Best Sir Gene Podcasts (2024)

1
Did Christian Art Make Richard Dawkins a Cultural Christian? (and Does it Matter?) 1:07:02

9h ago1:07:02

1:07:02

The dynamic duo dives into the headlines for this episode, breaking down Richard Dawkins's viral interview and exploring the question of one of the culture's most forceful atheists identifying as a cultural Christian, and even going so far as to call it "fundamentally decent religion." What's up with that? Is this the weirdest timeline? The guys di…

1
EP 131: The potential of somatic genomics in drug discovery and development with Jake Rubens 44:57

9h ago44:57

44:57

0:00 Intro 0:40 Jake’s experiences as a serial entrepreneur starting five companies with a basis in genomic science 5:30 Opportunities for research and drug development in the realm of somatic science 9:20 Somatic evolution and how it provides valuable insights into disease mechanisms 12:30 Advantages and disadvantages of studying germline genome-w…

1
EP 130: Quarterly insights into noncoding variants and GWAS with Dr. Veera Rajagopal 51:56

7d ago51:56

51:56

Show Notes: 0:00 Introduction 1:20 How polydactyl mutations can inform research on non-coding variant mechanisms The importance of low-affinity binding between transcription factors and targets How these lessons can help us improve our understanding of drug and target discovery See Veera’s January round-up for more information: https://www.gwasstor…

1
Genes, Guidance, and the Role of the Genetic Counsellor 33:46

11d ago33:46

33:46

In the last episode of our first series, your host Helen Bethell is in conversation with…… herself! For one episode only, Helen turns the tables and hands the mic to Jack Darling, to interview the interviewer! As a Genetic Counsellor, Helen is quizzed from the patient perspective, shares the twists and turns of her own fascinating career in educati…

1
Story Journal: 3 Body Problem, Spaceman, Dragon Ball, and more! 1:07:21

14d ago1:07:21

1:07:21

Logan and Tyler talk about the stories they've been engaging with recently, including 3 Body Problem, Hi-Fi Rush, God Emperor of Dune, Spaceman, Dragon Ball, and the Friends per Second Podcast. -- Join our community on Discord! If you have a question for the show, send it to logan@wisedisciple.org or tyler@wisedisciple.org. Get your Wise Disciple m…

1
EP 129: Patient advocacy for genetic ALS and FTD with Jean Swidler, Executive Director of End the Legacy 38:44

15d ago38:44

38:44

0:00 Introduction 0:45 Jean’s personal experiences with family members with genetic ALS 10:00 Jean’s thoughts on the barriers and facilitators to providing treatment for those with genetic ALS 13:20 Insights into C9orf72, a common genetic determinant of ALS, and how it can also be associated with FTD 16:10 Jean’s experiences as an active advocate f…

1
Decoding Lynch syndrome, with Professor Sir John Burn 32:11

18d ago32:11

32:11

This week, Helen completes her interview with Professor Sir John Burn, focusing on his ground-breaking research and discoveries in the specialist field of Lynch Syndrome - one of the more common causes of inherited cancer, including bowel cancer and endometrial cancer. He also talks about the trials he has led over many years demonstrating the impo…

1
Virtue and Chivalry in 'Sir Gawain & the Green Knight' (and David Lowery's 'The Green Knight') 1:11:22

21d ago1:11:22

1:11:22

Your original dynamic duo is back for a chat about the beloved Arthurian legend of Sir Gawain and the Green Knight! The guys break down the story, why they love it so much, and what the strange story structure is exploring about virtue in the context of Arthurian legend. Then they dig into the critically-acclaimed (but also controversial) film vers…

1
EP 128: Parkinson’s disease and precision medicine with Drs. James Beck and Ignacio Mata 50:18

21d ago50:18

50:18

0:00 Introduction 1:05 Insights into the PD GENEration’s (a programme from the Parkinson's Foundation) milestones and progress points for the upcoming year 3:30 The shifting attitudes and perspectives of neurologists and healthcare workers at the PD GENEration 5:50 Insights into Nacho’s work with the genetics of Parkinson’s disease 10:20 Barriers a…

1
Genomic Pioneers: In Conversation with Professor Sir John Burn 35:18

25d ago35:18

35:18

This week, your host Helen Bethell is in conversation with Professor Sir John Burn, who perhaps needs little introduction. Sir John is a colossus in the field of genomic medicine and research, and he reflects on his incredible medical and academic career to date. Tracking his fascinating journey from growing up in a pit village in County Durham thr…

