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Breakthroughs

Northwestern University Feinberg School of Medicine

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Breakthroughs is a podcast about groundbreaking research and the scientists leading these discoveries at Northwestern University Feinberg School of Medicine. We are driven by our mission to transform the practice of medicine and profoundly impact human health beyond the individual patient. We believe better answers only come from discovery.
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Applying to medical school can be a very complex and confusing process! All Access: Med School Admissions by Christian Essman, Senior Director of Admissions & Financial Aid at Case Western Reserve University School of Medicine in Cleveland, Ohio, brings listeners into informative and entertaining conversations between admissions colleagues from medical schools across the US. Christian and his guests try to bring transparency to the medical school application process and help prospective appl ...
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Against the Grain

Samir Kakodkar

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Host: Samir Kakodkar, MD - specialist in Crohn's disease and ulcerative colitis Medical School: Northwestern Feinberg School of Medicine Internal Medicine Residency: Rush University Medical Center Fellowship in Gastroenterology and Hepatology: Advocate Lutheran General Hospital Advanced Fellowship in Inflammatory Bowel Disease (Crohn's and Colitis): Northwestern Memorial Hospital Practice Location 7900 N Milwaukee Ave Suite 19, Niles, IL 60714 For appointments: 847-318-9595 Contact: samir3@g ...
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Welcome to So You Want to Transform Healthcare, a podcast series created by Health2047 Inc., the innovation subsidiary of the American Medical Association. At Health2047, our mission is to find, found and scale innovative startups that transform healthcare at the system level before the AMA’s 200th anniversary in 2047. Innovating with intention is our business. In this podcast series, our Managing Director of Medical Affairs, Dr. M. Christine Stock—Professor Emerita from Northwestern’s Feinb ...
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Northwestern Medicine physician-scientist Jaehyuk Choi, MD, PhD joins the show again to discuss another breakthrough. This time for lupus, a chronic autoimmune condition affecting 300,000 Americans that can cause inflammation in many body parts, including joints, skin, kidneys, blood cells, brain, heart and lungs. Findings by Choi and his lab membe…
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Anne DeGheest, Managing Director of HealthTech Capital, joins Dr. M. Christine Stock, Managing Director of Medical Affairs at Health2047. Anne discusses her pioneering experience in the health tech industry since 1986 and emphasizes the importance of founders having a flexible mindset to be experimental in learning and adjust accordingly as they de…
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For decades, Marcus Peter, PhD, has drilled into an area of research focused on cell death and the roles of toxic and protective short RNAs, with the goal of developing a novel form of cancer treatment. Now, this same line of research has led Peter’s team to uncover new insights into the cause of Alzheimer's disease. In this episode, Peter explains…
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New advances in digital pathology are revolutionizing the analysis of disease, paving the way for greater accuracy and efficiency when it comes to diagnostics, predicting outcomes and treatment. In this episode, Lee Cooper, PhD, discusses the future of digital and computational pathology and his research on machine learning and pathology, including…
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Northwestern University Feinberg School of Medicine is home to a team of premier faculty and staff biostatisticians who are a driving force of data analytic innovation and excellence. In this episode, Denise Scholtens, PhD, a leader in biostatistics at Feinberg, discusses the growing importance of the field of biostatistics and how she leverages he…
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Charles Aunger, founder and CEO of HEAL Security, speaks with Dr. Christine Stock, Managing Director of Medical Affairs at Health2047. They discuss the pressing need for healthcare systems to identify and address vulnerabilities in their systems and devices. Charles shares his extensive experience in IT leadership and underscores the importance of …
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Northwestern Medicine scientists are at the forefront of research investigating the most effective ways of treating obesity in children and teens and improving their access to care. In this episode, Justin Ryder, PhD, a clinical and translational obesity scientist at Feinberg, talks about the use of new GLP-1–based medications for childhood obesity…
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An estimated 32,000 Americans are currently living with ALS, or amyotrophic lateral sclerosis, a progressive neurodegenerative disease that attacks motor neurons in the brain and spinal cord. Northwestern investigators have uncovered novel cellular mechanisms involved in two types of genetic ALS that might lead to future targeted therapies. Evangel…
