Jimmy and Rob love milkshakes and mockumentaries! Jimmy Tatro joins Rob Lowe to discuss his new “Real Bros of Simi Valley” movie, the genius of “American Vandal,” Jimmy’s morbid thought during a flight with Don Cheadle and Dave Grohl, getting hit in the crotch by Logan Roy in “Super Troopers 2,” the unique constraints of network television, and muc…

Cercle is building a unique moat with their AI/ML knowledge graph that can both improve clinic/lab EBITDA and match patients to clinical trials at scale like no one else in women’s healthcare. The healthcare Graph, built on anonymized data from 2M+ patients, identifies patterns and profiles at scale for labs, clinics and contract research organizat…

“Yoga with Adriene” host Adriene Mishler and Rob want you to slow down! Adriene joins Rob Lowe to discuss her wildly popular “Yoga with Adriene” YouTube channel, her beloved dog Benji, the benefits of a regular yoga practice, why you should find the time and space to do nothing, how a naked rock star first introduced Rob to yoga, Rob’s pitch for a …

Exploring internal corporate dynamics and investment strategies towards startups. We will dissect the fundamentals that contribute to an impressive investment track record. The underlying principles are straightforward yet impactful. Additionally, we will provide founders with advice on capturing investor attention and strategies for defining a gen…

“Crime Junkie" host Ashley Flowers and Rob are talking true crime! Ashley joins Rob Lowe to talk about their shared love for Indiana, the cases they are obsessed with, Ashley’s dream of making a cameo on “Law & Order: SVU,” naming her company after her beloved dog, why they both adore Caitlin Clark, her new show "Crime Junkie AF" on her SiriusXM ch…

Ted and Woody are back together to bring you a brand new podcast from Team Coco! It’s called “Where Everybody Knows Your Name with Ted Danson and Woody Harrelson (Sometimes)" and it’s out right now! They’re talking to guests like Conan O’Brien, Will Arnett, Jane Fonda, Billy Eichner, Kristen Bell, and yours truly! I got to join Ted for an episode a…

At long last, Rob’s son Matthew Lowe is on the show! VC investor, attorney, and fisherman Matthew Lowe joins Rob to discuss golfing with his mom Sheryl Lowe in Hawaii, appearing in “The West Wing” as a kid, watching Dad’s movies as a family, encouraging his father to join “Parks & Rec,” sitting next to Rob in the iconic NFL hat photo, studying for …

Exploring the dynamic intersection of AI and the music industry. We’ll start by examining the public’s initial reactions to early AI innovators like LANDR and discuss whether the concerns from a decade ago have materialized. Delve into the various domains where AI is currently being harnessed, highlighting some of the most notable companies and pro…

Wildlife biologist and outdoor adventurer Forrest Galante joins Rob Lowe to discuss re-discovering animals thought to be extinct, his recent “Shark Week” shoots, the real-life story that inspired “Jaws”, Rob’s recent experience getting stung by a stingray, and much more. Plus, Rob shares his thoughts on the Roast of Tom Brady and his suggestions fo…

Adam and Rob remember the days of woodshop class! Comedian and podcaster Adam Carolla joins Rob Lowe to discuss the odd jobs he did before entering show business, his unconventional first encounter with longtime friend Jimmy Kimmel, betting big on podcasting back in 2009, listening to “Loveline” as a teenager, the value of woodshop class, and his n…

Dive into the seventh edition of the AI Index report, the most detailed analysis yet, at a critical time when AI’s impact on society is at its peak. This year’s report expands to cover key trends including technological advancements, public perceptions, and the geopolitical dynamics of AI. With more original data than ever, the report introduces ne…

When Rob has questions about the future of technology and artificial intelligence, he goes to Marc Andreessen! Legendary investor and entrepreneur Marc Andreessen joins Rob Lowe to discuss the future of TikTok in the U.S., three major ways that artificial intelligence will improve the lives of everyday people, how a simple photo landed Kenny G in a…

Things get very silly when Thomas and Rob are together. Actor, writer, and comedian Thomas Lennon joins Rob Lowe to discuss the new Netflix film “Unfrosted,” receiving notes from Jerry Seinfeld, Thomas and Rob's ridiculous on-set jokes from the filming of “Monster Trucks,” getting fired gracefully, how studio lot parking spaces reveal your true sta…

Jeff and Rob both love performing drama AND comedy! Jeff Daniels joins Rob Lowe to discuss how working with Jim Carrey on “Dumb and Dumber” taught him fearlessness, committing to his thick accent in Netflix’s “A Man in Full,” his memories of the brilliant James Gandolfini, their experiences performing Aaron Sorkin dialogue, watching Shirley MacLain…

