Presented by Doctor, writer and TV Presenter Xand Van Tulleken and community health psychologist, UCL lecturer and self-proclaimed hippie, Dr Rochelle Burgess. This podcast is about public health, but more importantly, it’s about the systems that need disrupting to make public health better. In each episode, we’ll be challenging the status quo of this field, asking what needs to change, why and how to get there. Each month we’ll be joined by activists, scholars, artists, comedians and indust ...
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Oh Pod! x UCL is a co-produced podcast tackling the taboos of healthcare issues. In this series, Shakira and Iman have insightful conversations with leading academics about common health related misconceptions, covering everything from anxiety to perinatal mental health. Each month Shakira and Iman are joined by a leading academic to offer their perspective on the big questions, cut through frivolous news and to de-bunk urban myths. Oh Pod! x UCL is a warm, inclusive, and inviting podcast. E ...
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The Trial Talk Podcast explores how our work at the MRC Clinical Trials Unit at UCL is improving health in the UK and worldwide. In this new series, we will hear from world-leading experts about the studies we carry out. We will get inside trials on cancer, infections, and neurodegenerative diseases, explore how public and patient involvement is shaping our studies, and discover new ways to run smarter studies.
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UCL's award-winning campaign, Disruptive Thinking Since 1826 and hashtag #MadeAtUCL, has been phenomenal in its scope with hoardings at UCL East in London, graphics and animations on our website; a festival, podcast series, and involvement of the wider public to vote for their favourite breakthrough UCL research. This year, we continue to feature more UCL breakthrough stories through Season Two of the podcast! This time, we are also sharing stories from our community, our pioneering research ...
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The Trial Talk podcast explores how our work at the MRC Clinical Trials Unit at UCL is improving health in the UK and worldwide. In this series, we hear from world-leading experts about the studies we carry out. We delve into trials on cancer, infections and neurodegenerative diseases, explore how public and patient involvement shapes our work, and discover new ways to run smarter studies.
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Episode 4: Estimands - Answering the right research questions
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An estimand is a description of the research question a trial seeks to answer, which can help researchers better understand how their study should be designed and analysed. Estimands also provide a clear way to communicate treatment effects to different stakeholders. This episode of the Trial Talk podcast features Principal Research Fellow Brennan …
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Episode 3: Redefining the Classroom: Nurturing Mental Health Through Nature, Arts, and Understanding
39:34
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"It's not our children who are disordered, it's the environment in which we're expecting them to operate." In this month’s episode, our experts explore the pressing issue of children's mental health in the UK. With one in five young individuals facing probable mental health disorders, the urgency for effective support systems is undeniable. Joining…
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Episode 3: Subgroup analysis - Who benefits most from a treatment?
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Clinical trial results usually tell us how effective a treatment was on average for the overall group of participants, but a key question for clinicians, patients and policy makers is: which individual patients benefit most from the treatment and which don’t benefit as much? In the latest episode of the Trial Talk podcast, Peter Godolphin and David…
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Episode 2: AI for Good - Tech and Ethics in Humanitarian Crises
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"Is technology the magic bullet for humanitarian aid, or does it come with its own set of ethical dilemmas?" In this episode, hosts Dr Xand van Tulleken and Dr Rochelle Burgess delve into the complex world of humanitarian crises and the transformative role of technology in emergency responses. With the expertise of Professor Maria Kett, an anthropo…
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Episode 2: Lessons from UKCTOCS, a large-scale trial in ovarian cancer screening
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UKCTOCS (UK Collaborative Trial of Ovarian Cancer Screening) is one of the largest screening trials in ovarian cancer. More than 200,000 women from England, Wales and Northern Ireland took part in it, and it ran for almost two decades. Designing and running such a large and lengthy trial came with its own challenges. In this episode, Professor Usha…
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S1, E3 Anxiety and Psychological Distress with Professor Oliver Robinson
46:21
46:21
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Anxiety is a natural human response. It’s what we feel when we are worried, tense, or afraid – particularly about the unknown or things that are about to happen. However, for approximately 23% of the UKs population, anxiety involves repeated episodes of intense fear or terror about everyday situations and activities. Professor Oliver Robinson is th…
