Precision Medicine Made Simple podcast

2:17

Podcast Suggestion Survey

Precision Medicine Made Simple

1
When Genes Collide: A Rare Diagnosis Reveals Complex Health Interactions with Dr. Philip Bretsky 1:24:43

13 weeks ago1:24:43

1:24:43

When Genes Collide: A Rare Diagnosis Reveals Complex Health Interactions with Dr. Philip Bretsky For this episode, Dr. Bretsky shares a remarkable case study that unravels the complex relationship between genes and inflammation. When a patient's mysterious symptoms led to the rare diagnosis of VEXAS syndrome, it revealed an unexpected connection with cardiovascular health, demonstrating how different genetic factors can interact to amplify health risks. Timestamps: 3:50 - Introduction to Lp(a) and its role in cardiovascular health 10:09 - Patient's initial presentation with testicular swelling 17:55 - Discussion of environmental factors and genetic mutations 23:28 - Understanding inflammation's role in cardiovascular risk 35:32 - Treatment decisions and stent placement 41:51 - Prevention strategies for inflammatory conditions 1:24:19 - Episode wrap-up and closing Dr. Philip Bretsky's Contact Information: Philip M. Bretsky MD PhD MPH FACP 1301 20th Street, Suite 230 Santa Monica, CA 90404 TEL: 310.828.4411 FAX: 310.828.2411 Facebook:@santamonicaprimarycare Twitter / X: @santa_care Instagram: @santa_monica_primary_care Web: www.drbretsky.com & www.santamonicaprimarycare.com My monthly newsletter: https://lp.constantcontactpages.com/su/JtF9zzR Dr. William Stanford MD PHD FACP Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians. A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine, enhancing his role as a leading expert in the field. Sponsored by: Biography Health Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today. Other Resources Mentioned: https://www.cnn.com/2023/01/24/health/vexas-syndrome-prevalence-study-wellness/index.html https://www.amazon.com/Implementation-Personalized-Precision-Medicine-Prevention/dp/0323988083…

Precision Medicine Made Simple

1
Beauty Span and Health Span: Where Aesthetics Meets Longevity with Dr. Cory Goldberg 1:32:46

15 weeks ago1:32:46

1:32:46

Beauty Span and Health Span: Where Aesthetics Meets Longevity with Dr. Cory Goldberg For this episode, we dive deep into the intersection of aesthetics and longevity with Dr. Cory Goldberg, a renowned plastic and craniofacial surgeon. Dr. Goldberg bridges the art of aesthetic medicine with the science of precision medicine, sharing groundbreaking insights on how oxidative stress affects both beauty and overall health, and discussing innovative approaches to extending both beauty span and health span. Timestamps: 03:27:24 - Dr. Goldberg shares his background and journey from physiology to plastic surgery to precision medicine 23:31:24 - Deep discussion on senescent cells (zombie cells) and their impact on aging and health 35:13:13 - Exploration of the gut-skin-brain axis and microbiome connections 43:51:24 - Detailed explanation of reactive oxygen species (ROS) and their role in aging 57:46:07 - Discussion of GliSODin supplement and superoxide dismutase 1:18:52:13 - Dr. Goldberg's insights on diet, plant-based eating, and oxidative stress 1:27:27:15 - Overview of Dr. Goldberg's practice evolution and his vision for integrating longevity medicine with aesthetic medicine Dr. Cory Goldberg https://www.linkedin.com/in/corygoldbergmd/ https://www.corygoldbergmd.com/ https://www.instagram.com/drcorygoldbergmd/ Dr. Cory S. Goldberg BSc, MD, MASc, FRCS(C), FACS, MBA is a Plastic Surgeon with a fellowship in the Royal College of Physicians and Surgeons of Canada. He is a diplomat of the American Board of Plastic Surgeons and is also a Fellow of the American College of Surgeons. He earned his MD degree from Queen’s University, Canada and completed his Plastic Surgery residency training at the University of Toronto, including a Master’s of Applied Science in Biomedical Engineering. He subsequently did sub-specialty fellowship training in Craniofacial Plastic Surgery at University of Southern California in Los Angeles, California. Dr. William Stanford MD PHD FACP drstanford@bhipm.com Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians. A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Sponsored by: Biography Health Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.…

