show episodes
 
Upstream is where host Erik Torenberg goes deeper with the world's most interesting thinkers to map the constellation of ideas that matter across tech, culture, and politics. On this season of Upstream, you'll hear from Marc Andreessen, David Sacks, Balaji Srinivasan, Sam Harris, Joe Lonsdale, Katherine Boyle, and more. Upstream is part of the Turpentine podcast network. To learn more: turpentine.co
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Acquired

Ben Gilbert and David Rosenthal

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Every company has a story. Learn the playbooks that built the world’s greatest companies — and how you can apply them as a founder, operator, or investor.
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Iain Lee (11 O’Clock Show, I'm A Celebrity Get Me Out Of Here, talkRADIO) and award winning journalist and producer Katherine Boyle (BBC Radio, talkRADIO) bring you a proper phone-in minus the pearl clutching topics. Their unique blend of silliness, wonder and mental health support has garnered the pair a loyal cult following. Join the gang at www.radioanywhere.live, call the show live on 0203 286 6370, or Skype TLNA to leave a message out of hours. Hosted on Acast. See acast.com/privacy for ...
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Raising Health

Andreessen Horowitz

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A myriad of AI, science, and technology experts explore the real challenges and enormous opportunities facing entrepreneurs who are building the future of health. Raising Health, a podcast by a16z Bio + Health and hosted by Kris Tatiossian and Olivia Webb, dives deep into the heart of biotechnology and healthcare innovation. Join veteran company builders, operators, and investors Vijay Pande, Julie Yoo, Vineeta Agarwala, and Jorge Conde, along with distinguished guests like Mark Cuban, Greg ...
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Paradox Podcast

Kyle Tibbitts

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Join 35,000+ listeners for commute-length conversations with original thinkers who will push your perspective and pull you into the marketplace of ideas. _______________________________________ "Paradox Podcast is citizen journalism at its best. Long-form discussions of important ideas, freely available to all." — Balaji Srinivasan, Angel Investor & Entrepreneur "Had fun talking with Kyle on the Paradox Podcast. We hit a variety of topics we both care about while still diving into substance. ...
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An inside look at law enforcement through a civilian’s interviews. These are stories of police told by officers themselves. They talk frankly about what it’s like to be a cop in these tough times, what drew them to the job, and what the people they serve don’t know about the challenges of their work. It’s a view from the front lines and some very personal and emotional stories, especially about why each of these officers chose to serve. I draw on my 14 years of interviewing, filming and phot ...
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N. E. Thing Funny

Peff Soulsby & Kate Murphy

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Everything to do with North East comedy, all in one place. You'll find news, reviews, interviews, and in-depth discussion on this brand new weekly radio show. Broadcasting live on Spark Sunderland every Monday 10am
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Welcome to "Nick Needs to Know”. Unfiltered conversations on life and success with your host, Nick. Get ready for some raw and honest discussions as Nick brings on guests from all walks of life to spill the beans on their career journeys, the hurdles they faced, and the invaluable lessons they learned along the way. These down-to-earth conversations are filled with real-world experiences that provide listeners with an authentic and relatable perspective on different career paths. Join us for ...
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show series
 
