On Translating Aging, we talk with the worldwide community of researchers, entrepreneurs, and investors who are moving longevity science from the lab to the clinic. We bring you a commanding view of the entire field, in the words of the people and companies who are moving it forward today. The podcast is sponsored by BioAge labs, a clinical-stage biotechnology company developing therapies to extend human healthspan by targeting the molecular causes of aging.
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Hevolution: Extending Global Healthspan (Dr. Mehmood Khan, CEO)
43:14
43:14
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In this episode, Chris Patil speaks with Dr. Mehmood Khan, CEO of Hevolution Foundation, about the organization's mission to extend healthy human lifespan and better understand the aging process. Dr. Khan discusses Hevolution's unique approach to funding global scientific discovery and investing in private companies dedicated to advancing aging sci…
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Harnessing the Secretome to Combat Age-Related Immune Dysfunction (Dr. Hans Keirstead, Immunis)
47:38
47:38
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47:38
Hans Keirstead, PhD, is the Chairman of the Board at Immunis, a biotechnology company researching and developing immune secretome products to address age-driven immune deficits. In this episode, Chris and Hans discuss Immunis' approach to targeting the aging immune system as a key driver of age-related disease. They explore the potential of immune …
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Delaying menopause, extending healthspan: The promise of AMH-based therapeutics (Daisy Robinton, Oviva Therapeutics)
36:35
36:35
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36:35
Dr. Daisy Robinton, co-founder and CEO of Oviva Therapeutics, discusses the company's innovative approach to improving women's healthspan by targeting the biology of ovarian aging. Motivated by her personal experiences and the realization that female physiology is underserved by research and medicine, Daisy outlines how menopause is a key inflectio…
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Gene Therapies to Treat and Reverse Aging (Noah Davidsohn, Rejuvenate Bio)
35:14
35:14
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Dr. Noah Davidsohn, co-founder and CSO of Rejuvenate Bio, discusses the company's innovative work using gene therapies to treat age-related diseases in dogs and humans. In his conversation with host Chris Patil, he explains his recent groundbreaking study showing that partial cellular reprogramming with Yamanaka factors extended lifespan and health…
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30 Years of Aging Biology: A Pioneer's Perspective (Cynthia Kenyon, VP-Aging Research at Calico Labs)
44:06
44:06
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44:06
30 Years of Aging Biology: A Pioneer’s Perspective (Cynthia Kenyon - VP Aging Biology, Calico Labs) Dr. Cynthia Kenyon reflects on the evolution of the longevity field over the 30 years since the publication of her groundbreaking paper, “A C. elegans mutant that lives twice as long as wild type,” a genetic analysis of one of the first single-gene m…
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XPRIZE Healthspan: Catalyzing Therapies for Aging (Jamie Justice, PhD)
55:16
55:16
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55:16
Dr. Jamie Justice is Executive Director of the newly launched XPRIZE Healthspan, a $101 M international competition to accelerate therapeutics targeting aging biology. In conversation with host Chris Patil, Dr. Justice outlines the motivation, structure, and timeline of the prize, as well as how teams can get involved. She also explains unique aspe…
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"How We Age: The Science of Longevity" (Professor Coleen Murphy, Princeton)
36:33
36:33
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36:33
Dr. Coleen Murphy is a prominent aging researcher and author of the upcoming book “How We Age: The Science of Longevity” from Princeton University Press. In this wide-ranging discussion, Coleen provides insights into her motivation for writing this book, key topics covered, and her unique perspective on the field. Key ideas: Addressing ethical conc…
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From Startup to Acquisition (Nick Hertz, Mitokinin)
41:59
41:59
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41:59
Dr. Nicholas Hertz is the co-founder and former CSO of Mitokinin, a biotech company developing therapies targeting damaged mitochondria in neurodegenerative disease. Mitokinin was recently acquired by pharmaceutical giant AbbVie. In this episode, Nick recounts the journey from academic research on PINK1 biology to founding a startup and advancing a…
