Best Tessera Podcasts (2024)

1
EP 143: Harnessing human data in drug development with Jakob Steinfeldt, Co-Founder and Chief Scientific Officer at Pheiron 36:17

11m ago36:17

36:17

0:00 Intro to The Genetics Podcast 01:00 Welcome to Jakob and background on Pheiron 02:14 What made Jakob decide to start Pheiron, what the company does, and how his scientific background inspired him to found a start-up 5:24 Jakob’s excitement and inspiration around the power and potential of machine learning 07:07 Cardiology and heart failure as …

1
EP 142: From genome to bedside: How genetics is transforming modern medical practice with Dr. Andrea Gropman 42:45

3d ago42:45

42:45

0:00 Introduction 1:40 Andrea’s background and how she got into the field of genetics, neuroimaging, and metabolic disorders 4:00 Insights into Andrea’s clinical practice, including the diverse families and patients she serves and her approach to clinical decision-making 6:30 How genetics and genomics have changed the diagnostic journey in the last…

1
EP 141: Bringing genomics to the clinic with Lori Orlando, Associate Prof at Duke University 43:24

10d ago43:24

43:24

0:00 Intro to The Genetics Podcast 01:00 Welcome to Lori Orlando 03:00 Lori’s career: From mathematical modelling to genetics and family history 05:11 The study that revealed 20% of the general population is at a higher risk of disease than average and needs preventative care 07:36 The first five diseases that Lori started analysing through informa…

1
EP 140: The future of Electronic Health Records and data analysis with Ben Goldacre 52:51

17d ago52:51

52:51

0:00 Intro to The Genetics Podcast 1:00 Welcome to Ben Goldacre 02:22 Ben’s open data projects at the Bennett Institute and the challenges they aim to tackle 04:03 Using Electronic Health Records (EHR) to help the National Health Service improve care 06:18 The importance of software development within healthcare data and how to manage salary scales…

1
EP 139: Rare disease breakthroughs using tRNA with Michelle Werner, CEO of Alltrna and CEO-Partner of Flagship Pioneering 44:42

24d ago44:42

44:42

0:00 Intro to The Genetics Podcast. 01:00 Welcome to Michelle. 02:00 Sstop codon diseases and how are they characterised 03:45 Diseases caused by premature stop codons in haploinsufficient genes. 04:35 The role of transfer RNA technology in finding solutions for premature stop codon diseases. 06:16 How Alltrna is engineering tRNAs which can bind to…

1
EP 138: Personalised medicine using microbiome models with Dr. Almut Heinken 40:22

1M ago40:22

40:22

0:00 Introduction 1:45 Almut’s research experience, including two recent publications on genome-scale metabolic reconstruction human microorganisms Genome-scale metabolic reconstruction of 7,302 human microorganisms for personalized medicine APOLLO: A genome-scale metabolic reconstruction resource of 247,092 diverse human microbes spanning multiple…

1
EP 137: Mavis Machirori on promoting equity, diversity, and social justice in genomics research 41:40

2M ago41:40

41:40

0:00 Intro 1:30 Mavis’ career arc, from starting as a midwife to researching medical innovation and technology with an emphasis on advocacy and equity 7:00 Systemic issues that are easily overlooked in medical research and advancements Webinar: Participant Diversity: Increasing the Impact of Biomedical Research Webinar 10:00 Addressing Eurocentrici…

1
EP 136: Developments in ring chromosome 20 research and advocacy with Allison Watson 40:57

2M ago40:57

40:57

0:00 Introduction 2:00 Allison’s personal journey to researching epilepsy and ring chromosome 20 syndrome 4:00 Biggest challenges families face with ring chromosome 20 syndrome 11:00 Incidence and prevalence of r(20) syndrome, and how we can improve data reliability 21:00 Applying next generation sequencing to r(20) syndrome gene research 29:00 Eng…

