Fasting Inhibiting Muscle, No Sun For Pretty Skin, Using Mice For Diet Science | THRR077


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Fasting Inhibit Muscle Growth; Controlling Insulin - Risk of Colon Polyps; Basement Dwelling = Pretty Skin; Neanderthals Carb Loaded, helping grow their big brains; Using Mice in Human Diet Experiments

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1. Fasting inhibit muscle growth? [22:51]

Sheila says:

Hi Guys!

I'm a 56 yr old woman, very lean and fit (5'5", 120 lbs). I do primarily weight lifting 6x/wk. I eat low carb/higher fat, mostly animal protein, above ground veggies, and healthy fats. I also do intermittent fasting... fasting between 16-20 hrs. I usually lift around 11:30am (I also do Kion Aminos before my workout (while fasted)), and have my first meal around 1pm (a post workout shake), and then 2 food meals.

I do prioritize protein making sure to get enough (100-140g). I love my eating style and timing, but I'm wondering if the intermittent fasting could be slowing down muscle growth? I'm specifically trying to make Booty-gains, LOL... and it's going very slow despite training this muscle group 3x/wk.

Not sure if it's just my age or what (and the fact that I sit all day other than my lifting and short walk after dinner), but I heard something in a podcast about it being better to eat more frequently for muscle growth...but I hope that's not the case because I love IF.

Would love to hear your thoughts on this!

Thank you so much!


2. Controlling Insulin - Risk of Colon Polyps [26:55]

Shawn says:

Hi Rob,

Long time listener of the podcast. Have read both of your books and really enjoy your perspective on diet, training, and especially your jiu-jitsu journey. I myself started out with more of a powerlifting template around the age of 28. Currently I'm 41 and doing more of a crossfit type training session 2 to 3 times a week along with the "old man jiu-jitsu" twice a week. My question surrounds insulin and glucose levels and colon polyps. I had my first colonoscopy at 33 due to family history of colon cancer. They found 1 pre-cancerous polyp the first time around. Five years later they found 4. I recall Dr. Steven Gundry making the statement that he never saw a patient that had colon polyps that did not also have a high fasted insulin. My fasting glucose is usually in the upper 90's. Never had a fasted insulin test (but plan to). My hba1c has looked good at around 5.0. My diet is predominantly lower carb, but have always struggled with performance if I go too low. I've heard others recommend Metformin for helping keep glucose and insulin levels more in check as well. Just wanted to get your take on the relationship between glucose, insulin, and the risk of colon polyps / cancer.

Love the Q/A format. Please keep doing what you're doing.

BTW, would love to train BJJ with you if the opportunity ever arose.


3. Basement dwelling = Pretty skin? [32:56]

Kristi says:

Hi, love the podcast etc.

So, I'm a 27 year old female. And I spent most of my youth (junior high, high school, up until I was about 25) fearing the sun and sunburn. I would obsessively wear sunscreen, and I was as white as a ghost. I did catch a couple bad burns in junior high, which horrified me at the time, I didn't want to become one of those monster grandmothers that they showed in the future face cameras.

After a bit of college, I spent several years as a literal basement dweller -- I woke up in time to play World of Warcraft with my team at 5 pm. I even did most of my grocery shopping at night.

However the problem with this was I was pretty depressed, and I soon learned that sunlight, and sleeping more, can be important factors. When I was about 25 I started coming around to my old enemy, The Sun. This year, my goal has been to get as much sun as possible during the short Canadian summer -- without burning -- and store up some vitamin D for winter.

However, when I meet new people and reveal my age, they don't believe me, they think I'm 18 or 20. Was this because of my basement dwelling? Was I preventing wrinkles like they say? Should I even care, because I now know how wonderful the sun feels?

¯\_(ツ)_/¯ Maybe it's just genetics, my parents look pretty great and they are around 58. But still... I kind of like looking 20 years old. Thoughts?

4. "Neanderthals carb loaded, helping grow their big brains" [39:58]

Chris says:

I've been dabbling in the keto/paleo/carnivore world for several years. I lost 30 lbs after reading "Wired to Eat" just by eliminating grains. I'm not really strict right now, but I drank the carnivore Kool-Aid for a while and I believe eating nose-to-tail and perhaps a little bit of fruit and non-starchy vegetables is probably the best way for most people to eat. So when I read the article "Neanderthals carb loaded, helping grow their big brains" that someone posted on Facebook, it set me off just a bit. Their premise is that human brain development is a result of bacteria in our mouths converting starches into sugars (the only macronutrient that we do not need to survive) because our brains NEED glucose to grow, and not that: humans cooking and eating meat, fat and organs, which our bodies can readily digest and use without a bacterial go-between, caused our brains to grow. I need someone way smarter than me to argue this one... my emotions wouldn't allow me to have a civil discussion/debate. Thanks for all you do.

5. Using Mice in Human Diet Experiments [47:34]

Andrew says:

In your opinion, is it ever valid to use Mice as good data for experiments revolving around human diets? I'm confused because they're used all the time, but i thought that mice naturally eat grains/oats/fruits. It seems to me that any time you feed them a diet involving meat proteins that it would be unnatural for them, and affect their bodies vastly differently than human bodies. Honestly though, i know nothing about "mouse biology", so i might be missing something obvious here. Seems to me like mice experiments involving diet in humans are totally useless.

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