[REPLAY] Understanding Your Genetic Hormone Pathways with Dr Mansoor Mohammed

Pushing The Limits

Our hormones affect almost every aspect of your body. Mood, metabolism and many physical processes are all governed by hormones. However, you might not recognise just how unique you are genetically. Our genetic profile and predisposition to certain hormones impact our daily lives more than we think it does. Learning more about ourselves can drastically improve our quality of life and allow us to make informed and empowered decisions.

Dr Mansoor Mohammed joins us in this episode to explain the importance of understanding our genetic predisposition and the hormone cascade. He also talks about women's hormones. Finally, he explains why we should take our genetic profile into account before experimenting with pharmaceutical treatments and different types of therapy.

If you want to know more about the science behind your genetics and hormones, this episode is for you.

Hormone Report with The DNA Company If you would like to have your hormone test done, understand your genetics in regards to your hormones and would like to then have these interpreted by Lisa, please go to this link to get the test done. Lisa will then contact you once the DNA has been processed to have a consultation. The Report can be purchased here: https://www.peakwellness.co.nz/dna

Please note The DNA Company is based in Canada and this price is in Canadian dollars. It may take up to 6 weeks depending on where you are located in the world for your results to get back to you.

For any questions, please email [e-mail].

Here are three reasons why you should listen to the full episode:

1. Understand why it is essential to learn about the nuances of the menstrual cycle.
2. Discover your individuality as a person going through hormonal cascades.
3. Learn more about the effect of estrogen and why being on the pill fundamentally changes you up to the cellular level.

Resources

• Your DNA Company Female Hormone Profile Report
• In the FLO by Alisa Vitti
• The DNA Company
• The DNA Company on Facebook

Episode Highlights [06:47] The Journey Going Through Hormones

• Menarche is the first menstrual cycle, which is when a female enters young womanhood. After menarche comes pre-menopause, perimenopause and then post-menopause.
• Our sex hormones are fundamental at a holistic, physiological and phenotypic level, as they affect functions at the cellular level.
• Hormones have a circadian nature, which affects metabolism, oxidative stress and other physiological processes.
• Some of the top female athletes in the world are still unaware of their menstrual cycles’ health and how it affects them.
• The phases of the menstrual cycle and variety of hormones affect ligament flexibility, likelihood of injury and exercise response, among others.

[12:45] The Circadian Rhythm of Hormones

• The nuances of your hormonal circadian rhythm rely heavily upon your genetic predisposition.
• Women have different mental, emotional and physical responses, depending on where they are in their cycle.
• We should focus on the individuality of women when it comes to the genetic traits of their hormonal circadian rhythms.
• Females need to listen to their bodies and be wary of one-size-fits-all approaches to hormones such as birth control. The pill can either be a saving grace or bring complications.

[18:39] Understanding Hormones, Treatment and Therapies

• Even without the extremes such as hormonally-related cancers, daily issues such as migraines, fatigue, weight gain, and nutrient deficiencies can occur.
• Knowing your innate tendencies is essential to feeling healthy and optimal.
• Most women enter womanhood without clearly understanding their innate patterns. This lack of understanding forces them to accept the routine or resort to pharmaceutical treatment.
• Symptoms of what was thought of as supposedly lyme disease and other complications vanish when women enter pregnancy.
• Some hydroxy-dominant women have a genetic predisposition to inflammation and oxidative stress due to hormones, regardless of their diet.

[29:44] Estrogen and Testosterone

• Estrogen is essentially aromatised testosterone.
• Four hydroxy estrogen metabolites in men contribute to prostate enlargement, leading to inflammation.
• Men who have a genetic predisposition to aggressively convert estrogen into metabolites are more likely to experience benign prostatic hyperplasia.
• Both men and women will benefit from understanding their tendencies when it comes to converting metabolites.