Precision Medicine Made Simple

1
From Flight Medic to Precision Medicine with Dr. Kat Schmolly 1:02:47

17 weeks ago1:02:47

1:02:47

From Flight Medic to Precision Medicine with Dr. Kat Schmolly In this episode, we're joined by Dr. Kat Schmolly. From her adventurous past as an Air Force Flight Medic to her current mission revolutionizing rare disease diagnosis, Dr. Schmolly shares her unique journey into precision medicine. We discuss why bringing personalized care to the frontlines of medicine is crucial, and explore how innovative technologies can transform the future of healthcare. Timestamps: 2:58 - How Dr. Schmolly and Dr. Stanford connected over precision medicine 7:35 - Early observations of environmental impacts on military health 13:22 - The near-disaster flight mission that changed her path 26:43 - Why precision medicine stays in research vs clinical practice 43:58 - Starting ZebraMD to transform rare disease diagnosis 47:19 - Vision for bringing precision medicine to primary care Dr. Kat Schmolly linkedin.com/in/kat-schmolly kschmolly@gmail.com Dr. Kat Schmolly is a physician at Dartmouth Health, combining her clinical expertise with a passion for advancing personalized medicine. As the founder of ZebraMD, she focuses on innovative solutions for rare disease diagnostics through algorithm development and AI-powered clinical tools. A graduate of the David Geffen School of Medicine at UCLA, her work has included groundbreaking research in genetic and rare diseases. Before pursuing medicine, Dr. Schmolly served as a flight medic in the United States Air Force, where she honed her skills in aerospace and critical care medicine. With experience ranging from cardiac R&D at Medtronic to porphyria research and precision medicine development, Dr. Schmolly continues to lead efforts that bridge cutting-edge technology with patient-centered care. Dr. William Stanford MD PHD FACP drstanford@bhipm.com Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians. A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Sponsored by: Biography Health Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.…

