Best Astrocytes Podcasts (2024)

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96. Brain Power: Understanding the Brain's Energy Supply and Use with Dr. Tim Ryan 32:42

42m ago32:42

32:42

In this episode, Dr. Tim Ryan joins hosts Lesley and Joe to discuss how neurons rely on a constant source of energy to function. They discuss how the brain's energy supply is maintained and regulated and what happens when this energy supply is disrupted.Episode Guest:Timothy RyanRyan Lab: https://biochem.weill.cornell.edu/directory/primary-faculty/…

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Alexander Disease Research Update - Episode #23: Albee Messing's presentation at the recent conference in Philadelphia 22:22

13d ago22:22

22:22

Albee Messing’s presentation at the recent Alexander disease conference in Philadelphia, August 3, 2024. Send your questions and feedback to: amessing@wisc.edu Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center: https://alexander-disease.waisman.wisc.edu/donate/…

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Modeling Kidney Disease and Regeneration with Organoids Derived from Human Pluripotent Stem Cells 56:20

8d ago56:20

56:20

Benjamin Freedman, Ph.D., delves into the creation and functionality of kidney organoids. He discusses their focus on filtration over hormone functions, and answer intriguing questions about urine characterization and the necessity of organoid structures. Freedman explores the use of scaffolds for implants and ponder the philosophical implications …

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EP. 95 Visual Neuroscience Objects & Scenes With Tony Movshon 32:22

27d ago32:22

32:22

In this episode, Dr. Tony Movshon returns to the podcast to chat with hosts Jeremy and Akash about his work in understanding visual pathways and the differences between 'constructionist' and 'reductionist' approaches in neuroscience. Dr. Movshon is a university professor researching vision and visual development at NYU School of Medicine. He has ma…

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A Closer Look at...Stem Cells and Human Longevity 58:02

1M ago58:02

58:02

Can we not only live longer but better, healthier lives? Robert A.J. Signer and Shiri Gur-Cohen describe how stem cell research may hold the key to longevity. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39869]By UCTV: UC San Diego

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Capturing Late-Onset Neurodegeneration in Patient-Derived Neurons via Direct Reprogramming - Breaking News in Stem Cells 59:16

1M ago59:16

59:16

Andrew Yoo, Ph.D., provides insight into the ongoing research on neurodegeneration and neuronal reprogramming, highlighting the complexities and challenges in modeling and understanding these processes. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39454]By UCTV: UC San Diego

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Alexander Disease Research Update - Episode #22: 1) anesthesia and AxD, and 2) GFAP cross-linking to itself 20:46

1M ago20:46

20:46

Albee Messing, Amy Waldman, and Natasha Snider discuss the following recent publications: [02:07] A retrospective observational cohort study of the anesthetic management and outcomes of pediatric patients with Alexander disease undergoing lumbar puncture or magnetic resonance imaging Paediatric Anesthessia (in press) [10:17] Glial fibrillary acidic…

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94. Perception And Abstraction With Jerry Chen 35:02

2M ago35:02

35:02

In this episode of Max Planck Florida's Neurotransmissions Podcast, we meet new cohost Dr. Akash Pal, who joins Jeremy in a discussion with Associate Professor of Biology at Boston University, Dr. Jerry Chen. They discuss how the brain can make sense of our complex sensory world through the processes of perception and abstraction and how Dr. Chen's…

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A Closer Look at...Stem Cells in Space 59:56

2M ago59:56

59:56

Why explore stem cells in space when we have the comfort of Earth's laboratories? Join Robert A.J. Signer, Ph.D., alongside Catriona Jamieson, M.D., Ph.D., and Alysson Muotri, Ph.D., as they delve into the untapped potential of space experiments for expediting medical breakthroughs. Patient advocate Alexandria Allen offers a poignant narrative, rev…

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Alexander Disease Research Update - Episode #21: 1) Blood levels of GFAP, neurofilaments, and tau, and 2) planning for in-person conference in Philadelphia this summer. 15:21

3M ago15:21

15:21

Albee Messing, Jenny Pearson, Natasha Snider, and Amy Waldman discuss the following recent publication and the conference planned for this summer in Philadelphia: [02:02] Plasma concentrations of glial fibrillary acidic protein, neurofilament light, and tau in Alexander disease Neurological Sciences (2024) [full text] [04:16] Discussion about Phila…