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Catalyzing moonshots in longevity biotech (Alex Colville, Age1)
40:34
40:34
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40:34
Dr. Alex Colville is the co-founder and General Partner of Age1 Ventures, a recently launched VC firm focused on funding contrarian, founder-led biotech companies aiming to extend healthy human lifespan. In this episode, Alex outlines Age1's thesis of identifying and empowering talented founders with ambitious visions for the longevity field. He sh…
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Reversing Skin Aging at the Cellular Level (Carolina Reis Oliveira and Alessandra Zonari, OneSkin)
35:51
35:51
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35:51
Dr. Carolina Reis Oliveira and Dr. Alessandra Zonari are the co-founders of OneSkin, a company developing science-backed skincare products to reverse skin aging at the cellular level. In this episode, Carolina and Alessandra tell host Dr. Chris Patil how OneSkin is leveraging recent advances in longevity science to create novel peptides that target…
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Discovering New Senolytics with Neural Networks (Felix Wong, Integrated Biosciences)
37:01
37:01
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37:01
Dr. Felix Wong is a co-founder of Integrated Biosciences, an early-stage biotech company developing next-generation therapeutics for cellular rejuvenation. He is also a postdoc at MIT and the Broad Institute and was a lead author on a recent Nature Aging paper describing the use of graph neural networks to discover new senolytic compounds. In this …
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“Taking disease by sTORm”: Developing Rapalogs to Extend Healthy Lifespan (Joan Mannick, Tornado Therapeutics)
29:16
29:16
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Joan Mannick, CEO and co-Founder of Tornado Therapeutics, joins the podcast to discuss her company’s exciting mission of developing a new generation of rapalog compounds specifically targeting the TORC1 complex. Rapalogs are analogs of the natural compound rapamycin, which has been shown to extend lifespan and healthspan in animal models by inhibit…
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Discovering Healthspan Interventions through Phenotype-Based Drug Screening (Mitchell Lee, Ora Biomedical)
32:16
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Mitchell Lee is the CEO and co-founder of Ora Biomedical, a Seattle-based biotech company using large-scale phenotypic drug screening in C. elegans to discover small molecule therapeutics that extend lifespan and healthspan. In this episode, Chris and Mitch discuss Ora's approach to drug discovery, which focuses on function and phenotype rather tha…
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Synergizing Synbio & Longevity: A Panel Discussion at SynBioBeta 2023
42:31
42:31
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42:31
This special episode features a panel discussion moderated by Chris Patil at the 2023 SynBioBeta conference. The panel brings together leaders from the synthetic biology and longevity communities to explore opportunities for collaboration and cross-pollination between these fields. Panelists discuss the talent bottleneck in longevity research, chal…
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Nurturing the Next Generation of Leaders in Aging Biology (Dr. Courtney Hudson-Paz, Time Initiative)
22:50
22:50
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22:50
In this episode of Translating Aging, host Chris Patil is joined by Dr. Courtney Hudson-Paz, the Founder and Program Director of the Time Initiative, an organization whose mission is to build a network of undergraduate leaders in aging biology. Courtney takes us on a journey into the world of aging biology and the mission of the Time Initiative, hi…
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Epigenetic Reprogramming Therapies to Extend Healthspan (Dr. Jacob Kimmel, Head of Research, NewLimit)
40:25
40:25
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40:25
Jacob Kimball is the Head of Research and co-founder of NewLimit, a company aiming to develop epigenetic reprogramming therapies to treat age-related diseases and extend human healthspan. In this episode, Chris and Jacob have an in-depth discussion about NewLimit’s mission and approach. They explore how NewLimit is leveraging epigenetics and machin…
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A New Approach for Cardiovascular Disease (Dr. Matthew O’Connor, Cyclarity Therapeutics)
37:52
37:52
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37:52
