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Brandi N. Smith, PharmD, BCPPS defines necrotizing enterocolitis and late-onset sepsis in the premature neonate and proposed mechanisms of prevention with probiotic use, reviews literature supporting the use of probiotics in premature neonates and recognizes ongoing questions in using probiotics in premature neonates. For more pharmacy content, fol…
 
On this episode, we discuss the management of rheumatoid arthritis. We start by reviewing some background information. Then, we compare and contrast the various medications options including DMARDs, TNF-alpha biologics, and non-TNF-alpha biologics. Thanks for listening! If you want to support the podcast, check out our Patreon account. Subscribers …
 
Kaitlyn J. Bailey, PharmD (@pharmgirl1821) describes the mechanisms of action of select CDK46, PI3K, and PARP inhibitors, reviews the outcomes data related to CDK46, PI3K, and PARP inhibitors for treatment of metastatic breast cancer and discusses toxicity management for CDK46, PI3K, and PARP inhibitors. For more pharmacy content, follow Mayo Clini…
 
On this episode, we are joined by 4th year, MUSC students, Shannon Himes and Blake Adams. We discuss a patient case that involves HFpEF (with uncontrolled hypertension), type-2 diabetes, stage 2 chronic kidney disease, and benign prostatic hyperplasia. Thanks for listening! If you want to support the podcast, check out our Patreon account. Subscrib…
 
Mai Uyen Alissa Le, PharmD describes the utility and importance of anticoagulation in ECMO, identifies clinical factors to consider with the use of bivalirudin anticoagulation in ECMO and discusses literature evaluating the use of bivalirudin and its comparison to heparin for anticoagulation in pediatric patients supported on ECMO. For more pharmac…
 
Joseph C. Osborne III, PharmD (@JOzempic) describes the current framework of deprescribing, reviews literature pertinent to deprescribing in the inpatient setting and identifies facilitators, barriers, and future directions for deprescribing. For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garret…
 
On this episode, we discuss immunologically mediated adverse reactions that patients can have to foods (food allergies). We provide a brief overview of some background information and pathophysiology. We then review the pharmacological management of an acute allergic reaction and close with some noteworthy information about the drug, Palforzia (pea…
 
On this episode, we are joined by PGY1 resident, Dr. Kristen Ingold, PharmD. Kristen came on the show to discuss her series of training videos designed to help students prep for their residency/fellowship interviews. She virtually interviewed 20-25 residency program directors (RPDs) from across the United States. Each RPD was asked the same list of…
 
Natalie A. Haddad, PharmD (@NatalieHaddadRx) describes the epidemiology of multisystem inflammatory syndrome in children (MIS-C), outlines key similarities and differences between MIS-C and other comparable pediatric conditions and discusses current potential therapeutic options for the treatment of MIS-C. For more pharmacy content, follow Mayo Cli…
 
On this episode, we discuss the latest pharmacotherapy recommendations for asthma management based on the 2021 GINA guidelines. We review the various medication options as well as compare and contrast the different options for rescue/maintenance therapies. We also discuss the use of biologics in patients with worsening asthma and evidence of type-2…
 
Kyle S. Wamsley, PharmD (@KyleWamsley1) describes the pathophysiology and complications associated with alcohol withdrawal syndrome (AWS), reviews treatment modalities and commonly utilized agents for AWS in the ICU setting and outlines appropriate phenobarbital dosing regiments based on current literature. For more pharmacy content, follow Mayo Cl…
 
Erin D. Wieruszewski, PharmD, BCCCP (@EDWieru) describes the goals of treatment for intracranial hemorrhage, discusses literature examining the use of desmopressin and tranexamic acid for intracranial hemorrhage and identifies appropriate patients to receive treatment with desmopressin or tranexamic acid. For more pharmacy content, follow Mayo Clin…
 
Danielle M. Hess, PharmD (@dhess_09) describes the role of nutrition in cirrhosis and deficiency patterns as it relates to disease severity, evaluates literature depicting the impact of vitamin A, vitamin D, and zinc deficiencies on complications associated with cirrhosis and discusses micronutrient supplementation and monitoring recommendations fo…
 
On this episode, we compare and contrast the various formulations of hormonal contraceptive options. We discuss some clinical pearls that are important for selecting the best option based on a patient's specific comorbidities and symptoms during her menstrual cycle. We then provide some examples of cormorbidities and explain the process for selecti…
 
Hannah M. Brokmeier, PharmD (@hannahbrokmeier) reviews current accepted standards in sedation practices, compares pharmacologic properties of propofol and dexmedetomidine for light sedation and evaluates evidence for choice of optimal sedative agent in light sedation. For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPh…
 
On this episode, we discuss medication safety during pregnancy. We start by listing common teratogens to watch for in patients that are currently pregnant or trying to become pregnant. We then review the preferred treatment options for common disease states in patients that are currently pregnant. The list of common pregnancy/lactation references w…
 
Cassandra J. Schmitt, PharmD (@cjschmitt2) identifies guideline recommendations for antiplatelet agents following percutaneous coronary intervention (PCI), reviews the literature examining the safety and efficacy of clopidogrel, ticagrelor, and prasugrel and discusses factors that influence the selection of a P2Y12 agent following PCI. For more pha…
 