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Effects of Astrocytic Circadian Clocks Disruption on Synaptic Pruning with Anca Pasca - Breaking News in Stem Cells 55:20

3M ago55:20

55:20

Medical advances have significantly improved the survival of preterm babies and term neonates with brain injuries due to environmental hypoxia or genetic causes. Anca Pasca, M.D., shares her work to understand the molecular mechanisms underlying neurodevelopmental disorders associated with fetal and neonatal brain injury. Series: "Stem Cell Channel…

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93. Neuro-Emotional Well-Being with Kuan Hong Wang 36:21

3M ago36:21

36:21

In this episode of MPFI's Neurotransmissions Lesley and Jeremy speak with Dr. Kuan Hong Wang, Professor at the University of Rochester and Co-Director of the New Brain Aging Center, about Emotional Well-Being, the power and challenges of big science approaches, and his scientific philosophy to exploring increasingly complex neuroscience questions.W…

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Episode 62: Josh Mandel-Brehm - CEO, CAMP4 Therapeutics 20:10

3M ago20:10

20:10

Explore the untapped potential of RNA amplifying therapeutics with the CEO of CAMP4 Therapeutics, Josh Mandel-Brehm. We uncover the power of antisense oligonucleotides in rewriting the narrative for genetic diseases characterized by protein deficiency. Josh takes us behind the scenes of their innovative RNA Actuating Platform (RAP), a map charting …

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Episode 61: William Korinek - CEO and Co-Founder, Astrocyte Pharmaceuticals 24:20

3M ago24:20

24:20

Embark on a journey through the neurons and synapses of brain science with William Korinek, the CEO of Astrocyte Pharmaceuticals. In a conversation that fuses the molecular intricacies of neuroprotection with the humanistic pursuit of medical advancement, Bill reveals his unique path from molecular biologist to biotech innovator. Together, we unrav…

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Stem Cells and Science in Space - Medicine Informing Novel Discoveries (MIND) 53:49

3M ago53:49

53:49

Explore cutting-edge research at the intersection of neuroscience, space exploration, and medical innovation. Researchers discuss revolutionary experiments with brain organoids cultivated from stem cells, conducted both in terrestrial labs and aboard the International Space Station. They investigate accelerated aging, neuroprotective agents, and po…

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Stem Cells and Space: Global Astrobiotechnology Hub 54:26

4M ago54:26

54:26

Marking the one-year anniversary of the Global Astrobiotechnology Hub, an esteemed panel convenes to envision the future of space exploration and stem cell research. Central to their discussion is the imperative to enhance accessibility and expedite scientific inquiry in space. They advocate for a shift towards establishing regular access to space,…

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Episode 60: Rachel Haines - VP of Clinical Development & Operations, Rinri Therapeutics 18:30

4M ago18:30

18:30

By Vial

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Episode 59: Bas van der Baan - President & CEO, Lixte Biotechnology 17:32

4M ago17:32

17:32

Join as we dive deep into the world of oncology drug development with Bas van der Baan of Lixte. Discover the inspiration behind Lixte's focus on PP2A inhibitors and how this innovative approach is poised to revolutionize cancer treatment by enhancing chemotherapy and immunotherapy responses. Bas shares insights into ongoing clinical trials, regula…

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Skin Development and Regeneration in Homeostasis and Disease with Elena Ezhkova - Breaking News in Stem Cells 1:05:49

4M ago1:05:49

1:05:49

Elena Ezhkova, Ph.D., discusses the role of Merkel cells in touch sensation and their connection to nerves. She shares research on skin cancer formation, focusing on the PRC1 complex's impact on gene expression. Ezhkova also investigates epithelial-to-mesenchymal transition (EMT), finding it contributes to cancer spread. Ezhkova offers insights for…

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92. Launching a Neuroplasticity Lab in India with Anant Jain 38:04

4M ago38:04

38:04

This episode of MPFI's Neurotransmissions Podcast dives into the fascinating world of neuroplasticity, the brain's ability to change and adapt. We're joined by Dr. Anant Jain. Anant joined Centre for High Impact Neuroscience and Translational Applications (CHINTA) in Kolkata, India in November 2023. His lab focuses on understanding the molecular si…

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Episode 58: Samarendra Mohanty - President & CSO, Nanoscope Therapeutics 16:36

