Monica Coenraads, the mother of a daughter with Rett Syndrome, has played a critical role in catalyzing development of therapies to treat the rare, neurological disease. She co-founded and served as director of research for the Rett Syndrome Research Foundation. She later founded and today serves as CEO of the Rett Syndrome Research Trust. Her work…

The boys are back and this time Crendor and Jesse have come under fire for having opinions that aren't totally bonkers. Meanwhile Jesse is still obsessed with Astrobot and Crendor is still playing WoW. Thankfully they take the time away from being giant nerds to make a podcast about being giants nerds. Also Doctor Hooey makes an appearance and pote…

Earlier this year, the company gained attention when it reported that developed a customized antisense oligonucleotide to treat a boy with an ultra-rare neurodevelopmental disorder in a year’s time. The company is leveraging AI to develop oligonucleotide medicines on demand. We spoke to Chris Hart, co-founder, president and CEO of Creyon Bio; about…

AT THIS POINT WE ARE RELIVING THE SAME DAY! The guys go over yet another dropped points experience in DC. Follow them on Twitter & Instagram @NYCFCForeverPod Dave Moncion - @doobie_rockz Jonathan Sanchez - @jonsanch3z Yousef Ricart - @_ricartist Music by: Intangiblez https://www.beatstars.com/intangiblez https://soundcloud.com/theintangiblez…

This week, host Jorden Guth is joined by Trinnov Audio general manager Jon Herron to discuss the company’s history, the synergy between physical room acoustics and DSP room optimization, why different frequencies of sound require a different approach, and how the company’s new WaveForming technology is a whole new approach to perfecting bass perfor…

THEY GUYS TALK THROUGH THE CLUB CHANGING THE BADGE AND THE WAY THE TEAM WENT ABOUT IT. Follow them on Twitter & Instagram @NYCFCForeverPod Dave Moncion - @doobie_rockz Jonathan Sanchez - @jonsanch3z Yousef Ricart - @_ricartist Music by: Intangiblez https://www.beatstars.com/intangiblez https://soundcloud.com/theintangiblez…

When Yiwei She’s son Leo was diagnosed with a severe neurodevelopmental condition, he was one of only two people known to have the ultra-rare disease. In a year, though, working with Creyon Bio, the family was able to move from the start of research for an ASO to treating Leo with the experimental therapy. We spoke to She, founder of the TNPO2 Foun…

YEERRRRR!!! We look beyond the planet for answers on how will NYCFC figure out how to finish a match! YKTFV!!! Follow them on Twitter & Instagram @NYCFCForeverPod Dave Moncion - @doobie_rockz Jonathan Sanchez - @jonsanch3z Yousef Ricart - @_ricartist Music by: Intangiblez https://www.beatstars.com/intangiblez https://soundcloud.com/theintangiblez…

The boys are back and this time Crendor takes it to the comment section! In fact we are all about the comment section this episode. Maybe even open to trying to a new segment on the show??? Meanwhile Jesse gets busy mismanaging his time - as he does. Also have you seen lego gollum? We love lego gollum! Then Ikea has a pajama party and didn't invite…

This week, host Jorden Guth is joined by Pro Audio Technology owner/president L. Paul Hales to discuss his history in audio, how audio research has guided the development of his speakers over the years, what really matters in audio and what doesn’t, and why most consumer speakers fall short in one significant way. Sources: “Theory Audio Design Sys5…

Rare disease patient organizations are increasingly driving the discovery and development of therapies to treat the conditions on which they are focused. Organizations are seeking ways to accelerate these programs and advance them to the point where a biopharmaceutical partner might be willing to take them over. DevineBio was created to partner wit…

YEERRRRR!!! The guys talk through another disappointing result vs Chicago. Celebrate Taty's call up, and more YKTFV!!! Follow them on Twitter & Instagram @NYCFCForeverPod Dave Moncion - @doobie_rockz Jonathan Sanchez - @jonsanch3z Yousef Ricart - @_ricartist Music by: Intangiblez https://www.beatstars.com/intangiblez https://soundcloud.com/theintan…

The boys are back and this time Crendor manages to grab some brunch and a few good stories. Meanwhile Jesse is still recovering from his cold. Thankfully there's plenty to talk about from gaming to trying to buy burgers with drugs...and for some reason choosing Burger King? All this and more on a brand new Cox n' Crendor!Go to https://bit.ly/3Lr5DE…

