Best Ethan Weiss Podcasts (2024)

1
FDA History and Breast Cancer Drug Controversy | Dr. Mikkael Sekeres 1:05:01

4h ago1:05:01

1:05:01

Dr. Mikkael Sekeres is the author of the book The Drugs and FDA. He served as the chair of the Oncology Drugs Advisory Committee of the FDA, and was on the jury for the controversial trial of the breast cancer drug Avastin.We discuss:- The history of the FDA,- The trial of Avastin which got FDA approval in 2008 and revoked in 2011- FDA's funding me…

1
#27 Women's Reproductive Aging, Menopause, & Hormone Replacement Therapy | Dr. Jennifer Garrison 1:03:06

5M ago1:03:06

1:03:06

Dr. Jennifer Garrison is a an Assistant professor at the Buck Institute for research on aging where she studies women's reproductive aging. In today’s conversation we discussed menopause and it’s effect on women’s health, hormone replacement therapy, and how increasing the number of quality eggs a woman has at age 40 by just 1% can be a game change…

1
#26 Scaling Laws in Longevity & Aging | Dr. Geoffrey West, Author of book Scale 2:03:25

10M ago2:03:25

2:03:25

Dr. Geoffrey West is the author of the bestselling book Scale, the Universal Laws of Life Growth and Death in Organisms, cities and Companies. He is a physicist who got fascinated by the field of aging and longevity and asked the question of why we live as long as we do and no longer. In today's episode, we dive into his research on the scaling law…

1
#25 Caloric Restriction Deep-Dive & Longevity Secrets of Long-Lived Animals | Dr. Steven Austad 1:08:36

1+ y ago1:08:36

1:08:36

All platforms / Episode Transcript: https://livelongerworld.substack.com/p/saustad Dr. Steven Austad is a professor in the Healthy Aging department at the University of Alabama and also scientific director of the American Federation for Aging research. He has a fascinating entry into the world of aging research - it all began with training lions! T…

1
#24 Dr. Dominic D'Agostino | Modified Ketogenic Diet for Optimal Health & Exercise (Part 2) 1:09:41

2y ago1:09:41

1:09:41

All platforms / Episode Transcript & Timestamps: https://livelongerworld.substack.com/p/dom2 Dr. Dom D’Agostino may require no introduction especially in the world of ketosis! He is an Associate Professor with his research focusing on metabolic therapies, ketogenic diets, ketone supplements, and other metabolic based drugs. He is also a research sc…

1
#23 Dominic D'Agostino | Ketogenic Diet for Brain Health and Longevity (Part 1) 56:35

2y ago56:35

56:35

All platforms / Episode Transcript & Timestamps: https://livelongerworld.substack.com/p/dom1 Dr. Dom D’Agostino may require no introduction especially in the world of ketosis! He is an Associate Professor with his research focusing on metabolic therapies, ketogenic diets, ketone supplements, and other metabolic based drugs. He is also a research sc…

1
#22 The Cancer Diet Connection & Otto Warburg - Nobel Prize Scientist under Hitler | Sam Apple, Author of Ravenous 1:03:21

2y ago1:03:21

1:03:21

All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/sapple Sam Apple is the author of Ravenous: Otto Warburg, The Nazis, and the Search for the Cancer-Diet Connection. Otto Warburg was a Nobel-Prize winning German scientist during the era of Hitler and the Nazi’s and he was the first person to put the metabolic story of cance…

1
#21 Selenium's Dual Role in Health & Aging in the Womb | Dr. Vadim Gladyshev 1:00:16

2y ago1:00:16

1:00:16

All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev Dr. Vadim Gladyshev is a professor at Harvard Medical school and a Director of redox medicine at Brigham and Women’s hospital, where he runs his own lab. We had a brilliant discussion which started off by talking about his work on selenium. Selenium is found is Br…

1
#20 Cardiovascular Disease Risk Assessment & Ketogenic Diets for Heart Health | Dr. Ethan Weiss 1:11:50

2y ago1:11:50

1:11:50

Dr. Ethan Weiss is a cardiologist and his special interests include preventive cardiology, genetics of coronary disease, risk assessment, and heart disease in the young. In today’s conversation we spoke about misconceptions people have about heart disease, genetic factors involved in heart disease, how to understand cholesterol and triglycerides in…