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This month, Shanta Whitaker, co-founder and managing director of Continuum Health Group, joins Dr. M. Christine Stock, Managing Director of Medical Affairs at Health2047. Shanta shares her journey from bench scientist to public health policy expert, driven by a desire to make a tangible impact on people's lives. She discusses how Continuum Health G…
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Inflammation is a common feature of many diseases and Northwestern Medicine investigators have identified how a calcium channel contributes to inflammation in the brain and lungs. This could aid in finding new types of therapeutics for inflammation-related diseases and conditions. In this episode, Murali Prakriya, PhD, discusses the evolution of th…
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Teens are reporting struggles with their mental health at unprecedented rates, but resources to help these young people deal with anxiety or depression can be difficult to access. In this episode, Ashley Knapp, PhD, assistant professor of Psychiatry and Behavioral Sciences, and Robert Simmons, MA, director of social services and public safety at Oa…
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This month, Dr. Khan Siddiqui, CEO and co-founder of HOPPR, joins Dr. M. Christine Stock, Managing Director of Medical Affairs at Health2047. They discuss challenges within radiology and the importance of building infrastructure to accelerate AI development and to improve efficiency and diagnostic accuracy in managing and interpreting medical imagi…
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Thanks to advancements in synthetic biology, scientists are now engineering bacterial communities with the goal of using these cells to monitor and treat diseases. In this episode, Arthur Prindle, PhD, explains how his lab is reprogramming bacteria that may be used in the future to detect disease and deliver therapeutics for many different conditio…
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A new study published in the journal Nature details breakthrough T-cell immunotherapy research from Northwestern Medicine. In this episode, Jaehyuk Choi, MD, PhD, senior author of the paper, explains how a gene mutation found in T-cells of patients with lymphoma could hold the key to a potent cancer-fighting immunotherapy for solid tumor cancers, w…
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In this enlightening episode, I sit down with the recently appointed, dynamic Assistant Dean for Admissions at the University of Michigan Medical School, Dr. Deborah Berman. Dr. Berman offers an in-depth look into the significant curricular updates, wellness initiatives, and the evolving admissions landscape at one of the premier medical schools in…
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Dr. Andrew Gostine, CEO of Artisight, focused on the transformative potential of augmented intelligence in healthcare, speaks with Dr. Christine Stock, Managing Director of Medical Affairs at Health2047. Dr. Gostine highlights the development of bedside AI and its aim to enhance workflows, reduce nurse turnover, and improve efficiency by offloading…
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Welcome to this special episode where we delve into the treasure trove of resources available for prospective medical school applicants. Today, we're joined by Tami Levin, MA, the Director of Premed and Applicant Resources at the AAMC, and Laura Fletcher, PhD, a senior research analyst in the Admissions & Selection Research and Development team at …
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Dr. James Madara, CEO of the American Medical Association (AMA), and Lawrence Cohen, CEO of Health2047, join Dr. Christine Stock, Managing Director of Medical Affairs at Health2047. They highlight the importance of assuring that the physician-patient interaction is at the heart of healthcare innovation and emphasize the need for collaboration with …
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When most of us think about dopamine, we think about reward signals. But new research from Northwestern Medicine, published in Nature Neuroscience, has found a genetic subtype of dopamine neurons that do not respond to rewards at all, and instead, fire when the body moves. Rajeshwar Awatramani, PhD, and Daniel Dombeck, PhD led this work. In this ep…
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Joe Marks, a seasoned expert in innovation and applied computing for over 30 years, discusses the development and applications of artificial intelligence, including generative AI. He speaks about the application of generative AI in healthcare, such as generating operating room schedules and drafting discharge summaries, but emphasizes the need for …
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As the primary investigator of The NIH Toolbox®, Richard Gershon, PhD, has led a team of hundreds of scientists to develop and evolve state-of-the-art digital assessments of cognition, motor, sensation and emotion which has been used by clinicians, investigators and academics for nearly two decades. In this episode, Gershon explains how the third v…
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Mitochondria are widely known as cellular “powerhouses” for their role in producing energy for cells. But pioneering research from Northwestern Medicine investigators over the last 20 years has proven mitochondria are also major players in lung disease, cancer, brain disease and immune-related diseases. Navdeep Chandel, PhD, a 2023 recipient of the…