1
Chikai - Founding Google Earth and the lifelong pursuit of creating for the sake of creating 1:52:21

2M ago1:52:21

1:52:21

In this week’s episode, we sit down with our good friend and one of the biggest supporters of the pod, Chikai Ohazama. Chikai is the co-founder of Keyhole which was acquired by Google and became Google Earth. He is one of the most caring art collectors in our space, as well as an extremely talented AI artist. We dive into Chikai’s progression as an…

1
EP 135: Integration of newborn sequencing programs into healthcare systems with Dr. Ingrid Holm 41:16

2M ago41:16

41:16

0:00 Introduction 1:30 Ingrid’s initial interests in genetics, paediatrics, and newborn screening 2:45 How the original BabySeq project, a pioneering newborn sequencing program got started, how it’s going, and the launch of BabySeq2 8:45 Lessons from BabySeq1 and goals for BabySeq2 10:30 Potential societal and long-term considerations for those inv…

1
Roger Dickerman - Why (24 Hours of) Art? 2:23:22

2M ago2:23:22

2:23:22

In this week’s episode, we sit down with our good friend and founder of the 24 Hours of Art, Roger Dickerman. We dive into Roger’s background in trading and fitness, his love of art, founding Artifex and 24 Hours of Art, the power of routines, and so much more. Season Four is officially powered by Arbitrum and our content is now redistributed acros…

1
EP 134: Prenatal genetic testing and the future of AI in genetic counselling with Kira Dineen, host of DNA Today 40:44

2M ago40:44

40:44

0:00 Introduction 1:00 The backstory of how Kira first started DNA Today in 2012, when she was still in high school! 3:30 Some of Kira’s favourite topics she has discussed on DNA Today, including the legacy of Henrietta Lacks, and the story of a Glee actress with down syndrome 10:00 Kira’s best practices for podcasting, from over 10 years of experi…

1
Funghibull - The power of psychedelics 1:41:11

3M ago1:41:11

1:41:11

In this week’s episode, we sit down with our good friend and co-founder of Shillr, Funghibull. Funghi is one of our favorite collectors, builders and overall people in the space. We dive into Funghi’s background playing rugby, going to medical school in Scotland, 10 gram mushroom trips, finding punks, forming Shillr, and so much more. Season Four i…

1
EP 133: Insights into pharmacogenomics and increasing diversity in genomics research with Dr. Emma Magavern 39:17

2M ago39:17

39:17

0:00 Introduction 2:00 The value of an English Literature degree in designing and analysing research studies in medicine 3:45 Emma’s entrance to pharmacogenomics and her transition from practising physician to genetics research 6:00 How the East London Genes and Health program is increasing representation of diverse populations, namely South Asians…

1
Mike Demarais - Making the future fun with Rainbow 2:09:52

3M ago2:09:52

2:09:52

In this week’s episode, we sit down with our friend and co-founder of Rainbow Wallet, Mike Demarais. We dive into Mike’s background as a software engineer, how he fell into the crypto rabbithole, co-founding Rainbow, important lessons learned from raising capital, and so much more. Season Four is officially powered by Arbitrum and our content is no…

1
EP 132: From mammoths to genome editing, trailblazing genetics with Dr. George Church 47:41

3M ago47:41

47:41

0:00 Introduction 1:00 George’s upcoming big projects, including developing full recycling, renewing energy, creating bioweather maps, and harnessing citizen science 6:45 Progress in engineering viral resistance in humans, including thoughts from pre- and post- pandemic 11:00 A swapped genetic code that prevents viral infections and gene transfer b…

1
Vinnie Hager - Evolving as an artist throughout market cycles 2:19:01

3M ago2:19:01

2:19:01

In this week’s episode, we sit down with Vinnie Hager. Vinnie is an artist from Baltimore who focuses on a wide variety of mediums spanning from digital art to streetwear and even tables and stools. His style is immediately recognizable with a mixture of glyphs and objects including his signature flowers, eyes, water drops, smileys, hearts and enve…

