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[Linkpost] “introduction to cancer vaccines” by bhauth
MP3•Episode home
Manage episode 426773007 series 3364760
Content provided by LessWrong. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by LessWrong or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
This is a linkpost for https://www.bhauth.com/blog/biology/cancer%20vaccines.html cancer neoantigens
For cells to become cancerous, they must have mutations that cause uncontrolled replication and mutations that prevent that uncontrolled replication from causing apoptosis. Because cancer requires several mutations, it often begins with damage to mutation-preventing mechanisms. As such, cancers often have many mutations not required for their growth, which often cause changes to structure of some surface proteins.
The modified surface proteins of cancer cells are called "neoantigens". An approach to cancer treatment that's currently being researched is to identify some specific neoantigens of a patient's cancer, and create a personalized vaccine to cause their immune system to recognize them. Such vaccines would use either mRNA or synthetic long peptides. The steps required are as follows:
First published:
May 5th, 2024
Source:
https://www.lesswrong.com/posts/xgrvmaLFvkFr4hKjz/introduction-to-cancer-vaccines
Linkpost URL:
https://www.bhauth.com/blog/biology/cancer vaccines.html
---
Narrated by TYPE III AUDIO.
…
continue reading
For cells to become cancerous, they must have mutations that cause uncontrolled replication and mutations that prevent that uncontrolled replication from causing apoptosis. Because cancer requires several mutations, it often begins with damage to mutation-preventing mechanisms. As such, cancers often have many mutations not required for their growth, which often cause changes to structure of some surface proteins.
The modified surface proteins of cancer cells are called "neoantigens". An approach to cancer treatment that's currently being researched is to identify some specific neoantigens of a patient's cancer, and create a personalized vaccine to cause their immune system to recognize them. Such vaccines would use either mRNA or synthetic long peptides. The steps required are as follows:
- The cancer must develop neoantigens that are sufficiently distinct from human surface proteins and consistent across the cancer.
- Cancer cells must [...]
First published:
May 5th, 2024
Source:
https://www.lesswrong.com/posts/xgrvmaLFvkFr4hKjz/introduction-to-cancer-vaccines
Linkpost URL:
https://www.bhauth.com/blog/biology/cancer vaccines.html
---
Narrated by TYPE III AUDIO.
324 episodes
MP3•Episode home
Manage episode 426773007 series 3364760
Content provided by LessWrong. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by LessWrong or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
This is a linkpost for https://www.bhauth.com/blog/biology/cancer%20vaccines.html cancer neoantigens
For cells to become cancerous, they must have mutations that cause uncontrolled replication and mutations that prevent that uncontrolled replication from causing apoptosis. Because cancer requires several mutations, it often begins with damage to mutation-preventing mechanisms. As such, cancers often have many mutations not required for their growth, which often cause changes to structure of some surface proteins.
The modified surface proteins of cancer cells are called "neoantigens". An approach to cancer treatment that's currently being researched is to identify some specific neoantigens of a patient's cancer, and create a personalized vaccine to cause their immune system to recognize them. Such vaccines would use either mRNA or synthetic long peptides. The steps required are as follows:
First published:
May 5th, 2024
Source:
https://www.lesswrong.com/posts/xgrvmaLFvkFr4hKjz/introduction-to-cancer-vaccines
Linkpost URL:
https://www.bhauth.com/blog/biology/cancer vaccines.html
---
Narrated by TYPE III AUDIO.
…
continue reading
For cells to become cancerous, they must have mutations that cause uncontrolled replication and mutations that prevent that uncontrolled replication from causing apoptosis. Because cancer requires several mutations, it often begins with damage to mutation-preventing mechanisms. As such, cancers often have many mutations not required for their growth, which often cause changes to structure of some surface proteins.
The modified surface proteins of cancer cells are called "neoantigens". An approach to cancer treatment that's currently being researched is to identify some specific neoantigens of a patient's cancer, and create a personalized vaccine to cause their immune system to recognize them. Such vaccines would use either mRNA or synthetic long peptides. The steps required are as follows:
- The cancer must develop neoantigens that are sufficiently distinct from human surface proteins and consistent across the cancer.
- Cancer cells must [...]
First published:
May 5th, 2024
Source:
https://www.lesswrong.com/posts/xgrvmaLFvkFr4hKjz/introduction-to-cancer-vaccines
Linkpost URL:
https://www.bhauth.com/blog/biology/cancer vaccines.html
---
Narrated by TYPE III AUDIO.
324 episodes
All episodes
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