Addressing Clinical Relevance in Medical Papers (12)
Archived series ("Inactive feed" status)
When? This feed was archived on July 01, 2022 01:50 (). Last successful fetch was on July 27, 2021 12:36 ()
Why? Inactive feed status. Our servers were unable to retrieve a valid podcast feed for a sustained period.
What now? You might be able to find a more up-to-date version using the search function. This series will no longer be checked for updates. If you believe this to be in error, please check if the publisher's feed link below is valid and contact support to request the feed be restored or if you have any other concerns about this.
Manage episode 292927636 series 2820537
Addressing Clinical Relevance in Medical Papers
Clinical trials and research should always aim to provide information that is meaningful and relevant for patients.
In the last episode, we looked at how many - or rather - how few researchers mentioned and argued for what they would see as clinically relevant outcomes when setting up a study and listing it on clinicaltrials.gov
In this episode, we go deeper to look at examples and why this is so important to improve the usefulness of the research
We want to make it mandatory to state the researchers' clinical relevance levels ahead of the trial, mentioning what they will consider clinically relevant when they pre-register their research on the clinicaltrials.gov website or similar websites. They then need to compare their findings in both the paper and abstract when publishing data from the study. #clinicalrelevance
LINKS:
Once-Weekly Semaglutide in Adults with Overweight or Obesity Paper https://www.nejm.org/doi/full/10.1056/NEJMoa2032183ClinicalTrials.gov: https://clinicaltrials.gov/ct2/show/study/NCT03548935
10-Year Update on Study Results Submitted to ClinicalTrials.gov
https://www.nejm.org/doi/full/10.1056/NEJMsr1907644
FDA and NIH let clinical trial sponsors keep results secret and break the law https://www.sciencemag.org/news/2020/01/fda-and-nih-let-clinical-trial-sponsors-keep-results-secret-and-break-lawCompliance with the legal requirement to report clinical trial results on ClinicalTrials.gov: a cohort study https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(19)33220-9.pdf
Our specific page on our website about requesting clinical relevance statement and evaluation https://www.precision-evidence.com/p/clinical-relevance/
Overview of clinical trials registers like clinicaltrials.gov: https://sites.google.com/a/york.ac.uk/yhectrialsregisters/home/clinicaltrials
Precision Evidence episode 11: “Clinical relevance - Looking at Recent Papers” https://www.precision-evidence.com/11
NOTES:
- Why is stating levels for clinical relevance important to make before a clinical trial starts?
- How should authors of clinical research papers refer and compare to clinical relevance statements?
- Looking at a specific study
- Importance of also looking at how the study is done
- In/exclusion criteria
- Compliance with listing on clinicaltrials.gov
- Compliance with publishing results on clinicaltrials.gov
- Challenges to make a comprehensive review and analysis of a medical paper to make sure the information is both trustworthy and clinically relevant
GET THE ABSTRACT SCREENING TOOL
It can be a challenge to screen papers for clinical relevance. As we go beyond the abstract in this podcast, we have created a screening tool to use when reading an abstract from a clinical research paper.
Using that tool enables you to quickly screen an abstract from a medical journal for clinical relevance selecting only those you want to read. At the same time, you will know why you skipped the rest. Get it at our website https://www.precision-evidence.com
Contact us at email: podcast@precision-evidence.com,
Twitter @PrecisionEBM,
You can learn more at our website, where you can also leave us a voice message.
Website: www.precision-evidence.com
Get the Precision Evidence Newsletter https://bit.ly/3tLBx3Z
Hosts:
Dr. Kim Kristiansen, M.D: @KKristiansenMD & https://www.linkedin.com/in/kim-kristiansen
JG Staal: @HealthyEvidence
Music thanks to mixkit.co
13 episodes