Taking cues from the European Renaissance, which emerged from the Dark Ages amidst plagues, trade, and wars, we fancy a new renaissance in the context of the 21st century, as we confront a potent mix of humanity-level existential challenges. What might enable a desperately-needed renewal, and catalyze a profound transformation? What lessons can we learn from history? How can we shape the future for better trajectories? How will the changing world order hasten or hinder such trajectories? What inspirations can be drawn for personal renewal, whether or not a large-scale societal renaissance materializes?