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S1, E2 Autism and Common Misconceptions with Professor Kurinchi Gurusamy
34:02
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Autism is a lifelong developmental disability that affects how people communicate and interact with the world. Though more than 1 in 100 people are on the autism spectrum in the UK, it is often taboo to talk about. This is one of the reasons some people with autism feel it is hard to be themselves and mask their autistic traits to appear more neuro…
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S1, E1 Perinatal Mental Health with Dr Kate Adlington
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Mental health illnesses that occur during pregnancy or in the first year following the birth of a child, affect 27% of new and expectant mothers in the UK. Common negative stigmatising perceptions are often what prevent people from speaking out and seeking help. Dr Kate Adlington is an Academic Clinical Fellow at Queen Mary University London and a …
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Lessons from UKCTOCS, a large-scale trial in ovarian cancer screening
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UKCTOCS (UK Collaborative Trial of Ovarian Cancer Screening) is one of the largest screening trials in ovarian cancer. More than 200,000 women from England, Wales and Northern Ireland took part in it, and it ran for almost two decades. Designing and running such a large and lengthy trial came with its own challenges. In this episode, Professor Usha…
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Episode 1: Careers in TB trials with Andrew Nunn and Sarah Meredith
28:57
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In the first episode of our new Trial Talk series, Hanif Esmail and Conor Tweed take over the microphones to interview Andrew Nunn and Sarah Meredith, who have both recently retired from the Unit, having spent a combined total of 92 years working in the field of tuberculosis (TB). As we celebrate Andrew and Sarah’s long and accomplished careers, we…
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Careers in TB trials with Andrew Nunn and Sarah Meredith
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In the first episode of our new Trial Talk series, Hanif Esmail and Conor Tweed take over the microphones to interview Andrew Nunn and Sarah Meredith, who have both recently retired from the Unit, having spent a combined total of 92 years working in the field of tuberculosis (TB). As we celebrate Andrew and Sarah’s long and accomplished careers, we…
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Episode 1: Injecting Innovation - Creative Ways to boost vaccination rates
38:58
38:58
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Join hosts Doctor Xand van Tulleken and Dr Rochelle Burgess for Season 4, Episode 1 of Public Health Disrupted with Prof Helen Bedford and Doctor Ranj Singh. "It's about building knowledge with communities and allowing people to ask questions without negative labelling." Why are vaccination rates declining, and how can we rebuild trust? Vaccine rat…
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Episode 10 (part 2): World AIDS Day: Bringing hope through research to young people living with HIV with Lungile Jafta and Gugu
19:02
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Every year on 1st December, we mark World AIDS Day to show solidarity in the fight against HIV and AIDS, and to remember those who have sadly lost their lives. Since the start of the global AIDS epidemic in the 1980s, researchers have made enormous progress towards preventing HIV transmission, and treating those who are living with HIV so that the …
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Episode 10 (part 1): World AIDS Day: Closing the gap between adults and children with Anna Turkova and Philippa Musoke
24:05
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Every year on 1st December, we mark World AIDS Day to show solidarity in the fight against HIV and AIDS, and to remember those who have sadly lost their lives. Since the start of the global AIDS epidemic in the 1980s, researchers have made enormous progress towards preventing HIV transmission, and treating those who are living with HIV so that the …
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World AIDS Day (part 2): Bringing hope through research to young people living with HIV
19:01
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Every year on 1st December, we mark World AIDS Day to show solidarity in the fight against HIV and AIDS, and to remember those who have sadly lost their lives. Since the start of the global AIDS epidemic in the 1980s, researchers have made enormous progress towards preventing HIV transmission, and treating those who are living with HIV so that the …
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1
World AIDS Day (part 1): Closing the gap between adults and children
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Every year on 1st December, we mark World AIDS Day to show solidarity in the fight against HIV and AIDS, and to remember those who have sadly lost their lives. Since the start of the global AIDS epidemic in the 1980s, researchers have made enormous progress towards preventing HIV transmission, and treating those who are living with HIV so that the …
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1