This week on Upstream, Erik is joined by David Friedman for a deep dive on anarcho-capitalism, utilitarianism, and more. To get Brave: Head to https://brave.com/brave-ads/ and mention “MoZ” when signing up for a 25% discount on your first campaign. -- RECOMMENDED PODCAST: Autopilot explores the adoption and rollout of AI in the industries that driv…
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As any healthcare founder knows, it can be difficult to get into a room with the executives making purchase decisions for payors and providers—so we’re bringing the executives to you. This episode features interviews with payor and provider leaders about what they’re seeing and how they’re thinking about AI. Guided by Julie Yoo, general partner, an…
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John Wayne Gacy raped, tortured, and murdered 33 boys and young men, burying most of them in the crawlspace under his Chicago home. Karen Conti was in high school at the time watching the bodies being removed on the television news. Fourteen years pass. Through a twist of fate, Conti, now a young and inexperienced attorney, is called upon to handle…
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In this special roundtable episode, Erik Torenberg is joined by Brad Hargreaves (the founder of Common, co-founder of General Assembly, and writer of Thesis Driven) and Noah Smith (podcast host, economist and writer of Noahpinion). They discuss the future of real estate and housing in America, the impact of regulations, and the potential of new cit…
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"There is a revolution unfolding in biotech. The confluence of new biological methods like CRISPR, virtually unlimited computational capacity, and machine learning has fundamentally transformed our ability to engineer biology for wide-ranging applications." Vijay Pande, founding general partner at a16z Bio + Health, joins the Software Engineering D…
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Sandra Bridewell was a beguiling Dallas socialite in the seventies and early eighties. Her first husband was a prominent dentist who was found shot to death in their home in 1975. The medical examiner ruled his death a suicide. Her second husband, Robert Bridewell, developed the Mansion on Turtle Creek—the first property of Rosewood Hotels and Reso…
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Renaissance Technologies is the best performing investment firm of all time. And yet no one at RenTec would consider themselves an “investor”, at least in any traditional sense of the word. It’d rather be more accurate to call them scientists — scientists who’ve discovered a system of math, computers and artificial intelligence that has evolved int…
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This week on Upstream, Erik is joined by Alex Blania, who, with Sam Altman, co-founded Tools for Humanity, the organizarion behind Worldcoin. Erik and Alex go deep on Worldcoin, AGI, and other future tech. To get Brave: Head to https://brave.com/brave-ads/ and mention “MoZ” when signing up for a 25% discount on your first campaign. -- RECOMMENDED P…
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Rosana Kapeller, CEO of Rome Therapeutics, and Marty Taylor, physician-scientist at Harvard Medical School, join Vineeta Agarwala, general partner, and Bryan Faust, investment partner at a16z Bio + Health. Together, they discuss Rosana and Marty's recent publication regarding a virus-like element in our genome known as LINE-1. LINE-1, part of our "…
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From historical accounts to modern cases, explore the captivating psychology behind these killer women, unraveling their motives and unveiling the dark complexities of human behavior.The fair sex. We’ve often heard this clichéd expression being used to refer to women. Although it has become increasingly outdated, the mindset still exists that women…
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This week on Upstream, Erik is joined by Igor Kurganov, poker player and founder of Raising for Effective Giving. They discuss similarities between poker and Effective Altruism, the successes and failures of EA, and where EA should go next. To get Brave: Head to https://brave.com/brave-ads/ and mention “MoZ” when signing up for a 25% discount on yo…
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Vijay Pande, founding partner of a16z Bio + Health, dives deep with a16z Podcast host Steph Smith into the potential of DNA as a data storage mechanism. This episode, a cross-post with the a16z Podcast, draws parallels between Moore's Law and the race for "Moore's Law for DNA." Vijay discusses the density, longevity, and ubiquity of DNA, and how th…
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At daybreak on January 6, 1986, a couple on a camping trip in the Mojave Desert set out for a stroll and never returned. The local sheriff’s office eventually discovered that Barry and Louise Berman had been murdered. As years passed and the double homicide remained unsolved, the Berman case spawned speculation and conjecture. Despite extensive inv…