Precision Medicine Made Simple

1
A Doctor's Mission: How Dr. Scoles Used Genetics to Transform Patient Care with Dr. Lyndell Scoles 55:22

19 weeks ago55:22

55:22

A Doctor's Mission: How Dr. Scoles Used Genetics to Transform Patient Care with Dr. Lyndell Scoles In this episode, we explore pharmacogenomics, also known as genetic pharmaceutical profiling with Dr. Lyndell Scoles with MDVIP. He’s an early pioneer in using genetic testing to optimize medication choices. With over 30 years of experience in internal medicine, Dr. Scoles shares how genetic pharmaceutical profiling helps determine which medications will work best for each patient based on their unique genetic makeup. He presents compelling examples of how this approach has prevented hospitalizations and improved patient outcomes, including cases of heart failure prevention and depression treatment. We also discuss why this hasn't been widely adopted yet in medical practice, despite its potential to save billions in healthcare costs. Note: As our first in-person recording, you may notice some echo and compressed audio quality in portions of the conversation - we appreciate your understanding as we continue to improve our in-person recording setup. Timestamps: 00:02:49 - Dr. Scoles begins explaining his journey into pharmacogenomics and why he started implementing it in his practice 00:08:28 - Description of how genetic testing is done through cheek swabs and the three-category report system 00:25:30 - Powerful patient case study about adjusting antidepressant dosing based on genetic testing 00:29:54 - Discussion of Metoprolol case studies and the 8% of patients who can't metabolize it properly 00:45:34 - Moving patient story about treating a 13-year ulcer patient successfully using genetic insights 00:50:35 - Resources for physicians to learn more about pharmacogenomics 00:52:43 - Contact information and closing thoughts Dr. Lyndell Scoles 5734246494 https://www.mdvip.com/doctors/lyndellscolesmd drscoles@socket.net Dr. Lyndell Scoles is a dedicated MDVIP-affiliated physician with over three decades of experience in internal medicine, renowned for his compassionate, patient-centered approach to healthcare. A strong advocate for personalized medicine, Dr. Scoles has integrated pharmacogenomics—also known as genetic pharmaceutical profiling—into his practice, completing this innovative testing for over 600 patients. This approach empowers him to tailor treatments to the unique genetic makeup of each individual, enhancing outcomes and minimizing adverse effects. Dr. Scoles graduated Magna Cum Laude as valedictorian from the University of Missouri School of Medicine, where he earned his Doctorate of Medicine in 1990. He completed his residency in Internal Medicine at the same institution and holds certifications from the American Board of Internal Medicine and the International Society of Clinical Densitometry. Throughout his career, Dr. Scoles has held numerous leadership positions, including Chief of Internal Medicine at Boone Hospital Center, and served as Medical Director for several care facilities, including nursing homes and Alzheimer's care units. His expertise and dedication to excellence have earned him numerous accolades, such as being named a Castle Connolly Top Doctor (2022–2024) and appearing in Inside Columbia’s Medical Guide as one of Columbia’s Favorite Doctors (2016) . Dr. Scoles is a member of esteemed professional societies, including the American Medical Association and the American Society of Internal Medicine. His practice is guided by the principle of treating the whole person—balancing physical, mental, and spiritual wellness—and building meaningful partnerships with his patients to achieve optimal health. Dr. William Stanford MD PHD FACP Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians. A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Sponsored by: Biography Health Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.…

Precision Medicine Made Simple

1
Beyond One-Size-Fits-All: The Science of Drug-Gene Interactions with Michelle Beckwith 1:14:11

21 weeks ago1:14:11

1:14:11

Ep. 15 - Beyond One-Size-Fits-All: The Science of Drug-Gene Interactions with Michelle Beckwith This episode features Michelle "Shelly" Beckwith, a genetics pioneer since the 1990s who worked on the Human Genome Project. She breaks down how pharmacogenetic testing helps optimize medication choices by analyzing how patients' genetic variations affect drug metabolism. The discussion covers testing methods, insurance challenges, and the real-world implementation of pharmacogenetics in clinical practice. Through her work with MedTrait, Shelly explains how understanding a patient's genetic profile can lead to more precise medication dosing and better outcomes. https://www.medtrait.net/ Timestamps: 00:02:34 - 00:04:18: Michelle Beckwith's Professional Background 00:04:19 - 00:08:34: Different Types of Genetic Testing 00:08:34 - 00:12:34: Technical Details of Testing Methods 00:12:34 - 00:27:24: Drug Metabolism & Clinical Applications 00:27:24 - 00:35:42: Population Genetics & Healthcare Access 00:35:42 - 00:45:52: Regulatory Environment & Future Challenges 00:45:52 - 01:12:32: Implementation & Practical Applications 01:12:32 - 01:14:10: Closing Remarks — Michelle Beckwith shelly@ptclabs.com Michelle Beckwith has been at the forefront of genetics since the 90s, contributing to projects like the Human Genome Project and co-founding a laboratory specializing in DNA Human Identity testing. Her work in clinical pharmacogenetics has evolved into the foundation of MedTrait, one of our key partners at Biography Health, providing genetic insights for personalized medicine. Dr. William Stanford MD PHD FACP drstanford@bhipm.com Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians. A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine Sponsored by: Biography Health Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.…

