Barron Lerner is a professor in the Departments of Medicine and Population Health at New York University Grossman School of Medicine. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. B.H. Lerner. Medical Expertise — Balancing Science, Values, and Trust. N Engl J Med 2024;391:577-579.…

Featuring articles on osimertinib in stage III EGFR-mutated lung cancer, cognitive motor dissociation in disorders of consciousness, rapid deployment of a brain–computer interface in ALS, and the longevity of a brain–computer interface for ALS; a review article on the genetics of chronic kidney disease; a case report of a boy with autism and decrea…

Gregg Gonsalves is an associate professor of epidemiology at the Yale School of Public Health. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. M.S. Sinha, W.E. Parmet, and G.S. Gonsalves. Déjà Vu All Over Again — Refusing to Learn the Lessons of Covid-19. N Engl J Med 2024;391:481-483.…

Featuring articles on crinecerfont in pediatric and adult congenital adrenal hyperplasia, the postacute sequelae of SARS-CoV-2 infection, and nipocalimab in early-onset severe hemolytic disease of the fetus and newborn; a review article on frailty in older adults; a case report of a woman with postpartum anxiety and intrusive thoughts; and Perspect…

How can employers provide health insurance coverage that’s both high quality and affordable?By Daniel Stein, Thomas H. Lee

Featuring articles on belantamab mafodotin for multiple myeloma, autoantibodies targeting nephrin in podocytopathies, neutralizing anti–interleukin-10 autoantibodies in IBD; a review article on Parkinson’s disease; a Clinical Problem-Solving on going down the rabbit hole; a Medicine and Society article on race-based screening under the ethics micro…

A health care CEO’s most important responsibility is to maintain the sacredness of the patient-clinician relationship and ensure that interaction is as valuable for both the physician and the patient as possible.By Daniel E. Greenleaf, Thomas H. Lee

What competencies are needed in the boardroom to advance the mission of creating healthier communities? How do health care system governance boards make these changes?By Brian Gragnolati, Thomas H. Lee

Elizabeth Tobin-Tyler is an associate professor at the Brown University School of Public Health and Warren Alpert Medical School. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. E. Tobin-Tyler and S.L. Dickman. Rape, Homicide, and Abortion Bans — The Abandonment of People Subjected to Sexual and Intimate Partner…

Featuring articles on treatments for metabolic dysfunction–associated steatohepatitis, blinatumomab in adults with ALL, and sotorasib for KRAS G12C–driven vascular malformations; a review article on HIV-associated tuberculosis; a case report of a woman with rapidly progressive dementia; and Perspectives on the abandonment of people subjected to sex…

Ida Sim is a professor of medicine at the University of California, San Francisco, and codirector of the Joint Program in Computational Precision Health at UC Berkeley and UCSF. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. I. Sim and C. Cassel. The Ethics of Relational AI — Expanding and Implementing the Belm…

Featuring articles on tenecteplase for ischemic stroke within 4.5 to 24 hours after the stroke, risankizumab vs. ustekinumab for Crohn’s disease, nirmatrelvir–ritonavir as Covid-19 postexposure prophylaxis, and efanesoctocog alfa in children with hemophilia A; a review article on the management of insomnia; a case report of a woman with postpartum …

Erin Fuse Brown is a professor of health services, policy, and practice at the Brown University School of Public Health and a member of the Journal’s Perspective Advisory Board. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. H. Rooke-Ley, S. Shah, and E.C. Fuse Brown. Medicare Advantage and Consolidation’s New …

Featuring articles on semaglutide and chronic kidney disease in type 2 diabetes, felzartamab in kidney-transplant rejection, bulevirtide and peginterferon for chronic hepatitis D, and nirsevimab and hospitalization for RSV bronchiolitis; a review article on malnutrition in adults; a case report of an infant with vomiting and hypercalcemia; and Pers…

A checklist of leadership skills for building trust through transparency, actions, and consistency that apply to health care mergers as well as day-to-day health care leadership.By Tina M. Freese Decker, Thomas H. Lee

Evan Mullen is a resident in the Department of Medicine at Stanford University. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. E. Mullen, E.J. Topol, and A. Verghese. Academic Freedom in America — In Support of Institutional Voices. N Engl J Med 2024;391:1-3.