5M ago16:36

16:36

Dr. Samar Mohanty, president and CSO of Nanoscope Therapeutics joins us to shed light on the revolutionary gene therapy that's giving hope to individuals with retinal degenerative diseases by pioneering a treatment that can re-sensitize the retina to detect low light levels. We open the curtains on their groundbreaking multi-characteristic opsins (…

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Alexander Disease Research Update - Episode #20: 3D bioprinting method for co-culture of neurons and astrocytes reveals new features of Alexander disease 15:37

5M ago15:37

15:37

Albee Messing and Linghai Kong discuss the following recent publication: [01:52] 3D bioprinting of human neural tissues with functional connectivity. Cell Stem Cell 31:260-274.e7 (2024) [full text] Send your questions and feedback to: amessing@wisc.edu Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Cente…

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91. 4D-Cellular Physiology with Jennifer Lippincott-Schwartz 30:37

5M ago30:37

30:37

In this episode, hosts Lesley and Jeremy speak with Dr. Jennifer Lippincott-Schwartz, Senior Group Leader and Head of Janelia's 4D Cellular Physiology Group, about how technology has shaped her career and her vision for developing a molecular understanding of tissue physiology. Episode Notes:Please help us create content you want to hear by giving …

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Episode 57: Rob Etherington- CEO and President at Clene Nanomedicine 20:06

5M ago20:06

20:06

Imagine unlocking the secrets to revitalizing the brain's energy centers and turning the tide on neurodegenerative diseases. In this episode, Rob introduces us to CNM-Au8, an oral nanotherapeutic with the potential to recharge failing mitochondria. Our discussion traverses the innovative path Clene has charted, from the drug's conception to the exc…

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Episode 56: Jason Bock- Founder and CEO at CTMC 22:28

6M ago22:28

22:28

Step into the future as Dr. Jason Bock, founder and CEO of CTMC discusses the company's unique approach to accelerating cell therapies from development to testing, and the power of collaboration in reshaping the future of cancer treatment. Listen in as we discuss how CTMC's partnership with MD Anderson is not just technical but deeply human in natu…

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Modeling Development with Stem Cells with Amander Clark - Breaking News in Stem Cells 1:07:59

6M ago1:07:59

1:07:59

Amander Clark, Ph.D., delves into crafting artificial ovaries for fertility and aging research. She stresses the importance of diversity in stem cell studies to ensure comprehensive findings. By assembling ovarian models from various genetic backgrounds, her team aims for inclusive representation in biomedical research, potentially offering insight…

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Podcast Survey 2024 1:49

6M ago1:49

1:49

Help Shape the Podcast. Visit the link to fill out a survey that will help us better understand our podcast audience, hear your likes and dislikes, and ultimately help us plan for future episodes. Podcast Survey: https://www.mpfi.org/podcast-surveyBy Max Planck Florida Institute for Neuroscience

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Episode 55: Alex Federation- Co-Founder at Talus Bio 15:27

6M ago15:27

15:27

Embark on a quest to unravel the 'undruggable' genome with Alex Federation, Co-founder of Talus Bio. Explore challenges in targeting transcription factors in cancer with Talus's innovative Marmot platform. Discover potential breakthroughs in rare diseases and pediatric cancers, and glimpse into the future of studying transcription factors within li…

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90. Mini 2-P Microscopy With Weijian Zong 34:22

6M ago34:22

34:22

In this episode, hosts Lesley and Joe speak with Dr. Weijian Zong about the motivation, challenges, and advancements behind the development of the MINI2P, an open-source miniaturized two-photon microscope that allows neuroscientists to visualize brain activity in freely behaving animals.Episode Notes:Help support the science, training, and outreach…

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Episode 54: Ahmed Hamdy- CEO at Vincerx Pharma 16:52

6M ago16:52

16:52

Join Dr. Ahmed Hamdy, CEO of Vincerx Pharma, on a compelling journey through oncology. From co-founding Acerta Pharma to pioneering patient-centric innovations, Dr. Hamdy shares his impactful career. Explore the groundbreaking VersAptx bioconjugation platform, designed to elevate cancer therapies and uncover the delicate balance between clinical ex…

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Episode 53: Sam Clark- CEO & Founder at Terran Biosciences 18:10