Precision Medicine Made Simple

1
Genotyping vs. Sequencing: What's the Difference? with Yelena Bykhovskaya, PhD 27:05

23 weeks ago27:05

27:05

Genotyping vs. Sequencing: What's the Difference? In this episode, Dr. William Stanford, Dr. Yelena Bykhovskaya and Taylor Cu discuss various genetic testing methods. The conversation compares genotyping, exome sequencing, and whole genome sequencing, with an emphasis on whole genome sequencing, which provides the most comprehensive genetic information. Timestamps: 00:03:22 - Discussion begins on what popular genetic testing companies use (genotyping) 00:05:09 - Explanation of how genotyping chips (microarrays) work 00:17:24 - Clarification on the difference between genotyping and sequencing 00:20:31 - Introduction of the book analogy to explain different genetic testing methods 00:23:32 - Discussion on the pros and cons of whole genome sequencing vs. exome sequencing 00:25:48 - Conclusion on why whole genome sequencing is becoming the preferred method -- Dr. William Stanford MD PHD FACP drstanford@bhipm.com Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians. A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine Dr. Yelena Bykhovskaya yelena@biographyhealth.com Dr. Yelena Bykhovskaya is an accomplished scientist specializing in genetics and precision medicine. As the former Principal Scientist at Avellino Labs, she developed genetic tests for Mendelian and complex eye diseases using national and international collaborations. As the former Research Scientist at Cedars-Sinai, she made major advances in complex genetic eye diseases with groundbreaking genome-wide genetic analyses. Her earlier work in mitochondrial genetics led to major discoveries in maternally inherited deafness and other rare mitochondrial disorders. Holding a PhD in Biochemistry, Yelena has a publication record of widely cited forty-five articles in high-impact journals and delivered numerous oral and poster presentations at the national and international conferences, solidifying her leadership in genetic research. Sponsored by: Biography Health Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.…

Precision Medicine Made Simple

1
Bridging the Gap: Scientists and Physicians in Precision Medicine with Yelena Bykhovskaya, PhD 1:15:41

25 weeks ago1:15:41

1:15:41

In this episode, Dr. Yelena Bykhovskaya, Chief Scientific Officer at Biography Health, shares her expertise in genetics. We explore the importance of both polygenic and monogenic risk scores in patient care. The conversation underscores the value of combining cutting-edge genetic analysis with traditional clinical factors in the evolving field of precision medicine, emphasizing the need for a comprehensive approach to patient care. Resources Mentioned: https://www.genomeweb.com/ https://www.insideprecisionmedicine.com/ Timestamps: 00:03:34 - LinkedIn sparks Bykhovskaya-Stanford collaboration 00:06:27 - Stanford highlights Bykhovskaya's genetic risk expertise 00:13:13 - Genetic risk vs. family history explained 00:18:18 - Human Genome Project revolutionizes genetic analysis 00:24:54 - Whole genome sequencing: Key to comprehensive risk assessment 00:28:49 - High polygenic scores rival monogenic variants in risk 00:33:33 - Early intervention: Combating genetic predispositions 00:38:09 - Integrated risk scores: Combining genetics and clinical factors 00:44:00 - Basic genetic knowledge empowers doctors 00:52:59 - Addressing European bias in genetic studies Dr. William Stanford MD PHD FACP Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians. A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Sponsored by: Biography Health Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.…

