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Pitfalls of Clinical Trials: Lessons From ADAURA
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Manage episode 376735321 series 2892359
Content provided by Healthcare Unfiltered and Chadi Nabhan. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Healthcare Unfiltered and Chadi Nabhan or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
Making their return to the show are Drs. Jack West and Nathan Pennell, of City of Hope Comprehensive Cancer Center and Cleveland Clinic, respectively, this time to use the ADAURA trial as a springboard to discussing pitfalls and shortcomings of modern clinical trial designs. The trio go back and forth on control arms keeping pace with standards of care, studies mandating the ability for crossovers, and appropriate endpoints for adjuvant studies. Then, they highlight underwhelming clinical trial data that have led to FDA approvals, whether ADAURA featured a “known inferior agent” and an “inferior crossover design,” and whether ADAURA proved to be an “unethical” trial, among many other points of contention. Listen to Drs. West and Pennell’s previous episode on the ADAURA trial from 20121. https://on.soundcloud.com/VQ4vb Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA
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194 episodes
MP3•Episode home
Manage episode 376735321 series 2892359
Content provided by Healthcare Unfiltered and Chadi Nabhan. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Healthcare Unfiltered and Chadi Nabhan or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
Making their return to the show are Drs. Jack West and Nathan Pennell, of City of Hope Comprehensive Cancer Center and Cleveland Clinic, respectively, this time to use the ADAURA trial as a springboard to discussing pitfalls and shortcomings of modern clinical trial designs. The trio go back and forth on control arms keeping pace with standards of care, studies mandating the ability for crossovers, and appropriate endpoints for adjuvant studies. Then, they highlight underwhelming clinical trial data that have led to FDA approvals, whether ADAURA featured a “known inferior agent” and an “inferior crossover design,” and whether ADAURA proved to be an “unethical” trial, among many other points of contention. Listen to Drs. West and Pennell’s previous episode on the ADAURA trial from 20121. https://on.soundcloud.com/VQ4vb Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA
…
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194 episodes
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