199 - Mass Spectrometers

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Guest: Alexander Makarov Host: Markus Voelter Shownoter: Bastian Hundt

Mass spectrometers are devices for measuring the mass-to-charge ratio of molecules and ions. They use many different measurement principles and are used in various areas of science. Our guest Alexander Makarov works as a Director Global Research for Thermo Fisher‘s Life Sciences Division and has invented the Orbitrap principle used widely in modern mass spectrometers. We talk about mass spectrometry in general, the different measurement principles, engineering challenges, the invention of the Orbitrap, use cases for mass spectrometers and the different machines sold by Thermo Fisher.

Introduction of Alexander Makarov

00:01:18

Thermo Fisher | Alexander Makarov

Introduction to Mass-Spectrometers

00:06:59

Mass Spectrometers | Mass | Electromagnetic field | Ionization | Mass-To-Charge ratio | Matrix-assisted laser desorption/ionization | Electrospray Ionization | Deconvolution | Carbon-13 | Isotope analysis | Ernst Rutherford | Isotope-ratio mass spectrometry

Description of a Mass Spectrometer

00:27:48

Signal Processing < | Electro ionization | Chemical ionization | Gas chromatography | Liquid chromatography mass spectrometry | Quadrupole mass analyzer | Targeted mass spectroscopy | Time-of-flight mass spectroscopy | Ion optics / Electrostatic lens | Ion trap mass analyzers | Fourier transform ion cyclotron resonance

Orbitrap

00:55:08

Orbitrap | Spark ionization | Ion trap | Chaos theory | Nonlinear system | DNA

Requirements for commercial Mass Spectrometers

01:10:48

Linear Response | Accuracy and prescision | Resolution in a mass spectrometer | Dynamic range | Quantification | Quantitative analysis

Challenges of modern Mass Spectrometers

01:32:38

Tour of the Factory / R&D

01:43:33

Electron Multiplier | Collision Cell

End

02:19:28