Mary A. Gilmer, PharmD, MHA, BCPS reviews common causes and origins of drug shortages, describes the impacts and implications of drug shortages and discusses strategies and processes for drug shortage management. For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garrett E. Schramm, Pharm.D., @garre…
 
On this episode, we revisit the topic of managing acute coronary syndrome. We review some background information and differentiate between a STEMI, NSTEMI, and unstable angina. We then review the inpatient treatment algorithm for each. We close by discussing the follow up including the length of dual anti-platelet therapy. Thanks for listening! If …
 
Ashley Kate Ragan, PharmD defines actionable proton pump inhibitor (PPI) drug-gene associations, discusses current pharmacogenomic PPI guidelines, including the 2018 Dutch Pharmacogenomic Working Group (DPWG) and 2020 Clinical Pharmacogenetic Implementation Consortium (CPIC) and reviews primary literature depicting CYP2C19 guided PPI dosing. For mo…
 
On this episode, we are joined by MUSC forth year PharmD student, Matthew Brock. We review a patient case that covers multiple co-morbidities. We start by discussing the patient's COPD management and the recommendations from the 2021 GOLD guidelines. We then review low dose rivaroxaban with lose dose aspirin in patients with PAD. Then, we talk abou…
 
Alicia E. Mattson, PharmD, BCPS, BCCCP (@AM_EM_PharmD) describes the goals of pharmacotherapy in RSI, discusses literature surrounding medication choice and dose for RSI and selects an appropriate induction and paralytic medication for a patient requiring RSI. For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes o…
 
On this episode, we do a deep dive into hypertension management. We discuss the various medication classes, and then go into the pharmacotherapy algorithm. Once again we’re excited to partner with freeCE for our listeners claim ACPE-accredited continuing education for this episode! Listeners will have the opportunity to claim 1 hour of home-study c…
 
On this episode, we are joined by Dr. Swathi Varanasi to review adaptogens, nutraceuticals, Ayurveda, and other elements of Integrative Health. We also discuss the upcoming webinar series called Integrative Health 101 that she developed along side Integrative Health expert, Dr. Pam Tarlow. More information about the upcoming webinar is below: https…
 
Nathan T. Smith, PharmD, BCPS recalls the clinical presentation of gender incongruence, identifies current treatment options for transgender men and women and describes potential cardiovascular risks associated with gender-affirming hormone therapy. For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host,…
 
Mikaela Hofer, Pharm.D., BSPS, BCCCP (@mikaelamhofer) identifies limitations of current vasopressor agents for the treatment of septic shock, reviews novel vasopressor therapies with a current or potential role in the management of septic shock and describes advancements in the development of biomarkers and pharmacogenomics for the monitoring and i…
 
Allison Golbach, PharmD, BCPS (@AllisonGPharmD) describes epidemiology, pathophysiology, and prognosis of acute myeloid leukemia (AML), reviews literature supporting induction regimens for patients with AML without targetable mutations and discusses how to select between AML induction regimens based on patient-specific factors. For more pharmacy co…
 
Nicole Hlavacek, PharmD (@HlavacekPharmD) recognizes the proposed mechanism of magnesium in different pathologies, recalls dosing and administration rates for magnesium and describes effectiveness of magnesium. For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garrett E. Schramm, Pharm.D., @garrett…
 
On this episode, we discuss treating community-acquired pneumonia. We start with the outpatient treatment options based on the 2019 IDSA CAP guidelines. We also discuss managing a patient that has been admitted. We review some reasons to use more broad-spectrum empiric therapy, and close by mentioning the new Prevnar 20 vaccine. We want to thank th…
 
Hannah Poppen, PharmD (@PoppenPharmD) reviews guideline recommendations for management of blood cholesterol, describes the risks and benefits associated with adjunct non-statin therapy and identifies patient-specific characteristics in which PCSK9 inhibitor therapy should be considered. For more pharmacy content, follow Mayo Clinic Pharmacy Residen…
 
On this episode, we discuss the utilization of injectable medications in the treatment of type 2 diabetes. We compare and contrast the different GLP-1 receptor agonists as well as the various insulin products. We review some dosing strategies for both basal and prandial insulin. We also go over the use of a sliding scale. Listeners can claim ACPE-a…
 
Nicholas Vollmer, PharmD (@VollmerNick) describes the mechanism through which thromboelastography works and how it differs from current assessments of coagulation, identifies patient scenarios where thromboelastography may be of benefit compared to standard of care and discovers barriers of widespread use of thromboelastography. For more pharmacy c…
 
On this episode, we revisit the acute and chronic management and treatment of atrial fibrillation. We review the various rate-controlling and anti-arrhythmic medications used. We also discuss long term anticoagulation therapy to prevent stroke risk. Thanks for listening! If you want to support the podcast, check out our Patreon account. Subscribers…
 
Yen Tran, PharmD, MBA (@YenTranlt) illustrates the consequences of antibody mediated rejection (AMR) on solid organ transplant recipients, develops a management strategy for AMR and outlines approaches to AMR management. For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garrett E. Schramm, Pharm.D.…
 
On this episode, we are joined by TJ Parkman, PharmD candidate 2022 to discuss the management of pediculosis and pthiriasis. We compare and contrast head, body, and pubic lice. Then, we review the medications used to eradicate the lice infestation. Thanks for listening! If you want to support the podcast, check out our Patreon account. Subscribers …
 
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