Breast Cancer | Dissecting the Decision: Optimizing the Use of CDK4/6 Inhibitors in the Management of ER-Positive, HER2-Negative Metastatic Breast Cancer

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A roundtable discussion with Drs Neelima Denduluri, Shom Goel, Erika Hamilton, Komal Jhaveri, Ruth M O’Regan and Sara M Tolaney featuring review of patterns of care survey results, presentation of relevant data sets and moderated panel discussion.

  • Module 1: Biology of the CDK4/6 Pathway and Pharmacology of the CDK4/6 Inhibitors Abemaciclib, Ribociclib and Palbociclib
    • General medical oncologist survey results (0:00)
    • Presentation of relevant data sets — Dr Goel (2:27)
    • Panel discussion (11:02)
  • Module 2: Management of ER-Positive, HER2-Negative Metastatic Breast Cancer (mBC) in Postmenopausal Patients
    • General medical oncologist survey results (17:17)
    • Presentation of relevant data sets — Dr Denduluri (18:54)
    • Panel discussion (21:53)
  • Module 3: Role of CDK4/6 Inhibitors for Premenopausal Patients with ER-Positive, HER2-Negative mBC
    • General medical oncologist survey results (30:38)
    • Presentation of relevant data sets — Dr Jhaveri (31:31)
    • Panel discussion (41:59)
  • Module 4: Site and Extent of Metastases, Including CNS Involvement, and Outcomes with CDK4/6 Inhibitors; Predictors of Response to Therapy
    • General medical oncologist survey results (1:5:57)
    • Presentation of relevant data sets — Dr Tolaney (1:7:28)
    • Panel discussion (1:19:33)
  • Module 5: Pathophysiology of Class- and Agent-Specific Toxicities and Optimal Management Strategies
    • General medical oncologist survey results (1:37:04)
    • Presentation of relevant data sets — Dr Hamilton (1:38:12)
    • Panel discussion (1:52:15)
  • Module 6: Mechanisms of Resistance to CDK4/6 Inhibitors, Treatment Beyond Disease Progression and Novel Strategies with Combinations
    • General medical oncologist survey results (2:00:03)
    • Presentation of relevant data sets — Dr O’Regan (2:01:39)
    • Panel discussion (2:06:26)

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