Jeff Sperry - Safer, earlier.

Modern Chemistry Podcast

One minor clarification Jeff asked me to make - at around 7:15 he mentions that Vertex does not do any commercial manufacturing in-house. Vertex does not perform in-house, commercial scale production of drug substances.

You will hear the following terms used during the interview. I’ve included some descriptions and links to deeper reading.

• Vertex - Vertex Pharmaceuticals - https://www.vrtx.com/
• Exotherm – An exothermic reaction is one that gives off heat. The phrase exotherm is often used as a shortened form of ‘exothermic reaction’. Unwanted exotherms in process safety cause a potential safety hazard, as they can potentially heat a reaction, beyond the safe limits of available cooling.
• DSC – Differential Scanning Calorimetry (DSC) is a technique for thermal analysis, in which, the difference in the amount of heat required to increased the temperature of a sample is measured as a function of temperature. It can be used to determine a number of properties of a sample.
• TSU – The Thermal Screening Unit (TSU) is a system used to screen materials for potential hazards associated with heating.
• ARC – Accelerating Rate Calorimeter (ARC) is a system used to measure heat generating characteristics of reactions, or reaction components at a range to temperatures.Other reaction data can be determined with this tool
• GLP Tox Lot. - A Good Laboratory Toxicology lot is a batch of a drug, or drug like material prepared during drug development with the intention of testing safety (and other) properties.
• API – The Active Pharmaceutical Ingredient (API) is the drug element of a medicine. The drug would be, for example, diluted down with saline solution to make a medicine ready for injection.
• Buller Empowerment - https://bullerempowerment.com/
• Taylor Howard – As Jeff mentioned, he follows Taylor on LinkedIn – she’s at https://www.linkedin.com/in/taylorhow

If you want to connect with Jeff, or find out more about his lab, you can find:

On LinkedIn, Jeff can be found at https://www.linkedin.com/in/jeffreybsperry/

On Twitter, Jeff goes by @SafeChem79 - https://twitter.com/SafeChem79

Our theme music is "Wholesome" by Kevin MacLeod (https://incompetech.com)

Music from https://filmmusic.io

License: CC BY (http://creativecommons.org/licenses/by/4.0/)

Connect with me (Paul) at https://www.linkedin.com/in/paulorange/

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