The Longevity Biotech Show public
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Interviews with the researchers, founders, and investors of the BioTech industry. An insiders look into what is going on in the world of BioTech, from curing aging to psychedelic therapy, we interview the game changers of the industry. The unsung hero's that are moving the industry forward in a significant way. The world is going to be a vastly different place in the next 10-20 years because of what's happening in the BioTech industry right now.Human civilization will move forward farther, f ...
 
The data revolution has begun. The knowledge you will gain over your body, your health, your performance, will explode in the next 5 years. Empowering you to make better decisions about your body and get the results you’re looking for, instead of just guessing or following the latest opinion fad in health or fitness or anti-aging. The Quantified Body introduces you to the cutting edge in this trend – wearable devices, biomarkers, the latest lab tests, quantified self protocols, biohacking ta ...
 
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Today is a very special episode where I will be discussing Biotech and Blockchain. Now you might be asking yourself - how do blockchain and biotech have anything to do with each other? That's exactly what i thought as well when I first heard of VitaDao. But after my conversation today I'm convinced that this is a collision of industries that was ab…
 
Our second monthly Future of Longevity panel discussion featuring: George Church (Harvard Medical School) Nir Barzilai (Albert Einstein College of Medicine) Kristen Fortney (BioAge Labs) Jim Mellon (Juvenescence) Jay Olshansky (University of Illinois at Chicago) Alejandro Ocampo (University of Lausanne)…
 
A panel talk with scientists and thought leaders in age reversal and longevity science. Featuring: Aubrey de Grey (Founder of SENS Research Foundation, author of "Ending Aging") David Sinclair (Harvard Medical School, Life Biosciences, author of "Lifespan: Why We Age -- and Why We Don't Have to") Joao Pedro de Magalhaes (University of Liverpool, CS…
 
Locked in every bite of food we take is a universe of hidden potential. Potential to cure disease, help our sleep, and improve our mood just to name a few. The food we eat has a galaxy of molecules we call peptides, these peptides have limitless possibilities that get destroyed by the black hole we call our digestive system. These peptides have som…
 
Sebastian Brunemeier is a geroscientist, biotech founder, and venture capitalist. He was formerly Principal at Apollo Health Ventures, one of the largest aging-focussed VC firms in the world. Sebastian was co-founder of Samsara Therapeutics, Cyclone Therapeutics, Cambrian Biopharma, and advisor to several other biotech startups and Healthspan Capit…
 
Matthew Scholz is the co-founder of Oisin Biotechnologies, a gene therapy platform company that is targeting aging by killing senescent cells. We discuss the technology behind Oisin, Matt's journey from computer science to biotech, and practical advice and wisdom he gained from building biotech startups.…
 
Jean Hebert is a professor of neurogenetics at Albert Einstein College of Medicine and the author of the book "Replacing Aging". We discuss his ambitious program to reverse aging in the brain by progressive replacement of neural tissue.By The Longevity Biotech Show
 
What if I were to tell you that each and every one of us has a universe inside of us that controls our mood, how we age, and even what we're allergic to. A universe inside of our guts filled with trillions of microorganisms that make up our gut microbiome that dictate our lives from the moment we're born. Having a healthy gut microbiome from birth …
 
Imagine if you could turn the characteristics of a cell on and off… or up and down like a volume trigger… constantly tuning things until everything is working just right. It might sound impossible, but that’s exactly what Obsidian therapeutics is working on. I’ll admit, it was tough for me to wrap my mind around this one at first, but my guest toda…
 
Everyone's dealt with anxiety and depression to some extent, at some point in their lives. It can be debilitating and can cause feelings of hopelessness and helplessness. My guest, Shawn Singh wants to change that. Him and his company, Vistagen Therapeutics are taking on anxiety and depression with their unique bio technology that aims to leave the…
 
Imagine being blind and you can see again. Imagine being paralyzed and you can move again. Imagine how amazing it would feel to be cured of cancer. Life changing would be an understatement. My guest today is the CEO of a company that is leading the way in cell therapy, a technology that can do just that; cure the blind, give movement to the paralyz…
 