Gene therapies have emerged as an important and growing area of medicine, but various players in the healthcare continuum are trying to understand the unique development, regulatory, and other issues surrounding this emerging modality. Avery McIntosh and Alex Sverdlov, both biostatisticians, have edited the new book “Development of Gene Therapies: …

YEEERRRRR! The guys talk over NYCFC's Leagues cup exit and how while they are out, it could be some positive momentum going forward. This and more YKTFV! Follow them on Twitter & Instagram @NYCFCForeverPod Dave Moncion - @doobie_rockz Jonathan Sanchez - @jonsanch3z Yousef Ricart - @_ricartist Music by: Intangiblez https://www.beatstars.com/intangib…

The boys are back and this time Jesse returns with a cold from his trip to NYC. Maybe it was the kid next to him, maybe it was the enormous amount of animals on his flight? Meanwhile Crendor discovers the origins of TAKE THE SOCK! It's just as amazing as you would think. Also did you know EVERYTHING is a remix? All this and the tale of a ground hog…

This week, host Jorden Guth is joined by the SoundStage! Network’s Joseph Taylor, Jason Thorpe, and Dennis Burger to discuss records and turntables, from the perspective of two old pros and one recent convert to the format. Sources: “A Vinyl-Apathist’s Quest for His Perfect First Turntable” by Dennis Burger: https://soundstageaccess.com/index.php/f…

Siblings and children of people with the rare, neurodegenerative disease amyotrophic lateral sclerosis are being offered a test in the United Kingdom at no-cost to see if they carry mutations to one of more than 40 genes that would make it likely for them to develop the condition. Sano Genetics developed the test under a grant from Innovate UK. The…

YEERRRR!!! THE BOYS ARE BACK WITH THEIR TAKES OF THE LEAGUES CUP MATCH VS NEW ENGLAND REVOLUTION, TALLES MAGNO & MORE... YKTFV Follow them on Twitter & Instagram @NYCFCForeverPod Dave Moncion - @doobie_rockz Jonathan Sanchez - @jonsanch3z Yousef Ricart - @_ricartist Music by: Intangiblez https://www.beatstars.com/intangiblez https://soundcloud.com/…

The boys are back and this Jesse decided to go out into the world looking like a mess and was rewarded by meeting a fan. He can hear his mothers voice telling him he should have looked better. Meanwhile Crendor meets a mythical creature and/or tiktoker who wants to know if he'll take the sock. All this and more on a brand new Cox n' Crendor!Go to h…

Multiple sulfatase deficiency is a rare and progressive neurodegenerative disease. The patient advocacy organization United MSD Foundation has been able to advance a gene therapy into preclinical development for the ultra-rare condition through modest investment by pursuing a focused research strategy and leveraging partnerships. In May 2023, The B…

YEERRRR!!! THE BOYS ARE BACK WITH THEIR TAKES OF THE LEAGUES CUP MATCH VS FC CINCY. Follow them on Twitter & Instagram @NYCFCForeverPod Dave Moncion - @doobie_rockz Jonathan Sanchez - @jonsanch3z Yousef Ricart - @_ricartist Music by: Intangiblez https://www.beatstars.com/intangiblez https://soundcloud.com/theintangiblez…

This week, host Jorden Guth is joined once again by Simaudio product director Dominique Poupart and marketing director Étienne Gautier to discuss how making its products locally affects the quality of the components, their serviceable life, rolling changes to production, and adapting to tough times like global pandemics. Sources: North Collection: …

Despite the growing demand for genomic data and the falling price of genome sequencing, costs continue to restrain its use. Single Technologies, which is developing a three-dimensional approach to sequencing, believes it can cut the cost to just $10 per genome for consumables. That’s a drop from estimates of about $600 today. We spoke to Johan Strö…

YEERRR The Dominicans have taken over! JK! Just Dave and Yousef this week going over some olympic action and leagues cup. #YKTFV Follow them on Twitter & Instagram @NYCFCForeverPod Dave Moncion - @doobie_rockz Jonathan Sanchez - @jonsanch3z Yousef Ricart - @_ricartist Music by: Intangiblez https://www.beatstars.com/intangiblez https://soundcloud.co…

