Go offline with the Player FM app!
How ADCs can deliver death cap mushroom toxins to treat cancer
Manage episode 424706936 series 3361449
Heidelberg Pharma is a clinical stage biotech company developing antibody drug conjugates (ADCs).
Its lead amanitin-based ADC product candidate, HDP-101, targets relapsed or refractory multiple myeloma. HDP-101 recently received orphan drug designation; it is currently in a phase I/IIa clinical trial, demonstrating first signs of clinical efficacy.
The company is also expanding its therapeutic product pipeline with a further four programs across a variety of malignant hematologic and solid tumors.
To tell us about how HDP-101 works, and what Heidelberg Pharma is doing in the space, we had a conversation with the company’s CEO, Prof. Andreas Pahl.
00:55-02:05: About Heidelberg Pharma
02:05-03:41: What are antibody-drug conjugates?
03:41-05:27: Why are antibody-drug conjugates in the news currently?
05:27-06:15: What is big pharma’s involvement in the field?
06:15-07:04: Will there be more antibody-drug conjugate approvals?
07:04-08:42: What can antibody-drug conjugates be used to treat?
08:42-09:48: How do you avoid toxicity issues?
09:48-10:31: How important is the linker?
10:31-12:06: What is alpha-amanitin?
12:06-13:28: How do you make a toxin not toxic?
13:28-14:11: What tumor types can be targeted?
14:11-15:59: How do you discover a toxin can treat a disease?
15:59-17:38: How is alpha-amanitin delivered?
17:38-19:27: Is alpha-amanitin a monotherapy?
19:27-22:16: What clinical trials are you doing?
22:16-23:31: What are the next steps now you have orphan drug designation?
23:31-24:14: What are the timelines?
24:14-25:36: Where are antibody-drug conjugates headed?
25:36-27:14: Are AI and machine learning making an impact?
Interested in being a sponsor of an episode of our podcast? Discover how you can get involved here!
Stay updated by subscribing to our newsletter
Chapters
1. How ADCs can deliver death cap mushroom toxins to treat cancer (00:00:00)
2. About Heidelberg Pharma (00:00:55)
3. What are antibody-drug conjugates? (00:02:05)
4. Why are antibody-drug conjugates in the news currently? (00:03:41)
5. How is big pharma involved in the field? (00:05:27)
6. Will there be more antibody-drug conjugate approvals? (00:06:15)
7. What can antibody-drug conjugates be used to treat? (00:07:04)
8. How do you avoid toxicity issues? (00:08:42)
9. How important is the linker? (00:09:48)
10. What is alpha-amanitin? (00:10:31)
11. How do you make a toxin not toxic? (00:12:06)
12. What tumor types can be targeted? (00:13:28)
13. How do you discover a toxin can treat a disease? (00:14:11)
14. How is alpha-amanitin delivered? (00:15:59)
15. Is alpha-amanitin a monotherapy? (00:17:38)
16. What clinical trials are you doing? (00:19:27)
17. What are the next steps now you have orphan drug designation? (00:22:16)
18. What are the timelines? (00:23:31)
19. Where is the field of antibody-drug conjugates headed? (00:24:14)
112 episodes
Manage episode 424706936 series 3361449
Heidelberg Pharma is a clinical stage biotech company developing antibody drug conjugates (ADCs).
Its lead amanitin-based ADC product candidate, HDP-101, targets relapsed or refractory multiple myeloma. HDP-101 recently received orphan drug designation; it is currently in a phase I/IIa clinical trial, demonstrating first signs of clinical efficacy.
The company is also expanding its therapeutic product pipeline with a further four programs across a variety of malignant hematologic and solid tumors.
To tell us about how HDP-101 works, and what Heidelberg Pharma is doing in the space, we had a conversation with the company’s CEO, Prof. Andreas Pahl.
00:55-02:05: About Heidelberg Pharma
02:05-03:41: What are antibody-drug conjugates?
03:41-05:27: Why are antibody-drug conjugates in the news currently?
05:27-06:15: What is big pharma’s involvement in the field?
06:15-07:04: Will there be more antibody-drug conjugate approvals?
07:04-08:42: What can antibody-drug conjugates be used to treat?
08:42-09:48: How do you avoid toxicity issues?
09:48-10:31: How important is the linker?
10:31-12:06: What is alpha-amanitin?
12:06-13:28: How do you make a toxin not toxic?
13:28-14:11: What tumor types can be targeted?
14:11-15:59: How do you discover a toxin can treat a disease?
15:59-17:38: How is alpha-amanitin delivered?
17:38-19:27: Is alpha-amanitin a monotherapy?
19:27-22:16: What clinical trials are you doing?
22:16-23:31: What are the next steps now you have orphan drug designation?
23:31-24:14: What are the timelines?
24:14-25:36: Where are antibody-drug conjugates headed?
25:36-27:14: Are AI and machine learning making an impact?
Interested in being a sponsor of an episode of our podcast? Discover how you can get involved here!
Stay updated by subscribing to our newsletter
Chapters
1. How ADCs can deliver death cap mushroom toxins to treat cancer (00:00:00)
2. About Heidelberg Pharma (00:00:55)
3. What are antibody-drug conjugates? (00:02:05)
4. Why are antibody-drug conjugates in the news currently? (00:03:41)
5. How is big pharma involved in the field? (00:05:27)
6. Will there be more antibody-drug conjugate approvals? (00:06:15)
7. What can antibody-drug conjugates be used to treat? (00:07:04)
8. How do you avoid toxicity issues? (00:08:42)
9. How important is the linker? (00:09:48)
10. What is alpha-amanitin? (00:10:31)
11. How do you make a toxin not toxic? (00:12:06)
12. What tumor types can be targeted? (00:13:28)
13. How do you discover a toxin can treat a disease? (00:14:11)
14. How is alpha-amanitin delivered? (00:15:59)
15. Is alpha-amanitin a monotherapy? (00:17:38)
16. What clinical trials are you doing? (00:19:27)
17. What are the next steps now you have orphan drug designation? (00:22:16)
18. What are the timelines? (00:23:31)
19. Where is the field of antibody-drug conjugates headed? (00:24:14)
112 episodes
Все серии
×Welcome to Player FM!
Player FM is scanning the web for high-quality podcasts for you to enjoy right now. It's the best podcast app and works on Android, iPhone, and the web. Signup to sync subscriptions across devices.