Best Charles Little II Podcasts (2024)

1
15 Billion Vaccines Doses: COVID & the Patent Dilemma... Dr. Antony Taubman, Former Director of the Intellectual Property Division at the World Trade Organization 23:14

6d ago23:14

23:14

Dr. Antony Taubman, the former Director of the Intellectual Property Division at the World Trade Organization, discusses the challenges faced during the COVID-19 pandemic, including the rapid development and distribution of 15 billion doses of Covid vaccines, and how international intellectual property rules influenced these efforts.…

1
From Illness to Wellness - Can Science Tell Us How Healthy We Really Are (Part II)?? Dr. Leroy Hood and Dr. Nathan Price 25:03

13d ago25:03

25:03

Part II - We continue our discussion with Dr. Leroy Hood and Dr. Nathan Price about the subject of their book "The Age of Scientific Wellness", delving into the role of artificial intelligence in healthcare and the ability to mine deep data to deliver hyper-personalized recommendations at a scale never before possible.…

1
From Illness to Wellness - Can Science Tell Us How Healthy We Really Are (Part I)?? Dr. Leroy Hood and Dr. Nathan Price 26:57

20d ago26:57

26:57

Dr. Leroy Hood and Dr. Nathan Price delve into the subject of their book "The Age of Scientific Wellness", which highlights the advancements in science that enable the prediction and personalization of healthcare based on an individual's wellness level, and the potential advantages of early diagnosis and treatment of illnesses…

1
One Pill to Stop Many Cancers??? Dr. Michael Weickert, CEO, Pacylex Pharmaceuticals 16:54

24d ago16:54

16:54

Dr. Michael Weickert, CEO of Pacylex Pharmaceuticals, about their once-daily pill in trials now for cancer treatment - it’s already showing early indicators of success in stopping cancer growth in not just one, but a number of cancers.By Moira Gunn

1
Engineering the Future of Vaccines... Dr. Robert Coleman, CEO, Codagenix 26:08

1M ago26:08

26:08

Dr. Robert Coleman, CEO of Codagenix, discusses their innovative approach to virus engineering, which includes developing a nasally-delivered COVID-19 vaccine that targets multiple virus proteins for broader protection. Codagenix's "rational virus design" method creates genetically stable vaccines and therapeutics, reducing the risk of harmful muta…

1
Did That Change To My Prescription Work??? -- Dr. Kal Patel, CEO, BrightInsight 35:13

1M ago35:13

35:13

Continuous monitoring ... when we want it, when we don’t, should we share it? Or not. Or perhaps just part of it. Dr. Kal Patel, the Co-Founder and CEO of BrightInsight talks about this brave new frontier.By Moira Gunn

1
Can the Mapping of Human Biology Lead to Better Drugs? Dr. Chris Gibson, Co-Founder & CEO Recursion Pharmaceuticals 21:42

2M ago21:42

21:42

Dr. Chris Gibson, the co-founder and CEO of Recursion Pharmaceuticals in Salt Lake City. We talk about their efforts to map ALL of human biology, and how this mapping will lead to better drugs.By Moira Gunn

1
Charles Dickens - The Writer Who Changed Britain 1:07:42

2M ago1:07:42

1:07:42

This podcast tells the dramatic story of the life of Charles Dickens. When his father was imprisoned for debt, he had to work as a child labourer. The excitement of his first publication, his troubled early romance, eventual marriage, success and secret affair – and relentless campaigning to improve the life of the poor and needy…

1
One Company, Two Different Drugs - It's All About Glucose - Too Much and Too Little! Nevan Charles Elam, Founder & CEO, Rezolute 18:52

2M ago18:52

18:52

Glucose is essential for life. And the insulin we produce is designed to leave just the right of amount in our bodies for healthy functioning. Thus, when we underproduce insulin - or we overproduce it - the results can be devastating. Nevan Charles Elam, Founder and CEO of Rezolute, tells us about their work to treat the “diabetic eye condition”, D…

1
A Vaccine for Breast Cancer??? Dr. Amit Kumar, President & CEO, Anixa Biosciences 25:39

2M ago25:39

25:39

This week on BioTech Nation, Dr. Amit Kumar, President and CEO of Anixa Biosciences, talks about their work on a breast cancer vaccine which targets a protein thought only to be expressed during breastfeeding. Building on research by the Cleveland Clinic, Dr. Kumar describes ongoing human clinical trials and their potential for women with BRCA muta…