1
EP 131: The potential of somatic genomics in drug discovery and development with Jake Rubens 44:57

3M ago44:57

44:57

0:00 Intro 0:40 Jake’s experiences as a serial entrepreneur starting five companies with a basis in genomic science 5:30 Opportunities for research and drug development in the realm of somatic science 9:20 Somatic evolution and how it provides valuable insights into disease mechanisms 12:30 Advantages and disadvantages of studying germline genome-w…

1
SHIPWRECKED #12: Goku & Maria - Our First Couple Interview 2:24:17

3M ago2:24:17

2:24:17

In this week’s episode, we did a little something different, again. We brought on our first ever couple, Goku and Maria. Goku is a badass artist and collector who has been a champion of the Solana art space since its inception. He is currently the marketing and community lead at Exchange Art. Maria Sutherland is an incredible producer, known for pl…

1
EP 130: Quarterly insights into noncoding variants and GWAS with Dr. Veera Rajagopal 51:56

3M ago51:56

51:56

Show Notes: 0:00 Introduction 1:20 How polydactyl mutations can inform research on non-coding variant mechanisms The importance of low-affinity binding between transcription factors and targets How these lessons can help us improve our understanding of drug and target discovery See Veera’s January round-up for more information: https://www.gwasstor…

1
Weesh - The Man Behind our Cameras 2:16:51

3M ago2:16:51

2:16:51

In this week’s episode, we did a little something different. We took the man who is usually behind the camera and put him in front of it. We sat down with our producer Weesh to dive into how in fell in love with art and became a collector, how he met Andy and fun childhood memories together, his biggest wins in crypto, and so much more. Season Four…

1
EP 129: Patient advocacy for genetic ALS and FTD with Jean Swidler, Executive Director of End the Legacy 38:44

3M ago38:44

38:44

0:00 Introduction 0:45 Jean’s personal experiences with family members with genetic ALS 10:00 Jean’s thoughts on the barriers and facilitators to providing treatment for those with genetic ALS 13:20 Insights into C9orf72, a common genetic determinant of ALS, and how it can also be associated with FTD 16:10 Jean’s experiences as an active advocate f…

1
EP 128: Parkinson’s disease and precision medicine with Drs. James Beck and Ignacio Mata 50:18

4M ago50:18

50:18

0:00 Introduction 1:05 Insights into the PD GENEration’s (a programme from the Parkinson's Foundation) milestones and progress points for the upcoming year 3:30 The shifting attitudes and perspectives of neurologists and healthcare workers at the PD GENEration 5:50 Insights into Nacho’s work with the genetics of Parkinson’s disease 10:20 Barriers a…

1
Spencer Gordon-Sand (Spencer Ventures) - Intelligent capital allocation in the NFT markets 2:28:08

4M ago2:28:08

2:28:08

In this week’s episode, we sit down with Spencer Gordon Sand, the mastermind behind Spencer Ventures. Before launching Spencer Ventures, Spencer was a competitive fencer, Magic the gathering player, and startup enjoyooor. We dive into Spencer’s investment thesis behind NFTs and how his fund invests, finding and buying distressed assets in a bear ma…

1
EP 127: Insights into precision medicine, fatty liver disease, and minimally invasive diagnostic tools with Dr. Mazen Noureddin 39:10

4M ago39:10

39:10

0:00 Intro 0:25 Mazen’s lifelong commitment to furthering the field of precision medicine in liver disease research, fueled by a personal connection of his grandmother developing MASH cirrhosis 2:30 Breakthroughs in the field of metabolic dysfunction-associated steatotic liver disease (MASLD) since the beginning of Mazen’s career 5:30 The potential…

1
Tunez and Intern from Monad - How to get your foot in the door and building during bear markets 1:45:37

4M ago1:45:37

1:45:37

In this week’s episode, we sit down with Intern and Tunez from the Monad team. Prior to Monad, Tunez was working with Delphi Digital and Intern was working at CMS Holdings. They’re two of my oldest friends from crypto twitter. We get into why they joined the Monad team, alpha for finding jobs in the space, biggest lessons from previous cycles, and …

