Best Society of Infectious Diseases Pharmacists Podcasts (2024)

1
#104 – Dosing Consult: Rifampin Part 1 38:50

1d ago38:50

38:50

In this episode of Breakpoints’ Dosing Consult series, Drs. Chuck Peloquin and Gerry Davies join Dr. Megan Klatt to discuss rifampin dosing for mycobacterial infections. Hear from the experts on if higher doses are really better, toxicity thresholds, and the role of alternative rifamycins for patients with MTB and NTMs. Learn more about the Society…

1
Heteroresistance: Mechanisms, Diagnosis and Clinical Implications 42:54

22d ago42:54

42:54

Heteroresistance is a phenomenon that has been well characterized for many years. However, we are only now starting to understand its mechanistic basis. Indeed, the manner how bacteria respond to antibiotics is complex and phenomena such as persistance, tolerance may be overlapping with heteroresistance. Furthermore, heteroresistance seems to be co…

1
#103 – Dosing Consult: Daptomycin 46:09

29d ago46:09

46:09

Drs. Jim Rhodes and Molly Steed join host Jeannette Bouchard to discuss all things related to optimal dosing of daptomycin. This podcast episode provides insight on why dosing matters with this antibiotic, especially with certain organisms (looking at you, E. faecium), why weight matters with dosing, and what that pesky CPK means. Listen to Breakpo…

1
#102 – Oh, the Places Stewardship Will Go! Best Practices for Outpatient Antibiotic Stewardship and Transitions of Care 1:10:10

1M ago1:10:10

1:10:10

In this episode, Drs. Erica Stohs, Ryan Stevens, and Jame McCrae join Dr. Megan Klatt to discuss antimicrobial stewardship practices at transitions of care and in the outpatient setting. Hear from the experts on how to establish programs in this space, best practices for data/reporting, and other tips for stewardship intervention. Follow us on Inst…

1
Microbiology in the Headlines: H5N1 in Dairy Cattle, The Plague, Measles, Neosporin and more! 28:37

2M ago28:37

28:37

Join Dr. Ben Pinsky and Dr. Greg Berry as they dissect recent news stories, including the USDA's testing for H5N1 in ground beef and a surprising bubonic plague case in Oregon. They also tackle the resurgence of measles in the U.S., the local reappearance of malaria, and a curious study on Neosporin's potential to prevent viral infections. Overview…

1
#101 – BLING III: Does Continuous Infusion Make the Whole Place Shimmer 1:01:46

2M ago1:01:46

1:01:46

Join Prof Jason Roberts and Dr. Erin McCreary for this episode dedicated to discussing the results of the BLING III trial, which explored the use of continuous versus intermittent infusion of a beta-lactam antibiotic in critically ill patients. Reference:Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis…

1
The Global Preclinical Antibacterial Pipeline 38:20

2M ago38:20

38:20

The pipeline of antibiotic discovery is a major necessity due to the continuous evolution of resistance to currently used antimicrobials. This pipeline faces important challenges due to the lack of investment on antimicrobial research in the private sector and an economic model that discourages investment. In the last few years, however, encouragin…

1
#100 – Tackling Tetracyclines: Breakpoints 100th Episode! 1:24:06

2M ago1:24:06

1:24:06

Drs. Jeffrey Pearson and Jason Pogue join Dr. Jeannette Bouchard as they take on all things tetracyclines. Starting with tetracycline, they walk through differences between each generation and drug in this class, from dosing all the way to pertinent resistance mechanisms. You will not want to miss out on this one! This podcast was supported by an u…

1
Turning the Output of the Microbiology Laboratory Into Gold 42:07

3M ago42:07

42:07

The European alchemists of the 12th century sought to find the philosopher’s stone, a substance that would transmute base metals, such as lead, into precious metals, such as silver and gold. Today, we discuss whether data analysis, including machine learning, can transmute base laboratory data into precious clinical tools. We will use antimicrobial…

