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The 'Cryo-Talk' podcast from Thermo Fisher Scientific and Bitesize Bio brings you the world’s most prominent Cryo-electron microscopists. In each episode of this engaging series, host Eva Amsen explores the fascinating world of cryo-electron microscopy through the eyes of the experts and delves beyond the electron beam into what drives them in their careers, their inspirations, and passions. https://bitesizebio.com/cryotalk/
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Bret and Nirmal are joined by Chris Kühl and Jose Blanquicet, the maintainers of Inspektor Gadget, the new eBPF-focused multitool, to see what it's all about. Inspektor Gadget, aims to solve some serious problems with managing Linux kernel-level tools via Kubernetes. Each security, troubleshooting, or observability utility is packaged in an OCI ima…
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Bret and Nirmal are joined by Maria Vechtomova, a MLOps Tech Lead and co-founder of Marvelous MLOps, to discuss the obvious and not-so obvious differences between a MLOps Engineer and traditional DevOps jobs. Maria is here to discuss how DevOps engineers can adopt and operate machine learning workloads, also known as MLOps. With her expertise, we'l…
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Bret and Nirmal were joined by Emile Vauge, CTO of Traefik Labs to talk all about Traefik 3.0. We talk about what's new in Traefik 3, 2.x to 3.0 migrations, Kubernetes Gateway API, WebAssembly (Cloud Native Wasm), HTTP3, Tailscale, OpenTelemetry, and much more! Be sure to check out the live recording of the complete show from June 6, 2024 on YouTub…
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Bret is joined by DockerSlim (now mintoolkit) founder Kyle Quest, to show off how to slim down your existing images with various options. The slimming down includes distroless images like Chainguard Images and Nix. We also look at using the new "mint debug" feature to exec into existing images and containers on Kubernetes, Docker, Podman, and conta…
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Bret is joined by Shahar Azulay, Groundcover CEO and Co-Founder, to discuss their new approach to fully observe K8s and its workloads with a "hybrid observability architecture." Groundcover is a new, cloud-native, eBPF-based platform that designed a new model for how observability solutions are architected and priced. It is a product that can drast…
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Bret and Nirmal are joined by Continue.dev co-founder, Nate Sesti, to walk through an open source replacement for GitHub Copilot. Continue lets you use a set of open source and closed source LLMs in JetBrains and VSCode IDEs for adding AI to your coding workflow without leaving the editor. You've probably heard about GitHub Copilot and other AI cod…
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Bret and Nirmal are joined by Michael Fischer of AWS to discuss why we should use Graviton, their arm64 compute with AWS-designed CPUs. Graviton is AWS' term for their custom ARM-based EC2 instances. We now have all major clouds offering an ARM-based option for their server instances, but AWS was first, way back in 2018. Fast forward 6 years and AW…
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Bret and Nirmal are joined by friend of the show, Matt Williams, to learn how to run your own local ChatGPT clone and GitHub Copilot clone with Ollama and Docker's "GenAI Stack," to build apps on top of open source LLMs. We've designed this conversation for tech people like myself, who are no strangers to using LLMs in web products like chat GPT, b…
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Bret is joined by Jasper Paul and Vinoth Kanagaraj, observability experts and Site24x7 Product Managers, to discuss achieving end-to-end visibility for applications on Kubernetes infrastructure. We answer questions on all things monitoring, OpenTelemetry, and KPIs for DevOps and SREs. We talk about the industry's evolution from monitoring to full o…
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Bret and Nirmal are joined by Neil Cresswell and Steven Kang from Portainer to look at K2D, a new project that enables us to leverage Kubernetes tooling to manage Docker containers on tiny devices at the far edge. K2D stands for Kubernetes to Docker, which is a bit of a crazy idea -- it's a partial Kubernetes API running on top of Docker Engine wit…
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Bret and Nirmal are joined by Dan Lorenc from Chainguard to walk them through Chainguard's approach to building secure, minimal container images for popular open source software. They discuss why it is important to have secure and minimal container images. Dan explains how Chainguard helps remove the pain of CVEs, laggy software updates and patches…
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Bret and Nirmal are joined by Phil Estes of AWS to show us the Finch project, which bundles the best open source tools for building and running containers locally. Now it runs on macOS and Windows WSL2. We've been talking with Phil about this show for months, and now that Finch has come to Windows, we thought it was the best time to clue you in as …