The boys are back and this Jesse is crashing hard on no caffeine, a town looks like a person, and Boneless Chicken Wings have bones now I guess. All this and more on a brand new Cox n' Crendor!Go to http://factormeals.com/cox50 and use code cox50 to get 50% off your first box plus 20% off your next month.Go to https://bit.ly/3Lr5DEK to download the…

Nonsense mutations prematurely end the translation of a gene into protein and can result in a serious deficiency. About 10 to 15 percent of inherited genetic diseases involve nonsense mutations. Alltrna is developing transfer RNA therapies designed to correct the problem in protein synthesis caused by these aberrations. What’s particularly exciting…

YEEERRRR!! THE GANG IS BACK IN FULL! WE TALK A LITTLE MUSIC FIRST BEFORE DIVING INTO OUT VIEWS OF THE TWO DRAWS ON THE ROAD VS ATLANTA AND ORLANDO. THIS AND MORE YKTFV! Follow them on Twitter & Instagram @NYCFCForeverPod Dave Moncion - @doobie_rockz Jonathan Sanchez - @jonsanch3z Yousef Ricart - @_ricartist Music by: Intangiblez https://www.beatsta…

The boys are back and this time LIVE!!! Enjoy our live show which is basically the same as a normal show expect people laugh at our faces insted of to themselves. Go to http://meundies.com/crendor to get 20% off your first order and free shipping.By Cox n' Crendor Show

This week, host Jorden Guth continues his conversation with Dr. Floyd Toole, exploring the origins of the Athena project at Canada’s NRC, the reasons for and details of his move to Harman International, some of the most misunderstood aspects of his research, the origins of his legendary book Sound Reproduction: The Acoustics and Psychoacoustics of …

Effie Parks is well known in the rare disease community as both a patient advocate and host of the Once Upon a Gene podcast. Like many advocates, she was thrust into the world of rare diseases following the diagnosis of her son Ford with an ultra-rare neurodevelopmental disorder known as CTNNB1 syndrome. Recently she published a map of the journey …

YEERRR!!! We’re back this week talking through some 3rd place Copa takeaways and how that led into the NYCFC’s match vs Chicago Fire match and our frustrations with the subs Cushing make start to boil over! Follow them on Twitter & Instagram @NYCFCForeverPod Dave Moncion - @doobie_rockz Jonathan Sanchez - @jonsanch3z Yousef Ricart - @_ricartist Mus…

Inherited retinal diseases are a group of genetic conditions that cause progressive and severe vision loss, such as retinitis pigmentosa, choroideremia, and Stargardt disease. Though they vary in terms of their genetic drivers, they are characterized by degeneration of photoreceptor cells in the retina. Collectively, inherited retinal diseases affe…

The boys are back and this time Crendor is rich lady day drunk and talking about Will Smith. Meanwhile Jesse has dreams that are basically press releases for upcoming nintendo products. But that's not all, have you ever had a pizza boat? Neither have we but we want one now! All this and more on Cox n' Crendor!Go to http://butcherbox.com/cox and use…

YEEERRRR!! DOOBIE IS BACK ON HIS BS! HE MAKES HIS RETURN AND TEAMS UP WITH SANCHEZ TO DISCUSS THE EURO'S, COPA AMERICA, NYC VS MONTREAL & AUSTIN.... YKTFV Follow them on Twitter & Instagram @NYCFCForeverPod Dave Moncion - @doobie_rockz Jonathan Sanchez - @jonsanch3z Yousef Ricart - @_ricartist Music by: Intangiblez https://www.beatstars.com/intangi…

This week, host Jorden Guth is joined by the loudspeaker legend himself, Dr. Floyd Toole, whose research at Canada’s National Research Council (NRC), followed by his tenure at Harman International, resulted in arguably more improvements to the fidelity of audio we hear at home than anything attributable to any one person. In this first of our two-p…

For people in rural communities, access to genomic testing can require getting on a waitlist, delays in clinical assessment, and multiple visits to urban medical centers. A pilot study from Children’s Mercy Research Institute in Kansas City, Missouri, found that by partnering with a rural clinic in a direct-to-provider model it was able to more tha…

The boys are back and this time Jesse exhausts himself playing video games like a real nerd. Meanwhile Crendor has a Warhammer problem and Jesse supports it. Also the internet! It's still a thing! And then Abe Lincoln melts in the summer heat! All this and more on Cox n' Crendor!Go to http://factormeals.com/cox50 and use code cox50 to get 50% off y…