1
#99 – Don’t be CRABby: Acinetobacter baumannii review 1:08:08

3M ago1:08:08

1:08:08

Drs. Yohei Doi and Emily Heil join Dr. Erin McCreary to dive into one of the most requested topics from our listeners and something that is consistently confusing in clinical practice: Acinetobacter baumannii! Hear from experts on their experience with treating this tricky organism and their thoughts on best approaches when you are presented with C…

1
Training in Antimicrobial Resistance: Gaps and Opportunities 40:31

4M ago40:31

40:31

Antimicrobial resistance is a priority public health problem with complex roots and connotations. However, due to a lack of focus on this topic, research training programs, specifically those focused on AMR are limited. Additionally, scientific meetings that particularly highlight the science of antimicrobial resistance are scarce. We recently publ…

1
#98 – Uncomplicated UTIs: Getting Uncomfortable with Uncertainty 1:13:14

4M ago1:13:14

1:13:14

Drs. Chris Crnich, Angela Huttner, and Jeannette Bouchard join Dr. Erin McCreary to discuss all things uncomplicated UTIs! Gain insight into where our new guidelines may be headed and pearls from experts in a variety of clinical settings, including a clinic specifically devoted to UTIs! Funding for this podcast was supported by an independent medic…

1
#97 – Hot Topics: What Did You Miss in Infectious Diseases in 2023-2024 (LIVE from MAD-ID) 1:26:38

5M ago1:26:38

1:26:38

In this special LIVE podcast episode, Drs. Emily Heil (@emilyheil) and Mandee Noval (@MandeeNoval) present the latest and greatest in ID literature from MAD-ID 2024 (@MAD_ID_ASP) in Orlando, FL. They cover everything from ECCMID late breakers to stewardship to the best things to come out of a good old shortage! You won’t want to miss this one! Goog…

1
10 Years of Rhodococcus: Clinical Trends and Susceptibility Profiles 37:38

6M ago37:38

37:38

Rhodococcus infections are uncommon, however they can cause serious disease in certain patients. There are a number of challenges though when dealing with Rhodococcus infections, including the fact that much of what we know around their susceptibility profiles and the clinical management of infected individuals actually comes from a number case ser…

1
#96 – The Tortured Stewards & Surgeons Department 1:06:21

6M ago1:06:21

1:06:21

Episode Notes The Society of Infectious Diseases Pharmacists is excited to invite you to the first ever meeting (via Breakpoints) of The Tortured Stewards & Surgeons Department. Today’s agenda items: optimal management of perioperative antibiotics and prevention of surgical site infections. Drs. Trisha Peel (@DrTrishaPeel), Michael Calderwood (@Cal…

1
Why Phage Therapy May Fail 37:32

6M ago37:32

37:32

Phage therapy has gained a lot of traction but the challenges created by this approach have not been properly assessed at a big scale. We often read about therapy successes on isolated cases but, rarely, we read or hear about failures. AAC recently published a case series of patients who failed phage therapy. Today, we will discuss this topic with …

1
#95 – A to Z on R&D: Challenges and Solutions for Sustained Antimicrobial Drug Development 1:02:16

6M ago1:02:16

1:02:16

In this episode, Drs. Helen Boucher (@hboucher3), Ramy Elshaboury, and Mike Dudley (@MikeMNDudley) join host, Megan Klatt (@MeganKlatt3), to discuss barriers to antimicrobial drug development, potential incentives and legislation to promote market growth, and what we can do to ensure the antimicrobial pipeline doesn’t run dry. Learn more about the …

1
#94 – Lock, Stock, & Sterilize: Strategies to Optimize Antimicrobial Lock Therapy & Prevent/Treat Catheter-Related Bloodstream Infections 1:05:25

7M ago1:05:25

1:05:25

It's time to arm yourselves with all the resources on antimicrobial locks! Join our experts, Drs. Louise-Marie Oleksiuk (@CanRowPharm), Nasia Safdar (@NasiaSafdar), Joel Topf (@kidney_boy), and our wonderful host, Dr. Julie Justo (@julie_justo), to discuss the ins and outs of antimicrobial locks and how to implement them! Funding for this podcast w…

