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Episode 5: Small molecule structure uncovered via femtosecond-crystallography & algorithm

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Content provided by MRS Bulletin. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by MRS Bulletin or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.

In this podcast episode, MRS Bulletin’s Laura Leay interviews Nate Hohman from The University of Connecticut about the structure of two chalcogenolates his group uncovered. By combining serial femtosecond crystallography —usually used to characterize large molecules—and a clique algorithm, Hohman’s group was able to analyze the structure of small molecules. With serial femtosecond crystallography, large molecules like proteins produce thousands of spots on the detector; in contrast, small molecule crystals only a produce a few spots. The algorithm uses the pattern that the spots make on the detector to determine the orientation of as many crystals in the liquid jet as possible. The data from each crystal can then be merged together to find the structure.

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97 episodes

Artwork
iconShare
 
Manage episode 324559114 series 2602554
Content provided by MRS Bulletin. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by MRS Bulletin or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.

In this podcast episode, MRS Bulletin’s Laura Leay interviews Nate Hohman from The University of Connecticut about the structure of two chalcogenolates his group uncovered. By combining serial femtosecond crystallography —usually used to characterize large molecules—and a clique algorithm, Hohman’s group was able to analyze the structure of small molecules. With serial femtosecond crystallography, large molecules like proteins produce thousands of spots on the detector; in contrast, small molecule crystals only a produce a few spots. The algorithm uses the pattern that the spots make on the detector to determine the orientation of as many crystals in the liquid jet as possible. The data from each crystal can then be merged together to find the structure.

  continue reading

97 episodes

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