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Brigadier General Mary Krueger speaks with Dr. Christine Stock, Managing Director of Medical Affairs at Health2047. The conversation explores medical readiness in the US Army, both for individuals and units, the importance of taking care of soldiers' families, the future of military medicine, focusing on leveraging technology for improved patient c…
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Northwestern Medicine is dedicated to improving outcomes for patients who are in need of organ transplants. Daniela Ladner, MD, MPH, is leading research that sheds light on the barriers to transplantation as the founding director of the Northwestern University Transplant Outcomes Research Collaborative (NUTORC). She discusses the groundbreaking res…
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Dr. Roopal Kundu, Associate Dean for Admissions, highlights the unique curricular features and educational philosophy at Northwestern University Feinberg School of Medicine, shedding light on their innovative approaches to medical education. From fostering curiosity and inquiry to promoting equity through group and problem-based learning, Dr. Kundu…
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Both long-term alcohol consumption and binge drinking can speed up biological aging, according to a Northwestern Medicine study published in the journal Aging. Lifang Hou, MD, PhD, chief of Cancer Epidemiology and Prevention in the Department of Preventive Medicine led the study and discusses the link between genetics and lifestyle in the context o…
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Dr. John Halamka, President of the Mayo Clinic Platform, speaks with Dr. Christine Stock, Managing Director of Medical Affairs at Health2047. They discuss the goal of transforming healthcare through platform thinking that leverages global data, focuses on de-identification and curation of data, and emphasizes equity and patient-centric solutions. D…
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Mozziyar “Mozzi” Etemadi, MD, PhD, is supporting the transformation of healthcare delivery and patient care at Northwestern Medicine by bringing engineers into direct contact with clinical providers. In this episode, he talks about the explosion of artificial intelligence in healthcare in recent years and how Northwestern Medicine is using this tec…
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Dr. Julien Pham, founder and managing partner of Third Culture Capital (3CC), speaks with Dr. Christine Stock, managing director of medical affairs at Health2047. Julien has over 15 years of leadership experience in clinical settings and in emerging medical technology companies, including a decade as a serial healthcare entrepreneur. They discuss h…
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Treating cancer has become increasingly difficult as cells develop resistance. Northwestern investigators have sought to address this issue on the cellular level through the development of a novel FateMap tool, used to predict the future behavior of cancer cells before they are exposed to cancer-fighting drugs. In this episode, Yogesh Goyal, PhD, d…
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Dr. Stephen Devries, preventive cardiologist and Executive Director of the Gaples Institute, an educational nonprofit with the mission of advancing the role of nutrition and lifestyle in medicine, speaks with Dr. Christine Stock, Managing Director of Medical Affairs at Health2047. They discuss how nutrition has not historically been prioritized in …
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The launch of the Simpson Querrey Lung Institute for Translational Science (SQLIFTS) at Northwestern University Feinberg School of Medicine aims to expedite the discovery and implementation of innovative lung disease treatments through a patient-centered approach. In this episode, Scott Budinger, MD, the new executive director of the institute, dis…
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Jeb Dunkelberger, Managing Partner of Dark Mountain Healthcare, an advisory firm for venture capital, private equity funds, and portfolio companies, speaks with Dr. Christine Stock, Managing Director of Medical Affairs at Health2047. Jeb published a book called, "Rich and Dying," about transforming the US healthcare economy, which was an Amazon 202…
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The global prevalence of Parkinson's disease has doubled in the past 25 years. While research into this extremely diverse neurodegenerative disorder is very active, there is much left to be uncovered about the underlying cause of the disease. Recently, Northwestern Medicine investigators have discovered novel genetic factors contributing to the ris…
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Join us for an exclusive Zoom event featuring Christian Essman, the host of "All Access: Med School Admissions." Are you an aspiring medical student with burning questions about the admissions process? Look no further! This is your chance to spend an engaging evening with Christian Essman and have all your inquiries answered. During this virtual ga…
