A podcast for all psychiatrists about the psychiatry literature and evidence-based practice. Hey, psychiatrists! Do you think “yeah, no” anytime you hear the words journal club? Have you felt like you don’t get much out of reading a journal article? Do you feel like you don’t have the time for that life-long learning thing? We’re here to help! Listen in as a group of board-certified, practicing psychiatrists—some with expertise in research and some without—tackle a paper. We’ll start with so ...
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Neuroscience+Clinical Trial=Effective Treatment of OCD
24:36
24:36
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The paper we discuss is H Tyagi et al. (2019) A Randomized Trial Directly Comparing Ventral Capsule and Anteromedial Subthalamic Nucleus Stimulation in Obsessive-Compulsive Disorder: Clinical and Imaging Evidence for Dissociable Effects. Biological Psychiatry 85:726-734. You can find a copy of the Yale Brown Obsessive Compulsive Scale (Y-BOCS), com…
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The paper we discuss is K Humphreys, JC Blodgett, and TH Wagner. Estimating the Efficacy of Alcoholics Anonymous Without Self-Selection Bias: An Instrumental Variables Re-Analysis of Randomized Clinical Trials. Alcoholism: Clinical and Experimental Research. 2014; 38(11): 2688-2694. The primary outcomes from Project MATCH, which looked at the effic…
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Is Prazosin Effective for PTSD? Depends on the Inclusion Criteria
22:39
22:39
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22:39
The article we discuss is MA Raskind et al. Trial of Prazosin for Post-Traumatic Stress Disorder in Military Veterans. New England Journal of Medicine 2018; 378(6):507-517 For an example of an earlier study that DID find benefit of prazosin for PTSD, check out Raskind, MA et al. A Trial of Prazosin for Combat Trauma PTSD with Nightmares in Active-D…
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Suicide Prevention in the ED: How Do You Know What's Effective?
25:39
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The paper we talk about: ED-SAFE Primary Outcomes . The authors discuss their approach to the study in the ED-SAFE Design Paper. Straight-forward reviews of cluster randomized trials and the step-wedge design.By Marisa Toups, Adriane dela Cruz, Adam Brenner
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What's a GWAS? What can it teach me about bipolar disorder?
24:54
24:54
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The paper we discuss is Psychiatric Genomics Consortium. Genome-Wide Association Study Identifies 30 Loci Associated with Bipolar Disorder. Nature Genetics 2019; 51:793-803. Here's an incredibly helpful review on understanding genome wide association studies (GWAS): TA Pearson and TA Manolio. How to Interpret a Genome-Wide Association Study. JAMA 2…
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Efficacy of Antipsychotics for Delirium and Odds Ratios
23:50
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The paper we discuss is TD Girard et al. Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness. N Engl J Med 2018; 379(26):2506-2516. This paper is part of the ABPN MOC program. The podcast authors are not associated with the MOC program and have no knowledge of the questions about the article included in the MOC program. The JA…
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The paper we discuss is BA Clementz et al. Identification of Psychosis Biotypes Using Brain-Based Biomarkers. Am J Psychiatry 2016; 173(4): 373-384. Here's the paper Dr Toups mentions about depression, biotypes, and treatment response: AT Drysdale et al. Resting-state connectivity biomarkers define neurophysiological subtypes of depression. Nature …
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Intranasal Esketamine and the Placebo Response
24:25
24:25
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The paper we discuss in this episode is V Popova et al. Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined with a Newly Initiated Oral Antidepressant in Treatment Resistant Depression: A Randomized Double-Blind Active-Controlled Study. Am J Psychiatry 2019; 176(6): 428-438. For a deeper understanding of the factors that contribut…
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What Part of DBT Actually Works and A Single-Sided P Value
21:26
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21:26
The paper we discuss is M Linehan et al. Dialectical Behavior Therapy for High Suicide Risk in Individuals with Borderline Personality Disorder: A Randomized Clinical Trial and Component Analysis. JAMA Psychiatry 2015; 72(5):475-482. We LOVE the JAMA Guide to Statistics and Medicine for quick, clinically relevant overviews of important issues in cl…
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Lithium, Suicide, and Confounding by Indication
23:34
23:34
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Suicidal Behavior During Lithium and Valproate Treatment Use the link above to get to the paper we discuss in this episode or use the following citation to find it. Song, J et al. Suicidal Behavior During Lithium and Valproate Treatment: A Within-Individual 8-Year Prospective Study of 50,000 Patients with Bipolar Disorder. Am J Psychiatry 2017; 174…
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OUD Treatment and Intent To Treat Analysis
20:02
20:02
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X:BOT primary outcomes We discuss the X:BOT primary outcomes paper in this episode of the podcast. Use the link above or the citation below to find it. Take a look at the figures! JD Lee et al. Comparative effectiveness of extended-release naltrexone versus buprenorphine-naloxone for opioid relapse prevention (X:BOT): a multicenter, open-label, ran…
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