1
A look into The World of Professional Animation (With Rachel White) 1:22:13

28d ago1:22:13

1:22:13

Logan and Tyler interview Rachel White, an award-winning animator who is soon to graduate from the George Shinn College of Entertainment & the Arts at Lipscomb University in Nashville, TN. In this episode, the guys get to talk about Rachel's pathway through life to the creative fields and how faith has helped shape her art. They also get to discuss…

1
EP 127: Insights into precision medicine, fatty liver disease, and minimally invasive diagnostic tools with Dr. Mazen Noureddin 39:10

28d ago39:10

39:10

0:00 Intro 0:25 Mazen’s lifelong commitment to furthering the field of precision medicine in liver disease research, fueled by a personal connection of his grandmother developing MASH cirrhosis 2:30 Breakthroughs in the field of metabolic dysfunction-associated steatotic liver disease (MASLD) since the beginning of Mazen’s career 5:30 The potential…

1
How Genomics Supports the Patient Journey 20:14

1M ago20:14

20:14

This week, Helen is in conversation with Consultant Clinical Geneticist, Dr Jackie Cook, who, during her 30 years or so in genomics, has seen it all, from small beginnings when genetic testing was very limited, through to the mapping of the first human genome and all the innovative advances in genomic medicine that followed, and the impact these ha…

1
Is 'Dune: Part 2' An Anti-Religious Screed or a Moving Cautionary Tale? (with Gene Gosewehr) 1:17:01

1M ago1:17:01

1:17:01

Gene joins Logan and Tyler to talk about Dune Part 2! What does Frank Herbert's highly influential science fiction novel have to say about religion, demagogery, and Messiah figures? Is it anti-religious, anti-Christian, anti-Islam, or none of these? Is Paul the hero or the villain? The guys discuss all this and more in a very spoilery, wide-ranging…

1
EP 126: Patient-led research for ultra-rare disease drug development with Julia Taravella, Executive Director of Rare Trait Hope Fund 39:41

1M ago39:41

39:41

0:00 Introduction 0:25 Julia’s personal experience with ultra-rare diseases within her family 10:25 The importance of increasing accessibility to genetic testing across populations to learn more about ultra-rare diseases 14:00 The origin story of Rare Trait Hope Fund 23:50 Current research and next steps in developing potential gene therapies for a…

1
A Patient's Journey Through Genetic Testing 33:23

1M ago33:23

33:23

This week host Helen Bethell is in conversation with patient, Jack Darling who works in the communications team with the NEY GMS. But he's also a patient with a rare genetic heart condition. In this episode, Jack openly shares his own emotional journey - from undergoing genetic testing as a teenager, through to receiving his diagnosis and treatment…

1
How to Tell the Story of Jesus 57:52

1M ago57:52

57:52

Logan and Tyler bring their experience as Bible teachers to this episode of the show, and talk about how the same instincts that make us lovers of stories can make us more effective at sharing the gospel. Why is so much of the Bible told in stories? How would you explain the story of the Bible if you only had one conversation? Is the common term "B…

1
EP 125: The future of UK Clinical Trial Policy: Innovation, integration, and game-changing legislation with Lord James O’Shaughnessy 45:23

1M ago45:23

45:23

0:00 Introduction 1:25 How Lord O’Shaughnessy became involved in scientific policy making and his path to writing the UK Commercial Clinical Trials Review. 04:05 How Lord O’Shaughnessy pivoted from education to a focus on life sciences 06:38 The biggest challenges Lord O’Shaughnessy faced during his time as Parliamentary Under Secretary for Health …

1
Story Journal: Helldivers 2, Peanut Butter Falcon, Buffy the Vampire Slayer & More! 59:32

2M ago59:32

59:32

Tyler and Logan talk about the stories and media they've been engaging with recently, incuding: Helldivers 2; Chains & Stakes by The Dead South; The Peanut Butter Falcon; Buffy the Vampire Slayer; Armored Core VI: Fires of Rubicon; and The Confessions of St. Augustine. -- If you have a question for the show, send it to logan@wisedisciple.org or tyl…

1
EP 124: How ReCode Therapeutics is pioneering tissue specific delivery of gene therapies for Primary Ciliary Dyskinesia with John Matthews 42:00

2M ago42:00

42:00

0:00 Introduction 01:10 How growing up in Malawi planted the seeds for John’s career in medicine and transition to therapeutic development 04:35 Why John focuses on rare diseases and conditions such as asthma 06:01 What has changed over the last decade in terms of treating and understanding asthma and the progress that genetics has enabled 07:31 Wh…

1
What's coming up on The Road to Genome! 1:14

2M ago1:14

1:14

A quick look at what to expect from Season 1 of The Road to Genome, launching 11th March at 6am. Subscribe to hear it first!By North East & Yorkshire Genomic Medicine Service