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Bret is joined by Neil Cresswell, CEO and co-founder of Portainer, to show us new features in Portainer and how it can manage, deploy, and orchestrate all your container workloads from a single Docker Engine, all the way to multi-cluster and IoT Kubernetes deployments. Portainer is much more comprehensive than you might think. Docker on the Edge, P…
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Bret and Nirmal are joined by Ivan Burazin and Chad Metcalf to debut Daytona, an open source "codespaces equivalent." Daytona is a development environment manager designed to automate all the tedious steps a developer needs to perform to set up their development environment. "Essentially, it transforms any machine into a codespaces equivalent." Whe…
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Bret and Nirmal are joined by Lukas Fittl of pganalyze to dive into Postgres in containers, in production, and in CI. Lukas is an expert and founder of pganalyze, and I invited him on the show to explain a lot of this to us and catch us up with what's going on in the Postgres community, particularly when it comes to containers and production. We di…
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Bret and Nirmal are joined by Melissa McKay, Developer Advocate at JFrog and Docker Captain, to discuss the best and worst of 2023. We recorded this episode in December of 2023 where we talked through our favorite tools. Whether a DevOps oriented tool or not, it just might be the things we like to use on containers and in Cloud Native DevOps. This …
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Bret is joined by Matan Mishan & Roy Razon of Livecycle to discuss developer platforms and how to improve developer collaboration and speeding up feedback and previews. We talk about the various delays encountered in pull requests due to feedback processes, and how Lifecycle's tools aim to shorten this feedback loop in Docker Desktop, local CLI wit…
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Bret and Nirmal are joined by Michael Irwin, DevRel at Docker, to talk about all the products and features Docker shipped in 2023, and what's coming in early 2024. Michael has been on this show many times as a Docker Captain and now as a Docker employee, and it's always great to dig into the details of the products with someone who's been using the…
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Bret is joined by Alex Kretzschmar to talk about Tailscale, a universal VPN that connects teams, devices, and development environments for easy access to remote resources. Alex and I talk about projects he's worked on in containers over the years and then we quickly get into Tailscale and talking about why he joined the team there. Tailscale is one…
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I break down why Dockerfile frontends exist and how Docker's build engine "BuildKit" is giving us updated Dockerfile features. The TL;DR of this podcast is to add this to your Dockerfiles as the first line, always and forever. # syntax=docker/dockerfile:1 It'll ensure your Dockerfile will have access to the latest v1.x features of the "Dockerfile f…
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Application delivery doesn’t have to suck. Bret and Nirmal are joined by Solomon Hykes, the founder or Docker, to talk about Dagger and their application delivery-as-code that runs anywhere. 💥 This episode is brought to you by our valued sponsor and friends at CAST AI! 💥 CAST AI is an all-in-one Kubernetes cost optimization and automation platform …
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The OCI specifications for registry and image are getting a minor version number update to 1.1 soon, and this could be a big deal for anyone storing artifacts other than images somewhere in their infrastructure. This episode digs into the problem with artifacts today, and how the OCI and CNCF are planning to fix it with the "one registry to serve t…
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Bret is joined by Nirmal and a host of friends from the floor of KubeCon, to talk about the latest news and goings-on. We wanted to get some of our friends and people we haven't seen in a while that are making great stuff out there on the show for just a few minutes and it's sort of a rapid panel of rotating guests. If you actually watched the vide…
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In this short episode, I tell the tale of my registrar DNS name hosting for the last 25 years and what I prefer for a cheap and reliable name registrar. ★Topics★ bret.lol: for anyone to use as a localhost wildcard solution for local dev with friendly names and TLS. Cloudflare, a service I was already using for many things, started offering registra…