1
#19 Michael Levin | Can Bioelectrical Signals Reverse Aging? 1:00:27

2y ago1:00:27

1:00:27

Dr. Michael Levin is an American developmental and synthetic biologist at Tufts University where he heads his own lab. He also directs the Tufts Center for Regenerative and Developmental Biology. His groundbreaking research focuses on bioelectrical signals that dictate the collective intelligence of cells and direct it to form tissues and organs. H…

1
#18 Longevity Supplements - Interventions Testing Program Results | Dr. Richard Miller 1:21:40

2y ago1:21:40

1:21:40

Dr. Richard Miller runs one of the labs for the Interventions Testing Program or the ITP, which is largely considered the gold standard for testing longevity drugs. This was one of the best conversations I’ve had on longevity supplements that affect lifespan and those that might me subject to mere hype. Dr. Miller is rigorous in his approach and st…

1
#17 Epigenetic Reprogramming, Yamanaka Factors, Cryonics & COVID Lab Leak | Yuri Deigin 1:02:51

2y ago1:02:51

1:02:51

Yuri Deigin is the founder and CEO of YouthBio Therapeutics which is a company that is working on Epigenetic reprogramming or using the Yamanka factors to achieve partial reprogramming. Epigenetic reprogramming has been in the news lately because of several companies being started in the space, with some notable ones being Altos Labs funded by Jeff…

1
#16 Cancer, Cellular Senescence & Senolytics | Dr. Peter Adams 1:09:30

2y ago1:09:30

1:09:30

Dr. Peter Adams, Professor at Sanford Burnham Prebys Medical Discovery Institute, is an expert in the biology of aging and cancer. The Peter Adams Lab is focused on the Epigenetics of Cancer & Aging and their goal is to contribute to development of epigenetic-based interventions that promote healthy aging and suppression of disease, including cance…

1
#15 Parkinson's Disease & Mitochondrial Dysfunction | Andy Lee, COO Vincere Biosciences 50:23

2y ago50:23

50:23

My guest today is Andy Lee who is the Chief Operating Officer at Vincere Biosciences. Vincere is working to stop Parkinson’s disease by creating small molecules or drugs that target mitochondrial dysfunction. There is increasing evidence that a dysfunctional mitochondria can lead to the onset of Parkinson’s disease. In today’s conversation, we disc…

1
#14 Dr. Bjorn Schumacher | DNA Damage & Aging, p53 & Cancer, and DNA repair in Reproductive Cells 55:48

2y ago55:48

55:48

My guest today is Dr. Bjorn Schumacher whose work focuses on the central role of DNA damage in the aging process. We discussed DNA damage accumulation with age, how DNA repair mechanisms play a role, how DNA damage in the reproductive cells can tell us a lot about aging, human fertility and reproductive capacity. We also discussed the role of p53 i…

1
#13 Dr. David Gems | Hyperfunction & Programmatic Theory of Aging and Critique of the Hallmarks of Aging 1:24:58

2y ago1:24:58

1:24:58

My guest today is Dr. David Gems who runs the C. Elegans Aging lab at the University College London. We had a fascinating discussion talking about emerging paradigms in the theories of aging. We discussed the hyperfunction theory or the programmatic theory of aging which gives a better integrated understanding of the different theories of aging tha…

1
#12 Dr. Bruce Ames | Longevity Micronutrients, Triage Theory, and Vitamin D for Healthy Aging 27:43

2y ago27:43

27:43

My guest today is Dr. Bruce Ames who has received several awards and accolades for developing the Ames test which is used to detect carcinogens in commercial products. He showed how there were carcinogens in products such as hair dyes and children’s pajamas! Later, Dr. Bruce Ames turned to studying micronutrients and how deficiency of important vit…

1
#11 Dr. Brian Kennedy | Aging Networks & Biomarkers, AKG, Spermidine and Longevity of Bats 58:26

2y ago58:26

58:26

My guest today is Dr. Brian Kennedy who is the Director for the Center of Healthy Aging at the National University of Singapore. He is also the former President and CEO of the Buck Institute of Research on Aging. Dr. Kennedy is well-known in the field of longevity & beyond and has been involved in critical aging research. Dr. Kennedy's lab is worki…