Examining core deficiencies in our digital economy: The absence of explicit ownership rights and transparent trading mechanisms for data as a currency results in significantly inefficient value allocation economically. Olaf offers insights and foresights on AI and emerging technologies to ensure effective transformations. Learn more about his two b…

Rob is entering his 60s and committing to a better diet…with the help of the esteemed Dr. Mark Hyman! Dr. Mark Hyman (renowned physician, medical advisor to the Clintons, and the host of “The Doctor's Farmacy” podcast) joins Rob Lowe to discuss the Ozempic revolution, the real key to longevity, the obesity statistic that shocked Rob, what foods to …

In the first episode of "AI Unplugged without Borders," part of the Transatlantic AI eXchange, host Thomas Neubert talks with AI enthusiast Fabian Westerheide in Berlin, Germany. As the founder and CEO of AI for Humans GmbH and a key figure in Europe's AI community, Fabian shares his vision of making Europe a strong and independent force in the glo…

Comedian, actor, and podcaster Paul Scheer joins Rob Lowe to discuss celebrity-owned restaurants, the “M*A*S*H” theme song, why the team behind “The League” decided to end the show while they were still on top, Rob’s traumatic childhood talent show memory, the greatest audition story ever, and Paul’s new memoir, “Joyful Recollections of Trauma.” Pr…

Kelly Ripa joins Rob Lowe to discuss getting “knighted” by Disney, the joys of working with her husband, why Rob was one of Kelly’s favorite guest co-hosts, trying out the Oculus headset, Rob’s 60th birthday party, her podcast “Let's Talk Off Camera with Kelly Ripa,” and her big goal to get out of hair and makeup! Got a question for Rob? Call our v…

Katey and Rob looooove talking to other sober people! Actress and musician Katey Sagal joins Rob Lowe to discuss her new podcast with husband Kurt Sutter, the joys of sobriety, the passing of her godfather Norman Lear, being a Keith Richards girl, working with the amazing John Ritter, why “Sons of Anarchy” convinced Rob to go buy a biker jacket, be…

Tig and Rob are silent laughers. Comedian Tig Notaro joins Rob Lowe to discuss their shared obsession with the song “Do They Know It’s Christmas?” by Band Aid, her foolproof method for testing potential TV show titles, her love for drama and despair, her podcast “Handsome,” and her new comedy special, “Hello Again.” Plus, Rob reveals a bit of White…

Rob is a huge admirer of the incredible activist and R&B musician Daryl Davis. He is the first Black author to write a book on the Ku Klux Klan (KKK) based on in-person interviews, and he has convinced dozens of Klansmen to leave and denounce the hate group. Today, Daryl joins Rob to discuss his incredible activism work, the power of conversation, …

Rob Lowe and Ted Sarandos love to quote their favorite movies together! Co-CEO of Netflix (and film fanatic) Ted Sarandos joins Rob Lowe to discuss his early days as a video store manager in Arizona, the little-seen Netflix comedy series that he is obsessed with, how the Netflix algorithm and his own fandom led to the company’s deal with Adam Sandl…

This episode of “Literally” is unlike any other. Rob Lowe is joined by Nando Parrado, one of the 16 survivors of the Uruguayan Air Force Flight 571, which crashed in the Andes mountains in 1972. After spending 72 days trapped in the mountains, Nando, along with his friend and teammate, climbed through the Andes mountains for 10 days to find help. N…

Hilary and Rob go waaaaaaaay back! Hilary Swank joins Rob Lowe to discuss her baby twins, being called “too half-hour” by a CBS executive, the photoshoot she did for Rob and Sheryl in the 90’s, the incredible animal rescue work Hilary did in the wake of 9/11, skiing with Clint Eastwood, memories from the Oscars, and why she feels her father would b…

Jon and Rob have been in the same circles for decades, but now they are finally getting some quality time together! Jon Cryer joins Rob Lowe to discuss the Brat Pack days, auditioning for "St. Elmo's Fire," the surprising connection between Jon’s mom and Rob’s mom, working with Charlie Sheen on "Two and a Half Men," and Jon’s new sitcom, "Extended …

Rob and Rev Run are kindred spirits! The legendary rapper, DJ, and minister Rev Run joins Rob Lowe to discuss the incredible legacy of his group Run-DMC, growing up in the sixties and seventies, focusing on family, finding inspiration in the tub, and the new Peacock docuseries, "Kings From Queens: The Run DMC Story.” Got a question for Rob? Call ou…

Cheryl and Rob have so much to catch up on! Cheryl Hines joins Rob Lowe to discuss the final season of “Curb Your Enthusiasm,” Larry David’s run-in with Elmo, how she would dress as First Lady, choosing your Secret Service code-name, Cheryl’s mom’s birthday at Thunder Down Under, and much more. Got a question for Rob? Call our voicemail at (323) 57…