Broadcasting the latest developments in GU cancer Hosted by Brian Rini and Tom Powles Brian Rini MD is Chief of Clinical Trials, Professor of Cancer Research and Professor of Medicine (Hematology/Oncology), Vanderbilt-Ingram Cancer Centre Tom Powles is Director of Barts Cancer Centre, St Bartholomews Hospital and Professor or Genitourinary oncology, Queen Mary University of London
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This is Sam and Karine, and we are Two Onc Docs! We both graduated from our Heme/Onc fellowships in 2021 and became board certified in both Hematology and Oncology. Our mission with Two Onc Docs is to create short board review episodes that you can listen to on your drive to work, while you make your morning coffee, or between pages on call. This is intended to be a supplement to other established board studying resources for busy trainees. *This podcast is intended to be an educational reso ...
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Localized Kidney Cancer x Uromigos 2024 UPDATES (Part 1)
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Today’s episode we will cover 2024 updates for localized renal cell carcinoma (RCC). We will discuss risk factors, the presentation, staging, and treatment options. We are so excited to have Dr. Tom Powles and Dr. Brian Rini from the urologic oncology podcast Uromigos sharing their expertise on today's episode as well!…
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Episode 316: APCCC 2024 Summary with Silke Gillessen
41:11
41:11
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Silke covers key aspects of the meeting, including surgery vs RT, genetic and somatic testing, PSMA imaging and 1st line triplet therapy.
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Episode 315: APCCC 2024 Quickfire - Bone health, hot flashes and gynecomastia in prostate cancer
18:17
18:17
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Chris Sweeney is joined by Matt Smith, Anthony Joshua and Lisa Horvath to discuss the management of these complex issues in advanced prostate cancer.
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Episode 314: APCCC 2024 Cardiovascular risks with hormone therapy in prostate cancer
25:15
25:15
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Thomas Suter and Chuck Ryan discuss identification and management of cardiovascular disease for patients starting therapy for prostate cancer.
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Episode 313: APCCC 2024 Debate - Radiation therapy in advanced disease
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35:40
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Thomas Zilli and Pierre Blanchard discuss this topic from Lugano.
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Episode 312: APCCC 2024 Radiation therapy after surgery for prostate cancer
23:56
23:56
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Jason Efstathiou and Piet Ost discuss the data for and against this approach.
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Episode 311: The Uromigos Paper of the Month - The POUT Trial
36:02
36:02
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Alison Birtle describes adjuvant chemotherapy in bladder cancer.
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Testicular Cancer 2024 x Dr. Larry Einhorn Part 2 (Non-Seminoma)
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24:44
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This week’s episode will be focusing on Testicular Cancer, including the treatment of Non-Seminomas. We are so honored to have Dr. Larry Einhorn here with us today and he provides key pearls, in addition to words of wisdom for trainees in oncology.
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Episode 310: Dosing and duration of drugs from a cost perspective
28:28
28:28
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Daniel Goldstein describes his work on this issue.
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Testicular Cancer 2024 x Dr. Larry Einhorn Part 1 (Seminoma)
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This week’s episode will be focusing on the risk factors, work-up, and staging of Testicular Cancer, as well as cover the treatment of Seminomas. We are so honored to have Dr. Larry Einhorn here with us today who is a legend when it comes to the treatment of germ cell tumors, and among many other accolades is Distinguished Professor of Medicine at …
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This week’s episode will be focusing on hematopoietic growth factors, including G-CSF, TPO agonists, and ESAs. This is another episode in our series on supportive care, and a highly testable and frequently discussed topics on consults and in clinic.
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Episode 309: EAU24 Checkmate 274 - OS for adjuvant nivolumab in bladder cancer
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27:13
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In this second part, Matt Galsky describes the OS signal data. We also look into the future.
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Episode 308: EAU24 IMVIGOR 011 - Outcome of ctDNA negative patients post-cystectomy
23:09
23:09
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Tom, Brian and Matt Galsky review the screening component of this study, presented at EAU24.
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Episode 307: Bladder-Sparing Approaches Part 2
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Michiel Van der Heijden explores the role of radiotherapy and other neoadjuvant and other neoadjuvant combinations to prevent the need for surgery.
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Today marks our 2 year mark of Two Onc Docs! It’s been a while since we’ve done a re-intro so we figured we would re-introduce ourselves and explain why we picked heme/onc as a speciality, and briefly cover our study plans.
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Episode 306: The Uromigos Paper of the Month - Chemo/Nivo as a bladder sparing approach in UC
29:56
29:56
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Matt Galsky describes his phase 2 study looking at gem/cis/nivo followed by nivo in responders. This potentially avoids cystectomy.
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This week’s episode will be focusing on Cancer Related Fatigue (CRF). We will go over important details on the definition, diagnosis, and management options of this condition which affects >2/3 of patients with cancer.
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Episode 305: FDA and Oncology Clinical Trials
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29:35
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FDA Deputy Oncology Director Dan Suzman described approaches to oncology trials. Tom asks 3 last questions which annoys Brian more than usual.
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Episode 304: A PSMA CD3 Bispecific T-cell Engager in CRPC
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30:43
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Tanya Dorff describes acapatamab, a prostate-specific membrane antigen (PSMA) CD3 bispecific engager.
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This week’s episode will be focusing on Primary CNS Lymphoma. We will go over important details on the epidemiology, diagnosis, staging and treatment options.
