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Concise summaries of everything published in the latest weekly issue of the New England Journal of Medicine (NEJM). NEJM publishes new medical research findings, review articles, and editorial opinion on topics of importance to biomedical science and clinical practice.
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NEJM Interviews

NEJM Group

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Insightful conversations with leading experts in the field of health care, medical research, policy, and more from the New England Journal of Medicine (NEJM). Each episode examines the many complexities found at the junction of medicine and society.
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NEJM AI Grand Rounds, hosted by Arjun (Raj) Manrai, Ph.D. and Andrew Beam, Ph.D., features informal conversations with a variety of unique experts exploring the deep issues at the intersection of artificial intelligence, machine learning, and medicine. You’ll learn how AI will change clinical practice and healthcare, how it will impact the patient experience, and about the people who are pushing for innovation. Whether you are an AI researcher or a practicing clinician, these conversations w ...
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This podcast from NEJM Catalyst features interviews with leaders in health care as they discuss innovative ideas and actionable solutions for enhancing the value of health care delivery, providing perspectives on what's working in the industry, what's not, and why.
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Curbside Consults

NEJM Group

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This podcast from NEJM Resident 360 takes a deep dive into key topics with expert clinicians and educators. As we explore the details of pathophysiology and critique the evidence behind clinical practice, these conversations are intended to give you better understanding of the topic and greater confidence when treating your patients.
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Core Internal Medicine via following series: 5 Pearls || Clinically relevant pearls Mind the Gap || Why do we do what we do? Gray Matters || Management Reasoning Hoofbeats || Dissecting clinical reasoning At the Bedside || Explore everyday challenges
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Yashaswini Singh is an assistant professor of health services, policy, and practice at Brown University. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. Y. Singh, E. Fuse Brown, and I. Papanicolas. The Rise of Private Equity in Health Care — Not a Uniquely American Phenomenon. N Engl J Med 2025;392:627-629.…
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Featuring articles on therapies in acute myocardial infarction and in neuroendocrine tumors, mpox in Africa, and T-cell lymphoma after CAR T-cell therapy; a review article on food and nutrition insecurity; a case report of a woman with headache and dysesthesia; and Perspectives on Marburg virus disease in Rwanda, on the rise of private equity in he…
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Joseph Ross is a professor in the Department of Internal Medicine at the Yale School of Medicine and in the Department of Health Policy and Management at the Yale School of Public Health. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. J.S. Ross. Cell and Gene Therapies — Improving Access and Outcomes for Medica…
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Featuring articles on IgA nephropathy, a treatment in children with obesity, NRG1 fusion–positive cancer, a case of a T-cell lymphoma, and the discovery of GLP-1–based drugs; a review article on hemophagocytic lymphohistiocytosis, a Clinical Problem-Solving on traveling companions; and Perspectives on cell and gene therapies, on gender-affirming ca…
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Incidental fibrosis on CT —what now? What does prone imaging tell you? Is it fibrosis, aspiration, or atelectasis? And once you diagnose ILD, does the “alphabet soup” really matter for treatment? Antifibrotics vs. immunosuppression? Plus, how do we bridge the gap when social barriers make care unsafe? Transcript and Show Notes Timestamps: (01:26) |…
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Daniel Aaron is an associate professor of law at the University of Utah S.J. Quinney College of Law. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. D.G. Aaron and C. Robertson. E-Cigarettes at the Supreme Court — Potential Implications for the FDA and Public Health. N Engl J Med 2025;392:417-419.…
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Featuring articles on heart failure and obesity, oral anticoagulation during TAVI, hemophilia A, hereditary angioedema, and tuberculosis; a review article on sport-related concussion; a case report of a man with syncope, ankle swelling, and abnormal chest imaging; and Perspectives on e-cigarettes at the Supreme Court, on providing interstate telehe…
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This discussion highlights the importance of recognizing that everyone can engage in leading within their roles, while also addressing the crucial skills of followership and the need for clarity in leadership roles to foster effective teamwork and improve patient outcomes.By James Mountford, Thomas H. Lee
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Craig Spencer is an emergency medicine physician and an associate professor of the practice of health services, policy, and practice at the Brown University School of Public Health. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. C. Spencer. Ebola and a Decade of Disparities — Forging a Future for Global Health …
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Featuring articles on esophageal cancer, out-of-hospital cardiac arrest, and atrial fibrillation; a review article on the physiology of hunger; a case report of a man with exertional dyspnea and chest pain; a Medicine and Society on evaluating the inclusion of sex in clinical algorithms; and Perspectives on Ebola, on U.S. generic drug shortages, on…