Precision Medicine Made Simple

1
How Doctors are Using Genetic Data to Transform Patient Care with Philip Bretsky MD PhD MPH FACP 58:33

27 weeks ago58:33

58:33

How Doctors are Using Genetic Data to Transform Patient Care with Philip Bretsky MD PhD MPH FACP In this episode, we're joined by Dr. Philip Bretsky, a board-certified internist from Santa Monica with expertise in epidemiology and Alzheimer's research. Dr. Bretsky discusses how precision medicine is transforming healthcare by integrating genetics, biomarkers, and lifestyle factors. He explores the challenges and opportunities in implementing this approach, the evolving role of general practitioners, and how patients can advocate for personalized care. Dr. Bretsky also shares valuable resources for both health-conscious individuals and primary care providers interested in precision medicine. Join us for insights into the future of healthcare and strategies for better disease prevention and treatment. Dr. Philip Bretsky's Contact Information: Philip M. Bretsky MD PhD MPH FACP 1301 20th Street, Suite 230 Santa Monica, CA 90404 TEL: 310.828.4411 FAX: 310.828.2411 Facebook: @santamonicaprimarycare Twitter / X: @santa_care Instagram: @santa_monica_primary_care Web: www.drbretsky.com & www.santamonicaprimarycare.com My monthly newsletter: https://lp.constantcontactpages.com/su/JtF9zzR Timestamps: 03:18 – Dr. Philip Bretsky’s career path and personalized care. 09:26 – Shifting from treating to preventing disease. 12:02 – Gene-environment interactions and polygenic risk scores. 19:15 – Managing complex health problems as a general practitioner. 29:06 – Reflections on the Human Genome Project’s impact. 36:29 – Case study: Preventing coronary events. 44:17 – Advice for patients on advocating for personalized Resources Mentioned: Books: "Outlive" by Peter Attia "The Age of Scientific Wellness" by Leroy Hood "The Covenant of Water" by Abraham Verghese (fiction, but related to genetic conditions) Podcasts/Newsletters: Eric Topol's substack and Twitter feed Peter Attia's podcast Dr. William Stanford MD PHD FACP Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians. A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine, enhancing his role as a leading expert in the field. Sponsored by: Biography Health Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.…

Precision Medicine Made Simple

1
Redefining the Healthcare Model: Insights from 20-Year Executive Lucy Janoyan 1:20:52

29 weeks ago1:20:52

1:20:52

Redefining the Healthcare Model: Insights from 20-Year Executive Lucy Janoyan In this episode, we're joined by special guest Lucy Janoyan, Chief Strategy Officer at Biography Health. With over two decades of healthcare executive experience, Lucy explores the transition from reactive to proactive healthcare. She discusses the challenges facing primary care providers, the role of genetic testing in personalized medicine, and how Biography Health is working to empower both patients and doctors. Lucy shares insights on continuous health monitoring, patient engagement, and the future of healthcare, offering valuable perspectives for healthcare professionals and health-conscious individuals alike. Timestamps: 00:02:09 - Introduction of guest Lucy Janoyan, Chief Strategy Officer at Biography Health 00:03:28 - Lucy discusses her background and connection with Dr. Stanford 00:06:55 - Discussion of challenges in current healthcare system and move towards precision medicine 00:16:27 - Discussion of issues with current reactive "sick care" system 00:25:52 - Discussion of barriers for physicians in providing preventive care 00:32:28 - Overview of how Biography Health platform works for providers 00:48:56 - Details on Biography Health's features and benefits for providers and patients 00:56:53 - Discussion of ongoing patient monitoring and updates through the platform 01:18:51 - Closing thoughts and how listeners can learn more about Biography Health Dr. William Stanford MD PHD FACP Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians. A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine, enhancing his role as a leading expert in the field. Sponsored by: Biography Health Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.…

Precision Medicine Made Simple

1
Gen Z Takes Action: The Preventive Health Shift 1:06:58

31 weeks ago1:06:58

1:06:58

Gen Z Takes Action: The Preventive Health Shift In this episode, we're joined by two younger guests for our Gen Z special featuring Eliana Stanford, Dr. Stanford's daughter, and Lexie Horizon, whose parents are fellow doctors and friends of Dr. Stanford, and who recently interned at Biography Health. This unique conversation explores why younger generations should care about and take action towards preventive healthcare. Timestamps: 03:39:19 - Elena and Lexie introduce themselves and their backgrounds. 07:50:13 - Discussion on why younger generations are becoming interested in preventive healthcare. 11:37:23 - Dr. Stanford explains what whole genome sequencing is and how it differs from other genetic testing methods. 25:28:19 - Conversation about privacy concerns related to genetic data. 38:46:12 - Discussion on how precision medicine can benefit mental health treatment. 46:57:18 - Exploration of the challenges in making preventive care accessible and affordable. 54:35:01 - Dr. Stanford discusses the potential for precision medicine to improve healthcare in developing countries. 01:05:06 - Concluding remarks on the future of healthcare and the role of the younger generation in shaping it. Dr. William Stanford MD PHD FACP Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians. A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine, enhancing his role as a leading expert in the field. Sponsored by: Biography Health Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.…