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Bret and Nirmal are joined by Chris Townsend, the engineering manager for Canonical's Multipass team, to discuss how to use Multipass as the easiest local virtual machine for Docker, Kubernetes and more! Multipass is my go-to solution for quickly creating local virtual machines of Ubuntu. I teach it in my courses, I've used it for many years, and I…
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After returning from DockerCon earlier this month (Oct 2023), Bret recorded this podcast where he breaks down all the product announcements and details from the event. We hope you enjoy it and share it with your friends and colleagues. You can read all about it and get updates and Links to all the tools, betas, and info in our newsletter post. Enjo…
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Bret is joined by Demetrius Malbrough and Joseph D'angelo from Veritas, the company that makes NetBackup amongst many other data protection tools. NetBackup has been around at least 25 years and I've been using it over 20 years, although not recently. So we had the two gentlemen from Veritas on the show to break down the evolution of NetBackup to a…
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Bret and Nirmal are joined by Ken Collins, AWS Serverless Hero and Principal Engineer at Custom Ink to discuss all things Lambda and to dig into the details of running containers in serverless. Ken and I have known each other for probably 15 years in the local tech scene here in coastal Virginia. And I've always respected him for being a leader in …
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Bret and Nirmal are joined by Grayson Adkins and Josh Thurman on the show. They are co-founders of Uffizzi, an environments-as-a-service company for Docker Compose and Kubernetes. We talk about ephemeral environments in all their forms. You might call them preview environments, developer environments, or pull release environments, which is my favor…
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Bret is joined by Dan Garfield of CodeFresh to talk about growth of GitOps as a standard, growth of Argo, and more. Dan is the Co-founder and Chief Open Source Officer of Codefresh, a CI/CD platform powered by GitOps and Argo. He helped launch the GitOps Working Group and helped lead the creation of the Open GitOps principles. As an Argo Maintainer…
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In this episode, Bret and Nirmal talk with Brian Douglas of OpenSauced. Brian Douglas, of GitHub fame, has founded OpenSauced, a cool web app and community of open source developers finding their next contribution and maybe their next job. Brian has so many stories of working with open source projects and having conversations with leading open sour…
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Bret and Nirmal welcome Idit Levine, Founder/CEO Solo.io. Idit focuses on Service Mesh, API-GW and Multi-Cloud networking, and security. Idit has been involved in the Containers/DevOps community for 10+ years, building products from Docker to Envoy to Kubernetes, and now Istio and Cilium. We talk about Istio, Ambient Mesh, Envoy, Zero-Trust Securit…
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#12 — Rhys Grinter is Lab Head in the Department of Microbiology at Monash University. In this episode of Cryo-Talk, Rhys joins Eva Amsen to talk about how he uses cryoEM to look at bacterial proteins, including an enzyme that converts air to electricity. They also talk about travel, career breaks, and cooking. Watch or listen to all episodes of th…
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Bret and Matt welcome special guest Brendan Burns, CVP Azure Cloud Native & Resource Management, and also a founding member of the Kubernetes project. Because Brendan is one of the three original co-founders of the Kubernetes project back in 2013 at Google, he's a little bit internet famous in open source and Cloud Native. So I was a little nervous…
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Bret and Matt welcome Michael Cade, the field CTO at Kasten by Veeam. If you've been around servers for a while, you probably have heard of Veeam. It made its debut back in the late 2000's when virtual machines and implementations of VMs were big. I first found out about them back in those days, because it was a great free product for small virtual…
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Bret and Matt welcome Jake Warner back to the show to talk about LowOps. What does LowOps mean? What can Cycle offer us as an alternative to Swarm and Kubernetes? Jake Warner is the CEO and founder of Cycle.io. And I had him on the show a few years ago when I first heard about Cycle and I wanted to get an update on their platform offering. On this …
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#11 — Peter Shen is an Assistant Professor of Biochemistry at the University of Utah. In this episode of Cryo-Talk, Peter joins Eva Amsen to talk about the CryoEM 101 course he co-developed and how this led to merit badges for the National Centers for CryoEM. They also talk about boardgames, basketball, and making music. Watch or listen to all epis…