6M ago18:10

18:10

Have you ever considered the untapped potential of abandoned drugs? Join Dr. Sam Clark to discuss how his personal drive to combat mental illness is leading to breakthroughs in treatments for neurological and psychiatric diseases. Witness how Terran is not only resurrecting discarded medications for new purposes, but also pioneering the next genera…

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Alexander Disease Research Update - Episode #19: Giant Axonal Neuropathy and Alexander Disease 18:24

6M ago18:24

18:24

Albee Messing, Rachel Battaglia, and Natasha Snider discuss the following publication: [00:59] Intermediate filament dysregulation in astrocytes in the human disease model of KLHL16 mutation in giant axonal neuropathy (GAN) Molecular Biology of the Cell (in press) [full text - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10846626/] Send your questi…

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Episode 52: Mark McDonough- President & CEO of ChromaCode 16:54

7M ago16:54

16:54

Ever wondered how technology could drastically improve early detection in healthcare? Let us take you on a journey with Mark McDonough, President and CEO of ChromaCode, as we unfold the world of molecular diagnostics with a special focus on HDPCR technology. Mark, with his diverse background in the military and healthcare, brings a fresh perspectiv…

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Episode 51: Bogdan Knezevic - Co-founder & CEO at Kaleidoscope.bio 21:16

7M ago21:16

21:16

Embark on a journey through the intricate world of biotech with Bogdan Kezevic, co-founder and CEO of Kaleidoscope Bio, and uncover the revolutionary software shaping the future of scientific research. Bogdan's leap from scientist to entrepreneur has led to groundbreaking solutions for the challenges plaguing biotech. In our chat, he shares how dat…

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Episode 50: Steven Reed - Co-Founder & CEO at HDT Bio 12:19

7M ago12:19

12:19

What does it take to revolutionize the world of vaccines and touch lives across the globe? Join us on a riveting journey with Steven Reed, CEO and co-founder of HDT-Bio, as we explore the creation of the first refined tuberculosis vaccine and dive into the remarkable strides in RNA technology. This episode lifts the veil on the science that could r…

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Dissecting Human HSC Self-Renewal Mechanisms Throughout Ontogeny with Hanna Mikkola - Sanford Stem Cell Symposium 2023 33:15

7M ago33:15

33:15

Hanna Mikkola, M.D., Ph.D., shares her work in hematopoietic stem cells (HSCs) and their complex renewal process. Her research aims to unravel these cells' behavior in mice and humans, offering potential insights for future medical advancements. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39258]…

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Examining the Therapeutic Potential of Stem Cell Derived Microglia with Mathew Blurton-Jones - Breaking News in Stem Cells 1:18:20

7M ago1:18:20

1:18:20

Mathew Blurton-Jones presents CRISPR-based interventions for a rare brain disorder in mice by substituting defective brain cells with healthy ones. He details experiments demonstrating the efficacy of corrected cells in mitigating brain pathologies. Blurton-Jones emphasizes the need for cautious translation to human trials, advocating gradual cell …

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Prenatal Inflammation Shapes Postnatal Immune Function by Reprogramming Fetal Hematopoiesis with Anna Beaudin - Sanford Stem Cell Symposium 2023 37:24

8M ago37:24

37:24

Anna Beaudin, Ph.D., delves into the intricacies of how prenatal inflammation impacts the immune system's blueprint, shaping its long-term function. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39257]By UCTV: UC San Diego

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Episode 49: Jeffrey Bacha - Chairman, Rakovina Therapeutics 21:45

8M ago21:45

21:45

Join Jeffrey Bacha, a pioneer in the fight against cancer and the creative force behind Rakovina Therapeutics. For 25 years, Jeffrey has been reshaping the industry landscape, and today, he gives us a peek into his world of innovation. We venture into Rakovina's research and development of oncology drugs. exploring their groundbreaking technique co…

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Working Together for Better Patient Care: Alpha Clinic Directors Panel - Sanford Stem Cell Symposium 2023 56:27

8M ago56:27

56:27

CIRM-funded Alpha Stem Cell Clinics are a network of California medical centers that specialize in delivering stem cell clinical trials to patients. In this fascinating panel, clinic directors discuss advanced treatments, therapies like gene editing, and sharing knowledge and creating networks across the country for better patient care.Featuring:Ge…

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89. Epigenetics, Astrocytes And Olfaction With Dr. Debosmita Sardar 39:59

