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biosights: January 2, 2018

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Content provided by Rockefeller University Press and The Rockefeller University Press. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Rockefeller University Press and The Rockefeller University Press or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.

Ring out your dead: MRCKα cleavage triggers epithelial extrusion

Dying epithelial cells are extruded from the tissue by a basal actomyosin ring formed in neighboring, healthy cells. Gagliardi et al. reveal that epithelial extrusion is also driven by actin rearrangements in the apoptotic cell, where cleavage of the kinase MRCKα induces the assembly of an apical actin ring that collapses the cell body and moves the dying cell upward. This biosights episode presents the paper by Gagliardi et al. from the January 2nd, 2018, issue of the Journal of Cell Biology and includes an interview with the paper's first author, Paolo Gagliardi (Candiolo Cancer Institute, Candiolo, Italy). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.

Subscribe to biosights via iTunes or RSS View biosights archive

The Rockefeller University Press biosights@rockefeller.edu

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119 episodes

Artwork

biosights: January 2, 2018

biosights

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Manage episode 198455421 series 2045212
Content provided by Rockefeller University Press and The Rockefeller University Press. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Rockefeller University Press and The Rockefeller University Press or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.

Ring out your dead: MRCKα cleavage triggers epithelial extrusion

Dying epithelial cells are extruded from the tissue by a basal actomyosin ring formed in neighboring, healthy cells. Gagliardi et al. reveal that epithelial extrusion is also driven by actin rearrangements in the apoptotic cell, where cleavage of the kinase MRCKα induces the assembly of an apical actin ring that collapses the cell body and moves the dying cell upward. This biosights episode presents the paper by Gagliardi et al. from the January 2nd, 2018, issue of the Journal of Cell Biology and includes an interview with the paper's first author, Paolo Gagliardi (Candiolo Cancer Institute, Candiolo, Italy). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.

Subscribe to biosights via iTunes or RSS View biosights archive

The Rockefeller University Press biosights@rockefeller.edu

  continue reading

119 episodes

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