Best Sir Blackwood Podcasts (2024)

1
The Ancient Light, by Algernon Blackwood 17:07

1h ago17:07

17:07

In which our hero goes for a little perambulation in the glorious afternoon light. Transcript: https://drive.google.com/file/d/15452827Y2Q2rr6G509TCaa1p-aUi6Z3j/view?usp=sharing The Colin Malatrat Museum of Curious Oddities and Strange Antiquities: https://www.amazon.com/Malatrat-Curious-Oddities-Strange-Antiquities/dp/B0BJ4MMW1N Darkhorse Road, an…

1
EP 131: The potential of somatic genomics in drug discovery and development with Jake Rubens 44:57

9h ago44:57

44:57

0:00 Intro 0:40 Jake’s experiences as a serial entrepreneur starting five companies with a basis in genomic science 5:30 Opportunities for research and drug development in the realm of somatic science 9:20 Somatic evolution and how it provides valuable insights into disease mechanisms 12:30 Advantages and disadvantages of studying germline genome-w…

1
The Cats of Ulthar, by H.P. Lovecraft 9:31

3d ago9:31

9:31

Transcript: https://drive.google.com/file/d/1F1FJGqnsstMn4n7MHL1wx4W7X9946TYs/view?usp=sharing The Colin Malatrat Museum of Curious Oddities and Strange Antiquities: https://www.amazon.com/Malatrat-Curious-Oddities-Strange-Antiquities/dp/B0BJ4MMW1N Darkhorse Road, and Other Stories: https://www.amazon.com/dp/B0CVFFLVNL Podcast artwork by Ruth Anna …

1
EP 130: Quarterly insights into noncoding variants and GWAS with Dr. Veera Rajagopal 51:56

13d ago51:56

51:56

Show Notes: 0:00 Introduction 1:20 How polydactyl mutations can inform research on non-coding variant mechanisms The importance of low-affinity binding between transcription factors and targets How these lessons can help us improve our understanding of drug and target discovery See Veera’s January round-up for more information: https://www.gwasstor…

1
Wicked Captain Walshawe, of Wauling, by Joseph Sheridan le Fanu 31:08

10d ago31:08

31:08

In which our hero receives a late night visitor. Transcript: https://drive.google.com/file/d/1F1FJGqnsstMn4n7MHL1wx4W7X9946TYs/view?usp=sharing The Colin Malatrat Museum of Curious Oddities and Strange Antiquities: https://www.amazon.com/Malatrat-Curious-Oddities-Strange-Antiquities/dp/B0BJ4MMW1N Darkhorse Road, and Other Stories: https://www.amazo…

1
EP 129: Patient advocacy for genetic ALS and FTD with Jean Swidler, Executive Director of End the Legacy 38:44

15d ago38:44

38:44

0:00 Introduction 0:45 Jean’s personal experiences with family members with genetic ALS 10:00 Jean’s thoughts on the barriers and facilitators to providing treatment for those with genetic ALS 13:20 Insights into C9orf72, a common genetic determinant of ALS, and how it can also be associated with FTD 16:10 Jean’s experiences as an active advocate f…

1
The Hound of the Baskervilles, Chapter 15: An Introspection 23:13

23d ago23:13

23:13

In which all these tales come to an end. Transcript: https://drive.google.com/file/d/1vEWbiI3DgvF0NnTd91ycrHOWa0tuDwaE/view?usp=sharing The Colin Malatrat Museum of Curious Oddities and Strange Antiquities: https://www.amazon.com/Malatrat-Curious-Oddities-Strange-Antiquities/dp/B0BJ4MMW1N Darkhorse Road, and Other Stories: https://www.amazon.com/dp…

1
EP 128: Parkinson’s disease and precision medicine with Drs. James Beck and Ignacio Mata 50:18

21d ago50:18

50:18

0:00 Introduction 1:05 Insights into the PD GENEration’s (a programme from the Parkinson's Foundation) milestones and progress points for the upcoming year 3:30 The shifting attitudes and perspectives of neurologists and healthcare workers at the PD GENEration 5:50 Insights into Nacho’s work with the genetics of Parkinson’s disease 10:20 Barriers a…

1
The Hound of the Baskervilles, Chapter 14: The Hound of the Baskervilles, by Sir Arthur Conan Doyle 25:38

24d ago25:38

25:38

In which our heroes stake out. Transcript: https://drive.google.com/file/d/1SGgWAX59IVytiL-_S6kT1WHRRQcGHjyB/view?usp=sharing The Colin Malatrat Museum of Curious Oddities and Strange Antiquities: https://www.amazon.com/Malatrat-Curious-Oddities-Strange-Antiquities/dp/B0BJ4MMW1N Darkhorse Road, and Other Stories: https://www.amazon.com/dp/B0CVFFLVN…

