLL and MCL throughout the past year, how these studies have impacted their practice, and what data they are looking forward to in the near future. The discussion includes analyses of: SHINE: First-Line Ibrutinib + Bendam…
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Expert Insight on Key Updates and New Clinical Trial Data From the ESMO 2023 Congress Informing Treatment for Endometrial, Ovarian, and Cervical Cancers
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33:18
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In this episode, Isabelle Ray-Coquard, MD, PhD, and Ana Oaknin, MD, PhD, provide expert insights on new clinical trial data presented at the 2023 ESMO annual congress for endometrial, ovarian, and cervical cancers, including: Results from the double-blind, randomized, placebo-controlled phase III AtTEnd trial of atezolizumab plus carboplatin/paclit…
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Expert Insights and Considerations for Precision Care With HER3-Targeted Agents in NSCLC and Breast Cancer
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38:51
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In this episode, Aakash Desai, MD; Narjust Florez, MD; and Paolo Tarantino, MD, discuss the biologic rationale and clinical development of agents targeting HER3 for the treatment of breast and lung cancers. The potential niche for HER3-targeted agents in these treatment landscapes is considered, with consideration of acquired resistance to previous…
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Improving Care for Black Patients With Endometrial Cancer
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26:58
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In this episode, Dr Leslie Boyd and Adrienne Moore, a patient advocate and endometrial cancer survivor, discuss how healthcare professionals can partner with Black patients to improve the diagnosis and management of endometrial cancer (EC). Topics include: Data on racial disparities in EC survival Importance of listening to Black patients to better…
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Expert Insight on Key Updates and New Clinical Trial Data From the ESGO 2023 Congress Informing Treatment for Cervical, Ovarian, and Endometrial Cancers
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24:54
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In this episode, Domenica Lorusso, MD, PhD, and Alexandra Leary, MD, PhD, provide expert insights on key updates and new clinical trial data presented at the ESGO 2023 Congress for cervical, endometrial, and ovarian cancers, including: Long-Term Follow Up From Phase III SIENDO Study of Selinexor vs Pbo Maintenance in Patients With TP53wt Advanced/R…
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New Evidence With BTK Inhibitor Therapy in CLL and MCL From SOHO 2023
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20:58
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In this episode, Catherine C. Coombs, MD, MS, and Toby Eyre, MBChB, MD, discuss key trials presented at SOHO 2023 evaluating the use of BTK inhibitors in chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). The discussion includes analyses of: Matching-adjusted indirect comparison of 3 randomized phase III trials of ibrutinib for rela…
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New Evidence With BTK Inhibitor Therapy in MCL From ICML 2023
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14:39
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In this episode, Catherine C. Coombs, MD, and Toby Eyre, MBChB, MD, discuss key trials presented at ICML 2023 evaluating the use of BTK inhibitors in mantle cell lymphoma (MCL). The discussion includes analyses of: Phase II trial of acalabrutinib with rituximab for older patients with untreated MCL BRUIN: updated results of pirtobrutinib in covalen…
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New Evidence With BTK Inhibitor Therapy in CLL From EHA 2023
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27:03
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In this episode, Catherine C. Coombs, MD, MS, and Toby Eyre, MBChB, MD, discuss key trials presented at EHA 2023 evaluating the use of BTK inhibitors in chronic lymphocytic leukemia (CLL). The discussion includes analyses of: CLL12: final results of the phase III trial of ibrutinib vs placebo in asymptomatic, treatment-naive CLL SEQUOIA: extended f…
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192 - My Fitness Journey 20 Years Later: From Self-Hate to Self-Love & Sustainable Success
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32:17
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Join Amy in her inspiring fitness journey, starting from her childhood struggles with weight and body image. She recalls being put on diets as a young child and facing teasing due to her weight. Her mother's constant dieting influenced her own approach to weight management as she grew older. She went through various weight loss methods, including e…
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191 - Chapter 3: Life Update! We Are Moving! A Journey of Change and Blessings.
