Estrogen In Men: Good, Bad, Indifferent? An Evidence-Based Review for Optimal Health w/Dr. Neal Rouzier


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A large population in the medical community believe that estrogen in men should be suppressed, even though the actual science shows that doing this has no real benefit. How does confirmation bias play into these views? What does the medical literature actually say about raising estradiol levels? On this episode, I’m honored to be joined by optimization medicine legend and expert, Dr. Neal Rouzier, who shares a lecture on the real effects of estrogen on men’s health.

The reason people want to block estrogen is because high levels are associated with harm, yet you don’t see that harm when you raise estrogen. -Dr. Neal Rouzier


  • Confirmation bias is a primary cause of doctors thinking that AIs are necessary. They first heard that estrogen was bad, and anything heard after that won’t be considered true.
  • High levels of hormones are associated with harm, but doctors tend to hang their hats on an observation even if it isn’t linked to a causation.
  • When you block estradiol levels, you’re adversely affecting bone health, memory, cognition, cardiovascular health, erectile function, and fat loss.
  • There are two ways to block estrogen: androgen deprivation therapy and with an AI. Both cause harm.

At the start of the show, Dr. Neal shared how he got to where he is today, and why so many people struggle to distinguish estrogen use when someone is taking supraphysiological doses of hormones and therapeutic levels. Next, Dr. Neal shared his lecture and talked about how confirmation bias and association play a role in the mistaken view many doctors have about estrogen. Dr. Neal shared on the various studies that prove that raising estrogen is actually beneficial and that suppressing it can actually cause harm.

We also discussed;

  • Why association does not prove causation when it comes to estrogen
  • How reducing estradiol actually increases fat
  • The role of the bodybuilding world in the view of estrogen today

Most doctors are hanging their hats on the idea the estrogen in men should be suppressed, based only on confirmation bias and associations that aren’t linked to any causation. High levels of estrogens are associated with harm, and even though this view came out of the bodybuilding world, it still persists today. The question is: why would we want to block estrogen if, in every study it is given, estrogen has showed great benefit? The point of contention is everyone thinks they’re preventing harm by blocking estrogen when in reality they are actually causing harm, and that’s something we should change.

Guest Bio- Dr. Rouzier is a world-renowned optimization medicine physician, educator, researcher, clinician, speaker and author. He is the founder of WorldLink Medical. He specializes in bioidentical hormone replacement for men and women. His passion for literature research has led him to be one of the most credible speakers in the field of bio identical hormone replacement.

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