1
Are Your Genes Failing You??? Dr. Noah Davidsohn, Co-Founder & CSO Rejuvenate Bio 16:50

2M ago16:50

16:50

This week on Biotech Nation, Dr. Noah Davidsohn, Co-Founder and Chief Scientific Officer of Rejuvenate Bio. The discussion centers around the regulation of protein expression and its implications for aging and health. Dr. Davidsohn explains how aging disrupts the balance of protein production, leading to various diseases. Rejuvenate Bio's gene ther…

1
Living Longer??? Dr. Peter Diamandis, XPrize Founder and Author, "Longevity" 25:33

3M ago25:33

25:33

This week of BioTech Nation, Dr. Peter Diamandis about his new book, "Longevity: Your Practical Playbook on Sleep, Diet, Exercise, Mindset, Medications, and Not Dying from Something Stupid". We explore his lifelong interest in extending human health span and discuss practical steps for a healthier, longer life, including sleep, diet, exercise, and …

1
Psychedelics... Prodrugs... What else? Dr. Sam Clark, CEO of Terran Biosciences 17:48

3M ago17:48

17:48

This week on BioTech Nation, Dr. Sam Clark, CEO of Terran Biosciences, discusses prodrugs—modified drugs that improve absorption and efficacy. Also, Terran Biosciences is developing non-hallucinogenic psychedelics by blocking the serotonin 2A receptor and manufacturing psychedelics like LSD and psilocybin for research. Dr. Clark highlights Terran's…

1
A Dual Approach to Combatting Hepatitis... Dr. Marianne De Backer, CEO at Vir Biotechnology 19:52

3M ago19:52

19:52

This week on Biotech Nation, Dr. Marianne De Backer, CEO of Vir Biotechnology talks about their Phase 2 clinical trials targeting hepatitis B and D co-infections. Vir's approach uses two drugs: tobevibart (an antibody) and elebsiran (an siRNA). These drugs prevent the virus from entering liver cells and stop it from replicating. Preliminary results…

1
Solving Genetic Diseases??? Dr. Neil Kumar, Founder & CEO, BridgeBio Pharma 23:18

3M ago23:18

23:18

This week on Biotech Nation, Dr. Neil Kumar, founder and CEO of BridgeBio Pharma. Dr. Kumar emphasizes that genetic diseases, particularly Mendelian diseases caused by single gene mutations, are solvable due to advancements in genetic measurement and understanding. He discusses BridgeBio Pharma's innovative corporate structure, which consists of mu…

1
The Next Ozempic or Wegovy... But Without the Injection??? Dr. Steffen-Sebastian Bolz, CSO, Aphaia Pharma 25:16

3M ago25:16

25:16

What’s next after Ozempic and Wegovy and the like? How about a drug in development which releases all the relevant hormones, and not just GLP-1. And doesn’t require injecting. Dr. Steffen-Sebastian Bolz from Aphaia (ah-phi-ah) Pharma explains their approach, currently in Phase 2.By Moira Gunn

1
FDA Approval! A New Model for BioPharma... Dr. Sam Blackman, Founder & Head of Research and Development, Day One Biopharmaceuticals 31:10

3M ago31:10

31:10

This week on BioTech Nation, Dr. Sam Blackman, Founder and Head of Research and Development from Day One Biopharmaceuticals, shares the story behind the FDA approval of a groundbreaking drug for the most common childhood brain cancer. He talks about their innovative approach to starting a biopharma company and how it led to a newly FDA approved dru…

1
Everybody Has a Thyroid... What Could Go Wrong??? Dr. Mark Sumeray, CMO of Amolyt Pharma 28:59

4M ago28:59

28:59

This week we have a best of rerun with Dr. Mark Sumeray from Amolyt Pharma. Dr. Sumeray talks about their innovative approach to treating hormonal conditions. We’ll talk about two – when your parathyroid has been injured or removed, often during thyroid surgery, and another – when the pituitary starts overproducing growth hormone.…

1
Wearable Wonders! Dr. Daniel Kraft, Tech Nation Health Chief Correspondent 13:38

4M ago13:38

13:38

This week Dr. Daniel Kraft, Tech Nation Health Chief Correspondent, discusses advanced health tech. Dr. Kraft highlights his use of wearables like the Apple Watch, Oura ring, and non-invasive blood pressure monitors. He also introduces "otherables," which track health without being worn, using devices like cameras and modified WiFi. These technolog…