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Join Amy Ledin in this heartfelt episode of the F* It! podcast as she shares her family's journey of embracing change, finding a new home, and rediscovering her passion for the podcast. From navigating life's uncertainties to making intentional decisions, Amy's story is filled with blessings and exciting new ventures. Links for mentions in this epi…
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Expert Insight on Key Updates and New Clinical Trial Data From the 2023 ASCO Annual Meeting, Informing Treatment for Cervical, Ovarian, and Endometrial Cancers
46:02
46:02
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In this episode, Kathleen Moore, MD, MS, and Nicoletta Colombo, MD, PhD, provide expert insights on key updates and new clinical trial data presented at the 2023 ASCO Annual Meeting for cervical, endometrial, and ovarian cancers, including: ENGOT-EN6-NSGO/GOG-3031/RUBY: phase III study of dostarlimab plus chemotherapy followed by dostarlimab mainte…
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Listen in as Amy helps us understand the power of modeling and it's impact beyond yourself. Sign up here to do the 5 for 50 challenge with us! If you enjoyed this episode, make sure and give us a five star rating and leave us a review on iTunes, Podcast Addict, Podchaser and Castbox. Sign up for the next Follow-Through Challenge Follow me on Social…
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Expert Insight on New Data From SGO 2023 Informing Treatment for Endometrial, Cervical, and Ovarian Cancers
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31:38
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In this episode, David Scott Miller, MD, FACOG, FACS, and Linda Duska, MD, MPH, provide expert insights on practice-changing data and other new findings presented at SGO 2023 in endometrial, cervical, and ovarian cancers, including: NRG GY018: randomized phase III study evaluating standard of care of carboplatin plus paclitaxel with or without pemb…
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Listen in and learn about the power of the reticular activating system through personal stories and experiences, and discover how it can help you filter out what matters and find what's important to you. Sign up for the next Follow-Through Challenge Sign up here to do the 5 for 50 challenge with us! If you enjoyed this episode, make sure and give u…
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Practical Insights on Using BCMA-Targeted Therapies in Multiple Myeloma
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In this episode, Suzanne Lentzsch, MD, Ph.D., and Joseph Mikhael, MD, MEd, FRCPC, FACP, discuss the role of BCMA-targeted therapies in the management of patients with multiple myeloma, including their experiences and challenges with implementing recent data. This overview will include a discussion of: Considerations with administration, including a…
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Listen in as Amy let's us in on how she gets her wins for the next day! Sign up here to do the 5 for 50 challenge with us! If you enjoyed this episode, make sure and give us a five star rating and leave us a review on iTunes, Podcast Addict, Podchaser and Castbox. Sign up for the next Follow-Through Challenge Follow me on Social Media: Amy on IG Am…
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Contemporary Approaches to Treating Myelofibrosis: A Conversation Between Experts
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15:58
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In this episode, John Mascarenhas, MD, and Ruben A. Mesa, MD, FACP, discuss current best practices and emerging approaches for treating patients with myelofibrosis, including: Overall approach to treatment Use of JAK inhibitors for treating myelofibrosis Treating patients with low platelets Defining JAK inhibitor failure Unmet needs in treatment an…
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187 - Stress Tips| Closing The Loop | Commanding Your Brain | Managing Cortisol
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Today we have Amy's tips for dealing with stress, it's potential good and bad effects on us, and how stress manifests as we grow older. Based on her own personal experiences with battling cancer, losing weight and coaching people, she gives us her tips to manage stress no matter your age. Listen in for these nuggets to help us continue to become ou…
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BRCA Testing and Adjuvant Therapy in Early Breast Cancer: Experiences and Challenges
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In this episode, Banu Arun, MD; Allison Butts, PharmD, BCOP; and Marissa Marti-Smith, MSN, APRN, AGNP-C, AOCNP, discuss the role of BRCA testing and adjuvant olaparib in early breast cancer, including their experiences and challenges with implementing recent data. This overview will include discussion of: Data supporting the use of adjuvant PARP in…