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SPEP vs. UPEP? What does it tell you and not tell you? What is the role for immunofixation and free light chains in diagnosis? Learn about paraneoplastic antibodies with MGCS and its renal, neurologic, and dermatologic manifestations! Sponsor: Freed is an AI scribe that listens and writes your note in < 30 seconds. Freed learns your style over time…
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Carmel Shachar is an assistant clinical professor of law and faculty director of the Health Law and Policy Clinic at Harvard Law School. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. T. Ramesh, C. Shachar, and H. Yu. Striking a Balance — Advancing Physician Collective-Bargaining Rights and Patient Protections.…
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Featuring articles on asymptomatic severe aortic stenosis, kidney disease, fracture prevention in women, and residual breast cancer, the future of the U.S. physician workforce, mutant KRAS signaling, and manufactured chemicals and children’s health; a review article on the identification and treatment of alcohol use disorder; a case report of a man…
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In this return appearance on NEJM AI Grand Rounds, Dr. Zak Kohane joins hosts Raj Manrai and Andy Beam to discuss the evolving landscape of AI in medicine. As the first repeat guest on the show, Dr. Kohane shares insights on health care system challenges, the Human Values Project, and his perspectives on the most significant AI developments of 2024…
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David Velasquez is an internal medicine resident physician at Brigham and Women's Hospital. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. D.E. Velasquez, E.T. Roberts, and J.F. Figueroa. The Plight of “Dual Noneligible” People in the United States. N Engl J Med 2025;392:105-107.…
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Featuring articles on transcatheter tricuspid-valve replacement, persistent chylomicronemia, multiple myeloma, myelofibrosis, and peripherally inserted central catheter materials; a review article on heart failure with preserved ejection fraction; a case report of a woman with shortness of breath and leg edema; and Perspectives on the plight of “du…
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How do you differentiate immune checkpoint inhibitor-related adverse events aka IrAEs from other conditions like infection? Join as we go through pneumonitis, colitis, dermatitis and endocrinopathies due to immune checkpoint inhibitor toxicity! Transcript and Show Notes ICIs & IrAEs 101 Episode Behind The Scenes video Sponsor: Interested in integra…
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Joey Mattingly is an associate professor in the Department of Pharmacotherapy at the University of Utah College of Pharmacy. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. S.S. Tu, S. Kottilil, and T.J. Mattingly II. Leveraging Old Hepatitis C Therapies. N Engl J Med 2025;392:1-4.…
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Featuring articles on advanced melanoma, atrial fibrillation, ATTR amyloidosis, and bladder cancer; a review article on cervical cancer; a Clinical Problem-Solving describing when blurry vision clouds the bigger picture; Medicine and Society’s on transitional justice and on rethinking access to HIV medicines; and Perspectives on hepatitis C therapi…
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YouTube Videos Anion Gap Metabolic Acidosis: https://youtu.be/oE0lygmMANM Inhaler Delivery Systems: https://youtu.be/yYPdjClm9Bg Iron Deficiency in Pregnancy https://youtu.be/xTzYSXUbLsc ** Register for 2025 Digital Education & Artificial Intelligence Conference !! ** Submit your most creative and impactful AI use cases for the following categories…
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Lauren Schiff is an associate professor of Ob/Gyn and a minimally invasive gynecologic surgeon at the University of North Carolina School of Medicine and the associate chief medical officer for quality and safety at UNC Hospitals. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. L.D. Schiff, A.O.D. Hester, and T.…
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Featuring articles on cancer cachexia, MDR tuberculosis, Ebola virus disease, and severe asthma; a review article on the nonsurgical management of chronic venous insufficiency; a case report of a woman with end-stage liver disease and headache; and Perspectives on providing effective medical care to autistic people, on independent physician associa…
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In this episode of NEJM AI Grand Rounds, hosts Raj Manrai and Andy Beam interview Larry Summers about artificial intelligence’s transformative potential and its implications for society. The conversation explores Summers’ perspective on AI as potentially the most significant technology ever invented, his role on OpenAI’s board following the Novembe…
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Bindu Kanapuru is a hematologist–oncologist physician in the Office of Oncologic Diseases at the FDA’s Center for Drug Evaluation and Research. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. B. Kanapuru and Others. Autopsy of a Drug Withdrawal — The Case of Melphalan Flufenamide. N Engl J Med 2024;391:2177-2179…
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Featuring articles on PCI before transcatheter aortic-valve implantation, treatments in patients with type 2 diabetes, in leprosy, in refractory adult ALL, and in ATTR cardiomyopathy; a review article on drug reaction with eosinophilia and systemic symptoms; a case report of a boy with recurrent fever; and Perspectives on an autopsy of a drug withd…
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What’s the evidence been for the use of PPIs in mechanically ventilated patients? What do more recent studies reveal about PPIs and possible harmful side effects of aspiration pneumonia and C. difficile colitis? To find out, tune into the second season of Beyond Journal Club, a series brought to you by Core IM in collaboration with NEJM Group. Spon…
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