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This week on Upstream, Erik is joined by Liron Shapira to discuss the case against further AI development, why Effective Altruism doesn’t deserve its reputation, and what is misunderstood about nuclear weapons. Upstream is sponsored by Brave: Head to https://brave.com/brave-ads/ and mention “MoZ” when signing up for a 25% discount on your first cam…
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Julie Klapstein, founding CEO of Availity, long-time healthcare executive, and a16z Bio + Health's newest advisory partner, joins Julie Yoo, general partner at a16z Bio + Health. Together, they delve into Julie Klapstein's rich career journey, which has spanned several decades of progress in healthcare. They also discussed building Availity, her ti…
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In the late 1800's in Rochester, New York, Monroe County—there were 5 sensational murders. The first story is about the home invasion murder of a young wife and mother. Her body was found in the cellar, a flour sack tied tightly around her neck, and her skirt hiked up. At first, of course, the husband is arrested amid rumors he and his wife are swi…
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This week on Upstream, Erik is joined by Rob Henderson, psychologist and author of the newly released Troubled: A Memoir of Foster Care, Family, and Social Class. They discuss dating, cancel culture, luxury beliefs, and more. Upstream is sponsored by Brave: Head to https://brave.com/brave-ads/ and mention “MoZ” when signing up for a 25% discount on…
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Scribe Therapeutics cofounder and CEO Benjamin Oakes, PhD, joins a16z Bio + Health founding general partner Vijay Pande. In this episode, Benjamin traces his journey from PhD student to pioneering CEO in genome editing. Benjamin discusses his early exposure to CRISPR technologies, his hands-on experience of transforming these bacterial immune syste…
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In luxury, there’s Hermès… and there’s everyone else. Stewarded by one French family over six generations, Hermès sells the absolute pinnacle of the French luxury dream. Loyal clients will wait years simply for the opportunity to buy one of the company’s flagship Birkin or Kelly bags. Unlike every other luxury brand, Hermès: Doesn’t increase supply…
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Ep. 54 Det. Matt Pitcher (Ret.) on working long-term deep undercover: creating and maintaining an identity; going years without spending time with family knowing that one slip could cost him the case – or his life. Matt and I connected on Instagram when he posted photos from his two long-term deep undercover cases. The visual instantly conveyed, mo…
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Was this small-town TV repair man “a harmless eccentric or a bizarre killer” (Atlanta Journal Constitution). For the first time, Alvin Ridley’s own defense attorney reveals the inside story of his case and trial in an extraordinary tale of friendship and an idealistic young attorney’s quest to clear his client’s name—and, in the process, rebuild hi…
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This week on Upstream, Erik is joined by Lyn Alden, an investment strategist known for her unique blend of engineering, tech, and finance expertise. They discuss her book Broken Money, macro trends, and her best advice in the face of an uncertain economic future. Upstream is sponsored by Brave: Head to https://brave.com/brave-ads/ and mention “MoZ”…
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Josh Clemente, cofounder and president of Levels, joins Vijay Pande, founding general partner, and Daisy Wolf, investment partner at a16z Bio + Health. In this episode, engineer-turned-entrepreneur Josh charts his journey from SpaceX and Hyperloop to cofounding metabolic health-focused company Levels. With a relentless drive for data-led health mon…
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From the outside, Hollywood starlet Lana Turner seemed to have it all―a thriving film career, a beautiful daughter, and the kind of fame and fortune that most people could only dream of. But when the famous femme fatale began dating mobster Johnny Stompanato, thug for the infamous west coast mob boss Mickey Cohen, her personal life became violent a…
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On this episode of Upstream, Erik sits down with e/acc founder Bayeslord and writer Nadia Asparouhova to discuss the foundations and future of the e/acc movement. Upstream is sponsored by Shopify: https://shopify.com/torenberg for a $1/month trial period. --- RECOMMENDED PODCAST: History 102 with WhatifAltHist Every week, creator of WhatifAltHist R…