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Michael Lattanzi discusses treatment plans and research in the community.
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This week’s episode will be focusing on cutaneous malignancies other than melanoma including squamous cell skin cancer and basal cell carcinoma. We will go over the important details on staging, diagnosis, & treatment options.
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This week’s episode will be focusing on Malignant Mesothelioma. We will go over the important details on diagnosis, work-up, the different subtypes, and staging as well as treatment options for operable and inoperable disease.
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Episode 302: Part 2- Adjuvant Therapy in solid tumors
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Hans Hammers discusses trial design and patient selection in the adjuvant setting.
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Episode 301: Cancer research from a global perspective.
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31:06
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Vania Wisdom, editor of the Lancet, talks about approaches to cancer treatment and research in developing countries
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We are starting a supportive care series, because these topics comes up very often in oncology. This week's episode will be focusing on Bone Modifying Agents, such as bisphosphonates and Denosumab - when they are indicated, mechanism of action, and key pearls/toxicities.
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This week’s episode will be focusing on acquired causes of underproduction anemias. We will go over the important details on iron deficiency, vitamin B12 and folate deficiencies as well as anemia of chronic disease, anemia of pregnancy, and a few other rarer causes of underproduction anemias. This topic will come up time and time again during consu…
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Episode 300: Adjuvant PD1 Therapy in Solid Tumours
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42:15
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David McDermott discusses melanoma and renal data. We never get to bladder or lung.
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Episode 299: Androgen receptor ligand-directed degrader BMS-986365
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36:40
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Dana Rathkopf describes phase 1 data for the androgen receptor ligand-directed degrader in prostate cancer
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This week’s episode will be focusing on occult cancers, or cancers of unknown primary (or CUP). We will go over the important details on the work-up, diagnostic markers, molecular testing, as well as treatment options.
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Silke, Tom and Brian cover the bases.
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Episode 297: ASCO GU 2024: CONTACT2 Part 2 - The Aftermath
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22:46
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Neeraj Agarwal addresses the issues raised at the meeting.
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This week’s episode will be focusing on Mantle Cell Lymphoma. We will go over the important details on the presentation, diagnosis and treatment.
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Episode 296: ASCO GU 2024: Novel approaches to QOL and belzutifan
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Cris Bergerot describes her modifications of existing QOL models while Tom describes the QOL data from LS005
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Episode 295: ASCO GU 2024: Adjuvant Therapy in Renal Cancer
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32:46
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Pedro Barata summarises his ASCO GU discussion on this topic.
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Episode 294: ASCO GU 2024: Adjuvant Pembrolizumab in Bladder Cancer
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33:17
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Andrea Apolo describes the results of this positive trial.
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Episode 293: ASCO GU 2024: BRCAaway and CONTACT2
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22:21
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Kim Chi discussed the prostate cancer oral session at ASCO GU 2024.
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Episode 292: ASCO GU 2024: HPN328 - A Tri-Specific T Cell Engager in Prostate Cancer
26:04
26:04
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Misha Beltran describes the activity of this novel agent in neuroendocrine prostate cancer.
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Episode 291: ASCO GU 2024: CONTACT2 - Cabozantinib and Atezolizumab in Prostate Cancer
31:15
31:15
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Neeraj Agarwal describes the results of this positive randomised Phase 3 trial.
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This week’s episode will be focusing on a rare tumor: Adrenocortical Carcinoma. We will go over the important details on the presentation, diagnosis and treatment.
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What to look out for in bladder, prostate and renal cancer at this year's meeting.
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Episode 289: The Uromigos Paper of the Month - TALAPRO2 in Nature Medicine
36:02
36:02
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Karim Fizazi discusses the clinical and biomarker components of this data.
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Episode 288: APCCC #3: Controversies around Radiotherapy
36:29
36:29
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Thomas Zilli discusses controversies around radiotherapy in prostate cancer.
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Happy 2024 and welcome to our THIRD season of Two Onc Docs! This week’s episode will be focusing on Hairy Cell Leukemia, we will cover important details on the symptoms, diagnosis and treatment of hairy cell leukemia.
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Episode 287 APCCC: Early Discontinuation of Therapy in HSPC
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34:48
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Silke Gillessen and Betrand Tombal discuss the questions which will address this issue in Lugano in March 2024.
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Episode 286: APCCC Prostate Cancer Meeting Overview
30:22
30:22
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Silke Gillessen discusses this biannual meeting taking place in Lugano in March 2024.
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Episode 285: Holiday Special: Renal Cancer in 2023
26:02
26:02
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Cristina Suarez discusses the year in review.
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Episode 284: Tres amigas: Lo más destacado del cáncer en urología en 2023
37:56
37:56
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Elena Castro, Begoña Valerrama y Cristina Suárez analizan lo más destacado del cáncer en urología en 2023
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Episode 283: Holiday Special: Prostate Cancer in 2023
34:34
34:34
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Tanya Dorff discusses her favourite prostate cancer studies of the year.
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Uromigos x Metastatic Bladder Cancer 2023 UPDATES
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24:07
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Today’s episode we will cover 2023 updates for metastatic bladder cancer. We will discuss staging, treatment options (with EV-302 groundbreaking updates), and variant histologies. We are so excited to have Dr. Tom Powles and Dr. Brian Rini from the urologic oncology podcast Uromigos sharing their expertise on today's episode as well!…
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