Broadcasting the latest developments in GU cancer Hosted by Brian Rini and Tom Powles Brian Rini MD is Chief of Clinical Trials, Professor of Cancer Research and Professor of Medicine (Hematology/Oncology), Vanderbilt-Ingram Cancer Centre Tom Powles is Director of Barts Cancer Centre, St Bartholomews Hospital and Professor or Genitourinary oncology, Queen Mary University of London
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Episode 339: Tres Uramigas discuss ESMO guidelines for GU
18:37
18:37
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18:37
Maria, Christina and Elena discuss recent changes to the ESMO guidelines in kidney, bladder and prostate cancer.
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Episode 338: RCC: Debulking Nephrectomy, Adjuvant Therapy Future and More
25:39
25:39
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25:39
Naomi Haas joins Tom and Brian in New York City at the World GU Conference to discuss several RCC topics
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Episode 337: Updated NCCN Guidelines in RCC
42:38
42:38
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42:38
Eric Jonasch, Co-Chair of the NCCN RCC Guidelines, gives insight into the process of guideline modification and discusses updates in adjuvant, front-line and refractory RCC
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Episode 336: Which patients are not suitable for 1st line EVP in bladder cancer
35:35
35:35
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35:35
Jonathan Rosenberg and a surprise guest discuss comorbidities and treatment-related side effects.
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Episode 335: Novel immune therapies for renal cancer
37:31
37:31
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37:31
David Braun divides immune therapies into four groups and describes how novel treatments and targets work. Tom and Brian are both excited and, at times, sceptical.
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Episodio 334 en español: Tres Uramigas ASCO 2024
36:33
36:33
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36:33
Escuche nuestro primer podcast sobre los aspectos más destacados de ASCO en cáncer de vejiga, riñón y próstata
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Episode 333: The Uromigos Cup - The Netherlands
26:20
26:20
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26:20
Axel Bex, Christian Blank, Laura Mertens and Micheil Van der Heijden answer a range of relevant and sometimes irrelevant questions
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Episode 332: The Uromigos Cup - Germany's Entry
35:55
35:55
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35:55
Viktor Gruenwald, Boris Hadaschik and Gunhild Von Amsberg answer questions around GU cancer and German football
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Aditya Bagrodia describes three new drugs/studies in NMIBC.
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Silke Gillessen joins Tom and Brian, who give their opinion on the data and new 'Take Home Message' format.
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Episode 329: Japan in the Uromigos Cup qualifying round
30:48
30:48
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30:48
Nobuaki Matsubara, Hiroshi Kitamura and Yuji Miura battle through the sometimes ridiculous questions set by Tom and Brian.
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Episode 328 ASCO24: Emergency podcast - what the NADINA trial means for preoperative GU cancer studies
26:32
26:32
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26:32
David McDermott discusses the adjuvant vs neoadjuvant immune therapy trial and its wider implications.
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Episode 327 ASCO24: CM901 and EV302 Efficacy and QOL Updates
24:02
24:02
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24:02
Guru Sonpavde describes the efficacy of chemotherapy with nivolumab in lymph node only 1st line UC patients. Tom describes the QOL data for EV pembro.
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Episode 326 ASCO24: KIM-1 in Renal Cancer
18:08
18:08
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18:08
Laurence Albiges discusses this circulating biomarker which may be predictive and prognostic.
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Episode 325 ASCO24: KN426 and the CLEAR trial - tissue based biomarkers for kidney cancer
33:44
33:44
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33:44
Toni Choueiri and Brian describe similarities and differences in the biomarker findings of these two trials. Debate about the value and future of this approach breaks out.
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Episode 324 ASCO24: SURE1 neoadjuvant sacituzumab govitecan in UC
20:43
20:43
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20:43
Andrea Necchi gives us the lowdown of efficacy and toxicity of this combination.
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Episode 323 ASCO24: TDXD in Bladder Cancer
29:47
29:47
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29:47
Jonathan Rosenberg gets to grips with the data available for the bladder cohort from the TDXD Destiny pan-tumour cohort.
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Episode 322 ASCO24: The role of ctDNA in the TheraP trial (LuPSMA vs cabazitaxel in CRPC)
22:16
22:16
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22:16
Alex Wyatt describes the predictive resistance of ctDNA fraction at baseline in predicting outcome.
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Episode 321 ASCO24: CHAARTED-2 in prostate cancer - is the sequel as good as the original?
23:25
23:25
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23:25
Christos Kyriakopoulos describes the outcome of this study, where cabazitaxel with abiraterone as combined with abiraterone alone in docetaxel refractory CRPC.
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Episode 320: Team Canada's entry for the Uromigos Cup
23:30
23:30
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23:30
Danny Heng, Christian Kollmannsberger and Kala Sridhar answer questions in an attempt to get to Nashville and take on LA to win the Uromigos Cup.
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Episode 319: ASCO 2024: A Preview of GU Data
33:49
33:49
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33:49
What to see at the ASCO 2024 Annual Meeting, with Silke Gillessen.
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Episode 318: The Lancet Commission on prostate cancer: planning for a surge in cases
31:59
31:59
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31:59
Nick James discusses this paper, which covers broad issues in prostate cancer - including diagnosis and treatment with a focus on the future.
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Episode 317: AUA 2024 Preview with the AUA Secretary
22:16
22:16
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22:16
David Penson discusses highlights for the upcoming meeting. He articulates his excitement around the NMIBC data.