8M ago39:59

39:59

In this episode, hosts Joe and Lesley chat with Dr. Debosmita Sardar about her research into the roles of astrocytes, epigenetics, and serotonylation during odor processing. Dr. Sardar is a K99 Postdoctoral Fellow at Baylor College of Medicine and a selected MPFI NeuroMEETS speaker.Episode Notes:Max Planck NeuroMEETS: https://www.mpfi.org/science/m…

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Episode 48: Jonathan Thon - Founder & CEO at STRM.BIO 21:52

8M ago21:52

21:52

Embark on a fascinating exploration of biotech entrepreneurship, guided by an expert who's been in the trenches: Jonathan Thon, CEO and founder of STRM.BIO. We'll give you an insider's view of his journey from academia to the cutting edge of biotech, unveiling his trailblazing work on platelet production and the transformative potential of extracel…

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Stem Cells and Space - Sanford Stem Cell Symposium 2023 55:24

9M ago55:24

55:24

Experts discuss the immense potential of conducting experiments and manufacturing goods in space. They explore how this could enhance our understanding of health issues, unveil new discoveries, and produce innovative technology for use on Earth. The conversation encompasses collaborations between various industries and scientists, aiming to explore…

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Episode 47: Oscar Segurado- CMO at ASC Therapeutics 22:00

9M ago22:00

22:00

Ever wondered how far we've truly come in the realm of gene and cell therapies, and where we're headed next? This captivating conversation with Oscar Segurado, the CMO of ASC Therapeutics, will satisfy your curiosity. Oscar, a veteran in the biopharmaceutical industry, shares fascinating insights on ASC Therapeutics' groundbreaking innovation in pe…

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Episodes 46: Spiro Rombotis- CEO at Cyclacel 21:28

9M ago21:28

21:28

We’re thrilled to share our enlightening exchange with Spiro Rombotis, the seasoned CEO of Cyclacel. He peels back the curtain on the breakthrough discovery of B53, a commonly mutated gene in cancer patients, and the inspiring success of FADRA, their lead drug in clinical trials. Furthermore, Spiro delves into the highs and lows faced by Cyclacel, …

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Using Stem Cells to Model and Treat Human Disease with Clive Svendsen - Sanford Stem Cell Symposium 2023 40:27

9M ago40:27

40:27

Clive Svendsen, Ph.D., leads groundbreaking experiments using stem cell transplants, uncovering unexpected findings. These trials aimed at improving ALS treatments, revealed higher success with upper motor neuron transplants compared to spinal cord methods. Svendsen's exploration of cortical transplants hints at a potential breakthrough. Moreover, …

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Alexander Disease Research Update - Episode #18: 1) Quantitative MRI in rat model, and 2) Developmental milestones in cerebral form of AxD 28:42

9M ago28:42

28:42

Albee Messing, Nick Stowe, JP Yu, and Amy Waldman discuss the following recent publications: [4:30] Stowe NA, Singh AP, Barnett BR, Yi SY, Frautschi PC, Messing A, et al. Quantitative diffusion imaging and genotype-by-sex interactions in a rat model of Alexander disease. Magnetic Resonance in Medicine (2023) in press [15:11] Acquisition and Loss of…

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88. SFN 2023 with Carolyn Rodriguez, Tim Holford, And Alexis Green 38:55

9M ago38:55

38:55

In this special 2023 Society for Neuroscience Meeting, Lesley discusses the experience of attending the SfN conference for the first time with postbaccalaureate at the National Eye Institute, Alexis Green; presenting a poster and developing connections at SfN with postdoctoral researcher at MPFI, Dr. Tim Holford; and further discuss new insights in…

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Organoids to Model Human Diseases with Hans Clevers - Sanford Stem Cell Symposium 2023 40:39

9M ago40:39

40:39

Hans Clevers, M.D., Ph.D., shares his research at the intersection of medicine and biology. Clevers discusses revolutionary advances in personalized medicine, where patient-specific treatments can be developed by studying small samples of patients' tissues. He explores the role of specialized cells known as "best for cells" in gastrointestinal heal…

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Regulation of Lung Progenitors in Homeostasis and Injury Repair - Carla Kim Sanford Stem Cell Symposium 2023 29:11

10M ago29:11

29:11

Carla Kim, Ph.D., explains how aging impacts lung cell biology and its potential to reshape our understanding of diseases, including lung cancer. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39254]By UCTV: UC San Diego

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