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Bret and Matt are joined by Corey Quinn to talk about AWS and containers. Corey Quinn is the Chief Cloud Economist at the Duckbill Group. You may have seen or heard some of his in-depth AWS content, including his Last Week in AWS newsletter and blog, Corey's podcast Screaming in the Cloud and the AWS Morning Brief, or his highly produced YouTube vi…
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Bret and Matt are joined by Brent Baude and Dan Walsh from Red Hat to talk about the latest with Podman, Quadlet, Podman Desktop and Podman machine, and how it all works with Kubernetes. Dan Walsh, a Senior Distinguished Engineer at Red Hat, has been working with containers since the beginning. He's a contributor to Docker, Project Atomic, SELinux,…
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#10 — Gökhan Tolun is an Associate Professor in the School of Chemistry and Molecular Bioscience at the University of Wollongong in Australia, and Research Group Leader at the Molecular Horizons Research Institute. In this episode of Cryo-Talk, Gökhan joins Eva Amsen to talk about his research, funding challenges in different countries, and how Mol…
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Bret and his co-host, Matt, are joined by Jason Dellaluce and Luca Guerra from Sysdig to talk about Falco, a tool I recommend for production clusters and knowing about any bad behavior on your servers. Falco is a security tool I've mentioned multiple times on this show, because I mostly think that a low level security focused logging product is som…
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Bret is joined by Lukas Gentele and Rich Burroughs from Loft Labs to look at a new project called DevPod, that supports dev containers and VMs. It works with local Docker instances and AWS, GCP, Azure, and several other cloud providers. The project is compatible with Microsoft's DevContainer standard, which means it works with the VC Code standalon…
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Bret and Matt are joined by two engineers in Docker's leadership - Chief Technology Officer Justin Cormack and Senior Manager of Developer Relations Michael Irwin, to talk about recent Docker Hub changes, as well as their latest product releases. We touch on Docker's latest updates and announcements, focusing on the early releases of Docker Scout, …
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#9 — Bret Freudenthal is Associate Professor in the Department of Biochemistry at the University of Kansas Medical Center. In this episode of Cryo-Talk, Bret joins Eva Amsen to talk about the importance of making CryoEM technologies accessible via shared facilities and the new facility opening in Kansas. They also talk about skiing, barbecuing, and…
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Bret and Matt are joined by Chad Crowell of KubeSkills to walk through how you can contribute to Kubernetes open source. Chad started the kubeskills.com community and podcast to focus on learning Kubernetes by doing and in this episode, he's taking us through a detailed guide on how to get involved in the Kubernetes community. Although Kubernetes a…
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Bret is joined by fellow Docker Captain Nuno do Carmo to talk about desktop container solutions and the best Docker setup for Windows 11. Nuno's a Docker Captain, Civo Ambassador, Microsoft MVP, and a big fan of Windows and Cloud Native. I've had him on the show before, because the more you use the Windows Subsystem for Linux and Docker Desktop, th…
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#8 — Ariane Briegel is Professor of Ultrastructural Biology at Leiden University and co-director of the Netherlands Centre for Electron Nanoscopy. In this episode of Cryo-Talk, Ariane joins Eva Amsen to share how she uses cryo-electron tomography to study how microbes interact with their environment. They also talk about Ariane’s initial interest i…
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Bret is joined by Project Calico's Tomas Hruby from Tigera to dig into Calico CNI features for Kubernetes and beyond. Calico can be used in a lot of places, including Linux, Windows, containers, bare metal, eBPF or iptables. Many of us learned about it as a CNI option for Kubernetes network and networking policy. Streamed live on YouTube on Februar…
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Bret is joined by Kyle Galbraith and Jacob Gillespie, co-founders of Depot, to discuss their new solution to slow Docker builds. If you've never dug into some of the details of Dockers BuildKit, that's the engine behind your Docker build command, then this episode is for you. I'm fairly confident that everyone who uses Docker will eventually come u…
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#7 — Rob Kirchdoerfer is Assistant Professor in the Department of Biochemistry and the Institute for Molecular Virology at the University of Wisconsin-Madison. In this episode of CryoTalk, Rob joins Eva Amsen to talk about using cryoEM to study virus interactions and how he ended up working on cutting-edge research. He also talks about possible fut…
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