Chit Chattin in out for a short and sweet good time! Come hang! Support the Show. Learn more about FLOCR (Hybrid athlete training) by contacting Tracey! https://www.instagram.com/trassishere/ One-on-one Alchemical Personal training online with Abigail! https://www.instagram.com/abigail.crowe/ https://calendly.com/alchemicaltraining…

The cornea is a transparent and multi-layered dome that sits at the front of the eye. It not only provides protection, but bends light to focus it on the retina. Many corneal diseases cause scarring that reduces the transparency of the cornea and results in the loss of vision. In fact, corneal diseases are a leading cause of blindness. Claris Bio i…

YEEERRRR!! A LITTLE REMOTE ACTION TODAY AS SANCHEZ IS OUT ON COPA DUTIES! SANCHEZ TAKES US THROUGH A CONCERNING COPA AMERICA EXPERIENCE AND OF COURSE WE TRY TO MAKE SENSE OF HOW NYCFC HAVE LOST 3 IN A ROW! YKTFV Follow them on Twitter & Instagram @NYCFCForeverPod Dave Moncion - @doobie_rockz Jonathan Sanchez - @jonsanch3z Yousef Ricart - @_ricartis…

Come see Cox n' Crendor Live! https://t.co/EeWQDuVDe1The boys are back and this time we've got a lot to catch up on after the father's day weekend. Oh, and Jesse's packages keep getting stolen. He may have finally had it with his apartment. Meanwhile Crendor HAS SEEN THE GARFIELD MOVIE! And boy does he have thoughts. All this and potentially our ve…

This week, host Jorden Guth is joined by Dr. Sean Olive, senior fellow at Harman International, to discuss his time at NRC with Dr. Floyd Toole, his move from there to Harman, the development of the Harman target curves for headphones and earphones, and his thoughts on the future of immersive audio and more. Sources: Dr. Sean Olive on 35 Years of “…

Welcome backkkkk! Been a minute it seems! We're here to talk about integrity. How to not loose yourself in the process of change, within business. A lot has been going on in the Tracey and Abigail area of business, and along the way we've both realized a few things. Here to grow, and talk about it. Join us! Support the Show. Learn more about FLOCR …

Lennox-Gastaut syndrome and Dravet syndrome are two rare, developmental and epileptic encephalopathies. Drug developers have sought to address epilepsies by altering the electrical activity in the brain. Ovid therapeutics, though, has taken a novel approach with its experimental therapy soticlestat by seeking to restore homeostasis to the brain. We…

YEERRRR!!!! We're back from a mini vacation to go over the wild FRIDAY NIGHT LIGHTS action vs the champs Columbus Crew! Rain couldn't stop the party but brought some funny reffing... Follow them on Twitter & Instagram @NYCFCForeverPod Dave Moncion - @doobie_rockz Jonathan Sanchez - @jonsanch3z Yousef Ricart - @_ricartist Music by: Intangiblez https…

Zevra Therapeutics, formerly KemPharm, rebranded itself in early 2023 following the acquisition of the experimental therapy arimoclomol for the rare lysosomal storage disorder Niemann Pick disease type C. Zevra is Greek for “zebra,” a symbol of rare disease. The company subsequently built out its rare disease pipeline through the acquisition of Ace…

Come see Cox n' Crendor Live! https://t.co/EeWQDuVDe1The boys are back and Crendor actually finally did a thing he said he was going to do on a previous podcast!!! Is this a first?! Meanwhile Jesse had a long week of playing games he can't talk about, but he can talk about pizza smuggling! All this and a man doing the thing he was arrested for doin…

This week, host Jorden Guth is joined by SoundStage’s Doug Schneider, Jason Thorpe, and Matt Bonaccio to discuss the biggest audio show in the world, what’s new, what’s different, and what were their favorite sights and sounds this time around. Sources: Coverage of High End 2024 - Munich, Germany: https://soundstageglobal.com/index.php/shows-events…

For certain rare diseases, therapies derived from human plasma, the largest component of blood, represent critical lifesaving and life-sustaining medicines. In many cases, it may represent the only therapeutic option. Takeda pharmaceutical’s Plasma-Derived Therapies Business Unit works across immunodeficiencies, neuroimmunology, hematology, pulmono…