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With the convergence of data, computing power, and new methods, computational biology is at its most exciting moment. At PSI, we're asking the leading researchers in the field to discover where we're headed for, and which exciting pathways will take us there. Whether you're just thinking of starting your research career or have been computing stuff for decades, come and join the conversation!
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show series
 
Send us a Text Message. In the sixteenth episode, Janusz Bujnicki tells me about his early switch to bioinformatics, a stroke of serendipity that defined his future career, and how he later managed to reincorporate both biophysics and experimental biology into his research agenda. We talk about the current state of the field of RNA structural predi…
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Send us a Text Message. In the fifteenth episode, Paulo Souza and I discuss the challenges inherent in managing a project of such a scope, and the philosophy behind the systematic way in which Martini is continuously improved and reparameterized. Paulo describes how a user-centric approach helps refine and troubleshoot the model through its widesca…
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Send us a Text Message. In the fourteenth episode, Syma Khalid and I talk about the challenges we're faced with when trying to understand the environment of the bacterial cell envelope, and the outer membrane in particular. We discuss how the lessons taken from the computational study of these structures can inform the design of future antibacteria…
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Send us a Text Message. In the thirteenth episode, Daniel Zuckerman and I talk about textbooks on statistical biophysics and a physics-based vision of biology, a few of which he himself authored. Daniel reveals that his passion for clarity in writing comes from his early humanities background, and makes a case for how well-thought and physically mo…
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Send us a Text Message. In the twelfth episode, Vlad Cojocaru and I discuss how the simulation field can integrate further layers of complexity in modeling transcription control and genome organization in humans. Vlad shares his insights on the computational biology of transcription factors, including DNA-mediated allostery and pioneer transcriptio…
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Send us a Text Message. In the eleventh episode, Justin Lemkul and I talk about the motivations and challenges behind providing technical help on online forums and mailing lists. Justin shares his story of becoming a prolific technical advisor for the Gromacs community, which evolves into a discussion about automatability, the role of expertise in …
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Send us a Text Message. In the tenth episode, Ariane Nunes-Alves and I talk about a kinetics-centric view of drug design, making the case that modeling kinetics in atomistic simulation is an important frontier that, despite clear biomedical relevance, is rarely explicitly addressed either in model parameterization or with the latest AI methods. We …
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Send us a Text Message. In the ninth episode, Michele Vendruscolo and I discuss the current state of research on misfolding diseases, typically associated with excessive protein aggregation and formation of insoluble amyloids. Michele presents an optimistic perspective in which the convergence of recent clinical and software developments opens up n…
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In this episode of The Advice Show, intermediary distribution director at Scottish Widows, Ranila Ravi-Burslem, talks about the trend of advice firms ‘white-labelling’ their platforms. Ravi-Burslem ponders why the trend has slowed in the advice market over the past year, the challenges facing advice firms – and why she believes the regulatory focus…
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Send us a Text Message. In the eight episode, Rossen Apostolov and I depart from the standard format to talk about the core concepts behind BioExcel, the European Center of Excellence for computational biology. We discuss their main objectives and challenges, from working with code to organizing schools and webinars, talk about the challenges of su…
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Send us a Text Message. In the seventh episode, Aleksei Aksimentiev and I delve into the intersection of physics, biology, and nanotechnology, exploring the innovative world of nanopores and biomolecular sequencing. Aleksei shares his journey from particle physics in Ukraine to leading-edge research in the US, and underscores how on the unpredictab…
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In our latest monthly roundup, NMA reporters discuss the biggest stories from the past (two) month(s), including St James’s Place’s back-book review of ongoing advice servicing, platforms’ cash interest changes and what the FCA revealed in its sector-wide review of retirement income advice.By Citywire
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Send us a Text Message. In the sixth episode, Giulia Palermo and I discuss the challenges of studying truly multiscale biomolecular systems, such as the CRISPR/Cas9 complex she famously got involved with. While such problems can take us way out of our comfort zones, they also provide us with clear pathways to innovative and transformative science, …
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Send us a Text Message. In the fifth episode, Paul Robustelli and I discuss how the once very sharp boundary between academia and industry has been becoming increasingly porous, and what implications it will have for future careers in science. Paul shares his experiences and observations about the competing models of funding scientific research, an…
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Send us a Text Message. In the fourth episode, Modesto Orozco and I talk about the rough path to the predictive power modern computational science has achieved in biology, and the immense possibilities it opens to today's computational biologists working across the scales of space and time. Modesto also reflects on why sharing simulation data is cr…