Episode 9 (part 4): Octopus: Involvement of people affected by MS with Susan Scott
20:03
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Octopus is a new clinical trial for people living with progressive multiple sclerosis (MS), which is designed and run by the MRC Clinical Trials Unit at UCL. Thanks to its multi-arm multi-stage platform design, Octopus has the potential to transform the way treatments for progressive MS are tested. The trial is now open in the UK and will be recrui…
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Octopus (part 4): Involvement of people affected by MS with Susan Scott
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Octopus is a new clinical trial for people living with progressive multiple sclerosis (MS), which is designed and run by the MRC Clinical Trials Unit at UCL. Thanks to its multi-arm multi-stage platform design, Octopus has the potential to transform the way treatments for progressive MS are tested. The trial is now open in the UK and will be recrui…
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Episode 9 (part 3): Octopus: The patients’ experience with Dawn Lyle and Matthew Justin
24:05
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Octopus is a new clinical trial for people living with progressive multiple sclerosis (MS), which is designed and run by the MRC Clinical Trials Unit at UCL. Thanks to its multi-arm multi-stage platform design, Octopus has the potential to transform the way treatments for progressive MS are tested. The trial is now open in the UK and will be recrui…
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Octopus (part 3): The patients’ experience with Dawn Lyle and Matthew Justin
24:04
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Octopus is a new clinical trial for people living with progressive multiple sclerosis (MS), which is designed and run by the MRC Clinical Trials Unit at UCL. Thanks to its multi-arm multi-stage platform design, Octopus has the potential to transform the way treatments for progressive MS are tested. The trial is now open in the UK and will be recrui…
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Episode 9 (part 2): Octopus: Introducing the trial with Jeremy Chataway
24:11
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Octopus is a new clinical trial for people living with progressive multiple sclerosis (MS), which is designed and run by the MRC Clinical Trials Unit at UCL.Thanks to its multi-arm multi-stage platform design, Octopus has the potential to transform the way treatments for progressive MS are tested. The trial is now open in the UK and will be recruit…
…
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1
Octopus (part 2): Introducing the trial with Jeremy Chataway
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Octopus is a new clinical trial for people living with progressive multiple sclerosis (MS), which is designed and run by the MRC Clinical Trials Unit at UCL. Thanks to its multi-arm multi-stage platform design, Octopus has the potential to transform the way treatments for progressive MS are tested. The trial is now open in the UK and will be recrui…
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Episode 9 (part 1): Octopus: The multiple sclerosis landscape with Jeremy Chataway, Dawn Lyle and Matthew Justin
17:21
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Octopus is a new clinical trial for people living with progressive multiple sclerosis (MS). Thanks to its multi-arm multi-stage platform design, Octopus has the potential to transform the way treatments for progressive MS are tested. The trial is now open in the UK and will be recruiting participants for the next few years. The podcast mini-series …
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Octopus (part 1): The MS landscape with Jeremy Chataway, Dawn Lyle and Matthew Justin
17:20
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Octopus is a new clinical trial for people living with progressive multiple sclerosis (MS), which is designed and run by the MRC CTU at UCL. Thanks to its multi-arm multi-stage platform design, Octopus has the potential to transform the way treatments for progressive MS are tested. The trial is now open in the UK and will be recruiting participants…
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Optimising treatments with the new MAMS-ROCI design
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Innovative platform designs present an opportunity to run faster and more efficient clinical trials. Clinical trials methodology is a research area that looks at how to improve the design, conduct, and analysis of clinical trials. It focuses on developing and implementing new methods to help run trials faster and more efficiently, that will ultimat…
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Episode 8: Optimising treatments with the new MAMS-ROCI design
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Innovative platform designs present an opportunity to run faster and more efficient clinical trials. Clinical trials methodology is a research area that looks at how to improve the design, conduct, and analysis of clinical trials. It focuses on developing and implementing new methods to help run trials faster and more efficiently, that will ultimat…
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1
Episode 7: STAMPEDE (part 3): Impact and legacy
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STAMPEDE is a long-running trial in advanced prostate cancer, in which nearly 12,000 men have taken part. Thanks to its multi-arm multi-stage platform design, STAMPEDE has tested many different treatments and directly led to improvements in the standard of prostate cancer care several times. This Trial Talk podcast mini-series will explore the tria…