Precision Medicine Made Simple

1
Taylor Can't Outrun His Genetics: Lipid Panel Reality Check 56:50

33 weeks ago56:50

56:50

Taylor Can't Outrun His Genetics: Lipid Panel Reality Check In this episode, Dr. Stanford and I uncover surprising truths from my advanced lipid panel. Despite my active lifestyle, the results reveal hidden risks for heart disease and diabetes. We explore how genetic factors and subtle imbalances can impact long-term health, and discuss targeted interventions that could make all the difference. Timestamps: 00:02:39 - Overview of advanced lipid panel and family history 00:05:16 - Discussion of lipoprotein and genetic risk factors 00:08:31 - Analysis of lab results and inflammation markers 00:13:06 - Exploration of uric acid levels and gout risk 00:17:11 - Review of A1C levels and insulin resistance 00:23:33 - Realization of potential atherosclerosis at age 30 00:27:31 - Discussion on genetics vs. lifestyle choices 00:32:10 - Conversation about sugar alternatives and diet 00:38:17 - Projections of future health issues without intervention 00:49:14 - Recap of interventions and lifestyle changes 00:55:07 - Closing thoughts and importance of preventive care Dr. William Stanford MD PHD FACP Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians. A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine, enhancing his role as a leading expert in the field. Sponsored by: Biography Health Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.…

Precision Medicine Made Simple

1
Lipids Explained: Insights for Heart Health 54:39

35 weeks ago54:39

54:39

In this informative episode of the Precision Medicine Made Simple Podcast, we delve into the world of lipids with Dr. Stanford. Learn what lipids are and why they're crucial for your health, especially regarding heart disease prevention. We explore the differences between HDL and LDL cholesterol, discuss genetic factors influencing lipid levels, and explain why even vegetarians need to pay attention to their lipid profiles. Dr. Stanford breaks down advanced lipid panels, explaining key markers like apolipoprotein B and lipoprotein(a). We address when to start checking your lipids and why family history is a powerful tool in assessing your risk. The episode also touches on exciting developments in lipid management, including potential new treatments for high lipoprotein(a) levels. Timestamps: 03:12 - Explanation of what lipids are and their importance 06:02 - Discussion of atherosclerosis and heart disease risk 07:35 - Explanation of "good" vs "bad" cholesterol (HDL vs LDL) 11:28 - Discussion of vegetarian diets and cholesterol levels 13:16 - Introduction of familial hypercholesterolemia and lipoprotein(a) 16:21 - Lifestyle factors and genetic predisposition to high cholesterol 19:36 - Discussion of new medications and treatments in development 25:53 - Guidelines for lipid testing and personalized medicine approach 34:22 - Detailed explanation of advanced lipid panel markers 46:56 - Explanation of new drug development processes for lipid management Dr. William Stanford MD PHD FACP Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians. A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine, enhancing his role as a leading expert in the field. Sponsored by: Biography Health Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.…