1
Is Lophomonas a Pathogen? 34:33

7M ago34:33

34:33

The protozoan Lophomonas has been reported to be a pathogen of humans in a large number of case reports and case series. Most of these case reports describe infections of the respiratory tract. Editors in Conversation is joined by two experts to discuss this possible parasite. Some of the questions addressed include: What are the characteristics of…

1
#93 – Global, Live Journal Club: Ceftobiprole for Complicated Staphylococcus aureus Bacteremia (ERADICATE Study) 58:22

8M ago58:22

58:22

Drs. Thomas Holland and Vance Fowler (@VanceFowler5) join Drs. Steven Tong (@syctong) and Erin McCreary (@ErinMcCreary) to discuss the ERADICATE study and the role of ceftobiprole for the treatment of complicated Staphylococcus aureus bacteremia. This session was recorded live on Tuesday, February 6th, 2024 featuring an international audience. List…

1
Treatment of Multidrug-resistant Tuberculosis 40:17

8M ago40:17

40:17

Tuberculosis is one of the most deadly infectious diseases that still causes significant burden of disease, particularly in the developing world. The emergence of resistance to first line agents severely limits the therapeutic options and threaten the ability to control dissemination of this disease. Fortunately, new drugs and regimens are now emer…

1
#92 – Antibiotic Alchemy: Metallo-Beta-Lactamases 1:10:30

8M ago1:10:30

1:10:30

Drs. Robert Bonomo, Ryan Shields (@ryankshields), and Erin McCreary (@ErinMcCreary) deep dive into the world of metallo-beta-lactamases. This riveting discussion is full of the nerdiest pub trivia nuggets and the “must know” details of novel beta lactams and beta-lactamase inhibitors, and their uses for MBLs. Funding for this podcast was provided b…

1
#91 – Teamwork Makes the Dream Work: Preparation Pearls for Stewardship and Microbiology Lab Accreditation Updates 1:06:21

9M ago1:06:21

1:06:21

New accreditation standards making your head spin? Are you stressed and don’t know where to start? Well, on this episode of Breakpoints Drs. Arjun Srinivasan and Jose Alexander (Alex) join Luis Plaza from Let’s Talk Micro (@letstalkmicro1) and Dr. Jeannette Bouchard (@jlbouchard001) to breakdown what you need to know and where to start when it come…

1
New generation B-lactam/B-lactamase inhibitors: Taniborbactam 47:47

9M ago47:47

47:47

A new generation of B-lactamase inhibitors is likely to reach the market in the upcoming year. These broad-spectrum inhibitors exhibit activity against the most feared class B metallo-B-lactamases maintaining the inhibition of other enzymes. Recently AAC has published three papers that describe the mechanistic bases of taniborbactam resistance amon…

1
#90 – IDWeek 2023 Recap: Pipeline Agents and Clinical Trials That May Change Your Practice 1:02:36

9M ago1:02:36

1:02:36

We are back with more exciting IDWeek 2023 content! If you listened to the last episode and want more? Than look no further. Join your Breakpoints hosts, Drs. Erin McCreary (@ErinMcCreary), Julie Ann Justo (@julie_justo), and Jeannette Bouchard (@jlbouchard001) for a review of key pipeline agents at IDWeek and highlights from everyone’s favorite se…

1
Favorite Clinical Microbiology Papers of 2023 (JCM ed.) 1:05:16

10M ago1:05:16

1:05:16

We managed to make it through 2023 without a major epidemic or pandemic, and as we get into the holiday spirit and look forward to the new year, some of us took a look back and picked out one of our favorite JCM paper published in 2023, which I will tell you, was no easy task as there were many of good ones to choose from! And personally, after loo…