1
EP 126: Patient-led research for ultra-rare disease drug development with Julia Taravella, Executive Director of Rare Trait Hope Fund 39:41

4M ago39:41

39:41

0:00 Introduction 0:25 Julia’s personal experience with ultra-rare diseases within her family 10:25 The importance of increasing accessibility to genetic testing across populations to learn more about ultra-rare diseases 14:00 The origin story of Rare Trait Hope Fund 23:50 Current research and next steps in developing potential gene therapies for a…

1
SHIPWRECKED #11 - Rhynotic and Toni Marinara 2:31:47

4M ago2:31:47

2:31:47

In this week’s episode, we sit down with Toni Marinara and Rhynotic, two of the most under the radar chad art patrons in the digital art space right now. Rhynotic is a gigabrain dev helping build out PREMINT which is the best allowlist platform in town. Toni is a badass lawyer who is representing and championing the culture of code with ArtXCode. T…

1
EP 125: The future of UK Clinical Trial Policy: Innovation, integration, and game-changing legislation with Lord James O’Shaughnessy 45:23

4M ago45:23

45:23

0:00 Introduction 1:25 How Lord O’Shaughnessy became involved in scientific policy making and his path to writing the UK Commercial Clinical Trials Review. 04:05 How Lord O’Shaughnessy pivoted from education to a focus on life sciences 06:38 The biggest challenges Lord O’Shaughnessy faced during his time as Parliamentary Under Secretary for Health …

1
Postwook - Training like an athlete as an artist, beating addiction, and dealing with ebbs and flows of being a full time creative. 2:34:38

5M ago2:34:38

2:34:38

In this week’s episode, we sit down with Natasha Chomko aka Postwook. Postwook is a Los Angeles based digital artist focused on cooking up some of the most visually pleasing and nostalgia provoking surreal landscape collage art. We dive into Postwook’s origin story, training like an athlete as an artist, diversifying income streams, beating addicti…

1
EP 124: How ReCode Therapeutics is pioneering tissue specific delivery of gene therapies for Primary Ciliary Dyskinesia with John Matthews 42:00

5M ago42:00

42:00

0:00 Introduction 01:10 How growing up in Malawi planted the seeds for John’s career in medicine and transition to therapeutic development 04:35 Why John focuses on rare diseases and conditions such as asthma 06:01 What has changed over the last decade in terms of treating and understanding asthma and the progress that genetics has enabled 07:31 Wh…

1
AJ Warner - Scaling Ethereum and Aligning Incentives with the Chief Strategic Officer of Offchain Labs 2:28:55

5M ago2:28:55

2:28:55

In this episode, we are joined by AJ Warner, the Chief Strategic Officer of Offchain Labs, the main contributors to the Arbitrum ecosystem. AJ is a gigabrain chad who joined the Offchain Labs in November 2020 and has been their CSO since January 2022. We dive into AJ’s crypto origin story, how he joined Offchain Labs, the technical and ideological …

1
EP 123: The ethics of newborn genome screening: Actionable insights and beyond with Holly Peay, Senior Research Scientist at the Research Triangle Institute 45:34

5M ago45:34

45:34

0:00 Introduction 0:50 Holly’s background and career so far 03:30 Complex decision-making and multiple risk factors: Family history, genetics, phenotypes and beyond 07:05 Changes within the last decade to help people make complex, sometimes subjective, healthcare decisions 09:20 Impact on people: The RTI’s mission and the Early Check Study 13:45 Ne…

1
EP 122: Building genome-scale engineered cells for biotechnology with Leslie Mitchell, Co-founder and CEO of Neochromosome 35:55

5M ago35:55

35:55

Summary: 0:00 Introduction 01:01 How Leslie got into the field of synthetic biology and engineering, and her career journey so far 02:45 What Leslie accomplished during her postdoc and recent transformations in the field of genomics 05:57 The impacts of non-coding regions of the genome and the outcome of deletions 08:20 How long it takes to make ch…