1
EP 127: Insights into precision medicine, fatty liver disease, and minimally invasive diagnostic tools with Dr. Mazen Noureddin 39:10

28d ago39:10

39:10

0:00 Intro 0:25 Mazen’s lifelong commitment to furthering the field of precision medicine in liver disease research, fueled by a personal connection of his grandmother developing MASH cirrhosis 2:30 Breakthroughs in the field of metabolic dysfunction-associated steatotic liver disease (MASLD) since the beginning of Mazen’s career 5:30 The potential…

1
No episode this week, cause baby. 1:15

1M ago1:15

1:15

By Tycho Alhambra

1
Special Announcement 2: Special Announcementer 1:21

1M ago1:21

1:21

By Tycho Alhambra

1
SPECIAL ANNOUNCEMENT! 1:18

1M ago1:18

1:18

By Tycho Alhambra

1
EP 126: Patient-led research for ultra-rare disease drug development with Julia Taravella, Executive Director of Rare Trait Hope Fund 39:41

1M ago39:41

39:41

0:00 Introduction 0:25 Julia’s personal experience with ultra-rare diseases within her family 10:25 The importance of increasing accessibility to genetic testing across populations to learn more about ultra-rare diseases 14:00 The origin story of Rare Trait Hope Fund 23:50 Current research and next steps in developing potential gene therapies for a…

1
The Hound of the Baskervilles, Chapter 13: Fixing the Nets 22:56

1M ago22:56

22:56

In which our heroes conduct interviews and make plans Transcript: https://drive.google.com/file/d/1gQJeeBswGFq5DD1VzaHzZE4upyhcVuJo/view?usp=sharing The Colin Malatrat Museum of Curious Oddities and Strange Antiquities: https://www.amazon.com/Malatrat-Curious-Oddities-Strange-Antiquities/dp/B0BJ4MMW1N Darkhorse Road, and Other Stories: https://www.…

1
EP 125: The future of UK Clinical Trial Policy: Innovation, integration, and game-changing legislation with Lord James O’Shaughnessy 45:23

1M ago45:23

45:23

0:00 Introduction 1:25 How Lord O’Shaughnessy became involved in scientific policy making and his path to writing the UK Commercial Clinical Trials Review. 04:05 How Lord O’Shaughnessy pivoted from education to a focus on life sciences 06:38 The biggest challenges Lord O’Shaughnessy faced during his time as Parliamentary Under Secretary for Health …

1
The Hound of the Baskervilles, Chapter 12: Murder on the Tor, by Sir Arthur Conan Doyle 27:17

2M ago27:17

27:17

In which our heroes exchange clues. Transcript: https://drive.google.com/file/d/1WOKiGygKzgaB1B2OEypGDKo79OF3Uwdg/view?usp=sharing The Colin Malatrat Museum of Curious Oddities and Strange Antiquities: https://www.amazon.com/Malatrat-Curious-Oddities-Strange-Antiquities/dp/B0BJ4MMW1N Darkhorse Road, and Other Stories: https://www.amazon.com/dp/B0CV…

1
EP 124: How ReCode Therapeutics is pioneering tissue specific delivery of gene therapies for Primary Ciliary Dyskinesia with John Matthews 42:00

2M ago42:00

42:00

0:00 Introduction 01:10 How growing up in Malawi planted the seeds for John’s career in medicine and transition to therapeutic development 04:35 Why John focuses on rare diseases and conditions such as asthma 06:01 What has changed over the last decade in terms of treating and understanding asthma and the progress that genetics has enabled 07:31 Wh…

1
The Hound of the Baskervilles, Chapter 11: The Man on the Tor, by Sir Arthur Conan Doyle 25:34

2M ago25:34

25:34

In which our hero partakes in local gossip. Transcript: https://drive.google.com/file/d/1cq0Sj2W0M7tGQeCM1aHmsVH82Qfy58yM/view?usp=sharing The Colin Malatrat Museum of Curious Oddities and Strange Antiquities: https://www.amazon.com/Malatrat-Curious-Oddities-Strange-Antiquities/dp/B0BJ4MMW1N Darkhorse Road, and Other Stories: https://www.amazon.com…