1
#10 Dr. Collin Ewald | Collagen Protein & Extracellular Matrix During Aging 1:02:15

2+ y ago1:02:15

1:02:15

My guest today is Dr. Collin Ewald who is a professor at the Health Sciences department at ETH Zurich. His lab focuses on understanding the extracellular matrix (ECM) and how it changes with age. Collin explains the role of the ECM in tissue repair, muscle strength, and overall longevity. In fact, Collin’s lab is also working on establishing the EC…

1
#09 Dr. Irina & Michael Conboy | Tissue Rejuvenation Via Plasma Dilution, Neutral Blood Exchange and Parabiosis 50:04

2+ y ago50:04

50:04

My guests in today's episode are Dr. Irina and Michael Conboy of the Department of Bioengineering at the University of California Berkeley. Their groundbreaking research focuses on tissue rejuvenation via plasma dilution and heterochronic parabiosis, where the Conboys took a young mouse and an older mouse and sutured them together, such that the an…

1
#08 Nir Barziali | Metformin, TAME Trial & Centenarian Longevity Research 1:01:51

2+ y ago1:01:51

1:01:51

Dr. Nir Barzilai is well-known in the field of longevity and beyond and is the director and chair of several institutes focused on Aging research. Just to name a few, he is the director of the Institute for Aging Research at the Albert Einstein College of Medicine and of the National Institutes of Health’s (NIH) Nathan Shock Centers of Excellence i…

1
#07 2021 Best of Live Longer World | Longevity Science 54:27

2+ y ago54:27

54:27

The final 2021 episode of the Live Longer World podcast is a rather special one. I've compiled some of the best & most informative parts of each of my previous episodes and highlighted them in this finale episode. Think of it as a tour showcasing some of the work being done in the field of longevity. Some topics included in the clips are Inflammagi…

1
#06 Morgan Levine | Epigenetic Clocks, SystemsAge Clock and Epigenetic Reprogramming 1:15:33

2+ y ago1:15:33

1:15:33

Dr. Morgan Levine is an Assistant Professor of Pathology and Epidemiology at the Yale School of Medicine. Morgan runs the lab for Aging in Living Systems at Yale. Her labs works on Epigenetic Clocks, Epigenetic reprogramming, cellular aging trajectories, and in trying to understand the causes of Alzheimer’s disease. I can’t even begin to tell you h…

1
#05 Matt Kaeberlein | Aging Interventions - Rapamycin, mTOR, CR, Sirtuins, NAD+ & Dog Aging Project 1:33:31

2+ y ago1:33:31

1:33:31

Dr. Matt Kaeberlein is a Professor of Pathology, Adjunct Professor of Genome Sciences, and Adjunct Professor of Oral Health Sciences at the University of Washington. His research interests are focused on basic mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. Matt has been ar…

1
#04 Dave Gobel, Founder & CEO of Methuselah Foundation | Longevity Funding, Regenerative Medicine & Longevity Escape Velocity 58:30

2+ y ago58:30

58:30

My guest today is David Gobel who is the co-founder & CEO of the Methuselah foundation. Methuselah foundation has donated several million dollars for the advancement of longevity research and regenerative medicine. Their goal is to make make 90 the New 50 by 2030. I’m definitely rooting for that! Dave was an entrepreneur before he decided to jump i…

1
#03 Carolina Oliveira, the founder & CEO of OneSkin Technologies | Skin Aging, OneSkin, and Building a Longevity Company 1:00:01

2+ y ago1:00:01

1:00:01

Carolina Reis Oliveira is the founder & CEO of OneSkin Technologies. OneSkin is pioneering technologies aimed at extending human healthspan. Their first product is a topical supplement designed to extend your skinspan by improving skin health and skin strength. Their proprietary peptide, OS-01, has been shown to rejuvenate your skin on a molecular …

1
#02 Dr. Jean Hebert | Brain Aging, Tissue Replacement, and Radical Strategy to Fight Aging (Potentially Forever!) 1:04:57