1
#89 – IDWeek 2023 Recap: Late Breaking Clinical Trials 1:14:35

10M ago1:14:35

1:14:35

Need help narrowing down your IDWeek re-watch content? Or maybe you were unable to make IDWeek so you want the pharmacy driven highlights? Well, look no further, Breakpoints has what you need! Join your Breakpoints hosts, Drs. Erin McCreary (@ErinMcCreary), Julie Ann Justo (@julie_justo), and Jeannette Bouchard (@jlbouchard001) for a review of some…

1
Antimicrobial Resistance in Neisseria Gonorrhoeae (JCM ed.) 28:14

10M ago28:14

28:14

Gonorrhea remains one of the more common sexually transmitted infections. In North America, the number of reported cases has generally risen for over ten years, with interruptions in the early days of the COVID-19 pandemic, followed by returns to rising rates of infection. Under the selective pressure of antimicrobial treatment, antimicrobial resis…

1
#88 – Dosing Consult: Can we BID farewell to Q8H Metronidazole? 32:04

10M ago32:04

32:04

Drs. Nicholas Torney (@NPT_PharmD) and Sunish Shah join Dr. Jeannette Bouchard (@jlbouchard001) to discuss our next topic in our Dosing Consult series: BID vs TID dosing for metronidazole. Deep dive into the PK/PD and real-world application of this switch with experts in this dosing strategy. References: Addition of anaerobic coverage in biliary in…

1
#87 – We Love T Cells: Updates in Cytomegalovirus 1:20:41

11M ago1:20:41

1:20:41

Dr. Ajit Limaye and Dr. Camille Kotton (@KottonNelson) join Dr. Erin McCreary (@ErinMcCreary) to discuss fascinating updates in the CMV space including new RCTs for prevention, vaccines, and more! Learn why a little "hair of the dog" might be a good thing, how great T cells are, and the trials we still need. References: CAPSIL study: Effect of Pree…

1
New Antifungals (AAC ed.) 45:49

11M ago45:49

45:49

In the last few years we have witnessed the rise of very resistant fungal species some of them likely influenced by environmental conditions and climate change. Fortunately, there has been a bit of an explosion in the development of new antifungals and the pipeline has been strengthened in the last decade. We will have the ability to have new molec…

1
A Novel Coccidioides Antibody LFA (JCM ed.) 44:00

12M ago44:00

44:00

Despite the many advances in diagnostic testing for infectious diseases, detection of Coccidoides infections continues to rely on serologic assessment for anti-fungal antibodies, and what is perhaps more astonishing is that the serologic methods we use today, such as complement fixation and immunodiffusion, were first developed about a century ago.…

1
#86 – The Robin to Your Batman: Ensuring Adequate Beta-lactamase Inhibitor Exposure to Restore Beta-lactam Activity 1:19:32

12M ago1:19:32

1:19:32

Episode Notes Drs. Paul Ambrose and Michael Dudley (@MikeMndudley) join Dr. Julie Ann Justo (@julie_justo) for a review of beta-lactamase inhibitor (BLI) pharmacokinetics & pharmacodynamics. They discuss factors affecting BLI’s restorative activity, the convoluted math behind establishing exposure-response relationships for BLIs, some geeky medicin…

1
Climate Change and Antimicrobial Resistance (AAC ed.) 29:26

12M ago29:26

29:26

Climate change is possibly the major threat that planet earth is experiencing in this century with potential catastrophic consequences. As the planet warms, the change in weather patterns is affecting the microbial ecology in such a manner that humans are facing new health threats including emerging diseases and facing species of organisms that are…

1
Emerging Antifungal-Resistant Dermatophytes (JCM ed.) 29:26

1y ago29:26

29:26

Fungi that are resistant to antifungal drugs have been very much in the news and even the subject of the hugely popular television program, The Last of Us. We talk with two experts in mycology and fungal susceptibility testing about the recent descriptions of terbinafine-resistant dermatophytes in the United States. Some of the questions we will ad…

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