24. Defy Aging: The Science of Cellular Senescence Explained with Dr. Greg Kelly

Healthy AF | Healthy After 50

In this episode of Healthy AF (Healthy After 50), Zane Griggs interviews Dr. Greg Kelly, a leading expert on aging and cellular health, to discuss a critical concept: cellular senescence. This scientific term may hold the key to longevity, muscle retention, and vitality as we age.

What is Cellular Senescence?

Dr. Kelly explains cellular senescence as a biological process where aging cells stop dividing but don't die off. Instead, they linger in the body, contributing to inflammation and accelerating the aging process. These “zombie cells” can disrupt the function of healthy cells and tissues, playing a role in age-related diseases.

The Impact on Longevity and Muscle Health

For individuals over 50 focused on muscle building, cellular senescence can be a hidden roadblock. Dr. Kelly highlights how managing these senescent cells can help optimize physical performance and recovery. Zane and Dr. Kelly discuss ways to target these aging cells to enhance longevity, preserve muscle, and maintain high performance.

Nutritional and Supplement Strategies

The conversation dives into cutting-edge nutritional and supplement strategies to combat cellular senescence. Dr. Kelly shares the latest research on compounds like quercetin and fisetin, which have shown promise in reducing senescent cells and promoting overall cellular health. These insights offer practical solutions for anyone looking to slow the effects of aging.

The Role of Lifestyle in Cellular Health

Beyond supplements, lifestyle choices play a critical role in managing cellular senescence. Dr. Kelly emphasizes the importance of regular exercise, stress management, and proper sleep to support the body's ability to clear out senescent cells. Zane adds his perspective on how building muscle and staying active can significantly influence cellular health and longevity.

Final Thoughts

In this episode, Zane Griggs and Dr. Greg Kelly explore the science behind cellular senescence and provide actionable insights into how we can slow the aging process, retain muscle, and maintain peak performance. Whether through targeted supplements or lifestyle adjustments, understanding cellular health is key to living a longer, healthier life after 50.

Listen to the Full Episode Hit play to hear the conversation on Healthy AF (Healthy After 50) to discover more about the fascinating world of cellular senescence and longevity.

Connect with Zane:

• Follow me on Instagram: https://www.instagram.com/zanegriggsfitness

• Website: https://zanegriggs.com

• ReLyte Electrolytes by Redmond Real Salt: https://shop.redmond.life?afmc=Zane

Quick Episode Summary:

• 0:00 Introduction: Zane introduces Dr. Greg Kelly and the topic of cellular senescence.
• 2:10 What Is Cellular Senescence? Dr. Kelly explains the science behind aging cells.
• 6:00 How Senescent Cells Impact Aging: The effects of these "zombie cells" on health and longevity.
• 10:45 Key Nutrients to Combat Senescence: The role of quercetin, fisetin, and other supplements.
• 15:30 Muscle Health and Senescence: Zane and Dr. Kelly discuss muscle recovery and aging.
• 20:50 Mitochondrial Function and Longevity: How maintaining energy production is key.
• 27:15 Lifestyle Choices to Support Cellular Health: Exercise, diet, and habits to slow aging.
• 32:40 Stress Management: The link between chronic stress and cellular aging.
• 37:30 Supplements for Longevity: Dr. Kelly shares top supplements to support brain and body health.
• 43:15 Practical Tips: How to start implementing anti-aging strategies today.
• 49:00 Final Thoughts: Zane and Dr. Kelly recap the importance of cellular health and longevity.