How ADCs can deliver death cap mushroom toxins to treat cancer

Beyond Biotech - the podcast from Labiotech

Heidelberg Pharma is a clinical stage biotech company developing antibody drug conjugates (ADCs).

Its lead amanitin-based ADC product candidate, HDP-101, targets relapsed or refractory multiple myeloma. HDP-101 recently received orphan drug designation; it is currently in a phase I/IIa clinical trial, demonstrating first signs of clinical efficacy.
The company is also expanding its therapeutic product pipeline with a further four programs across a variety of malignant hematologic and solid tumors.

To tell us about how HDP-101 works, and what Heidelberg Pharma is doing in the space, we had a conversation with the company’s CEO, Prof. Andreas Pahl.

00:55-02:05: About Heidelberg Pharma
02:05-03:41: What are antibody-drug conjugates?
03:41-05:27: Why are antibody-drug conjugates in the news currently?
05:27-06:15: What is big pharma’s involvement in the field?
06:15-07:04: Will there be more antibody-drug conjugate approvals?
07:04-08:42: What can antibody-drug conjugates be used to treat?
08:42-09:48: How do you avoid toxicity issues?
09:48-10:31: How important is the linker?
10:31-12:06: What is alpha-amanitin?
12:06-13:28: How do you make a toxin not toxic?
13:28-14:11: What tumor types can be targeted?
14:11-15:59: How do you discover a toxin can treat a disease?
15:59-17:38: How is alpha-amanitin delivered?
17:38-19:27: Is alpha-amanitin a monotherapy?
19:27-22:16: What clinical trials are you doing?
22:16-23:31: What are the next steps now you have orphan drug designation?
23:31-24:14: What are the timelines?
24:14-25:36: Where are antibody-drug conjugates headed?
25:36-27:14: Are AI and machine learning making an impact?

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Chapters

1. How ADCs can deliver death cap mushroom toxins to treat cancer (00:00:00)

2. About Heidelberg Pharma
 (00:00:55)

3. What are antibody-drug conjugates?
 (00:02:05)

4. Why are antibody-drug conjugates in the news currently?
 (00:03:41)

5. How is big pharma involved in the field?
 (00:05:27)

6. Will there be more antibody-drug conjugate approvals?
 (00:06:15)

7. What can antibody-drug conjugates be used to treat?
 (00:07:04)

8. How do you avoid toxicity issues?
 (00:08:42)

9. How important is the linker?
 (00:09:48)

10. What is alpha-amanitin?
 (00:10:31)

11. How do you make a toxin not toxic?
 (00:12:06)

12. What tumor types can be targeted?
 (00:13:28)

13. How do you discover a toxin can treat a disease?
 (00:14:11)

14. How is alpha-amanitin delivered?
 (00:15:59)

15. Is alpha-amanitin a monotherapy?
 (00:17:38)

16. What clinical trials are you doing?
 (00:19:27)

17. What are the next steps now you have orphan drug designation?
 (00:22:16)

18. What are the timelines?
 (00:23:31)

19. Where is the field of antibody-drug conjugates headed?
 (00:24:14)