2+ y ago1:04:57

1:04:57

Jean M. Hébert, PhD, is a Professor of Neuroscience and Genetics at the Albert Einstein College of Medicine in New York. Dr. Hebert was fascinated from a young age by how a single cell forms the whole human body following an innate genetic program and he got excited by how knowledge of this process might be used to improve our biological fates and …

1
#01 Reason, the Founder & CEO of Repair Biotechnologies | How to Fight Aging, NAD+ Boosters, Senolytics & Curing Atherosclerosis 1:04:47

2+ y ago1:04:47

1:04:47

Reason is the founder and CEO of Repair Biotechnologies. Repair Biotechnologies is a biotech company focused on developing therapies that treat medical conditions arising due to accumulation of excessive cholesterol. They have developed a unique Cholesterol Degrading Platform to reverse the damage that leads to heart disease and atherosclerosis. Mo…

1
Introducing Live Longer World 1:21

2+ y ago1:21

1:21

"Can I really live to be 200? Can I feel like I’m 20 when I’m 70? Can aging be reversed? Hold up, what even is aging? Now I’m curious to know about aging and longevity science!" Well then, you're at the right spot! Hello and welcome to Live Longer World! The science of aging is moving rapidly and making progress at defeating age-related diseases an…

1
16 - Bobby Yeh: Know Your Denominator 1:15:09

4y ago1:15:09

1:15:09

Dr. Robert W. Yeh, Director of the Richard A. and Susan F. Smith Center for Outcomes Research in Cardiology at the Beth Israel Deaconess Medical Center, joins Best Known Method to speak with host Ethan J. Weiss about his research career, the importance of 'knowing your denominator', and his criticism of modern health policy. This episode is sponsor…

1
15 - Jesse Horwitz: The Direct Success 55:59

4y ago55:59

55:59

Jesse Horwitz, co-founder of e-commerce contact lens company Hubble Contacts joins Best Known Method to speak with host Ethan J. Weiss about direct-to-consumer brands, social media marketing, and his path from film school to the world's biggest hedge fund. This episode is sponsored by Key Eats. Visit www.keyeats.com/bkm for a free sample pack of 3 …

1
14 - Nicola Guess: Diet Without Dogma 1:19:20

4y ago1:19:20

1:19:20

Dr. Nicola Guess, Head of the Nutrition Unit at Dasman Diabetes Institute (DDI) in Kuwait, joins Best Known Method to speak with host Ethan J. Weiss about her career path, using low-carb diets to combat disease, and nutritional epidemiology. This episode is sponsored by Key Eats. Visit http://www.keyeats.com/bkm for a free sample pack of 3 Key Eats…

1
13 - Margaret Johnson: Truth in Advertising 53:24

4y ago53:24

53:24

Margaret Johnson, Chief Creative Officer at Goodby Silverstein & Partners, joins Best Known Method to speak with host Ethan J. Weiss about why becoming a mother "...was the best thing that ever happened..." to her career, the philosophy of 'mass intimacy', and her view on Influencer Marketing. This episode is sponsored by Key Eats. Visit www.keyeat…

1
12 - Ann Miura-Ko: When One Door Closes, Another Opens 1:05:56

4y ago1:05:56

1:05:56

Ann Miura-Ko, co-founding partner at Floodgate, joins Best Known Method to speak with host Ethan J. Weiss about her remarkable path to venture capital, her belief that closing doors creates opportunities, and her investing philosophy. This episode is sponsored by Key Eats. Visit www.keyeats.com/bkm for a free sample pack of 3 Key Eats bars, shippin…

1
11 - Kevin Hall: Modelling an Opportunity 1:14:41

4y ago1:14:41

1:14:41

Dr. Kevin Hall, Senior Investigator at the National Institute of Diabetes & Digestive & Kidney Diseases joins Best Known Method to speak with host Ethan J. Weiss about designing mathematical models of various diseases, and how he jumped on the unexpected opportunity to test those models through a clinical trial. This episode is sponsored by Key Eat…

1
10 - David Ludwig: The Carbohydrate Crisis 56:14

4y ago56:14

56:14

Dr. David Ludwig, co-director of the New Balance Foundation Obesity Prevention Center, joins Best Known Method to speak with host Ethan J. Weiss about his groundbreaking research on the role of sugar and carbohydrates in metabolic disease, the obesity epidemic, his perspective on nutritional research methods, and best practices for a healthy diet.…