In today’s episode, Chris is joined by Dr. Matthew "Oki" O'Connor, CEO for Scientific Affairs at Cyclarity Therapeutics, a company focused on eliminating arterial plaque, a prevalent issue in old age. Dr. O'Connor shares his insights on the causes and effects of atherosclerosis, the leading cause of death worldwide, and how aging contributes to pla…
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Targeting Pathologic Cells to Preserve Biological Youth (Dr. Marco Quarta, Rubedo Life Sciences)
40:59
40:59
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Dr. Marco Quarta, CEO and Co-founder of Rubedo Life Sciences, joins Chris on today’s episode to discuss his company’s strategy of targeting pathologic cells to develop therapeutics for chronic degenerative conditions. The conversation covers the evolving definition of senescence and the challenges of identifying and classifying pathologic cells, wh…
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Bone Marrow Banking for Cell Therapy Material at Scale (Kevin Caldwell, Ossium Health)
41:20
41:20
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41:20
In today’s episode, Chris sits down with Kevin Caldwell, CEO, Co-Founder, and President of Ossium Health, a company that aims to improve human health and longevity through bioengineering - specifically using stem cell science to create materials for cell therapies. Together, they discuss Ossium’s approach: processing and banking of bone marrow from…
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Hacking the Complex System of Aging (Peter Fedichev, GERO)
41:26
41:26
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41:26
This week, we welcomes Peter Fedichev, an entrepreneur and scientist with over 20 years of experience in academic research and biotech business who has co-founded three biotech companies. He’s currently the co-founder & CEO of GERO, a longevity startup on a mission to hack aging. In this episode, Chris and Peter discuss GERO’s goal to accelerate ou…
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Understanding Aging to Develop Interventions (Morten Scheibye-Knudsen, University of Copenhagen)
32:57
32:57
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32:57
This week, Chris welcomes Morten Scheibye-Knudsen, Associate Professor at the University of Copenhagen, who’s on a mission to understand, modulate and treat aging and age-related diseases. His research group, The Scheibye-Knudsen Lab, is trying to understand the cellular and organismal consequences of DNA damage & repair with the aim of developing …
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Optimizing Healthspan through Longevity Medicine (Dr. Andrea Maier – The Center for Healthy Longevity)
37:07
37:07
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37:07
Optimizing Healthspan through Longevity Medicine (Dr. Andrea Maier – The Center for Healthy Longevity) Dr. Andrea Maier is an internal medicine specialist, geriatrician, and researcher whose work focuses on age-related disease, cellular senescence, and the translation of longevity science into clinical practice. Among her academic appointments are …
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Investing in Longbio True Believers (Sebastian Brunemeier, Healthspan Capital & ImmuneAge Pharma)
44:03
44:03
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44:03
In today’s episode, Chris welcomes Sebastian Brunemeier, a biotech VC and company builder focused on longevity and regenerative medicine. Sebastien is the Co-Founder and General Partner of Healthspan Capital, a longevity VC firm that invests in biotechnology startups developing therapies to slow or reverse aging, and the CEO and Co-Founder of Immun…
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Investing in Longevity (Nils Regge, Apollo Health Ventures)
27:08
27:08
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27:08
Joining Chris on the podcast today is Nils Regge, Co-founder and Managing Director of Apollo Health Ventures. As a social entrepreneur, company creator, and biotech expert, Nils built Apollo Health Ventures in 2016 to help health tech companies develop methods to prevent and reverse the aging process and extend the healthy human life span. At Apoll…
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Safe & Synergistic Combination Drugs to Promote Healthy Aging (Ann Beliën, Rejuvenate BioMed)
36:21
36:21
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36:21
In this episode of the BioAge podcast, Ann Beliën joins Chris Patil today to share the story behind Rejuvenate Biomed, and her journey into the longevity sector. She started her career at Johnson & Johnson after receiving her postdoctoral degree, and during her tenure, she worked in scientific, operational, and strategic roles. Twenty years later, …
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