1
EP 123: The ethics of newborn genome screening: Actionable insights and beyond with Holly Peay, Senior Research Scientist at the Research Triangle Institute 45:34

2M ago45:34

45:34

0:00 Introduction 0:50 Holly’s background and career so far 03:30 Complex decision-making and multiple risk factors: Family history, genetics, phenotypes and beyond 07:05 Changes within the last decade to help people make complex, sometimes subjective, healthcare decisions 09:20 Impact on people: The RTI’s mission and the Early Check Study 13:45 Ne…

1
The Hound of the Baskervilles, Chapter 10, by Sir Arthur Conan Doyle 21:21

2M ago21:21

21:21

In which our hero has some story time Transcript: https://drive.google.com/file/d/1LpeYPkg5-JO4L1qoahaTkYfoh2J6Jdjw/view?usp=sharing The Colin Malatrat Museum of Curious Oddities and Strange Antiquities: https://www.amazon.com/Malatrat-Curious-Oddities-Strange-Antiquities/dp/B0BJ4MMW1N Darkhorse Road, and Other Stories: https://www.amazon.com/dp/B0…

1
EP 122: Building genome-scale engineered cells for biotechnology with Leslie Mitchell, Co-founder and CEO of Neochromosome 35:55

2M ago35:55

35:55

Summary: 0:00 Introduction 01:01 How Leslie got into the field of synthetic biology and engineering, and her career journey so far 02:45 What Leslie accomplished during her postdoc and recent transformations in the field of genomics 05:57 The impacts of non-coding regions of the genome and the outcome of deletions 08:20 How long it takes to make ch…

1
The Hound of the Baskervilles, Chapter 9 (Part 2), by Sir Arthur Conan Doyle 28:00

2M ago28:00

28:00

In which our heroes uncover secrets Transcript: https://drive.google.com/file/d/1boUTwbTm1vBjfrP4mjG7_Ibl7V1kyQoX/view?usp=sharing The Colin Malatrat Museum of Curious Oddities and Strange Antiquities: https://www.amazon.com/Malatrat-Curious-Oddities-Strange-Antiquities/dp/B0BJ4MMW1N Podcast artwork by Ruth Anna Evans (https://twitter.com/ruthannae…

1
EP 121: Breakthroughs and insights in ALS research with Dr. Michael Benatar 44:10

2M ago44:10

44:10

Summary: 0:00 Introduction 0:50 Reflections from the 34th International Symposium on ALS/MND in Basel 1:50 Michael’s professional journey, initial challenges he encountered, and how the field of neurology has evolved over the years 3:10 An introduction to the ALS landscape, including its presentation, the genes involved, and potential treatment opt…

1
The Hound of the Baskervilles, Chapters 8 and 9 (Part 1), by Sir Arthur Conan Doyle 23:57

2M ago23:57

23:57

In which our heroes investigate Transcript: https://drive.google.com/file/d/1gcaGEkReTF3srJrfX2VoadPPoX_AgsGJ/view?usp=sharing The Colin Malatrat Museum of Curious Oddities and Strange Antiquities: https://www.amazon.com/Malatrat-Curious-Oddities-Strange-Antiquities/dp/B0BJ4MMW1N Podcast artwork by Ruth Anna Evans (https://twitter.com/ruthannaevans…

1
EP 120: Exploring the frontiers of gene therapy and AAVs with Dr. Nicole Paulk, CEO and Founder of Siren Biotechnology 43:47

3M ago43:47

43:47

0:00 Introduction to Dr. Nicole Paulk, a pioneer in AAV research and the founder of Siren Biotechnology 0:50 The moments that shaped Nicole’s career path and her passion for gene therapy and AAV research 9:20 Nicole’s academic research career and her transition from academia to the biotech industry 23:00 The story behind the founding of Siren Biote…

1
The Hound of the Baskervilles, Chapter 7: The Stapletons of Merripit House 27:59

3M ago27:59

27:59

In which our hero gets a geography lesson from a teacher. Transcript: https://drive.google.com/file/d/1A1iCP3PY8BT-MF_meihJmnM3jeW_oyjF/view?usp=sharing The Colin Malatrat Museum of Curious Oddities and Strange Antiquities: https://www.amazon.com/Malatrat-Curious-Oddities-Strange-Antiquities/dp/B0BJ4MMW1N Podcast artwork by Ruth Anna Evans (https:/…

1
EP 119: Revolutionising drug discovery: how the Pharma Proteomics Project is combining genetic and proteomic data with Chris Whelan 38:25