1
09 - Emily Oster: The Data-Driven Parent 1:08:57

4y ago1:08:57

1:08:57

Emily Oster, Professor of Economics at Brown University and bestselling author, joins Best Known Method to speak with host Ethan J. Weiss about her most recent book, "Cribsheet, A Data-Driven Guide to Better, More Relaxed Parenting, from Birth to Preschool", her best known method for parenting, and her thoughts on the nature of evidence in the inte…

1
08 - Sek Kathiresan: The Inherited Mission 1:18:40

4+ y ago1:18:40

1:18:40

Dr. Sek Kathiresan, CEO of Verve Therapeutics, joins Best Known Method to speak with host Ethan J. Weiss about his experiments to map the areas of our genome that are associated with different levels of blood cholesterol, the genetic basis underlying risk of heart attack, and his decision to step away from his roles as Director of the Center for Ge…

1
07 - Lisa Rosenbaum: Writing From The Heart 1:22:07

4+ y ago1:22:07

1:22:07

Dr. Lisa Rosenbaum, cardiologist on the faculty of Harvard Medical School and the Brigham and Women's hospital, and National Correspondent for New England Journal of Medicine, joins Best Known Method to speak with host Ethan J. Weiss about her storied career, split between the roles of physician and writer.…

1
06 - Rob Lustig: The Unsweetened Truth 1:27:32

5y ago1:27:32

1:27:32

Dr. Robert Lustig, Professor of Pediatrics in the Division of Endocrinology at UCSF and author, joins the Best Known Method to speak with host Ethan J. Weiss about how he shifted his research focus from the sex differentiation of the brain, to how the brain controls eating. Through this work, Rob became an outspoken researcher and activist on the o…

1
05 - Roger McNamee: The Whistleblowing Technologist 1:25:04

5y ago1:25:04

1:25:04

Roger McNamee, philanthropist, investor, venture capitalist and musician, joins the Best Known Method to speak with host Ethan J. Weiss about his great success as an early investor in tech startups such as Facebook and Yelp, and what led to him writing Zucked: The Education of an Unlikely Activist, a book warning about the dangers consumers face fr…

1
04 - Jessica Mega: The Data Doctor 1:00:45

5y ago1:00:45

1:00:45

Jessica Mega, Chief Medical and Scientific Officer at Verily, joins the Best Known Method to speak with host Ethan J. Weiss about the influence of the Yale system on her leadership ethos, a career switch from Harvard to Google, and how she approaches medical research as part of the world's largest search engine.…

1
03 - Eric Topol: The Optimistic Futurist 57:42

5y ago57:42

57:42

Dr. Eric Jeffrey Topol, cardiologist, geneticist, digital medicine researcher, author, and the Founder and Director of the Scripps Research Translational Institute, joins Best Known Method to speak with host Ethan J. Weiss about his innovative career, and the promise he sees in artificial intelligence and other emerging technologies to make medicin…

1
02 - Ron Krauss: The Pattern Guy 1:01:10

5y ago1:01:10

1:01:10

Dr. Ron Krauss, Senior Scientist and Director of Atherosclerosis Research at Children's Hospital Oakland Research Institute, joins the Best Known Method to speak with host Ethan J. Weiss about his life-long interest in cardiovascular disease, writing and subsequently re-writing the nutrition guidelines for the American Heart Association, and the re…

1
01 - Sid Mukherjee: The Napkin Moment 1:00:18

5y ago1:00:18

1:00:18

Dr. Sid Mukherjee, Indian-American physician, biologist, oncologist, and best-selling author, joins the Best Known Method to speak with host Ethan J. Weiss about his journey to studying at Stanford, Oxford and Harvard, becoming one of the great physician-writers of this time, and his recent research into the effect of the ketogenic diet on cancer.…

1
Trailer 1:53

5y ago1:53

1:53

Best Known Method is a podcast where host Ethan J. Weiss asks some of the most successful people how they approach making life’s most important decisions - all with less than perfect information to guide them. Produced by: Noah Sniderman voicemagic.caBy Key Eats

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