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Episode 7: STAMPEDE (part 2): The role of the patient voice
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STAMPEDE is a long-running trial in advanced prostate cancer, in which nearly 12,000 men have taken part. Thanks to its multi-arm multi-stage platform design, STAMPEDE has tested many different treatments and directly led to improvements in the standard of prostate cancer care several times. This Trial Talk podcast mini-series will explore the tria…
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STAMPEDE (part 3): Impact and legacy with Max Parmar & Nick James
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STAMPEDE is a long-running trial in advanced prostate cancer, in which nearly 12,000 men have taken part. Thanks to its multi-arm multi-stage platform design, STAMPEDE has tested many different treatments and directly led to improvements in the standard of prostate cancer care several times. This Trial Talk podcast mini-series will explore the tria…
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STAMPEDE (part 2): The role of the patient voice with David Matheson, Max Parmar & Nick James
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STAMPEDE is a long-running trial in advanced prostate cancer, in which nearly 12,000 men have taken part. Thanks to its multi-arm multi-stage platform design, STAMPEDE has tested many different treatments and directly led to improvements in the standard of prostate cancer care several times. This Trial Talk podcast mini-series will explore the tria…
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Episode 7: STAMPEDE (part 1): A new era for prostate cancer research
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STAMPEDE is a long-running trial in advanced prostate cancer, in which nearly 12,000 men have taken part. Thanks to its multi-arm multi-stage platform design, STAMPEDE has tested many different treatments and directly led to improvements in the standard of prostate cancer care several times. This Trial Talk podcast mini-series will explore the tria…
…
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STAMPEDE (part 1): A new era for prostate cancer research with Max Parmar & Nick James
18:03
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STAMPEDE is a long-running trial in advanced prostate cancer, in which nearly 12,000 men have taken part. Thanks to its multi-arm multi-stage platform design, STAMPEDE has tested many different treatments and directly led to improvements in the standard of prostate cancer care several times. This Trial Talk podcast mini-series will explore the tria…
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Episode 5. Unravelling Health Disparities: The Racial Divide
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“It’s the indirect act of racism that is leading to poorer outcomes for racialised groups.” How does racism impact people’s health? And how big is this problem? We're three years on from George Floyd's murder, which launched a wave of global protests under the banner never again. This, of course, has not been the case. We're also three years since …
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Episode 6: The REFINE trial: how can we improve the way we give cancer immunotherapy?
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Immunotherapy drugs fight cancer by helping the immune system recognise and attack cancer cells. These drugs have revolutionised cancer treatment over the last decade, improving survival for many people with different types of cancer. However, researchers are still unsure of the best way to give immunotherapy, which can come with unpredictable side…
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The REFINE trial: How can we improve the way we give cancer immunotherapy?
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Immunotherapy drugs fight cancer by helping the immune system recognise and attack cancer cells. These drugs have revolutionised cancer treatment over the last decade, improving survival for many people with different types of cancer. However, researchers are still unsure of the best way to give immunotherapy, which can come with unpredictable side…
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Episode 4: The change-up, demystifying the menopause
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Join hosts Doctor Xand van Tulleken and Dr Rochelle Burgess for Season 3, Episode 4 of Public Health Disrupted with Prof Joyce Harper and Rachel Lankester. “We’re more valuable to our communities post-menopause as leaders than as breeders.” How does our society value menopausal women? The lack of public awareness around this natural phase in a wome…
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Episode 5: How can clinical trials make the most of healthcare systems data?
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Running a clinical trial means collecting a lot of data from the trial participants. But some of this data might be collected and stored in healthcare systems, as well as in clinical trial case report forms. What if we could avoid this doubling up, save time and resources, improve recruitment and reduce missing data? In this episode we explore the …
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How can clinical trials make the most of healthcare systems data?