If you've lived in the twentieth century you've likely, at one point or another, had an attachment to a non human furry friend... and with any attachment comes the inevitable realization that our furry friend is a mere mortal... one that will age, slow down, and become frail in our life time. If this is something you dread, then this episode is for…
 
If you're confused about NAD and it's precursors then this is the podcast for you. Dr. Joseph Baur, an Associate Professor of Physiology from University of Pennsylvania, is a leading NAD researcher. His lab currently studies metabolic and signaling pathways by which nutrient intake can influence longevity, with a particular emphasis on NAD and mTOR…
 
Dr. Gregory Bailey is the CEO of Juvenescence, one of the biggest players in the Longevity industry. Dr. Bailey has a medical degree from the University of Western Ontario and practiced emergency medicine for more than 10 years before entering the world of finance. We talked about all the different things that Juvenescence is working on, as well as…
 
Alex Zhavoronkov is a particularly high level human being, originally working in the field of computer science, Alex had a realization that contributing to aging and aging research would be the biggest contribution he could make for humanity. Utilizing his expertise in computer science and artificial intelligence, he began using these skills to ent…
 
Andy Koff is the Founder of Atropos Therapeutics. A company with a new approach to tackling senescent cells, one fo the biggest hallmarks of aging. Atropos Therapeutics uses a bio marker to identify when a cell starts transitioning from a quiescent cell into a senescent cell. Using this bio marker, Atropos aims to be able to prevent the cell from t…
 
Mike West is a legend in the field of Gerontology, the study of aging. Back in the 90's, Mike's company Geron Corp, was the first company to not only successfully isolate embryonic stem cells, but to also isolate the telomerase gene, also known as the immortalizing gene. Gerons discoveries were so significant they prompted the former President of t…
 
In this interview Graham Pawelec, a top academic in cancer research and immunotherapy, breaks down exactly how the immune system protects us, why it becomes less effect as we age, and how scientists are utilizing the immune system to cure cancer. Yes... to CURE cancer. If you're curious just how close we are to eliminating cancer, tune in to this e…
 
Today's episode is an interview with Tim Cash, Chief Science Officer of Senolytx Therapeutics, one of the six daughter companies of David Sinclair's Life BioSciences. In this episode Tim helps me to understand exactly why senescent cells, and the damage they cause to the human body is such an important issue we, as humans, need to fix. If you're in…
 
Rejuvenation biotech is a new industry forming around the theme of life extension technologies. This episode provides a broad look at the state of the industry, its most promising life extension technologies and their potential timelines. Life extension - this is something I've wanted to spend time on for a while. In this episode, I interview 5 tho…
 
Microbiome testing can be confusing: many companies, different technologies and a lack of standards make it hard to get actionable insights from the data. Find out how technologies and labs differ and what information is actionable from today's microbiome tests. In this episode we continue our discussion of the microbiome that we started in Episode…
 
Looking at an example of Machine Learning applied to functional medicine with the goal of helping athletes optimize performance. The question - with the help of artificial intelligence, can a 7-minute questionnaire identify physiological weaknesses and bypass the need to spend money on expensive lab tests? This episode focuses on Machine Learning a…
 
What is carbohydrate intolerance? Do each of us have a personal tolerance or intolerance of carbohydrates? Does this also vary by source of carbohydrate? Learn how evolutionary tools may explain appetite regulation and carbohydrate metabolism and offer ways to regain carb tolerance through diet and lifestyle modifications. In this episode, we explo…
 
Is your glucose metabolism driven by your personal microbiome? Recent research reveals how the microbiome influences blood glucose, weight gain and weight loss. And how the new company, "Day Two", is using microbiome sequencing data to provide personalized nutrition recommendations. In this episode we discuss how personal your blood glucose respons…
 
Recent investigations have shown supplements to not always contain what they say they do. Or at other times to have unwanted contaminants such as heavy metals. Learn to use 3rd party lab testing to select supplements that contain the active ingredients needed to provide the results you seek. Sometimes on this show, we discuss using supplements as t…
 
Micronutrient status is a foundation of health, performance and chronic disease minimization. This episode looks at how to optimize fat soluble micronutrients status. In this episode we look at ensuring micronutrient status. Ensuring your body has the building blocks it needs to do what it needs to do. This is an important lever to increasing your …
 
