PARDS--Beyond the Basics Part 4 with Dr. Nadir Yehya: Adjunctive Strategies (prone positioning, steroids, paralysis, iNO etc)


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About our Guest:
Dr. Yehya is a graduate of the University of California at Berkeley and the University of California at Los Angeles School of Medicine. After completing pediatrics training at Children’s Hospital of Los Angeles, he completed his pediatric critical care fellowship at Children’s Hospital of Philadelphia (CHOP), and joined the faculty after graduation in 2011. He is currently an Assistant Professor of Anesthesiology and Critical Care and Pediatrics at the Perelman School of Medicine at the University of Pennsylvania and an attending physician in the pediatric intensive care unit at CHOP.

Dr. Yehya’s research interests encompass all aspects of pediatric respiratory failure, with a particular emphasis on pediatric acute respiratory syndrome (ARDS) and mechanical ventilation. ARDS consists of sudden, severe flooding of the lungs in response to an inflammatory insult causing difficulty breathing, frequently requiring mechanical ventilation. Sepsis is a leading cause of ARDS in children. His long-term goal is better characterization of ARDS in children and to test therapies designed to improve outcomes. His NIH-funded work is assessing the utility of specific plasma biomarkers in pediatric ARDS, with subsequent proteomic characterization and testing in pre-clinical models. Dr. Yehya has several active studies involving biomarkers, clinical epidemiology, and pathophysiological mechanisms in the field of pediatric ARDS, and is involved in several multicenter and multinational collaborations.

After listening to this episode, learners should be able to:
Describe the rationale supporting and “ideal” patient that may benefit from various adjunctive therapies for PARDS:

  1. Corticosteroids
  2. Neuromuscular blockade
  3. Prone positioning
  4. Inhaled nitric oxide
  5. Surfactant

Thank you to Dr. Nick Bartel for his help in creating learning objectives for this series.
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Thank you for listening to this episode of PedsCrit. Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at Check out for detailed show notes. And visit @critpeds on twitter and @pedscrit on instagram for real time show updates.
Selected references:
PMID: 10793162
PMID: 25693014.
PMID: 15269312
PMID: 30361119
PMID: 17426195
PMID: 31112383
PMID: 25647235
PMID: 19001507
PMID: 32043986.
PMID: 15671432.

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