1
Harvest time: Why the UK should unleash the power of gene editing, by Cameron English 31:47

2M ago31:47

31:47

This is an audiobook version of the Institute of Economic Affairs publication 'Harvest time: Why the UK should unleash the power of gene editing', by Cameron English. The full publication can be read at: https://iea.org.uk/publications/harvest-time-why-the-uk-should-unleash-the-power-of-gene-editing/ This audiobook was read by Cormac Diamond.…

1
0111 Sir Gene Speaks with Ni**arificEnergy - Racial Relations 2:55:24

2M ago2:55:24

2:55:24

Support the show I recommend listening at 1.25X And check out Gene's other podcasts: justtwogoodoldboys.com and unrelenting.show Gene's Youtube Channel: Sir Gene Speaks Donate via Paypal http://bit.ly/39tV7JY Bitcoin or Lightning strike.me/sirgene Can't donate? sub to my GAMING youtube channel (even if you never watch!) Sub Here Weekend Gaming Live…

1
Does Mythology Glorify Idols? 1:10:44

2M ago1:10:44

1:10:44

The guys return to the world of myth to do a deep dive on the question of Christians engaging with works of mythology. Do the stories of Homer, Virgil, and others which tell stories of gods and goddesses glorify idols? Should Christians dive into these stories, knowing that they were inspired by false gods? Why did early Christians like Justin Mart…

1
EP 123: The ethics of newborn genome screening: Actionable insights and beyond with Holly Peay, Senior Research Scientist at the Research Triangle Institute 45:34

2M ago45:34

45:34

0:00 Introduction 0:50 Holly’s background and career so far 03:30 Complex decision-making and multiple risk factors: Family history, genetics, phenotypes and beyond 07:05 Changes within the last decade to help people make complex, sometimes subjective, healthcare decisions 09:20 Impact on people: The RTI’s mission and the Early Check Study 13:45 Ne…

1
Does 'Returnal' Have a Biblical View of Guilt and Hell? 1:16:19

2M ago1:16:19

1:16:19

Tyler and Logan return to the world of video games for this analysis of Returnal. What does the game's giant twist say about guilt and the subconscious? Should Christians be wary of the surrealist style the game utilizes? Plus, Super Bowl commercials! Discussed on the Show: Video Essay on Returnal -- If you have a question for the show, send it to …

1
EP 122: Building genome-scale engineered cells for biotechnology with Leslie Mitchell, Co-founder and CEO of Neochromosome 35:55

2M ago35:55

35:55

Summary: 0:00 Introduction 01:01 How Leslie got into the field of synthetic biology and engineering, and her career journey so far 02:45 What Leslie accomplished during her postdoc and recent transformations in the field of genomics 05:57 The impacts of non-coding regions of the genome and the outcome of deletions 08:20 How long it takes to make ch…

1
0110 Sir Gene Speaks with Ni**arificEnergy - Prepping 1:58:27

2M ago1:58:27

1:58:27

Support the show I recommend listening at 1.25X And check out Gene's other podcasts: justtwogoodoldboys.com and unrelenting.show Gene's Youtube Channel: Sir Gene Speaks Donate via Paypal http://bit.ly/39tV7JY Bitcoin or Lightning strike.me/sirgene Can't donate? sub to my GAMING youtube channel (even if you never watch!) Sub Here Weekend Gaming Live…

1
0109 Sir Gene Speaks with Dr. Sarah Sun Liew 56:21

2M ago56:21

56:21

Link to campaign Vote Dr. Sarah Sun Liew – 2024 Republican Candidate for United States Senate (sarahsenator.org) Support the show I recommend listening at 1.25X And check out Gene's other podcasts: justtwogoodoldboys.com and unrelenting.show Gene's Youtube Channel: Sir Gene Speaks Donate via Paypal http://bit.ly/39tV7JY Bitcoin or Lightning strike.…

1
Was 'Barbie' Snubbed at the Oscars? (with Gene Gosewehr) 1:15:11

2M ago1:15:11

1:15:11

Gene Gosewehr joins Logan and Tyler to talk about the Oscars. Are they actually important? Is it a scandal that Greta Gerwig and Margot Robbie didn't receive nominations while the Ken doll did? Then they break down some of the Oscar nominees, including Barbie, Oppenheimer, and Killers of the Flower Moon. -- If you have a question for the show, send…