Featuring articles on stress ulcer prophylaxis during invasive mechanical ventilation, new therapies for hereditary angioedema, tissue factor–directed therapy in cervical cancer, and normalization of C1 inhibitor in a patient with hereditary angioedema; a review article on acute abdomen in the modern era; a Clinical Problem-Solving article on aggre…

Innovative examples of overcoming challenges in rural health care access caused by distance, weather, clinician shortages, and other reasons, by connecting with patients virtually and locally.By Jeremy Cauwels, Thomas H. Lee

Nathaniel Chin is an associate professor in the Division of Geriatrics and Gerontology and medical director of the Alzheimer's Disease Research Center at the University of Wisconsin School of Medicine and Public Health. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. N.A. Chin and C.M. Erickson. Alzheimer’s Dise…

Featuring articles on treatments for eosinophilic esophagitis, reteplase versus alteplase for acute ischemic stroke, dupilumab for COPD with type 2 inflammation, and brigatinib in NF2-related schwannomatosis; a review article on amyloidosis; a case report of a man with recurrent fever and liver lesions; and Perspectives on Alzheimer’s disease, biom…

Value-based care frees up health care organizations to go upstream and invest in the health and well-being of their community members.By Robert W. Allen, Thomas H. Lee

Christine Grady is chief of the Department of Bioethics at the National Institutes of Health Clinical Center. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. S. Hendriks and C. Grady. Ethics and Highly Innovative Research on Brain Diseases. N Engl J Med 2024;390:2133-2136.…

Featuring articles on combination therapy for diffuse large B-cell lymphoma, autosomal dominant Alzheimer’s disease, noninvasive ventilation for preoxygenation during emergency intubation, a novel anti-CD38 antibody in immune thrombocytopenia, and a glucose-responsive insulin for type 2 diabetes; a review article on congenital and acquired Chiari s…

Jessica Lewis is a research scientist at the Yale School of Medicine. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. J.B. Lewis and J.R. Ickovics. Expect With Me — Group Prenatal Care to Reduce Disparities. N Engl J Med 2024;390:2039-2040.

Featuring articles on T-cell cancer after CAR T-cell therapy, the early diagnosis and treatment of COPD and asthma, and the implications of race adjustment in lung-function equations; a review article on diets; a case report of a woman with the worst headache of her life; and Perspectives on efforts toward equity and on feeling guilty.…

Featuring articles on neoadjuvant immunotherapy for dMMR colon cancer, TAVR in patients with a small aortic annulus, gene editing and retinal degeneration, and the genetic diagnosis of rare diseases; a review article on disorders of magnesium; a case report of a woman with metastatic breast cancer; and a Perspective on malicious midwives, fruitful …

In strategic partnerships with others focused on improving costs and efficiencies, a health system needs to continue to be the right side of the brain, looking for the opportunities, not doing the routine tasks.By Timothy J. Dentry, Thomas H. Lee

Katharine Silbaugh is a professor at the Boston University School of Law. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. K. Silbaugh, L. Del Valle, and C. Robertson. Toward a Tobacco-free Generation — A Birth Date–Based Phaseout Approach. N Engl J Med 2024;390:1837-1839.…

Featuring articles on aficamten for obstructive hypertrophic cardiomyopathy; early blood-pressure reduction in acute stroke; interferon-γ in autoimmune polyendocrine syndrome type 1; video laryngoscopy for intubation in neonates; hunger, thirst, and Buridan’s ass; and global health law for a safer and fairer world; a review article on medical AI an…