1
Robo-Docs & VR Surgery??? Dr. Daniel Kraft, Tech Nation Health Chief Correspondent 13:56

4M ago13:56

13:56

This week on BioTech Nation, Dr. Moira Gunn and Dr. Daniel Kraft discuss how robotics, AI, and virtual reality are transforming surgery. These technologies make procedures less invasive and improve training and outcomes worldwide. Future advancements may include tiny robots performing internal procedures. Security is crucial to prevent hacking of m…

1
Bedlam - The Story of a Madhouse 49:54

4M ago49:54

49:54

St Mary’s Bethlem was England’s first psychiatric hospital. This podcast tells the story of the hospital, from its medieval origins to its home in a grand 17th century palace. We follow the lives of its famous inmates: the woman who tried to kill King George III, the first documented case of paranoid schizophrenia and a brilliant Victorian artist w…

1
No More Transfusions!!! Dr. John Scarlett, President and CEO of Geron Corporation 16:10

5M ago16:10

16:10

Dr. John Scarlett, President and CEO of Geron Corporation talks about their drug Imetelstat for myelodysplastic syndrome (MDS). MDS patients often require frequent blood transfusions, impacting their quality of life. Imetelstat, a telomerase inhibitor, aims to reduce transfusion dependence by targeting cancer cells in the bone marrow. Phase three t…

1
Closing the Innovation Gap!!! Dr. Daniel Kraft, Tech Nation Health Chief Correspondent 10:26

5M ago10:26

10:26

Dr. Daniel Kraft, Tech Nation Health Chief Correspondent discusses the gap between medical innovation and its adoption into standard practice. He highlights that it typically takes 17 years for a medical discovery to become common practice, but big data and AI could accelerate this. He emphasizes the importance of sharing medical data and initiativ…

1
The Virtual Cell??? Dr. Steve Quake, Head of Science at Chan Zuckerberg Initiative 21:21

5M ago21:21

21:21

This week, Dr. Steve Quake from the Chan Zuckerberg Initiative about their goal to tackle all human diseases in the next century. We discuss CZI's innovative approach, including building Biohubs and funding collaborative research. Dr. Quake explains the importance of something called The Virtual Cell project, aiming to use AI to model every human c…

1
How Can Sound Deliver Drugs??? Dr. Neal Kassell, Founder & Chair of Focused Ultrasound Foundation 16:48

5M ago16:48

16:48

This week on Biotech Nation, I speak with Dr. Neal Kassell about focused ultrasound technology. We discuss its noninvasive approach, its diverse applications in treating various medical conditions, and its potential to revolutionize treatments for diseases like Alzheimer's, Parkinson's, and cancer. Dr. Kassell also shares insights into ongoing clin…

1
70% of Breast Cancers and a Link to Prostate Cancer... Dr. Sean Bohen, President & CEO, Olema Oncology 23:02

6M ago23:02

23:02

This week on BioTech Nation, we explore new efforts in treating cancer with Dr. Sean Bohen, President and CEO of Olema Oncology. We discuss progress in treating breast cancer, particularly ER+/HER2- breast cancer, which accounts for 70% of diagnoses this year. They examine the biology behind these cancers and how Olema's lead compound, palazestrant…

1
Tiny RNAs, Big Cures!!! Dr. Sanjay Shukla, President and CEO, ATyr (ah-tire) Pharma 19:54

6M ago19:54

19:54

This week - Dr. Sanjay Shukla, CEO of Atyr Pharma, discusses the revolutionary potential of mRNA technology in creating new medicines. They explore Atyr's pioneering approach to leveraging tRNA fragments for treating pulmonary sarcoidosis and other organ-specific conditions, aiming to improve patient outcomes while minimizing reliance on convention…

1
How Can a Treatment Become a Vaccine??? Dr. Peter DeMuth, Chief Scientific Officer at Elicio Therapeutics 23:33

6M ago23:33

23:33

Dr. Peter DeMuth, Chief Scientific Officer of Elicio Therapeutics, discusses the revolutionary approach of detecting cancer at its earliest stages through circulating tumor DNA (ctDNA) tests. Highlighting their innovative treatment method, which aims to train the body's immune cells to recognize and destroy cancer cells, the episode explores the po…