1
EP 121: Breakthroughs and insights in ALS research with Dr. Michael Benatar 44:10

2M ago44:10

44:10

Summary: 0:00 Introduction 0:50 Reflections from the 34th International Symposium on ALS/MND in Basel 1:50 Michael’s professional journey, initial challenges he encountered, and how the field of neurology has evolved over the years 3:10 An introduction to the ALS landscape, including its presentation, the genes involved, and potential treatment opt…

1
EP 120: Exploring the frontiers of gene therapy and AAVs with Dr. Nicole Paulk, CEO and Founder of Siren Biotechnology 43:47

3M ago43:47

43:47

0:00 Introduction to Dr. Nicole Paulk, a pioneer in AAV research and the founder of Siren Biotechnology 0:50 The moments that shaped Nicole’s career path and her passion for gene therapy and AAV research 9:20 Nicole’s academic research career and her transition from academia to the biotech industry 23:00 The story behind the founding of Siren Biote…

1
What Can Stephen King's 'On Writing' Teach Us About Storytelling? 1:15:27

3M ago1:15:27

1:15:27

Tyler and Logan examine the work and legacy of Stephen King, especially his part-memoir part-writing manual On Writing. How do you incorporate theme into stories without beating readers over the head? Is profanity in stories ever justified? How do King's stories understand good and evil? Tune in to find out! -- If you have a question for the show, …

1
0108 Sir Gene Speaks with Dude named Ni**arificEnergy 1:52:32

3M ago1:52:32

1:52:32

Support the show I recommend listening at 1.25X And check out Gene's other podcasts: justtwogoodoldboys.com and unrelenting.show Gene's Youtube Channel: Sir Gene Speaks Donate via Paypal http://bit.ly/39tV7JY Bitcoin or Lightning strike.me/sirgene Can't donate? sub to my GAMING youtube channel (even if you never watch!) Sub Here Weekend Gaming Live…

1
EP 119: Revolutionising drug discovery: how the Pharma Proteomics Project is combining genetic and proteomic data with Chris Whelan 38:25

3M ago38:25

38:25

0:00 Introduction 01:00 Chris’ background and career to date 02:10 What is the Enigma Project? 04:48 How is genetics being applied to drug discovery today and how does proteomics fit in? 09:23 When the UKBiobank Pharma Proteomics Project began and how long it took to set up 10:57 54k UK Biobank participants tested - discussion of findings 14:33 The…

1
How Sir Orfeo, Poetry, and Mythology Explore the Christian Story 1:10:49

3M ago1:10:49

1:10:49

On return from a holiday hiatus/ These hosts two/ Delve into the forests of Sir Orpheus/ His trails prove/ A tale of love lost, of godly truth and beauty/ Virtue made plain/ But not alone of faeries does this story tell/ But the Christian story/ Finds voice among the echoes here, where myth gives way to truth. -- Also, Logan bad at remembering song…

1
EP 118: The role of genetics in drug discovery and development with Dr. Matt Nelson 42:56

3M ago42:56

42:56

Summary: 0:00 Introduction 5:45 Lessons learned from 15 years at GSK: How has genetics and drug discovery evolved over time? 8:10 Matt’s seminal 2015 paper: Quantifying the impact of human genetic evidence on the probability of success in drug development 11:40 Which types of genetic evidence are the best drivers of success in clinical trials? 13:3…

1
Accounts and Accountability: The UK Government’s misguided plans to regulate corporate reporting and auditing, by Jamie Whyte 43:53

3M ago43:53

43:53

This is an audiobook version of the Institute of Economic Affairs publication 'Accounts and Accountability: The UK Government's misguyided plans to regulate corporate reporting and auditing'. The full publication can be read at: https://iea.org.uk/publications/accounts-and-accountability-the-uk-governments-misguided-plans-to-regulate-corporate-repo…

1
EP 117: Wendy Chung: whole genome newborn screening and other big opportunities in genomic medicine. 47:51

3M ago47:51

47:51

Summary: 0:00 Introduction 1:45 Wendy’s early career looking into the genetics of diabetes through mouse models 6:23 A high altitude view: Cutting through hype to spot the next wave of game-changing technology 8:03 The role of policy and communication: how Wendy’s work goes beyond the lab to create real-world impact 11:20 Wendy’s choice to do an MD…

1
New Vision: Transforming the BBC into a subscriber-owned mutual, by Philip Booth 32:32

3M ago32:32

32:32

This is an audiobook version of the Institute of Economic Affairs publication 'New Vision: Transforming the BBC into a subscriber-owned mutual', by Professor Philip Booth. The full publication can be read at: https://iea.org.uk/publications/new-vision This audiobook was read by Elise Busset.By Institute of Economic Affairs

