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EP 152: Unlocking the secrets of gene regulation with Nadav Ahituv, Director of the Institute of Human Genetics at UCSF

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Manage episode 440731182 series 2631947
Content provided by Sano Genetics. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Sano Genetics or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
01:15 - Introductions

02:02 - How our understanding of the non-coding genome has evolved throughout Nadav’s career

04:56 - Our current understanding of non-coding genome grammar

07:40 - Is there a missing piece to the common variant, common disease paradigm?

10:25 - Introducing ultraconserved elements (UCEs) and human accelerated regions (HARs)

12:50 - Can a simple code explain changes in certain regions of the genome? Does this require “messier” solutions, such as large language models?

14:25 - The potential of machine learning

16:56 - Using CRISPR and non-coding elements to treat haploinsufficiency-caused pediatric diseases

20:19 - Nadav’s experience of starting a company

24:44 - How CRISPR A minimizes the risks associated with traditional CRISPR editing

26:04 - How engineering fat cells can starve cancer
32:08 - What’s on the horizon for Nadav’s lab?

34:52 - Bats as unlikely “superheroes,”, and what we can learn from their glucose levels

38:43 - The genetic differences between archaic humans, like Neanderthals and Denisovans, and modern humans

40:33 - Closing remarks
  continue reading

188 episodes

Artwork
iconShare
 
Manage episode 440731182 series 2631947
Content provided by Sano Genetics. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Sano Genetics or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
01:15 - Introductions

02:02 - How our understanding of the non-coding genome has evolved throughout Nadav’s career

04:56 - Our current understanding of non-coding genome grammar

07:40 - Is there a missing piece to the common variant, common disease paradigm?

10:25 - Introducing ultraconserved elements (UCEs) and human accelerated regions (HARs)

12:50 - Can a simple code explain changes in certain regions of the genome? Does this require “messier” solutions, such as large language models?

14:25 - The potential of machine learning

16:56 - Using CRISPR and non-coding elements to treat haploinsufficiency-caused pediatric diseases

20:19 - Nadav’s experience of starting a company

24:44 - How CRISPR A minimizes the risks associated with traditional CRISPR editing

26:04 - How engineering fat cells can starve cancer
32:08 - What’s on the horizon for Nadav’s lab?

34:52 - Bats as unlikely “superheroes,”, and what we can learn from their glucose levels

38:43 - The genetic differences between archaic humans, like Neanderthals and Denisovans, and modern humans

40:33 - Closing remarks
  continue reading

188 episodes

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