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Chemistry AND Reinventing Progress with Professor Katalin Karikó
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Professor Katalin Karikó’s research led to the creation of the messenger RNA Covid-19 vaccine, which has saved so many lives and helped curb the impact of the pandemic. She has quite literally changed the world! Ilham sits down with Professor Karikó to talk about her invaluable research; her passion for science; her upbringing in Hungary; women in science, technology, engineering and math (STEM) careers; her advice for young scientists, and much more
1:42 - Upbringing in Hungary
5:26 - Move to the United States
7:43 - Development of the Covid-19 vaccine
11:23 - mRNA technology as a potential solution for other diseases
13:49 - Receiving the covid-19 vaccine - the results of her work
15:19 - Story of resilience and determination amid challenges
21:15 - Adjusting to almost overnight fame
22:50 - Educating the public
24:06 - Championing women scientists
24:44 - Role models
28:28 - Advice to young scientists
Professor Katalin Karikó is an adjunct professor at the University of Pennsylvania, where she worked for 24 years before joining BioNTech SE in 2013 as a senior VP. She is also professor at University of Szeged, Hungary from where she received her PhD in biochemistry in 1982. For decades, her research has focused on RNA-mediated mechanisms with the ultimate goal of developing mRNA for protein therapy. She investigated RNA-mediated immune activation and together with Drew Weissman discovered that nucleoside modifications suppress the immunogenicity of RNA, which widened the therapeutic potentials of mRNA. Her patent, co-invented with Drew Weissman, was used to create the FDA-approved covid-19 mRNA vaccines by BioNTech/Pfizer and Moderna.
Her groundbreaking contribution was to use chemistry to modify the mRNA so that it wouldn't be rejected by the immune system. In the future, her research could be applied to many other diseases such as cancer, influenza, malaria, tuberculosis, and so much more.
Professor Karikó has won numerous awards for her incredible work, including the Solvay Prize.
For additional details about the podcast, show notes, and access to resources mentioned during the show, please visit https://www.syensqo.com/en/podcast
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