3M ago38:25

38:25

0:00 Introduction 01:00 Chris’ background and career to date 02:10 What is the Enigma Project? 04:48 How is genetics being applied to drug discovery today and how does proteomics fit in? 09:23 When the UKBiobank Pharma Proteomics Project began and how long it took to set up 10:57 54k UK Biobank participants tested - discussion of findings 14:33 The…

1
The Hound of the Baskervilles, Chapter 5: Baskerville Hall, by Sir Arthur Conan Doyle 20:28

3M ago20:28

20:28

In which our heroes arrive at home Transcript: https://drive.google.com/file/d/1p_2yKXmpt3hcJroWmIBr4qSU6Tq9rvR1/view?usp=sharing The Colin Malatrat Museum of Curious Oddities and Strange Antiquities: https://www.amazon.com/Malatrat-Curious-Oddities-Strange-Antiquities/dp/B0BJ4MMW1N Podcast artwork by Ruth Anna Evans (https://twitter.com/ruthannaev…

1
EP 118: The role of genetics in drug discovery and development with Dr. Matt Nelson 42:56

3M ago42:56

42:56

Summary: 0:00 Introduction 5:45 Lessons learned from 15 years at GSK: How has genetics and drug discovery evolved over time? 8:10 Matt’s seminal 2015 paper: Quantifying the impact of human genetic evidence on the probability of success in drug development 11:40 Which types of genetic evidence are the best drivers of success in clinical trials? 13:3…

1
The Hound of the Baskervilles, Chapter 5: Three Broken Threads, by Sir Arthur Conan Doyle 19:11

3M ago19:11

19:11

In which our heroes do some bad sewing. Transcript: https://drive.google.com/file/d/1rcBbYU5YEEuGcTkvF80oS9gaQjUgWwmK/view?usp=sharing The Colin Malatrat Museum of Curious Oddities and Strange Antiquities: https://www.amazon.com/Malatrat-Curious-Oddities-Strange-Antiquities/dp/B0BJ4MMW1N Podcast artwork by Ruth Anna Evans (https://twitter.com/rutha…

1
EP 117: Wendy Chung: whole genome newborn screening and other big opportunities in genomic medicine. 47:51

3M ago47:51

47:51

Summary: 0:00 Introduction 1:45 Wendy’s early career looking into the genetics of diabetes through mouse models 6:23 A high altitude view: Cutting through hype to spot the next wave of game-changing technology 8:03 The role of policy and communication: how Wendy’s work goes beyond the lab to create real-world impact 11:20 Wendy’s choice to do an MD…

1
The Hound of the Baskervilles, Chapters 3 and 4, by Sir Arthur Conan Doyle 36:27

3M ago36:27

36:27

In which our heroes begin their investigation Transcript: https://drive.google.com/file/d/1AekViU22H27zPS41QMQMsPExF8GfDZ6W/view?usp=sharing The Colin Malatrat Museum of Curious Oddities and Strange Antiquities: https://www.amazon.com/Malatrat-Curious-Oddities-Strange-Antiquities/dp/B0BJ4MMW1N Podcast artwork by Ruth Anna Evans (https://twitter.com…

1
EP 116: Genetics and Medicine: Clonal hematopoiesis, genomics in healthcare, and a new discovery in APOL1 kidney disease with Dr. Alex Bick 52:34

4M ago52:34

52:34

0:00 Introduction 4:23 Insights into clonal hematopoiesis from the pioneering Framingham Heart Study 8:30 Linking clonal hematopoiesis to cancer and cardiovascular health 11:22 Interplay of germline and somatic variants in clonal expansion 17:20 How the rate of clonal expansion can provide insights into cancer and cardiovascular risk 19:00 How clon…

1
The Hound of the Baskervilles, Chapters 1 and 2, by Sir Arthur Conan Doyle 34:07

4M ago34:07

34:07

In which our heroes hear a family history Transcript: https://drive.google.com/file/d/1KrzTel7JZxSixhr5CnT5uchrttM5_US1/view?usp=sharing The Colin Malatrat Museum of Curious Oddities and Strange Antiquities: https://www.amazon.com/Malatrat-Curious-Oddities-Strange-Antiquities/dp/B0BJ4MMW1N Podcast artwork by Ruth Anna Evans (https://twitter.com/rut…

