Talking Biotech is a weekly podcast that uncovers the stories, ideas and research of people at the frontier of biology and engineering. Each episode explores how science and technology will transform agriculture, protect the environment, and feed 10 billion people by 2050. Interviews are led by Dr. Kevin Folta, a professor of molecular biology and genomics.
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Sunny Ormonde (Lilian Bellamy in the Archers) and her old friend and collaborator Jane James chat about The Archers, chuckle about getting older and complain about the indignities of the week. Follow us @onestiletto65 - On Twitter and One Stiletto In The Grave Podcast - On Facebook. Produced by Jake Wilson Wainwright at Raggedy House Productions. Music by Tom Smith
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Update on Controlled Environment Agriculture - Chris Higgins
50:57
50:57
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50:57
Two decades ago the idea of growing crops indoors seemed like an excellent way to grow food closer to urban centers. Greenhouses and 100% indoor operations grew with significant investment. Years later we see that major efforts have not succeeded. What have we learned and where is the industry going? We speak with Chris Higgins, President and CEO o…
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The GMO Tree You Never Heard About - Dr. Chris Dardick, USDA/ARS
34:14
34:14
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34:14
We regularly discuss a small suite of commercial crops that have been genetically enhanced with transgenes. However, one additional genotype was transformed long ago, and approved for use in the USA, Canada and EU-- but nobody talks about it much. It is the plum resistant to plum pox virus (PPV), a devastating virus of stonefruits. While rare in th…
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Anti-GMO Hawaii Memories; A Career in Ag Science - Dr. Steve Savage
59:17
59:17
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59:17
In 2013 a number of county ordinances sought to end the use of biotech crops on various Hawaiian islands. Hawaii's warm year-'round climate permits several corn seasons a year, so seed corn for the mainland is produced in these locations. However, these technologies are not appreciated by a subset of the population, who see these companies as poiso…
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Enabling Local Production of Protein Therapeutics - Dr. Kerry Love, Sunflower Therapeutics
34:53
34:53
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34:53
Great products and ideas are everywhere, yet limited by the ability to actually produce them in needed quantitites. The technologies from Sunflower Therapeutics enable bioprocess applications throughout the globe in a deployable unit with a small footprint. Dr. Kerry Love describes the technology and it's applications, along with the philosophy of …
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Measuring the Health of T-Cells - Dr. Nigel McCracken, Virax Biolabs
50:35
50:35
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50:35
T-cells are a critical part of the adaptive immune system, actively targeting problematic invaders. From pathogens to cancers, T-cells seek and destroy potentially dangerous cells, and maintain a memory of their presence. In today's episode Dr. Nigel McCracken describes this part of the adaptive immune system and how Virax Biolabs is using speciali…
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Resistance to Correction, Breaking Trust in Science - Drs. Andrea Love and Nicole Keller
44:04
44:04
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44:04
Disinformation clouds the public understanding of science, especially technology in agriculture and medicine. So when a leading journal publishes false information, academic experts have an obligation to help correct the process. This may be done via a variety of methods, but cordial and collegial discussion is the first step. When that fails, note…
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Your Role in Editing Wikipedia - Susan Gerbic
42:32
42:32
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42:32
Wikipedia is the go-to source for many people when starting to research a subject. But is the information correct, or does the information even exist in Wikipedia at all? Susan Gerbic has been training people to edit Wikipedia pages through the Gorilla Skeptics of Wikipedia project. They have edited tens of thousands of pages with over 16 million v…
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Gene Editing in Specialty Crops - Dr. Tom Adams, CEO Pairwise
32:06
32:06
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32:06
Crop genetic engineering has focused primarily on large-acreage crops like corn. But what about the universe of specialty crops that tantalize consumers, things like blackberries or salad greens? Pairwise has used precision twists on gene editing to change specific traits in fruit and vegetable crops. Pairwise founder and CEO, Dr. Tom Adams, discus…
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Special Panel - From Pre-Clinical to Clinical Trials
33:33
33:33
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Advancement of a new drug from pre-clinical trials to clinical trials is a pivotal time in validation of its therapeutic effects and safety. A panel of experts discusses the process.By Colabra
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Talking Biotech Begins Year 10! with Dr. Liza Dunn
1:03:32
1:03:32
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Today's episode marks the beginning of the 10th year of the Talking Biotech Podcast. To celebrate, Drs. Liza Dunn and Kevin Folta discuss the last decade of biotech breakthroughs and communications efforts, the fight against technology and the amazing progress in gene editing and human genetic therapies. Plus, what you can do to help the effort goi…
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Targeting Chronic Inflammation Via the Inflamasome - Dr. David Bearss
47:33
47:33
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47:33
Chronic inflammation goes hand-in-hand with many diseases, complicating symptoms and affecting routes of treatment. What is the molecular basis of inflammation, and can it be targeted by new drugs? Scientists have studied the molecular basis of the inflammatory response and have identified specific proteins that complex to initiate the response. Ne…
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Strategic partnerships are becoming more important in development and deployment of biotechnology solutions. Today's panel discusses the way partnerships are formed, some of the important considerations with IP and licensing, and how relationships are managed.By Colabra
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Journal Club - Were "High Levels" of Glyphosate Found in Sperm? - Dr. Andrea Love
27:59
27:59
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27:59
The news reports say that scientists have found "high levels" of herbicide in human sperm, and suggest it is a cause of infertility. But what do the data really say? Dr. Andrea Love and I discuss the paper. A report by Vasseur et al., in the June 2024 Ecotoxicology and Environmental Safety entitled Glyphosate presence in human sperm: First report a…
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Standardizing Therapeutic Protein Production in Plants - Jim Wilson
47:53
47:53
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47:53
Where many therapeutic compounds are raised in bacteria or fungi, plants sometimes offer many advantages as bioreactors. Capital and production costs are lower, and products may be edible instead of injectable. The problem tends to be standardization, and conditions that ensure that the desired proteins are produced This episode features Jim Wilson…
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S4 Special – Live at the Academic Archers conference 2024
58:16
58:16
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58:16
Sunny and Jane chat with Susie Riddell (Tracy) and Madeleine Leslay (Chelsea) about the highs and lows of the Year in Horrobin and answer questions from a live audience at the Academic Archers conference 2024.By One Stiletto In The Grave Podcast
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Canadian Rules for Gene Editing - Jennifer Hubert
27:00
27:00
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27:00
Canada has a unique approach to plant genetic improvement that follows the product, not the process. In other words, if there is potential risk from any genetic manipulation technique, from polyploidization to transgenic to gene edits, Canadian regulators assess the relative risk in the final product. But what does the regulatory climate look like …
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Overcoming CAR-T Cell Bottlenecks - Dr. Andy Scharenberg
46:41
46:41
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46:41
Immunotherapy is weaponizing the body's immune system against cancer or other disease. One of the most promising approaches is CAR-T cell therapy, yet as this technology has been implemented, it's limitations have been identified. Dr. Andy Scharenberg described the current drawbacks of CAR-T cells and how his company, Umoja, is re-engineering CAR-T…
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The FDA Regulatory Ecosystem- Expert Panel Discusses the Process
1:01:33
1:01:33
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How do new drug applications move forward to approval? Four experts discuss the partnership between the FDA, the drug developer, and the data needed to move a product forward. It is a surprising discussion that reveals the depth of the FDA process. Joined by Dr. Debra Webster, Dr. Julia Marre, Dr. Michael Matthews and Dr. Jonathan Helfgott.…
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