[35:57] Athleticism, Menstrual Health and Birth Control

• Some women can eat the same food and do the same exercises but can never achieve the same musculature.
• World-class athletes need to understand their monthly cycle thoroughly to be in an optimal state.
• Being on the pill makes you estrogenised for 21 days instead of the usual five days, which can be wonderful or detrimental for you depending on your genetic makeup.
• Estrogen binding to its receptors radically changes gene expression. Being on the pill fundamentally changes you on a cellular level.
• The pill can be right or wrong for you; taking it is not a trivial matter. Women aren't designed to be estrogenised continuously in the long-term, as it affects mitochondrial efficiency.

[47:46] The Effect of Having a Proclivity to Produce 4-Hydroxy and Being on the Pill

• Being on the pill exacerbates the effects of having a genetic predisposition to inflammatory and oxidative traits in hormones.
• Women who already have a disadvantageous genetic profile expose themselves to greater toxicity if they estrogenise themselves non-stop.
• Estrogen isn't evil, and it keeps us young. However, we have to find a balance.
• Listen to the full episode to understand the entire process and the chemical processes and genetic pathways involved!

[53:32] The Importance of Cellular Balance

• Cells have other receptors, and there has to be a proper balance and circadian rhythms to have healthy processes.
• Optimal health comes when the presence of hormones come in optimal waves.
• There are many nutraceutical or nutritional intake and environmental exposures that can further slow down essential processes. An example is a glass of red wine.
• If you know your genetic predispositions, you can improve your quality of life.
• This knowledge empowers us to make choices to either live a healthier life or at least mitigate negative consequences and know our genetic limits.

[1:03:57] Hormonal Implications for Men

• Older men can erroneously assume testosterone is the magic fix to declining sex drive and athletic performance due to aging.
• However, the reality is that you may have a genetic predisposition to convert testosterone into estrogen and become more estrogenised.
• These have implications with undergoing testosterone replacement therapy and can undermine your goals.

7 Powerful Quotes from This Episode

‘Your listeners have to understand that the way in which their bodies respond to these hormones define and contribute every aspect of cellular function’.

‘Few aspects of medicine are as boldly innately different as the nuances and the individuality of a young woman's innate genetic control of the circadian rhythm’.

‘It defines why she can eat the same foods, exercise the same as her mate, in fact, exercise more than her mate and be fit and be beautiful and be strong, but never get that cut or that sort of musculature’.

‘When you are naturally menstruating, there's only a window of about five to seven days, give or take, in your 28- or 30-day or thereabouts, where you are in your unit, but recycle that your body is actively producing estrogens. Those estrogens are actively circulating in your bloodstream. And the cells of your body are actively responding to that estrogen’.

‘It's about the balance... A healthy female cell is one that is having, it's a traffic system, and it's one that is being trafficked into it at the proper ratios at the proper circadian pulses and rhythms’.

‘If you do not know these things, you're going to be at risk of using a one size fits all approach that will be beneficial for 10%, 20%, 50% of women, but that most certainly equally can be deleterious for a group of young women, unwittingly’.

‘This is about empowerment, it is the empowerment of being informed — being informed about your unique predisposition. What is your operating manual, making your more normative choices, if you will, of these cascades? And then how do you optimise the things that you want to do and the things you don't want to do’?

About Dr Mansoor

Dr Mansoor Mohammed is the President and CSO of The DNA Company, a leading and innovative provider of comprehensive Functional Genomics testing, consulting and personalised health solutions.

He is widely regarded as a pioneer in medical genomics and has been the recipient of multiple academic and industry awards. He is the holder of several patents in the general fields of molecular diagnostics and genomics research and is one of the most sought-after national and international conference speakers in the genre of personalised medicine.

Prior to his role at The DNA Company, Dr Mansoor was also the former Founder and President of ManaGene, CEO of Combimatrix, Director of Genomics at Quest Diagnostics and Director of Research and Development at Spectral Genomics.

He continuously maintains an active clinical practice as a genomics consultant to some of the leading executive health clinics in Canada and abroad, has served on the Canadian Board of Autistic Research and is a consultant to the world-renowned Toronto Center of Applied Genomics.

If you want to learn more about Dr Mansoor and his work on genetics, you may visit his website. Alternatively, you can check out his Facebook and Twitter.

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