1
EP 116: Genetics and Medicine: Clonal hematopoiesis, genomics in healthcare, and a new discovery in APOL1 kidney disease with Dr. Alex Bick 52:34

4M ago52:34

52:34

0:00 Introduction 4:23 Insights into clonal hematopoiesis from the pioneering Framingham Heart Study 8:30 Linking clonal hematopoiesis to cancer and cardiovascular health 11:22 Interplay of germline and somatic variants in clonal expansion 17:20 How the rate of clonal expansion can provide insights into cancer and cardiovascular risk 19:00 How clon…

1
The Best of 2023 2:03:17

4M ago2:03:17

2:03:17

On this mammoth-sized episode, Logan and Tyler talk about their favorite stories of 2023, including books, films, podcasts, music, and more! -- If you have a question for the show, send it to logan@wisedisciple.org. Get your Wise Disciple merch here: www.wisedisciple.store Check out our YouTube channel here: https://www.youtube.com/@WiseDisciple. W…

1
EP 115: The Biggest Stories of 2023 with Dr. Veera Rajagopal (Part 2) 1:35:11

4M ago1:35:11

1:35:11

In the second instalment of our annual round-up episode, we welcome back Dr. Veera Rajagopal to cover the biggest stories in genetics and precision medicine of the last 12 months. Don’t forget to give the first instalment of our 2023 round-up a listen. Veera is a scientist at Regeneron with an interest in human genetics and drug target discovery in…

1
Redemption and Compassion in A Christmas Carol by Charles Dickens 1:06:06

4M ago1:06:06

1:06:06

On this episode of the show, Logan and Tyler talk about Charles Dickens's A Christmas Carol. They open with a dicussion about the novel itself, how it resembles a traditional fairy tale, the redemptive nature of making Scrooge the protagonist, and more. Then they shift to a comparison of two adaptations: the most dreary they could find (Christmas C…

1
EP 114: The Biggest Stories of 2023 with Dr. Veera Rajagopal (Part 1) 1:10:35

4M ago1:10:35

1:10:35

0:00 Introduction 1:30 Veera’s personal highlights of 2023 Publication in Nature Genetics: Rare coding variants in CHRNB2 reduce the likelihood of smoking, an exome-wide association study identifying rare coding variants in CHRNB2 that may reduce the likelihood of smoking. Designing cover art Genetic links to neural circuits and their role in addic…

1
An Ode to Hymns 1:10:18

4M ago1:10:18

1:10:18

Tyler and Logan dive into the subject of hymns. Why exactly is music a part of Christian worship? Why must it be collective? Is there a difference between corporate and private worship? And what hymns do the guys find most impactful and why? Give it a listen to find out! -- If you have a question for the show, send it to logan@wisedisciple.org Get …

1
The New Great Inflation: How Western Central Banks Got It Wrong…and What They Should Do About It by Sir John Redwood MP 40:32

4M ago40:32

40:32

This is an audiobook version of the Institute of Economic Affairs publication 'The New Great Inflation: How Western Central Banks Got It Wrong... and What They Should Do About It',written by Sir John Redwood MP. The full publication can be read at: https://iea.org.uk/publications/the-new-great-inflation-how-western-central-banks-got-it-wrong-and-wh…

1
EP 113: Harnessing human genetics to discover co-evolved small molecule medicines with Dr. Jason Park, CEO of Empress Therapeutics 44:31

4M ago44:31

44:31

In this episode of The Genetics Podcast, we welcome Dr. Jason, founder and CEO of Empress Therapeutics, a Flagship Pioneering company. Join us as we discuss how human genetics can identify small molecules with therapeutic potential that are already created by our bodies, paving the way for faster discovery of new medicines. Summary: 0:00 Intro 1:20…

1
The Princess and the Goblin & The Princess and Curdie by George MacDonald 1:11:32

4M ago1:11:32

1:11:32

The guys dive into two of the books by George MacDonald, a writer revered by such literary titans as C.S. Lewis, J.R.R. Tolkien, and G.K. Chesterton. Join us as we dig beneath the surface of these children's fairy tales in The Princess and the Goblin and The Princess and Curdie, and examine how MacDonald used the fairy tale and knightly quest forms…

1
God Rest Ye Merry Gentle Folk 1:08:34

5M ago1:08:34

1:08:34

Scott, Mike and Lisa talk about some aspects of resting in Gods ways . As we are in the thick of the Holiday season we want to give some great biblical insight on rest . How did God design it for us . “Come to me, all you who are weary and burdened, and I will give you rest. Take my yoke upon you and learn from me, for I am gentle and humble in hea…

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