Regulation of Gluconeogenesis | MWM Energy Metabolism Cliff Notes #30

Mastering Nutrition

Content provided by Chris Masterjohn, PhD and Chris Masterjohn. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Chris Masterjohn, PhD and Chris Masterjohn or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.

6+ y ago 13:39

MP3•Episode home

Archived series ("Inactive feed" status)

When? This feed was archived on February 29, 2024 22:05 (2M ago). Last successful fetch was on January 24, 2024 13:38 (3M ago)

Why? Inactive feed status. Our servers were unable to retrieve a valid podcast feed for a sustained period.

What now? You might be able to find a more up-to-date version using the search function. This series will no longer be checked for updates. If you believe this to be in error, please check if the publisher's feed link below is valid and contact support to request the feed be restored or if you have any other concerns about this.

Since gluconeogenesis is extremely expensive, it has to be tightly regulated so that it only occurs when both of two conditions are met: 1) the liver has enough energy to invest a portion into synthesizing glucose, and 2) the rest of the body is in need of that glucose.

Since the liver is the metabolic hub of the body that also plays a major role in anabolic synthesis and nitrogen disposal, it also regulates glycolysis and gluconeogenesis according to whether amino acids are available to supply energy in place of glucose and whether there is sufficient citrate and associated energy for biosynthesis. This lesson covers how insulin, glucagon, alanine, citrate, fructose 2-6-bisphosphate, ATP, ADP, and AMP regulate the flux between glycolysis and gluconeogenesis.

For the full episode, go to chrismasterjohnphd.com/mwm/2/30

Sign up for MWM Pro for early access to content, enhanced keyword searching, self-pacing tools, downloadable audio and transcripts, a rich array of hyperlinked further reading suggestions, and a community with a forum for each lesson.

718 episodes