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Former gymnast and current investor Aly Raisman joins general partner Julie Yoo and investment partner Daisy Wolf of a16z Bio + Health. In this episode, Aly Raisman shares her quest for healthier living—physically, mentally and financially—on her journey from gymnast to a business investor. Having herself transitioned from an intensely structured r…
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In the tight-knit community of Lorain, Ohio, a whirlwind of horror swept through as unsettling allegations surfaced - a trusted bus driver and her alleged companion accused of shattering the innocence of preschoolers in the respected Head Start program. The verdict? Life-long prison sentences that would cast a shadow over a community, and initiate …
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Ep. 53 Officer Mike from a mid-sized agency in the Mid-Atlantic has been in law enforcement for seven years. He wrote to me saying, “I want to discuss the mental health aspect of the job and juggling it with family life. I've been married for about five years. We have two daughters who are four and almost two. I've gone through times when I see thi…
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On this episode of Upstream, Erik sits down with Tyler Cowen to discuss Harvard, AI, Javier Milei's legacy, the value of non-legibility in talent spotting, and more. Upstream is sponsored by Shopify: https://shopify.com/torenberg for a $1/month trial period. -- RECOMMENDED PODCAST: History 102 with WhatifAltHist Every week, creator of WhatifAltHist…
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Max Cohen, cofounder and CEO of Sprinter Health, and Eren Bali, founder and CEO of Carbon Health, join Julie Yoo, general partner at a16z Bio + Health. Together, they talk about becoming healthcare entrepreneurs despite non-healthcare backgrounds and what they had to learn along the way. They also discuss finding product-market fit, how they track …
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On January 21, 1958, nineteen-year-old Charles Starkweather changed the course of crime in the United States when he murdered the parents and sister of his fourteen-year-old girlfriend (and possible accomplice), Caril Ann Fugate, in a house on the edge of Lincoln, Nebraska. They then drove to the nearby town of Bennet, where a farmer was robbed and…
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This week on Upstream, political scientist and writer Ricard Hanania returns to the show. Erik and Richard discuss wokeness, the Israel-Palestine conflict, the mythos of the modern right, Richard's upcoming debate with Curtis Yarvin, and more. Upstream is sponsored by Shopify: https://shopify.com/torenberg for a $1/month trial period. -- RECOMMENDE…
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In this episode, Joe Grogan, a senior fellow at the Leonard D. Schaeffer Center for Health Policy and Economics and a former senior government official, joins Vijay Pande, founding partner of a16z Bio + Health to discuss all things regulation. Together, they dive into Joe’s experience working in the early days of the Covid pandemic, how he thinks a…
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In their book, A Special Kind of Evil: The Colonial Parkway Serial Killings, authors Blaine Pardoe and Victoria Hester wrote about Alan Wade Wilmer, Sr., who was the prime suspect in the 1988 disappearance and murders of Richard Keith Call and Cassandra Hailey. He was under police surveillance and fit the profile the F.B.I. had developed. An expert…
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Last year Novo Nordisk, the Danish pharmaceutical company behind Ozempic and Wegovy, overtook LVMH to become Europe’s most valuable company. And the pull for Acquired to finally tackle healthcare (18% of US GDP!) became too strong for us to resist. While we didn’t know much about Novo Nordisk before diving in, our first thought was, “wow, seems lik…
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This week on Upstream, the tables are turned, and Erik is sitting in the guest seat. We're airing an episode the podcast Where It Happens hosted by Greg Isenberg. Greg and Erik discuss B2B creators, how to find profitable niches, how to monetize media businesses, and more. Upstream is sponsored by Shopify: https://shopify.com/torenberg for a $1/mon…
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Today's episode features the CEO of Tome Biosciences, Rahul Kakkar, alongside John Finn, CSO of Tome. They are joined by Jorge Conde, general partner at a16z Bio + Health. Together, the three of them discuss the technology underlying Tome's work, known as PASTE, a genome editing technique. They also dive deep into how this technology could be appli…
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By the time of her execution at thirty-six, Maria Mandl had achieved the highest rank possible for a woman in the Third Reich. As Head Overseer of the women’s camp at Auschwitz-Birkenau, she was personally responsible for the murders of thousands, and for the torture and suffering of countless more. In this riveting biography, Susan J. Eischeid exp…
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