1
Nick and Pio - Founding The Nifty & BoDoggos, learnings from multiple years of hosting daily shows, and leveling up the crypto content industry. 1:56:23

5M ago1:56:23

1:56:23

Kicking off Season 4 of We Do A Little with a 💥with the 🐐 duo Nick and Pio from The Nifty and BoDoggos. Nick and Pio are some of the most dedicated grinders we know in the media space. On top of building their business and brand, they’ve been hosting daily morning shows for a few years while putting out hilarious content around the spectacles happe…

1
EP 121: Breakthroughs and insights in ALS research with Dr. Michael Benatar 44:10

5M ago44:10

44:10

Summary: 0:00 Introduction 0:50 Reflections from the 34th International Symposium on ALS/MND in Basel 1:50 Michael’s professional journey, initial challenges he encountered, and how the field of neurology has evolved over the years 3:10 An introduction to the ALS landscape, including its presentation, the genes involved, and potential treatment opt…

1
EP 120: Exploring the frontiers of gene therapy and AAVs with Dr. Nicole Paulk, CEO and Founder of Siren Biotechnology 43:47

5M ago43:47

43:47

0:00 Introduction to Dr. Nicole Paulk, a pioneer in AAV research and the founder of Siren Biotechnology 0:50 The moments that shaped Nicole’s career path and her passion for gene therapy and AAV research 9:20 Nicole’s academic research career and her transition from academia to the biotech industry 23:00 The story behind the founding of Siren Biote…

1
EP 119: Revolutionising drug discovery: how the Pharma Proteomics Project is combining genetic and proteomic data with Chris Whelan 38:25

6M ago38:25

38:25

0:00 Introduction 01:00 Chris’ background and career to date 02:10 What is the Enigma Project? 04:48 How is genetics being applied to drug discovery today and how does proteomics fit in? 09:23 When the UKBiobank Pharma Proteomics Project began and how long it took to set up 10:57 54k UK Biobank participants tested - discussion of findings 14:33 The…

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EP 118: The role of genetics in drug discovery and development with Dr. Matt Nelson 42:56

6M ago42:56

42:56

Summary: 0:00 Introduction 5:45 Lessons learned from 15 years at GSK: How has genetics and drug discovery evolved over time? 8:10 Matt’s seminal 2015 paper: Quantifying the impact of human genetic evidence on the probability of success in drug development 11:40 Which types of genetic evidence are the best drivers of success in clinical trials? 13:3…

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EP 117: Wendy Chung: whole genome newborn screening and other big opportunities in genomic medicine. 47:51

6M ago47:51

47:51

Summary: 0:00 Introduction 1:45 Wendy’s early career looking into the genetics of diabetes through mouse models 6:23 A high altitude view: Cutting through hype to spot the next wave of game-changing technology 8:03 The role of policy and communication: how Wendy’s work goes beyond the lab to create real-world impact 11:20 Wendy’s choice to do an MD…

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We Do A Little Duo Pod #2 - What We're Doing in 2024 and our Favorite Narratives 1:20:57

7M ago1:20:57

1:20:57

In this episode, Andy and Deeze discuss their favorite narratives for 2024, how it has been building IKB, things we paid less than $250 for that made our lives better, some of our favorite content, and more. Show Notes 00:00 Introduction and Holiday Recap 03:10 Exploring Bitcoin 06:10 Solana and Other Ecosystems 09:55 Staking TIA and Airdrops 11:29…

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EP 116: Genetics and Medicine: Clonal hematopoiesis, genomics in healthcare, and a new discovery in APOL1 kidney disease with Dr. Alex Bick 52:34

6M ago52:34

52:34

0:00 Introduction 4:23 Insights into clonal hematopoiesis from the pioneering Framingham Heart Study 8:30 Linking clonal hematopoiesis to cancer and cardiovascular health 11:22 Interplay of germline and somatic variants in clonal expansion 17:20 How the rate of clonal expansion can provide insights into cancer and cardiovascular risk 19:00 How clon…

