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Protective mutations with Vyas Ramanan (Third Rock Ventures, Maze Therapeutics)

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Manage episode 277026234 series 2769784
Content provided by Anika Gupta. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Anika Gupta or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.

Today I discuss with Vyas Ramanan, of Third Rock Ventures and Maze Therapeutics, the evolution of the field's understanding of genetic modifiers and the role they play in disease, how drug discovery works when attempting to recapitulate protective effects of certain mutations, and how the convergence of certain advances in statistics and genomic sequencing and perturbation tools enable pressure testing of hypotheses at an unprecedented scale.

Check out the glossary of terms, definitions, and resources (and get a sneak peak of the future conversations lined up!) here: bit.ly/datapulse-glossary

--- Support this podcast: https://podcasters.spotify.com/pod/show/the-data-pulse/support
  continue reading

25 episodes

Artwork
iconShare
 
Manage episode 277026234 series 2769784
Content provided by Anika Gupta. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Anika Gupta or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.

Today I discuss with Vyas Ramanan, of Third Rock Ventures and Maze Therapeutics, the evolution of the field's understanding of genetic modifiers and the role they play in disease, how drug discovery works when attempting to recapitulate protective effects of certain mutations, and how the convergence of certain advances in statistics and genomic sequencing and perturbation tools enable pressure testing of hypotheses at an unprecedented scale.

Check out the glossary of terms, definitions, and resources (and get a sneak peak of the future conversations lined up!) here: bit.ly/datapulse-glossary

--- Support this podcast: https://podcasters.spotify.com/pod/show/the-data-pulse/support
  continue reading

25 episodes

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