Optimal management of bipolar disorder begins with accurate diagnosis. The Depression and Bipolar Alliance reported that the misdiagnosis rate is 67% for bipolar patients with the most common misdiagnoses being unipolar depression (60%), anxiety disorder (26%), schizophrenia (18%), and borderline or antisocial personality disorder (17%). When diagnosis is inaccurate or delayed, initial therapy is not properly derived or promptly delivered. In this series of neuroscienceCME Chart Reviews, the faculty will take participants through a series of patient cases focusing on assessment, treatment, and treatment adherence to improve the long-term management of patients with bipolar disorder. Faculty will engage participants in the discussion and development of best practice tips to apply in practice.