EPISODE 135 - DNA FOCUS - TRHR

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The next gene in our “DNA Focus” series to get put under the spotlight is TRHR. This gene encodes for the thyrotropin-releasing hormone receptor, which is a receptor for a hormone called thyrotropic-releasing hormone (TRH), which is released from the hypothalamus. When TRH binds to TRHR, it causes a number of different cellular signals to occur, which in turn stimulate the thyroid gland to produce thyroxin, which in turn plays a role in the growth and development of skeletal muscle. Small changes in the TRHR gene mean that the hormone receptor is not quite as good at binding with TRH, which in turn can reduce or limit the amount of muscle that can be produced following training.

Genotype

Effect

Training Modification

GG

Most likely to achieve favourable improvements in lean body mass and muscle growth with strength training programmes.

Strongest bias training towards to power end of the spectrum.

GT

A more moderate form of the GG genotype; a good response to strength training, but not as good as CC

Moderate bias towards power-based training

TT

Least responsive genotype in terms of lean body mass increases following strength training

Follow a mixed approach towards strength training.

Resources & Studies Mentioned

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668008/

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