How can we, humans, look at our relationship to nature differently? In season three of Going Wild, on top of stories about animals, we invite you to journey through the entire ecological web — from the tiniest of life forms to apex predators — alongside the scientists, activists and adventurers who study it. Wildlife biologist and host Dr. Rae Wynn-Grant has been studying wild animals in their natural habitats all over the world for years. Our award-winning podcast takes you inside the hidde ...
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EP 152: Unlocking the secrets of gene regulation with Nadav Ahituv, Director of the Institute of Human Genetics at UCSF
MP3•Episode home
Manage episode 440731182 series 2631947
Content provided by Sano Genetics. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Sano Genetics or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
01:15 - Introductions
02:02 - How our understanding of the non-coding genome has evolved throughout Nadav’s career
04:56 - Our current understanding of non-coding genome grammar
07:40 - Is there a missing piece to the common variant, common disease paradigm?
10:25 - Introducing ultraconserved elements (UCEs) and human accelerated regions (HARs)
12:50 - Can a simple code explain changes in certain regions of the genome? Does this require “messier” solutions, such as large language models?
14:25 - The potential of machine learning
16:56 - Using CRISPR and non-coding elements to treat haploinsufficiency-caused pediatric diseases
20:19 - Nadav’s experience of starting a company
24:44 - How CRISPR A minimizes the risks associated with traditional CRISPR editing
26:04 - How engineering fat cells can starve cancer
32:08 - What’s on the horizon for Nadav’s lab?
34:52 - Bats as unlikely “superheroes,”, and what we can learn from their glucose levels
38:43 - The genetic differences between archaic humans, like Neanderthals and Denisovans, and modern humans
40:33 - Closing remarks
188 episodes
MP3•Episode home
Manage episode 440731182 series 2631947
Content provided by Sano Genetics. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Sano Genetics or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
01:15 - Introductions
02:02 - How our understanding of the non-coding genome has evolved throughout Nadav’s career
04:56 - Our current understanding of non-coding genome grammar
07:40 - Is there a missing piece to the common variant, common disease paradigm?
10:25 - Introducing ultraconserved elements (UCEs) and human accelerated regions (HARs)
12:50 - Can a simple code explain changes in certain regions of the genome? Does this require “messier” solutions, such as large language models?
14:25 - The potential of machine learning
16:56 - Using CRISPR and non-coding elements to treat haploinsufficiency-caused pediatric diseases
20:19 - Nadav’s experience of starting a company
24:44 - How CRISPR A minimizes the risks associated with traditional CRISPR editing
26:04 - How engineering fat cells can starve cancer
32:08 - What’s on the horizon for Nadav’s lab?
34:52 - Bats as unlikely “superheroes,”, and what we can learn from their glucose levels
38:43 - The genetic differences between archaic humans, like Neanderthals and Denisovans, and modern humans
40:33 - Closing remarks
188 episodes
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