The Role of Mitochondrial Quality Control Pathways in Familial and Non-Familial Variants of Disease, with David Tumbarello

The Genomics Lab

Join us today as we speak to Dr David Tumbarello, from the University of Southampton, as he talks to us about his dynamic and varied academic career that has taken him from New York, to Southampton, stopping off at a number of places in between!! David's lab currently focuses on understanding the cellular mechanisms and molecular machinery required for subcellular trafficking of membrane associated and cytosolic cargo via endocytosis and autophagy. Knowledge of these mechanisms is critical for understanding the molecular mechanisms of cancer and neurodegenerative diseases , which stem from defects in various membrane trafficking and cell signalling pathways.

Today we discuss one of David's lab's recent papers, published June 2020, which looks at multiple mitochondrial quality control pathways that exist to maintain the health of mitochondria, the mitochondrial stress response and identify the interaction of molecules associated with this response with E3 ubiquitin ligase Parkin - involved in Parkinson's disease.

Read the paper here: https://eprints.soton.ac.uk/438725/

Find David on Twitter here: @DavidTumbarello

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