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Let's listen in as Amy get's real with her loss and what she's doing afterwards. Losses are inevitable. It's what you do after that defines you! This latest episode is about how to overcome personal setbacks and challenges. Amy shares her personal story of breaking her 556-day activity streak, discussing how investing in long-going streaks can be a…
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Experts Discuss Claudin 18.2: A New Target for Precision Care of Gastric and Gastroesophageal Cancers
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In this podcast episode, Samuel Klempner, MD, and Gregory Botta, MD, PhD, provide expert commentary on the rationale and development of novel agents under investigation for targeting claudin 18.2 in gastric and gastroesophageal cancers, with topics including: Expression patterns and function of the claudin family of proteins in normal gastric tissu…
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185 - Life Stresses, navigating change, and Canada
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12:59
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Let's listen in as Amy shares with us the current stresses she's going through and how she and Erik are overcoming them. Use these tools in your life and share with us how they have helped you! Sign up here to do the 5 for 50 challenge with us! If you enjoyed this episode, make sure and give us a five star rating and leave us a review on iTunes, Po…
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184 - Sabotage and Making The Food Connection
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12:19
Listen in as Amy shares with us her mindset methods to battle self sabotage, and how to avoid it. Look inside yourself to find why you are doing this to you! Sign up here to do the 5 for 50 challenge with us! If you enjoyed this episode, make sure and give us a five star rating and leave us a review on iTunes, Podcast Addict, Podchaser and Castbox.…
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183 - Saturday Rant: Do not make this dieting mistake
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Saturday Rant: Do not make this dieting mistake Sign up here to do the 5 for 50 challenge with us! If you enjoyed this episode, make sure and give us a five star rating and leave us a review on iTunes, Podcast Addict, Podchaser and Castbox. Sign up for the next Follow-Through Challenge Follow me on Social Media: Amy on IG Amy on Facebook Check out …
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182 - Changing Your Identity: Controlling your RAS (reticular activating system)
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Listen in as Amy takes us through using our Reticular Activating System (RAS) to help us change our identity so we can become our best self! Sign up here to do the 5 for 50 challenge with us! If you enjoyed this episode, make sure and give us a five star rating and leave us a review on iTunes, Podcast Addict, Podchaser and Castbox. Sign up for the …
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Treatment Considerations for Patients With Essential Thrombocythemia: A Conversation Between Experts
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In this podcast episode, Prithviraj Bose, MD, and Andrew Kuykendall, MD, discuss their contemporary approaches to the treatment of patients with essential thrombocythemia. The topics covered include: When to use cytoreduction therapies and which therapies to use in low-risk patients Type 1 and type 2 CALR mutations and addressing patient concerns w…
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181 - Confidence & Change: Changing Your Identity With These 2 Tools
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Listen in on how Amy used enclothed cognition and anchoring to overcome her last bout with cancer, and by using these tools, we too can help us become our best selves! Sign up here to do the 5 for 50 challenge with us! If you enjoyed this episode, make sure and give us a five star rating and leave us a review on iTunes, Podcast Addict, Podchaser an…
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180 - Confidence & Change Creating A Best-Self Character
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Listen in as Amy gives us the tools to create our best self characters for every part of our lives! She also gives us an example of a Queen who uses this very method to overcome her fears to perform on the greatest of stages! Find out why we need to identify the following in order to create our best self characters: Who does your best self look lik…
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FAQs on the Use of Asparaginase Therapy in Young and Older Adults With Acute Lymphoblastic Leukemia
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26:12
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In this episode, Daniel J. DeAngelo, MD, PhD; Kjeld Schmiegelow, MD, DMSci; and Emily Curran, MD, answer key questions asked by the audience during a live satellite symposium at the 2022 American Society of Hematology Annual Meeting on optimizing pediatric or pediatric-inspired regimens containing asparaginase for the treatment of young and older a…
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