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Content provided by Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist, Eric Christianson, PharmD; Pharmacology Expert, and Clinical Pharmacist. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist, Eric Christianson, PharmD; Pharmacology Expert, and Clinical Pharmacist or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
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Morphine Pharmacology

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Manage episode 245774117 series 2462890
Content provided by Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist, Eric Christianson, PharmD; Pharmacology Expert, and Clinical Pharmacist. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist, Eric Christianson, PharmD; Pharmacology Expert, and Clinical Pharmacist or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.

Morphine has opioid agonist activity that can cause respiratory depression and death in overdose.

Morphine-6-glucuronide is the metabolite that can accumulate and cause CNS toxicity in renal failure.

Be aware of CNS depressants that may enhance the effect of morphine and other opioids. Some examples of CNS depressants include gabapentin, benzodiazepines, older antihistamine, skeletal muscle relaxants, and pregabalin.

Opioid withdrawal is a significant concern when patients have their morphine or another opioid abruptly stopped. Some signs of withdrawal include agitation, mood swings, anxiety, sweating, GI upset, pain, and insomnia.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!



  continue reading

323 episodes

Artwork
iconShare
 
Manage episode 245774117 series 2462890
Content provided by Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist, Eric Christianson, PharmD; Pharmacology Expert, and Clinical Pharmacist. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist, Eric Christianson, PharmD; Pharmacology Expert, and Clinical Pharmacist or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.

Morphine has opioid agonist activity that can cause respiratory depression and death in overdose.

Morphine-6-glucuronide is the metabolite that can accumulate and cause CNS toxicity in renal failure.

Be aware of CNS depressants that may enhance the effect of morphine and other opioids. Some examples of CNS depressants include gabapentin, benzodiazepines, older antihistamine, skeletal muscle relaxants, and pregabalin.

Opioid withdrawal is a significant concern when patients have their morphine or another opioid abruptly stopped. Some signs of withdrawal include agitation, mood swings, anxiety, sweating, GI upset, pain, and insomnia.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!



  continue reading

323 episodes

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