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Episode 316: APCCC 2024 Summary with Silke Gillessen
41:11
41:11
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41:11
Silke covers key aspects of the meeting, including surgery vs RT, genetic and somatic testing, PSMA imaging and 1st line triplet therapy.
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Episode 315: APCCC 2024 Quickfire - Bone health, hot flashes and gynecomastia in prostate cancer
18:17
18:17
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18:17
Chris Sweeney is joined by Matt Smith, Anthony Joshua and Lisa Horvath to discuss the management of these complex issues in advanced prostate cancer.
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Episode 314: APCCC 2024 Cardiovascular risks with hormone therapy in prostate cancer
25:15
25:15
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25:15
Thomas Suter and Chuck Ryan discuss identification and management of cardiovascular disease for patients starting therapy for prostate cancer.
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Episode 313: APCCC 2024 Debate - Radiation therapy in advanced disease
35:40
35:40
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35:40
Thomas Zilli and Pierre Blanchard discuss this topic from Lugano.
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Episode 312: APCCC 2024 Radiation therapy after surgery for prostate cancer
23:56
23:56
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23:56
Jason Efstathiou and Piet Ost discuss the data for and against this approach.
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Episode 311: The Uromigos Paper of the Month - The POUT Trial
36:02
36:02
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36:02
Alison Birtle describes adjuvant chemotherapy in bladder cancer.
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Episode 310: Dosing and duration of drugs from a cost perspective
28:28
28:28
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28:28
Daniel Goldstein describes his work on this issue.
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Episode 309: EAU24 Checkmate 274 - OS for adjuvant nivolumab in bladder cancer
27:13
27:13
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27:13
In this second part, Matt Galsky describes the OS signal data. We also look into the future.
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Episode 308: EAU24 IMVIGOR 011 - Outcome of ctDNA negative patients post-cystectomy
23:09
23:09
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23:09
Tom, Brian and Matt Galsky review the screening component of this study, presented at EAU24.
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Episode 307: Bladder-Sparing Approaches Part 2
35:14
35:14
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35:14
Michiel Van der Heijden explores the role of radiotherapy and other neoadjuvant and other neoadjuvant combinations to prevent the need for surgery.
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Episode 306: The Uromigos Paper of the Month - Chemo/Nivo as a bladder sparing approach in UC
29:56
29:56
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29:56
Matt Galsky describes his phase 2 study looking at gem/cis/nivo followed by nivo in responders. This potentially avoids cystectomy.
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Episode 305: FDA and Oncology Clinical Trials
29:35
29:35
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29:35
FDA Deputy Oncology Director Dan Suzman described approaches to oncology trials. Tom asks 3 last questions which annoys Brian more than usual.
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Episode 304: A PSMA CD3 Bispecific T-cell Engager in CRPC
30:43
30:43
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30:43
Tanya Dorff describes acapatamab, a prostate-specific membrane antigen (PSMA) CD3 bispecific engager.
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Michael Lattanzi discusses treatment plans and research in the community.
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Episode 302: Part 2- Adjuvant Therapy in solid tumors
34:37
34:37
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34:37
Hans Hammers discusses trial design and patient selection in the adjuvant setting.
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Episode 301: Cancer research from a global perspective.
31:06
31:06
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31:06
Vania Wisdom, editor of the Lancet, talks about approaches to cancer treatment and research in developing countries
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Episode 300: Adjuvant PD1 Therapy in Solid Tumours
42:15
42:15
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42:15
David McDermott discusses melanoma and renal data. We never get to bladder or lung.
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Episode 299: Androgen receptor ligand-directed degrader BMS-986365
36:40
36:40
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36:40
Dana Rathkopf describes phase 1 data for the androgen receptor ligand-directed degrader in prostate cancer
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Silke, Tom and Brian cover the bases.
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Episode 297: ASCO GU 2024: CONTACT2 Part 2 - The Aftermath
22:46
22:46
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22:46
Neeraj Agarwal addresses the issues raised at the meeting.
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Episode 296: ASCO GU 2024: Novel approaches to QOL and belzutifan
23:58
23:58
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23:58
Cris Bergerot describes her modifications of existing QOL models while Tom describes the QOL data from LS005
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Episode 295: ASCO GU 2024: Adjuvant Therapy in Renal Cancer
32:46
32:46
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32:46
Pedro Barata summarises his ASCO GU discussion on this topic.
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Episode 294: ASCO GU 2024: Adjuvant Pembrolizumab in Bladder Cancer
33:17
33:17
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33:17
Andrea Apolo describes the results of this positive trial.
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Episode 293: ASCO GU 2024: BRCAaway and CONTACT2
22:21
22:21
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22:21
Kim Chi discussed the prostate cancer oral session at ASCO GU 2024.
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Episode 292: ASCO GU 2024: HPN328 - A Tri-Specific T Cell Engager in Prostate Cancer
26:04
26:04
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26:04
Misha Beltran describes the activity of this novel agent in neuroendocrine prostate cancer.
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Episode 291: ASCO GU 2024: CONTACT2 - Cabozantinib and Atezolizumab in Prostate Cancer
31:15
31:15
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31:15
Neeraj Agarwal describes the results of this positive randomised Phase 3 trial.
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What to look out for in bladder, prostate and renal cancer at this year's meeting.
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