1
Cancer Vaccines??? Dr. Chris Pirie, Co-Founder & COO of HDT Bio 17:08

6M ago17:08

17:08

In this week's episode, Dr. Moira Gunn interviews Dr. Chris Pirie from HDT Bio about their novel approach to cancer prevention through vaccines. They discuss leveraging mRNA technology to target specific tumor mutations and prime the immune system to recognize and eliminate cancer cells. Dr. Pirie highlights ongoing efforts to develop vaccines for …

1
Trapped by the Plague - Eyam Village 1665 29:00

6M ago29:00

29:00

In 1665 plague devastated England. The remote Derbyshire village of Eyam was spared the horror - until a tailor bought a roll of cloth from London. To stop the pestilence spreading, the local vicar closed down Eyam - and the villagers were locked in. Hear the dramatic story of the plague village in this podcast.…

1
Redefining Acute Myeloid Leukemia (AML) Treatment!!! Dr. Robert Ang, President & CEO of Vor Biopharma 15:20

6M ago15:20

15:20

This week I speak with Dr. Robert Ang from Vor Biopharma about their innovative approach to treating acute myeloid leukemia (AML). AML is a type of blood cancer that affects the bone marrow, leading to the overgrowth of cancerous cells. Dr. Ang explains that traditional treatments, such as chemotherapy and stem cell transplants, have limitations an…

1
Fighting Inflammation, and Alzheimer's??? Dr. David Bearss, President & CEO Halia Therapeutics 28:57

7M ago28:57

28:57

In this week's episode of BioTech Nation, Dr. David Bearss, President and CEO of Halia Therapeutics, discusses inflammation and its reduction over a lifetime and in response to various incidents. He unveils the inflammasome, a recently discovered protein complex critical in regulating inflammatory responses and its potential in treating chronic dis…

1
Food as Medicine, A Personalized Prescription... Dr. Daniel Kraft, Tech Nation Health Chief Correspondent 10:21

7M ago10:21

10:21

Tech Nation Health, Chief Correspondent Dr. Daniel Kraft discusses the concept of "food as medicine." Dr. Kraft emphasizes the evolving understanding of nutrition and its profound impact on health, advocating for a shift towards personalized nutrition using cutting-edge technologies. From continuous glucose monitors to AI-powered apps and sensor to…

1
Repairing Minds, Naturally??? Mark Litton, President & CEO, Athira Pharma 22:38

7M ago22:38

22:38

Alzheimer’s, Parkinson’s dementia, and other neurodegenerative diseases continue to be challenging, but now new science has led to a better understanding of the natural repair mechanisms in the brain. This, in turn, has generated new options for innovative treatments, and one such approach has entered late-stage human clinical trials. Dr. Mark Litt…

1
Combatting Blood Clots!!! Dr. Daniel Bloomfield, Chief Medical Officer, Anthos Therapeutics 14:31

7M ago14:31

14:31

This week, Dr. Daniel Bloomfield from Anthos Therapeutics discusses the prevalence and dangers of blood clots, particularly in patients with cancer. Dr. Bloomfield explains the difference between normal and abnormal blood clotting, the risks associated with blood clots in arteries and veins, and the challenges in balancing clot prevention with the …

1
A History of London Pubs - Pilgrims, Parrots, and Phantoms 33:00

7M ago33:00

33:00

Our history of London pubs pubcast visits the oldest tavern in London, including a pub haunted by phantasmal spirits. Hear about Parliamentary boozers, the smallest bar in the world, the Pilgrim Fathers Mayflower pub, and Gandalf’s riverside alehouse.By Stories of Britain

1
Heartburn, GERD, Cancer??? Dr. Lishan Aklog, CEO of Lucid Diagnostics 22:59

8M ago22:59

22:59

Dr. Lishan Aklog from Lucid Diagnostics tells us about the path from GERD to, unfortunately, esophageal cancer, and about Lucid’s two-minute diagnostic test which can detect precancerous cells.By Moira Gunn

1
From Tummy Tucks to Drug Trials??? Dr. Eric Merle, Chief Business Innovation Officer, GenoSkin 14:23

8M ago14:23

14:23

Dr. Eric Merle from GenoSkin talks about how they are transforming drug discovery using discarded human skin from surgeries like tummy tucks, revolutionizing the process and accelerating drug development timelines.By Moira Gunn

