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biosights: July 3, 2017

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Content provided by Rockefeller University Press and The Rockefeller University Press. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Rockefeller University Press and The Rockefeller University Press or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.

Myosins team up to help secretory granules integrate

Actomyosin contractility drives a variety of membrane remodeling events, including the integration of secretory granules into the apical plasma membrane after exocytosis. By visualizing granule integration in the salivary glands of live mice, Milberg et al. reveal that myosin IIA and myosin IIB act at different stages of the process and that the activation and assembly of these myosin isoforms into contractile filaments is regulated by the F-actin scaffold, which assembles on secretory granules and recruits myosin light chain kinase. This biosights episode presents the paper by Milberg et al. from the July 3rd, 2017, issue of The Journal of Cell Biology and includes an interview with the paper's senior author, Roberto Weigert (National Institutes of Health, Bethesda, MD). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.

Subscribe to biosights via iTunes or RSS View biosights archive

The Rockefeller University Press biosights@rockefeller.edu

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119 episodes

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biosights: July 3, 2017

biosights

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Manage episode 198086800 series 2045212
Content provided by Rockefeller University Press and The Rockefeller University Press. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Rockefeller University Press and The Rockefeller University Press or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.

Myosins team up to help secretory granules integrate

Actomyosin contractility drives a variety of membrane remodeling events, including the integration of secretory granules into the apical plasma membrane after exocytosis. By visualizing granule integration in the salivary glands of live mice, Milberg et al. reveal that myosin IIA and myosin IIB act at different stages of the process and that the activation and assembly of these myosin isoforms into contractile filaments is regulated by the F-actin scaffold, which assembles on secretory granules and recruits myosin light chain kinase. This biosights episode presents the paper by Milberg et al. from the July 3rd, 2017, issue of The Journal of Cell Biology and includes an interview with the paper's senior author, Roberto Weigert (National Institutes of Health, Bethesda, MD). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.

Subscribe to biosights via iTunes or RSS View biosights archive

The Rockefeller University Press biosights@rockefeller.edu

  continue reading

119 episodes

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