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Send us a Text Message. In the third episode, Wojtek Kopeć and I discuss the overlooked yet exciting social aspect of scientific collaboration, and what the world of academia could learn from the industry and statisticians to avoid falling behind. Wojtek also shares his personal experience of starting a lab as a new PI, and we reflect on the role o…
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Send us a Text Message. In the second episode, Max Bonomi and I discuss efforts to achieve interoperability and portability in the computational community, and how the AI structural revolution will unfold to bring us realistic molecular ensembles. We then move on to ask how the entire range of contributions to science can be recognized, particularl…
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In this episode of The Advice Show, Fundscape CEO Bella Caridade-Ferreira joins NMA’s reporters for a wide-reaching discussion about the future of platforms, the sector’s recovery after a difficult 2023 – and why she thinks Nucleus’ replatforming could take longer than the business anticipates. Plus, Caridade-Ferreira reveals which platforms she pr…
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Send us a Text Message. In the first episode, Pilar Cossio and I discuss the radical progress in integrating simulations with experiments, and the excitement about recent progress in modeling cryo-EM tomography data. We share thoughts on the sustainability of our publishing practices, and comment on the challenges of funding the maintenance of scie…
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Send us a Text Message. What is this all about? Does the computational community need a podcast? Along with the first interview, I'm sharing the idea behind PSI, and explaining why the time is ripe for a new marketplace of ideas to drive the changes in how we do science. Everyone is invited, from ambitious undergraduates to seasoned veterans!…
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Citywire New Model Adviser has previously reported on providers’ data leaks, including Scottish Widows recently leaking confidential client information to the wrong advice firm. This incident was not an isolated one. In this episode of The Advice Show, reporters Zach Sharif and Nicola Blackburn speak to Kate Shaw, financial planner at Financial Lif…
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New Model Adviser reporters Nicola, Zach and Victoria discuss some of the biggest stories from the past month, including SJP’s decision to scrap exit fees, the worst quarter on record for platform flows, and major providers suspending annuity quotes. The team also discuss some of the reported predictions for Jeremy Hunt’s Autumn Budget.…
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Just 16% of UK advisers are women, according to the FCA. How can we change this, and how much progress have we made? In this episode, Independent Women founder Lesley Mackintosh discusses the state of the advice industry, and how to bring in more female advisers.By Citywire
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Nick Powell has faced a variety of challenges in his career path to date. From appearing in the Champions League, to completing his financial planning exams – Powell’s path has not been traditional. Join NMA reporters Zachariah Sharif and Alicja Hagopian, as they chat to Nick Powell and Emmelia Davidson-Slack for this fascinating insight into finan…
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How do we address the dearth of diversity in financial advice? NMA Reporters Zachariah Sharif and Nicola Blackburn are joined by Jonathan Hawkins, principal business consultant at Bravura Solutions, to discuss how firms need to step up, the current state of diversity and the urgency of the situation.…
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Investors in the now-collapsed payment processing company Wirecard may have been willing to ‘explain away’ discrepancies in the company’s balance sheet due to close professional relationships with Wirecard CEO Markus Braun, according to investigative reporter Dan McCrum. In this episode of The Advice Show, McCrum reveals how Wirecard concealed a £1…
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In this episode, interviewees explain how political ‘flip-flopping’ on plans for a net-zero economy is discouraging asset managers from taking a stance on ESG. Morningstar’s ESG research lead for North America, ESG whistleblower Desiree Fixler, and other interviewees explain the impact this is having on the US sustainable investment industry – and …
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This week we talk greenwashing, SDR and ESG ratings in an exclusive interview with head of ESG Alicia Kedzierski from the FCA. Advisers share their thoughts – and criticisms – on the proposed regulation. As the FCA prepares to publish its biggest set of rules on ESG yet, The Advice Show has produced a podcast series reflecting on the history and tu…
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How can the industry accommodate different ways of thinking for advisers and clients? NMA chats to Katja Oakley-Bell, central investment proposition lead at Quilter, to see where can be improved and highlight best practice. Louise Allison, consultant at compliance firm Konexo and Holly Short, principal associate at Eversheds-Sutherland also join th…
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As the FCA prepares to publish its biggest set of rules on ESG yet, The Advice Show has produced a podcast series reflecting on the history and tumult of the ESG investment industry. This three-part series explores ESG's humble beginnings in the advice world, the challenges now faced by the $2.8tn industry, and where it will go next. In episode 1, …
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An investigation by Citywire New Model Adviser found that former pension scheme members were threatened with legal action earlier this month. Pension scheme administrators including Capita and Mercer demanded the return of tens of thousands of pounds, after errors were discovered in transfer value calculations. Carla Langley, founder of The Langley…
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New FCA data shows that the lack of trust in financial advice is as bad as ever. With failed firms still phoenixing, questions over independent advice, and the promotion of unregulated advice, the challenges for the industry are clear. How can we turn this around? We’re joined by co-founder of Celtic Financial Planning Rob Lewis to discuss.…
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