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I had the pleasure of speaking with Dr. Tracy Kedian, the Associate Dean for Admissions, at the UMass Chan Medical School in Worcester, MA. Dr. Kedian sheds light on the unique aspects of UMass Chan's curriculum, known as VISTA. This innovative curriculum fosters curiosity, inquiry, and equity through group and problem-based learning, along with ex…
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Peter Shen, Head of the Digital and Automation Business at Siemens Healthineers, speaks with Dr. Christine Stock, Managing Director of Medical Affairs at Health2047. Peter is an industry leader specifically focused on introducing new and emerging technologies to the healthcare market, including solutions in imaging IT, 3D Advanced Visualization, da…
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Disrupting our internal clocks can lead to diseases such as obesity and diabetes. Scientists at Northwestern have uncovered the mechanism behind why late-night eating is linked to weight gain and diabetes. Joseph Bass, MD, PhD, led the study published in the journal Science. He shares the results and details the two decades of work leading to this …
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This episode was released in February 2021, and is being re-shared to offer the research behind the popular weight loss drugs Ozempic and Wegovy. Northwestern's Robert Kushner, MD, discusses the drug semaglutide, typically prescribed for treatment of Type 2 diabetes and the results of the phase 3 clinical trial as a treatment for obesity with very …
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Dr. Tao Le, founder and CEO of ScholarRx, a global platform for shared medical education, and Health2047's most recent portfolio company, speaks with host Dr. Christine Stock, Managing Director of Medical Affairs at Health2047. Tao is an internationally recognized medical educator and physician executive. They discuss how ScholarRx is building a he…
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There's strong evidence that physical activity can play an important role in the health and lifespan of cancer survivors. Siobhan Phillips, PhD, MPH, leads the Exercise and Health Lab at Feinberg, which designs, tests, implements and disseminates physical activity interventions to support cancer survivors. In this episode, Phillips details interven…
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As a caution, and as the title suggests, we will be discussing mental health. If you need immediate assistance, you can speak chat or text with a counselor at the 988 crisis line. Dr. Megan Jones Bell, Clinical Director of Consumer and Mental Health at Google, speaks with host Dr. Christine Stock, Managing Director of Medical Affairs at Health2047.…
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Physicians are notorious for prescribing antibiotics as a "quick fix" when they aren't necessary. There are many reasons why, and Jeffrey Linder, MD, MPH, dives into those and discusses effective ways to reduce the number of inappropriate prescriptions by working with physicians. Originally released in fall 2018, this episode is still timely as the…
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Dr. Judianne Kellaway, the Associate Dean for Admissions & Outreach, at the Joe R. & Teresa Lozano Long School of Medicine at University of Texas Health San Antonio joins me for a entertaining and wonderfully informative conversation. Dr. Kellaway takes us through the highlights and unique aspects of their CIRCLE curriculum including, professional …
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The Assistant Dean of Medical Education and Admissions, Dr. Liesel Copeland, joins me to discuss the curricular highlights and admissions process at Rutgers University Robert Wood Johnson Medical School. In 2021, the medical school launched the 5 C’s Curriculum: Curiosity, Critical Thinking, Clinical Skills, Competence and Compassion which we talk …
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Northwestern scientists Yuan Luo, PhD, and Catherine Gao, MD, discuss a study they conducted using the artificial intelligence chatbot, ChatGPT. The results showcase the online tool's ability to produce convincing medical research abstracts. They also discuss the tool’s potential to help with writing-intensive tasks in healthcare and medical resear…
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I sat down with Dr. Lina Mehta, Associate Dean for Admissions at the CWRU School of Medicine to discuss some admissions-related topics. We reflected on the previous application cycle, current topics is admissions, and looking ahead to the next cycle. We think you'll find this episode to be informative and, hopefully, entertaining! If you find this …
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As a caution, and as the title suggests, we will be discussing suicide and suicide prevention. If you need immediate assistance, you can speak, chat, or text with a counselor at the 988 crisis hotline. Dr. Stephen O'Connor, Chief of the Suicide Prevention Research Program and the National Institute of Mental Health Division of Services and interven…
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A theoretical neuroscientist, Ann Kennedy, PhD, is investigating neural computation and the structure of behavior. In this episode, she talks about her recent research in the area of aggression and how it's regulated in the brains of animals. She was recently named the winner of the 2022 Eppendorf and Science Prize for Neurobiology.…
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