1
EP 115: The Biggest Stories of 2023 with Dr. Veera Rajagopal (Part 2) 1:35:11

4M ago1:35:11

1:35:11

In the second instalment of our annual round-up episode, we welcome back Dr. Veera Rajagopal to cover the biggest stories in genetics and precision medicine of the last 12 months. Don’t forget to give the first instalment of our 2023 round-up a listen. Veera is a scientist at Regeneron with an interest in human genetics and drug target discovery in…

1
Christmas Ghost Stories, Season 6: Photographs 34:09

4M ago34:09

34:09

In which our hero follows directionsBy Tycho Alhambra

1
Amour Dure, Dec 25, by Vernon Lee 5:17

4M ago5:17

5:17

In which our hero goes to a meetingBy Tycho Alhambra

1
Amour Dure, December 24, by Vernon Lee 3:49

4M ago3:49

3:49

In which our hero runs some testsBy Tycho Alhambra

1
Christmas Ghost Stories, Season 6: Smee, by A.R. Barrage 23:34

4M ago23:34

23:34

In which our hero plays a gameBy Tycho Alhambra

1
Amour Dure, December 23, by Vernon Lee 6:38

4M ago6:38

6:38

In which our hero has... moments.By Tycho Alhambra

1
Christmas Ghost Stories, Season 6: The Ghost of Lord Clarenceaux, by Arnold Bennett 9:08

4M ago9:08

9:08

In which our hero locks himself in a roomBy Tycho Alhambra

1
Christmas Ghost Stories, Season 6: The Bowmen, by Arthur Machen 7:27

4M ago7:27

7:27

In which our heroes ask for helpBy Tycho Alhambra

1
Christmas Ghost Stories Season 6: The Goodwood Ghost Story, Doubtfully Attributed to Charles Dickens 11:26

4M ago11:26

11:26

In which our hero makes a promiseBy Tycho Alhambra

1
EP 114: The Biggest Stories of 2023 with Dr. Veera Rajagopal (Part 1) 1:10:35

4M ago1:10:35

1:10:35

0:00 Introduction 1:30 Veera’s personal highlights of 2023 Publication in Nature Genetics: Rare coding variants in CHRNB2 reduce the likelihood of smoking, an exome-wide association study identifying rare coding variants in CHRNB2 that may reduce the likelihood of smoking. Designing cover art Genetic links to neural circuits and their role in addic…

1
Correction! 0:24

4M ago0:24

0:24

I'm a dummy. There's nothing more to say. I'm a dumb. Dummy.By Tycho Alhambra

1
(Full Fixed Version) NOT Amour Dure, Part 4, by Vernon Lee 58:47

4M ago58:47

58:47

Tangents: Our heroes’s religious history, Weird Al’s innuendo, Lindsey Stirling, O Holy Crap, Mike’s own little personal Mandela Effect, Garett’s Toys R Us life, Frank Sinatra can save anything, Feel free to click on the links below, but you’ll spoil the episode by seeing our lists. But, these are show notes, not cops, so you can’t be stopped if yo…

1
Amour Dure, part 3, by Vernon Lee 22:20

4M ago22:20

22:20

In which our hero goes to church. Transcript: https://drive.google.com/file/d/1ADdT9dUzDiIeH0Oi3HIAY7erukjwkh25/view?usp=sharing The Colin Malatrat Museum of Curious Oddities and Strange Antiquities: https://www.amazon.com/Malatrat-Curious-Oddities-Strange-Antiquities/dp/B0BJ4MMW1N Podcast artwork by Ruth Anna Evans (https://twitter.com/ruthannaeva…

1
EP 113: Harnessing human genetics to discover co-evolved small molecule medicines with Dr. Jason Park, CEO of Empress Therapeutics 44:31

4M ago44:31

44:31

In this episode of The Genetics Podcast, we welcome Dr. Jason, founder and CEO of Empress Therapeutics, a Flagship Pioneering company. Join us as we discuss how human genetics can identify small molecules with therapeutic potential that are already created by our bodies, paving the way for faster discovery of new medicines. Summary: 0:00 Intro 1:20…

1
Amour Dure, Part 2, by Vernon Lee 25:31

5M ago25:31

25:31

In which our hero recounts the history lesson from last week and then FINALLY the story starts. Transcript: https://drive.google.com/file/d/1HPwerLhtliVxRm20TFS22BQ5UEPr6qgR/view?usp=sharing The Colin Malatrat Museum of Curious Oddities and Strange Antiquities: https://www.amazon.com/Malatrat-Curious-Oddities-Strange-Antiquities/dp/B0BJ4MMW1N Podca…

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