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Running a clinical trial means collecting a lot of data from the trial participants. But some of this data might be collected and stored in healthcare systems, as well as in clinical trial case report forms. What if we could avoid this doubling up, save time and resources, improve recruitment and reduce missing data? In this episode we explore the …
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“A remarkable number of claims you see in newspapers and magazines about sex are essentially made up.” What does the average British person think about sex? For over 40 years the Natsal surveys have been recording sexual data, capturing striking changes in our behaviour and sexual lifestyles across the decades. They have been pivotal in the populat…
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Episode 4: Neonatal infections (part 2): How the NeoSep1 trial will help treat sick newborns
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Neonatal sepsis is a life-threatening infection that affects up to 3 million babies per year globally. In an effort to identify better treatments, the NeoSep1 clinical trial evaluates new antibiotic combinations for newborn babies with sepsis. To learn more about the trial, we speak to Adrie Bekker and Cristina Obiero, principal investigators of th…
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Neonatal infections (part 2): How the NeoSep1 trial will help treat sick newborns
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Neonatal sepsis is a life-threatening infection that affects up to 3 million babies per year globally. In an effort to identify better treatments, the NeoSep1 clinical trial evaluates new antibiotic combinations for newborn babies with sepsis. To learn more about the trial, we speak to Adrie Bekker and Cristina Obiero, principal investigators of th…
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Episode 4: Neonatal infections (part 1): The NeoOBS study and the global challenge of neonatal sepsis
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23:53
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214,000 newborn babies die of sepsis caused by infections that are resistant to antibiotics every year. This is a major problem worldwide, but disproportionally affects low- and middle- income countries. Reenu Thomas and Adrie Bekker, two neonatologists from South Africa, and Francesca Schiavone, clinical project manager at the MRC CTU at UCL in Lo…
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Neonatal infections (part 1): The NeoOBS study and the global challenge of neonatal sepsis
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214,000 newborn babies die of sepsis caused by infections that are resistant to antibiotics every year. This is a major problem worldwide, but disproportionally affects low- and middle- income countries.Reenu Thomas and Adrie Bekker, two neonatologists from South Africa, and Francesca Schiavone, clinical project manager at the MRC CTU at UCL in Lon…
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“It’s really not our fault that we struggle with our health, we have to look to the system around us and hold them accountable.” In our fast-paced world, convenience is king where food is concerned and many of us are now fuelling our bodies with an entirely novel set of substances called Ultra-Processed Food. In today’s episode, we’re taking a clos…
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Episode 3: The STREAM2 trial - how should we treat multi-drug resistant tuberculosis?
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For World TB Day, this episode explores the global burden of tuberculosis (TB) and how growing antibiotic resistance can complicate treatment options. Andrew Nunn, a Professor of Epidemiology, discusses his work on the STREAM2 trial, which investigated how treatment for multi-drug resistant TB could be shortened and made more acceptable for patient…
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The STREAM2 trial: How should we treat multi-drug resistant tuberculosis?
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For World TB Day, this episode explores the global burden of tuberculosis (TB) and how growing antibiotic resistance can complicate treatment options. Andrew Nunn, a Professor of Epidemiology, discusses his work on the STREAM2 trial, which investigated how treatment for multi-drug resistant TB could be shortened and made more acceptable for patient…
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Episode 1: Living on the edge - health inequalities and rising costs
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EPISODE DESCRIPTION “The way to get economic growth in a sustainable way is to improve the income of the bottom 60% of the population.” How does the cost-of-living crisis affect the health of the public? What impact does financial stress have on our physical and mental wellbeing? This episode aims to reshape the narrative and create a clearer under…
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Episode 2: Part 2 - Sharing the Results of Clinical Trials with Participants
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We have an ethical obligation to offer results to trial participants. Annabelle South explores the challenges of sharing results and talks about the best ways of communicating results from an ovarian cancer trial. As a final note, Annabelle reflects on what should be the next steps to ensure that all trial participants find out about the results. T…
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Episode 2: Part 1 - Sharing Results of Clinical Trials with Participants
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Clinical trials depend on people volunteering to take part, often at increased risk or inconvenience. Research shows that most trial participants want to know what the trial finds, but many never get to find this out. Annabelle South talks about why sharing results is important and how the Show RESPECT study tested different ways of sharing results…
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Episode 1: The ARCHERY study – Can AI transform the way we plan radiotherapy treatment globally?
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More than 50% of people living with cancer that need radiotherapy in low- and middle-income countries can't have it. Ajay Aggarwal presents the ARCHERY study, an exciting trial looking at the benefits of using artificial intelligence (AI) for radiotherapy treatment planning, which could improve access to high-quality cancer treatment globally. For …
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