Precision Medicine Made Simple

1
From Genes to Actions: Taylor's DNAbled Blueprint Experience 1:21:48

37 weeks ago1:21:48

1:21:48

From Genes to Actions: Taylor's DNAbled Blueprint Experience Today marks the beginning of an ongoing series where I'm pulling back the curtain on my personal journey through the DNAbled Blueprint process. You'll get an exclusive, firsthand look at: My own intake form: Revealing insights from my personal and family health history One of my genetic reports: Dr. Stanford examines my polygenic risk score, discussing my genetic predisposition to certain health conditions My personalized DNAbled Blueprint consultation: Experience the moment I receive my tailored health recommendations and action plan This intimate look at my health journey aims to demystify the process and inspire you to take charge of your own wellbeing. Dr. Stanford has equipped me with specific action items, so we'll be recording numerous episodes discussing my results and the strategies I'm implementing. Join me as we explore the ongoing impact of precision medicine in real-time. Plus, our sponsor Biography Health is offering early access users a special introductory rate for the DNAbled Blueprint. This includes app access, reports, and a personalized recommended health strategy. If you're interested in participating, feel free to email me directly at taylor@biographyhealth.com . Timestamps: 00:04:36 - Intake Form Walkthrough 00:38:26 - Allelica Report, Polygenic Risk Scores 00:53:25 - DNAbled Blueprint Consultation Dr. William Stanford MD PHD FACP Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians. A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine, enhancing his role as a leading expert in the field. Sponsored by: Biography Health Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.…

Precision Medicine Made Simple

1
Cracked the Genetic Code! Methylation and the Future of Precision Medicine 35:28

39 weeks ago35:28

35:28

Cracked the Genetic Code! Methylation and the Future of Precision Medicine This is the second half of the two part series to Dr. Stanford’s presentation called, “Optimizing Healthspan and Longevity by Implementing Personalized Precision Medicine.” For this episode, we dive into the science of methylation patterns and how we can use it to detect various cancers and their tissue origins enabling early intervention for better treatment outcomes and ultimately paving the way for tailored therapies. Similar to the last episode, there are supporting graphics and diagrams so we highly recommend watching this episode on our YouTube channel as this discussion does get pretty technical in various parts of the conversation. Timestamps: [00:04:22] Detecting cancer through DNA methylation patterns. [00:08:56] DNA sequencing reveals gene expression patterns. [00:12:15] Cancer turns off genes, DNA sequencing detects. [00:16:01] Detect tumor DNA in bloodstream. Identify cancer signal. [00:19:20] Methylation patterns in DNA detect cancer. [00:22:55] Screening for cancer over fifty. Insurance doesn't cover yet. [00:26:09] Precision medicine case study on heart health. [00:29:25] Imaging center found life-saving genetic risk. [00:32:24] Personalized medicine increases health span, reduces costs. Dr. William Stanford MD PHD FACP Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians. A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine, enhancing his role as a leading expert in the field. Sponsored by: Biography Health Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.…

Precision Medicine Made Simple

1
Precision Medicine 101: Crash Course 55:22

41 weeks ago55:22

55:22

These next two episodes are a two part series to Dr. Stanford’s presentation called “Optimizing Healthspan and Longevity by Implementing Personalized Precision Medicine. Think of this episode like Precision Medicine 101. Dr. Stanford dives into a number of different topics including the evolution of personalized precision medicine and how its changing healthcare, the significance of knowing your risks by looking at genetics, family history, monogenic risks and polygenic risk scores, and pharmacogenomics which is tailoring drug treatments based on individual genetic variations. While this episode is available on audio platforms, we highly recommend watching this episode on YouTube as Dr. Stanford references numerous visuals and graphs. Timestamps: [00:06:05] Personalized precision medicine focuses on prevention and early detection. Patient-centered care needed for effectiveness. Regulatory bodies must adapt to rapid advancements. [00:11:48] Genetic sequencing now faster, cheaper. Exciting advancements. [00:18:06] Genetic variation leads to personalized medicine. [00:22:53] Future of healthcare: personalized, predictive, proactive. [00:28:20] Combining genetic and clinical factors. [00:33:32] Assess risk using family history and polygenic risk scores. [00:39:43] Risk stratification crucial for preventive care. [00:45:03] Genetic testing can personalize drug treatment. [00:49:39] Precision medicine improves drug reactions prediction. Dr. William Stanford MD PHD FACP Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians. A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine, enhancing his role as a leading expert in the field. Sponsored by: Biography Health Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.…

