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The logic behind the science: Conversations with Broad researchers exploring what they do and why they do it, from Broad Institute of MIT and Harvard.
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Our podcast features researchers supported by BroadIgnite, a program that connects rising philanthropists with emerging scientific talent at the Broad Institute of MIT and Harvard.
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Utopia or dystopia? It’s up to us.In the 21st century, powerful technologies have been appearing at a breathtaking pace—related to the internet, artificial intelligence, genetic engineering, and more. They have amazing potential upsides, but we can’t ignore the serious risks that come with them.Brave New Planet is a podcast that delves deep into the most exciting and challenging scientific frontiers, helping us understand them and grapple with their implications. Dr. Eric Lander, president a ...
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What is ‘structure-based’ vaccine design? Before scientists used these techniques to design vaccines against Covid, they were testing them in the lab to combat RSV. Keren Landman joins the show to talk about how this respiratory virus endangers the lives of babies and the elderly. Then, we hear about an early RSV vaccine trial that cast a shadow ov…
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At Pushkin, we think of Juneteenth as an opportunity to reflect on the past and think about the future: How do we build a more just and equitable society? We strive to make podcasts that help answer that question, and in honor of Juneteenth, we’re highlighting two of them. In this episode, you'll hear previews of our new shows Be Antiracist and A S…
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How can we come together to tackle big challenges in science and society? Dr. Eric Lander and Niala Boodhoo, veteran journalist and Axios Today host, talk about the importance of trust, humility, and skepticism in the worlds of science and media. Together, they ask how we can find the common ground we’ll need to make progress. For links to material…
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Reshaping Nature Through Gene Drives
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A new technology, called gene drives, has the power to spread any genetic instructions you wish across an entire animal or plant species in the wild. It might let us restore ecosystems ravaged by invasive species, or help species adapt to climate change. And, it might save millions of children from dying of malaria. But could altering nature in thi…
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Artificial intelligence is letting us make predictive algorithms that translate languages and spot diseases as well or better than humans. But these systems are also being used to make decisions about hiring and criminal sentencing. Do computers trained on vast datasets of human experience learn human biases, like sexism and racism? Is it possible …
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Killer Robots and the Future of War
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Fully autonomous lethal weapons—robots that can select and engage targets without human intervention—are fast becoming possible. They might minimize casualties and protect civilians in times of war. But is it morally wrong to put a computer in charge of life or death decisions? Could system errors lead to flash wars? But, as war gets faster and mor…
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Could altering the Earth’s atmosphere to reflect back some of the sun’s rays be a solution to climate change? It would likely decrease global temperatures, but it might lead to climate wars. Humanity might become “addicted” to it for survival. And ultimately, would this technology only distract us from tackling the real problem of carbon emissions?…
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It’s getting easy to create convincing—but false—videos through artificial intelligence. These “deepfakes” can have interesting applications in art and education, but they can also cause great harm—from ruining the reputation of an ex-partner to provoking international conflicts or swinging elections. When seeing is not believing, who can we trust,…
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Malcolm Gladwell joins host Dr. Eric Lander for a conversation about science, society, and how the decisions we make today will impact generations to come. At a moment when science is becoming more important than ever for meeting the challenges ahead, can we solve the growing tensions between society and science? For links to materials referenced i…
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Introducing Brave New Planet, a seven-part series that delves deep into powerful technologies changing our world. They have amazing potential upsides, but we can’t ignore the serious risks. Hosted by Dr. Eric Lander, Brave New Planet is a partnership between the Broad Institute, Pushkin Industries, and the Boston Globe. Learn more about your ad-cho…
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BroadIgnite Podcast, S2, E1: Interview with Mariella Filbin and Anna Greka
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From Clinic to the Lab and Back to the Clinic: Two physician-scientists talk about how their work with patients informs their research (and vice versa).By Broad Institute of MIT and Harvard
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BioLogic: The transformative power of CRISPR in the lab, with John Doench and Ruth Hanna
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John Doench, associate director of the Genetic Perturbation Platform (GPP) and institute scientist at the Broad Institute, and Ruth Hanna, research associate in GPP, discuss how the CRISPR system has revolutionized studies of gene function.By Broad Institute of MIT and Harvard
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BroadIgnite Podcast, S1, E8: Interview with Evan Macosko
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BroadIgnite awardee Evan Macosko discusses his quest to learn more about brain cells through new, scalable technologies. His specific interest is learning which brain cells malfunction in complex psychiatric disorders.By Broad Institute of MIT and Harvard
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BroadIgnite Podcast, S1, E7: Interview with Elinor Karlsson
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BroadIgnite awardee Elinor Karlsson, an expert in dog genetics, discusses how her team is plumbing the genomic depths of wolf-dog hybrids for clues to the genetics of autism spectrum disorders and related psychiatric diseases in humans.By Broad Institute of MIT and Harvard
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BroadIgnite Podcast, S1, E6: Interview with Moran Yassour
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BroadIgnite awardee Moran Yassour discusses how we acquire our microbiomes at birth—and how they change in early childhood.By Broad Institute of MIT and Harvard