1
EP 115: The Biggest Stories of 2023 with Dr. Veera Rajagopal (Part 2) 1:35:11

7M ago1:35:11

1:35:11

In the second instalment of our annual round-up episode, we welcome back Dr. Veera Rajagopal to cover the biggest stories in genetics and precision medicine of the last 12 months. Don’t forget to give the first instalment of our 2023 round-up a listen. Veera is a scientist at Regeneron with an interest in human genetics and drug target discovery in…

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EP 114: The Biggest Stories of 2023 with Dr. Veera Rajagopal (Part 1) 1:10:35

7M ago1:10:35

1:10:35

0:00 Introduction 1:30 Veera’s personal highlights of 2023 Publication in Nature Genetics: Rare coding variants in CHRNB2 reduce the likelihood of smoking, an exome-wide association study identifying rare coding variants in CHRNB2 that may reduce the likelihood of smoking. Designing cover art Genetic links to neural circuits and their role in addic…

1
EP 113: Harnessing human genetics to discover co-evolved small molecule medicines with Dr. Jason Park, CEO of Empress Therapeutics 44:31

8M ago44:31

44:31

In this episode of The Genetics Podcast, we welcome Dr. Jason, founder and CEO of Empress Therapeutics, a Flagship Pioneering company. Join us as we discuss how human genetics can identify small molecules with therapeutic potential that are already created by our bodies, paving the way for faster discovery of new medicines. Summary: 0:00 Intro 1:20…

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EP 112: Making the leap: the scientists collaborating to transform genetic targets into next generation treatments, with David Ochoa 41:36

8M ago41:36

41:36

This week on The Genetics Podcast Patrick is joined by David Ochoa, Platform Coordinator at Open Targets. They discuss how the Open Targets platform is enabling game-changing collaboration between academic research and big pharma. Working with partners including Sanofi, GlaxoSmithKline, Bristol Myers Squibb, Genentech and Pfizer, Open Targets power…

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EP 111: Combining human and machine intelligence in protein engineering with Dr. James Field, CEO of LabGenius 35:34

8M ago35:34

35:34

In this episode of The Genetics Podcast, we welcome Dr. James Field, founder and CEO of LabGenius. Join us as we delve into LabGenius' cutting-edge approach that utilises machine learning, artificial intelligence, and sophisticated robotics to advance antibody discovery and drug development. As a bonus, learn about James’ path from scientist to CEO…

1
Ovie Faruq (OSF) - Modern Day Renaissance man aka how to succeed as a professional trader, collector, artist, and show host. 1:46:41

9M ago1:46:41

1:46:41

In our 11th and final episode of Season 3, we are joined by modern day renaissance man Ovie Faruq aka OSF. OSF is a well known professional trader, art collector, artist, golfer, fighter, and talk show host. There is nothing this man cannot do. We dive into OSF’s background growing up in England, how he met Mando, how he got into crypto and NFTs, h…

1
EP 110: Educating the next generation of genomics talent, and the intersection of genetics and environment in cancer with Barbara Kraatz Fortini 35:41

9M ago35:41

35:41

On this episode of The Genetics Podcast we welcome Dr. Barbara Kraatz Fortini, Associate Professor of Genetics at Keck Graduate Institute (KGI). Tune in to learn about Barbara's research on non-coding variants in colorectal cancer and the interplay between genetics and the environment on lifetime cancer risk. As the Program Director for the MS in H…

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DieWithTheMostLikes - Prolific creating habits, slinging digital waste, fascinations with ground beef and Midwest culture. 2:12:17

9M ago2:12:17

2:12:17

In our Tenth episode of Season 3, we are joined by hilarious and grotesque Mark Wilson aka DieWithTheMostLikes. Mark is an artist and writer (among other things) based out of Indiana known for his absurdly sad, introspective, and remorseful caricatures of modern society. One thing is for sure, Mark is able to find humor in the darkest recesses of h…

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