Precision Medicine Made Simple

1
The Challenge with Cancer: It's Not That Simple 1:21:08

43 weeks ago1:21:08

1:21:08

For this episode, Dr. Stanford, Alyssa Stanford, and Taylor Cu discuss the topic of cancer. Dr. Stanford provides a comprehensive breakdown of cancer cells, stressing the need for genetic and molecular profiling to tailor treatments. They explore the factors that contribute to cancer development, including lifestyle choices and genetic mutations, and emphasize the importance of early detection through screenings and genetic analysis. They also dive into the exciting advancements in early cancer identification, as well as the role of the immune system in fighting cancer cells. Timestamps: [00:15:36] Preventative measures key to reducing cancer. [00:30:57] Early detection key for cancer survival. [00:47:08] Precision medicine uses genetic risk factors to predict future cancer risk and inform treatment decisions. Inflammation and oxidative stress play a role in cancer development. [01:02:36] Cancer complexity and precision medicine summary. Dr. William Stanford MD PHD FACP Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians. A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Sponsored by: Biography Health Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.…

Precision Medicine Made Simple

1
The Root of All Evil: Insulin Resistance 59:18

45 weeks ago59:18

59:18

For this episode, Dr. Stanford, Alyssa Stanford, and Taylor Cu dive into the complexities of metabolic syndrome, how it can relate to several chronic diseases and discuss the impact of genetics, diet, and exercise on our overall health. We also touch on the importance of precision medicine and continuous glucose monitoring in managing conditions like diabetes and touch on some of the benefits of medications currently out there like Ozempic. Timestamps: [00:05:44] Metabolic syndrome increases chronic disease risk. [00:10:26] Fatty liver disease is a modern problem. [00:16:27] Processed foods worsen metabolic health, inflammation. [00:22:40] Eating standing up may worsen insulin resistance. [00:29:05] High insulin levels lead to diabetes. [00:35:15] Dexcom for diabetics, Ozempic for symptoms. [00:40:59] Medications show promise for various benefits. [00:46:22] Metabolic syndrome is often overlooked. [00:52:39] Improve health with precision medicine steps. Dr. William Stanford MD PHD FACP Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians. A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Sponsored by: Biography Health Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.…

Precision Medicine Made Simple

1
Alzheimer's: Could it Be Prevented? 48:39

47 weeks ago48:39

48:39

In this episode, we’re joined by Dr. Stanford and Taylor Cu to explore neurodegenerative diseases such as Alzheimer’s and Parkinson's. It's a particularly personal discussion as Dr. Stanford shares his own genetic risk for Alzheimer’s, linked to the APOE4 gene. Dr. Stanford explains what neurodegenerative diseases are and dives into the specifics of Alzheimer's, including how genetics play a role in its risk. We wrap up the episode by looking at lifestyle changes that could make a significant impact in prevention. Timestamps: [00:04:50] Degenerative diseases share commonality in brain shrinkage. Alzheimer's is most common, starts early. [00:09:24] APOE Epsilon four leads to abnormal function in cholesterol transport, amyloid plaques and tau proteins play a role in Alzheimer's disease progression. [00:14:03] Alzheimer's disease is complex and mysterious. [00:18:00] Lifestyle impacts neurodegenerative disease risk. [00:22:37] Difference between Alzheimer's and general dementia. [00:27:07] Inflammation bad for heart and brain. [00:32:23] Genetic testing can predict future health. [00:37:44] Prevent dementia with lifestyle changes. [00:43:01] Improve brain health with exercise, socialization. Dr. William Stanford MD PHD FACP Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians. A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Sponsored by: Biography Health Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.…

Precision Medicine Made Simple

1
Heart Disease and More 47:15

49 weeks ago47:15