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BioLogic: Ten years of perspective on GWAS, with Joel Hirschhorn
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Joel Hirschhorn, institute member and co-director of the Metabolism Program at the Broad Institute and professor of pediatrics and genetics at Harvard Medical School and Boston Children’s Hospital, sits down with BioLogic to talk about how the research community has approached genome-wide association studies (GWAS) from concept to execution through…
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BroadIgnite Podcast, S1, E5: Interview with Eli Van Allen
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BroadIgnite awardee Eli Van Allen discusses his research of patients with exceptional responses to immunotherapies.By Broad Institute of MIT and Harvard
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BioLogic: Empowering psychiatric disease research through genetics, with Mark Daly
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10:37
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Broad Institute member Mark Daly, co-director of the Program in Medical and Population Genetics, investigator with the Stanley Center for Psychiatric Research, and chief of the Analytic and Translational Genetics Unit at Massachusetts General Hospital, describes how modern tools for analyzing the genome have empowered the study of psychiatric disor…
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BroadIgnite Podcast, S1, E4: Interview with Daniel Neafsey
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Daniel Neafsey, associate director of the Broad Institute’s Genomic Center for Infectious Diseases in the Infectious Disease and Microbiome Program, discusses his research into a new technique to track mosquitoes using incredibly tiny, invisible, and harmless DNA ‘barcode’ tags stuck to their bodies.…
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BioLogic: The future of genome sequencing in healthcare, with Heidi Rehm and Robert Green
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Genome sequencing may someday become a routine part of medical care, but questions still surround best practices for returning genetic information to patients in a way that will optimally impact their health. Geneticists Robert Green and Heidi Rehm explain their research into developing such protocols, the benefits and risks inherent in providing g…
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BioLogic: Harnessing the immune system to fight cancer, with Nir Hacohen
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11:48
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Nir Hacohen, an institute member at Broad, director of the Center for Cancer Immunotherapy at Massachusetts General Hospital, and an associate professor at Harvard Medical School, takes us to the intersection of cancer, immunotherapy, and autoimmune disease to explore how researchers are steering the immune system to fight tumors.…
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BioLogic: The fight against antibiotic resistance, with Jim Collins
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Jim Collins, an institute member at the Broad Institute, a core faculty member at the Wyss Institute for Biologically Inspired Engineering, and a professor at MIT, dives into the social and scientific causes of antibiotic resistance and explains some of what his lab is doing to combat the problem.By Broad Institute of MIT and Harvard
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BroadIgnite Podcast, S1, E3: Interview with Sara Jones
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BroadIgnite awardee Sara Jones discusses her research with a microorganism whose unique reproductive process could become the basis of a next-generation gene-editing tool.By Broad Institute of MIT and Harvard
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BioLogic: Rare disease research inspired by patient care, with Anna Greka
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In recognition of Rare Disease Day, Anna Greka, an institute member at the Broad Institute, an associate physician at Brigham and Women’s Hospital, and an assistant professor at Harvard Medical School, shares part of her journey as a physician-scientist studying rare kidney diseases and highlights the deep impacts of patient involvement in research…
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BroadIgnite Podcast, S1, E2: Interview with Daniel MacArthur and Monkol Lek
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9:46
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Broad Institute member and BroadIgnite awardee Daniel MacArthur and his lead analyst Monkol Lek share how they're improving the diagnosis of rare genetic diseases. Recorded and produced at the Broad Institute of MIT and Harvard in Cambridge, Massachusetts, this podcast features researchers supported by the BroadIgnite program, which connects rising…
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BroadIgnite Podcast, S1, E1: Interview with Jesse Boehm
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13:20
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Jesse Boehm, associate director of the Broad’s Cancer Program, discusses how fundraising initiatives like BroadIgnite provide a crucial boost for early-career scientists.Recorded and produced at the Broad Institute of MIT and Harvard in Cambridge, Massachusetts, the BroadIgnite podcast features researchers supported by the BroadIgnite program, whic…
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BioLogic: Revealing the genetic basis of ecological adaptation, with Hopi Hoekstra
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Hopi Hoekstra, an institute member at the Broad Institute, a Howard Hughes Medical Investigator at Harvard University, and the curator of mammals at Harvard’s Museum of Comparative Zoology, tells us how her lab combines the genetic, environmental, and morphological traits of wild deer mice to answer questions about evolution and behavior.…
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BioLogic: Structural variation and disease in the human genome, with Steve McCarroll
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Steve McCarroll, an institute member at the Broad Institute, director of genetics for the Stanley Center for Psychiatric Genetics, and an associate professor at Harvard Medical School, takes us beyond single base-pair deletions and misspellings to explore variations in the human genome on a structural level. With the analytical tools available toda…
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Microbiome genes on the move - how the study came to be, with Ilana Brito and Eric Alm
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8:42
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The largest metagenomic view of the developing world has uncovered “mobile genes” that reveal how culture shapes the human microbiome. Broad Institute authors of the paper, published in the journal Nature, discuss how the study came to be.By Broad Institute of MIT and Harvard
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