Ketone bodies, whether gained from fasting, keto diets, MCTs or exogenous ketones have many potential applications with benefits ranging from performance, to health, to longevity and mitigating symptoms and risks of certain diseases. There is growing evidence that ketone bodies, whether they come from fasting, keto diets, MCTs or exogenous ketones …
 
Putting the body into ketosis and controlling blood glucose levels may prove to be effective therapy against certain cancers. This real case reveals one aggressive self-experimenter who used a combination of the ketogenic diet, fasting and other tools to control his epilepsy and send his brain cancer into remission. This episode examines the ketoge…
 
Most of us have non-optimal blood glucose regulation today.The impact? Reduced performance, and reduced longevity. We wrongly assume that it's only diabetics that are exposed to these issues. This episode explores using continuous glucose monitoring and other tech to optimize blood sugar through the eyes of a diabetic self-experimenter. How can blo…
 
Part 3 in our series of Fasting Self-Experiments. In this longer 10 day water fast I tracked results with a broad set of biomarkers (ketones, glucose, weight, hormones and cognitive performance panels). This is a long post - if that scares you, jump directly to what you're looking for: Why Do a 10 Day Water Fast? (The health benefits that we're opt…
 
A look at how to accurately quantify your cardiovascular fitness in order to optimize endurance sports or your cardiovascular health. Is VO2Max the gold standard? Are the metrics in the current "fitness trackers" useful for this goal? In this episode we look at different ways to track fitness. Previously we have talked about VO2 max and Heart Rate …
 
Heart disease affects 50% of the U.S. population in their lifetime. Learn how to accurately quantify your personal heart disease status and risk, and if necessary, take clear actions to reduce that risk by eliminating plaque in the arteries. This episode presents an in depth look at heart disease because this is one of the most likely things to sho…
 
Meditation - ever more popular as studies pile up proving its benefits. However, how do you assure yourself that you gain the same benefits with your meditation practice? Muse Calm is a neurofeedback device that promises accurate feedback on the quality of your meditation. In this episode we talk about improving your focus and meditation practice w…
 
What is genetic testing able to do and not do with current services? We talk with one of the top genetic lab services to understand how technologies differ in accuracy and where it is working, where it is not yet ready and why. In this episode we look at the impact that genetics has on our health and wellness. With rapid discoveries in epigenetics,…
 
What defines human microbiome health? The co-founder of American Gut Project discusses the differences we've found in the gut microbiome and how it influences our health. We look at tools and lifestyle choices that have been shown to change the microbiome (for good, and for bad). Our microbiome plays an important role in our ability to overcome hea…
 
Water fasting or ketogenic therapies may be effective with some cancers, and not with others. Learn about the PET scan and how it can provide insights into whether a cancer is likely to be responsive or not to the water fast tactic we've covered in previous episodes. In this episode, we return to look at ketosis and water fasts as a tool to help tr…
 
An in-depth look at using heart rate variability biofeedback with slow breathing to reduce stress, enhance athletic performance and provide therapeutic support for some chronic health issues. Heart rate variability biofeedback is being used primarily to reset the nervous system and thus as an antidote to different types of stressors. These include …
 
A look at a collection of high impact endurance tools and tactics - and the top biomarkers to watch for optimization. Vetted by an endurance athlete with years of experiments and competitions behind him. Today's episode is about endurance training and using high-impact tools to get the most out of it. We look at self-tracking in diet and exercise w…
 
We strive for the best mental performance but how do you know if your routines (sleep patterns, coffee habits, etc.) are helping or hurting? The Quantified Mind is a web-based project that allows you to quickly check your cognitive function in a few minutes. In previous episodes, we have discussed and identified ways to improve our mental performan…
 
Can physicians improve health outcomes using new self-tracking tech with their patients? Or is the tech still too inaccurate or impractical? We take a hard look at the reality and potential with a physician testing quantified self practices in his clinic for the last 3 years. This episode is about quantified medicine or the reality of cooperating w…
 
Oxaloacetate is an important metabolic intermediate in the energy pathway of the mitochondria. Recent case studies support the use of oxaloacetate as a nutritional supplement to help regulate blood glucose levels, potentially support longevity and protect the brain. Can you get similar beneficial results from a nutritional supplement as you can fro…
 
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