1
One Drug, Many Diseases??? Dr. David Fajgenbaum, UPenn School of Medicine Professor and President of Every Cure 27:56

8M ago27:56

27:56

Not just seeking treatment for every disease, but making sure the treatments we have already developed are being used in every possible way. I speak with Dr. David Fajgenbaum (Fay-gen-baum), a Professor of Translational Medicine and Human Genetics at the University of Pennsylvania School of Medicine, and President of Every Cure.…

1
Alcohol-Associated Hepatitis Treatment on the Horizon!!! Dr. Jim Brown, CEO of DURECT 14:52

8M ago14:52

14:52

Dr. Jim Brown from DURECT talks about their clinical trials for Alcohol-Associated Hepatitis, a condition for which there is no approved treatment.By Moira Gunn

1
Pub Names, Ghosts and Flying Ale - A History of Beer Part 2 39:25

8M ago39:25

39:25

What is the oldest pub name in Britain? And the most popular pub name in the country? Where is our oldest pub? What are the boozy origins of the nursery rhyme “Pop Goes the Weasel”? What caused the London beer flood? And where is Britain’s most haunted pub? Find out in our latest History of Beer podcast…

1
Building Technology and Solving Problems!!! Dave Pacitti, President & Head of the Americas, Siemens Healthineers 20:30

9M ago20:30

20:30

When is a medical technology company more than a medical technology company? We’ll hear all about it when I speak with Dave Pacitti, the President and Head of the Americas at Siemens Healthineers. They’re out to solve problems bigger than the products they are known for.By Moira Gunn

1
XPrize Foundation and $101 Million!!! Dr. Daniel Kraft, Tech Nation Health Chief Correspondent 11:14

9M ago11:14

11:14

Tech Nation Health Chief Correspondent Dr. Daniel Kraft talks about the newest XPrize worth an unprecedented $101 Million.By Moira Gunn

1
Wound Healing 2.0!!! Dr. Nik Sopko, Chief Scientific Officer at PolarityTE 15:19

9M ago15:19

15:19

Dr. Nik Sopko, the Chief Scientific Officer of PolarityTE talks about their design for wound healing. Their first treatment candidate is diabetic foot ulcers.By Moira Gunn

1
Harnessing Natural Killer Cells!!! Dr. Eric Vivier, SVP & CSO of Innate Pharma 20:25

9M ago20:25

20:25

Dr. Eric Vivier from Innate Pharma in Marseilles tells us about the next wave of immunotherapy treatments – harnessing Natural Killer cells.By Moira Gunn

1
Can Every Medicine Be a Pill??? Dr. Ray Stevens, CEO of ShouTi Pharma 24:24

10M ago24:24

24:24

Dr. Ray Stevens, CEO of ShouTi Pharma, talks about their approach in turning IV drugs into pills. Current projects include Diabetes and obesity, and two Pulmonary and Cardiovascular disorders. And these are just their first candidates …By Moira Gunn

1
Gut-Brain Connections to Autism, Parkinson's, and More!!! Dr. Stewart Campbell, CEO Axial Therapeutics 25:38

10M ago25:38

25:38

Dr. Stewart Campbell, CEO of Axial Therapeutics, about their groundbreaking work in Autism–related irritability in teenagers, in Parkinson’s, and in complementing the latest cancer treatments.By Moira Gunn

1
Boozy Britain – History of Beer. Part 1 36:04

10M ago36:04

36:04

The story of Beer. From Britain’s first brewer, to ancient ales made with psychedelic plants. From rules on Viking drinking horns to the English king who drank himself to death. From the rise of female brewers, to a drunk Queen Elizabeth I. From the legend of the ale-conner, to pubs forced to change names.…

1
Ancient Viruses in our DNA??? Dr. Neil Shubin, Professor & Author University of Chicago 28:55

10M ago28:55

28:55

On this week’s BioTech Nation University of Chicago professor Dr. Neil Shubin talks about his book “Some Assembly required … Decoding Four Billion Years of Life, from Ancient Fossils to DNA.” Ancient viruses in our DNA? And what about “jumping genes”?By Moira Gunn

1
Treating Diseases with Brain Implants??? Nicolas Vachicouras, CEO & Co-Founder Neurosoft Bioelectronics 15:44

10M ago15:44

15:44

This week we visit the brain, and look at what a flexible brain implant might do – from sensing how your brain is working to actual treatment. Nicolas Vachicouras from Neurosoft Bioelectronics in Geneva, Switzerland talks about the target for their first treatment: severe tinnitus.By Moira Gunn

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Charles Little II Podcasts

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